{"slug":"ll-37","verification":{"valid":true,"entries":20,"head":"4ebbcbd468bc167d08330bb40e297ce263e49cd370a58e1094e11135242b47da"},"count":20,"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41270816/","title":"Decoding LL-37: Structure and antimicrobial mechanisms ...","quote":"LL-37 effectively combats over 38 bacteria, 16 fungi, and 16 viruses through various mechanisms, including membrane rupture, targeting, and ...","summary":"Details structure, broad antimicrobial activity of LL-37 against bacteria, fungi, viruses.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"c310088a83c7e5765aca0df8fffdf0d2a5481216dc68f416d67ca8f0f30f07bb"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41544412/","title":"LL-37 antimicrobial peptide: Molecular characterisation ...","quote":"LL-37 plays a multifaceted role in oral immunity by integrating antimicrobial, immunomodulatory, and tissue-regenerative functions.","summary":"Narrative review on LL-37 in oral health and disease, 2026 publication.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"verified","prev":"c310088a83c7e5765aca0df8fffdf0d2a5481216dc68f416d67ca8f0f30f07bb","hash":"b80c17a98c3339d0034946b32d8d5c05cbc0f4db3292630e3595490d431bb7c6"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40869425/","title":"Antimicrobial Peptides of the Cathelicidin Family: Focus on ...","quote":"LL-37-based analogs represent promising candidates for the development of next-generation antimicrobial and immunomodulatory therapies.","summary":"Review focusing on LL-37 and modifications for therapies, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"verified","prev":"b80c17a98c3339d0034946b32d8d5c05cbc0f4db3292630e3595490d431bb7c6","hash":"2eb72bca774032ad4227b5b23eb378bc30b2112322589e4a2127a293b3210f9b"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40960088/","title":"Significance of the LL-37 Peptide Delivered from Human ...","quote":"One approach to develop new treatments for patients with sepsis is to better understand the pleiotropic function of the human LL-37 peptide that ...","summary":"Explores LL-37 in sepsis treatment contexts, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"unverified","prev":"2eb72bca774032ad4227b5b23eb378bc30b2112322589e4a2127a293b3210f9b","hash":"387835ed67b3a6a56011aabf2e6c48930ce89a4b2e5718e597748a3b08c21060"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39837472/","title":"Human cathelicidin LL-37 rapidly disrupted colonic ...","quote":"LL-37 increases epithelial cell permeability by degrading TJ proteins occludin and claudin-2 through endocytosis and lysosomal degradation.","summary":"Study on LL-37 effects on colonic epithelium and tight junctions, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"verified","prev":"387835ed67b3a6a56011aabf2e6c48930ce89a4b2e5718e597748a3b08c21060","hash":"75fdfeec48837b3dde7cf509b74f4bbc11684615c075fe580b0ee197655737f0"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40063262/","title":"Human antimicrobial/host defense peptide LL-37 may ...","quote":"LL-37 may prevent the spread of a local infection through multiple mechanisms: an update","summary":"Update on LL-37 preventing infection spread, 2025 review.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"verified","prev":"75fdfeec48837b3dde7cf509b74f4bbc11684615c075fe580b0ee197655737f0","hash":"2d23da955bd68a3cf68da4ff42841c62d14ad413f0ba869db6119734644d34ad"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39643165/","title":"LL-37, the master antimicrobial peptide, its multifaceted ...","quote":"LL-37 has emerged as a significant player, demonstrating its multifaceted roles during bacterial, fungal, and viral infections, as well as exhibiting ...","summary":"Review on LL-37 roles in infections to cancer immunity, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"unverified","prev":"2d23da955bd68a3cf68da4ff42841c62d14ad413f0ba869db6119734644d34ad","hash":"3a0ef9b4df22a986a61d7821416ff20da7c0b985273a89e9d2cfdc5a42ebebd5"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40612001/","title":"Antimicrobial peptide LL-37 increases rhinovirus-induced ...","quote":"The human cathelicidin LL-37 is active against both bacteria and viruses , but it also shows immunomodulatory properties.","summary":"LL-37 effects on rhinovirus and immunomodulation, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"unverified","prev":"3a0ef9b4df22a986a61d7821416ff20da7c0b985273a89e9d2cfdc5a42ebebd5","hash":"213c804900bae5bed0b6fb73473ff9e333a98d5248b03ffa55d67aa8c7026763"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39873762/","title":"Study of cathelicidin (LL-37) immunoexpression in the skin ...","quote":"The present work aimed to study the immunoexpression of cathelicidin in the vitiligo patients' skin to elucidate its possible role in vitiligo pathogenesis.","summary":"Immunoexpression study of LL-37 in vitiligo, 2025.