{"slug":"melanotan-ii","verification":{"valid":true,"entries":4,"head":"bde45647758fb70bfbb5a2acef6146e491a1a7bda5f51eea022cec607d6cb95b"},"count":4,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40210573/","title":"Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?","quote":"The case of a 22-year-old female who developed a mass in the anterior maxilla after using Melanotan II, a nasal spray containing a synthetic analogue of melanocyte-stimulating hormone, is reported. ... Histological analysis confirmed the diagnosis of a mucosal malignant melanoma.","summary":"2025 case report linking Melanotan II nasal spray use to oral mucosal malignant melanoma in a young female; highlights unlicensed status and need for awareness of serious side effects.","author":"","publisher":"","date":"","claim_ids":["c1"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:07:16.920Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"9a521120b00db5003e950bcc79b88131f8747109e7a00685c0b4fc8c39985b65","source_role":"mechanism_support"},{"id":"s2","type":"clinical_trial","url":"https://www.trialx.com/clinical-trials/listings/337033/melanotan-ii-mt-ii-as/","title":"Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental Vitiligo","quote":"This example interventional study record describes a randomized Phase 2 clinical trial evaluating investigational Melanotan II (MT-II) as an adjunct to standard NB-UVB phototherapy for repigmentation in adults with stable nonsegmental vitiligo. ... Recruiting","summary":"May 2026 listing of ongoing Phase 2 RCT (NCT07437560) testing MT-II safety and efficacy as add-on to phototherapy for vitiligo repigmentation.","author":"","publisher":"","date":"","claim_ids":["c2"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:07:16.920Z","link_status":"ok","quote_status":"verified","prev":"9a521120b00db5003e950bcc79b88131f8747109e7a00685c0b4fc8c39985b65","hash":"38b23f3fc8a365505b1aea535c189a4797f24e7c9c421d41f17c4d542f90237c","source_role":"adjacent_context"},{"id":"s3","type":"medical","url":"https://www.sciencedirect.com/science/article/pii/S2352512626002766","title":"Five primary melanomas in situ in a patient with recent tanning bed use, melanotan exposure, and anabolic hormone use","quote":"Five primary melanomas in situ in a patient with recent tanning bed use, melanotan exposure, and anabolic hormone use. ... Melanotan I primarily targets MC1R, whereas melanotan II is a nonselective agonist with broader systemic effects","summary":"2026 case report of multiple primary melanomas in situ associated with recent Melanotan (II) exposure along with other risk factors.","author":"","publisher":"","date":"","claim_ids":["c3"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:07:16.920Z","link_status":"http_400","quote_status":"unverified","prev":"38b23f3fc8a365505b1aea535c189a4797f24e7c9c421d41f17c4d542f90237c","hash":"10edff64ddcdc5c655638f4014c88ae8a08808f8dfbcd843f118e1e70c364ecc","source_role":"adjacent_context"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41752902/","title":"Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report","quote":"This case report presents a three-month follow-up of a patient who self-administered Melanotan II injections over a period of 64 days with the goal of achieving a deeper tanning effect.","summary":"2026 case report documenting oral mucosal pigmentation changes following Melanotan II use, with follow-up observations on resolution after discontinuation.","author":"","publisher":"","date":"","claim_ids":["c4"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T17:07:35.557Z","link_status":"ok","quote_status":"verified","prev":"10edff64ddcdc5c655638f4014c88ae8a08808f8dfbcd843f118e1e70c364ecc","hash":"bde45647758fb70bfbb5a2acef6146e491a1a7bda5f51eea022cec607d6cb95b","source_role":"mechanism_support"}]}