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"verified","prev":"213c804900bae5bed0b6fb73473ff9e333a98d5248b03ffa55d67aa8c7026763","hash":"b7225cefadf8c305c5bb17998e5ce5bf997cb76229029c99a578a9eca75eeb78"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40410820/","title":"LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated ...","quote":"Overall, our findings showed that LL-37 and citLL-37 can selectively suppress the abundance of IL-17A/F-mediated LCN-2, a protein that is ...","summary":"Modulation of IL-17 by LL-37 variants, 2025 study.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:16.333Z","link_status":"ok","quote_status":"unverified","prev":"b7225cefadf8c305c5bb17998e5ce5bf997cb76229029c99a578a9eca75eeb78","hash":"48fa6d06147281e5c30fbfaf11481aa6ba175af25415d7793e4b1208d02ee54d"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39954662/","title":"Cathelicidin LL-37 in periodontitis: current research progress and prospects","quote":"This review summarizes the expression and roles of LL-37 in periodontitis, providing new perspectives and insights into its pathogenesis and treatment.","summary":"Review on LL-37 expression and roles in periodontitis pathogenesis and treatment.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:35.241Z","link_status":"ok","quote_status":"unverified","prev":"48fa6d06147281e5c30fbfaf11481aa6ba175af25415d7793e4b1208d02ee54d","hash":"47c01869d02b9bc0bbef64d01f03ef9885194f91a2a77c1f3b5a8f378ae39d43"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41791569/","title":"Exploring the Role of Cathelicidin LL-37 and Ceragenins in Wound Healing","quote":"This work reviews literature describing the role of AMPs, particularly LL-37 and synthetic ceragenins, in wound healing.","summary":"Review on LL-37 and ceragenins in wound healing.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:35.241Z","link_status":"ok","quote_status":"verified","prev":"47c01869d02b9bc0bbef64d01f03ef9885194f91a2a77c1f3b5a8f378ae39d43","hash":"e747cc5eb3b55ad0337a7bb25db8c3e4f33ce41f22f41c86747da0eeb0f2dace"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41064641/","title":"Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike, ORF7a, and ORF8 proteins and inhibits viral replication","quote":"LL-37 disrupts key viral-host interactions by binding to Spike, ORF7a, and ORF8, thereby reducing SARS-CoV-2 infectivity.","summary":"LL-37 binds SARS-CoV-2 proteins and inhibits replication.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:35.241Z","link_status":"ok","quote_status":"verified","prev":"e747cc5eb3b55ad0337a7bb25db8c3e4f33ce41f22f41c86747da0eeb0f2dace","hash":"dcf0546b0a77a9a7a589c6de22e6bf9624de4de1c66eae9e30eefa02e67ffa9e"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41862276/","title":"LL-37 and bacterial DNA complexes in dental plaque","quote":"This review summarizes current knowledge of the molecular mechanisms and immunological consequences of LL-37-bacterial DNA interactions in dental plaque.","summary":"Review on LL-37 and bacterial DNA in dental plaque.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:35.241Z","link_status":"ok","quote_status":"unverified","prev":"dcf0546b0a77a9a7a589c6de22e6bf9624de4de1c66eae9e30eefa02e67ffa9e","hash":"1d71ee1acc05e1f826520b8228dbea8bfd3953afb08ee442a621fab5a2e0d190"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883500/","title":"Vicenin-2 attenuates rosacea-like inflammation by targeting the IL-17RA/NF-κB pathway","quote":"Vicenin-2 alleviates LL-37-induced rosacea-like inflammation by regulating the IL-17RA/NF-κB pathway.","summary":"LL-37-induced rosacea model and anti-inflammatory effects.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:35.241Z","link_status":"ok","quote_status":"unverified","prev":"1d71ee1acc05e1f826520b8228dbea8bfd3953afb08ee442a621fab5a2e0d190","hash":"89e11b2694a1629b57dcff0bf21c277955bb91f5cfb9f3b5a4afcab7527340e5"},{"id":"s16","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41485275/","title":"LL-37-derived peptide shows promising antimicrobial ...","quote":"In this study, we designed a series of antimicrobial peptides by fusing the two fragments of antimicrobial peptides Cathelicidin-BF (1-9) and LL-37 (17-29), and ...","summary":"Study on LL-37-derived peptides for antimicrobial activity.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:59.261Z","link_status":"ok","quote_status":"unverified","prev":"89e11b2694a1629b57dcff0bf21c277955bb91f5cfb9f3b5a4afcab7527340e5","hash":"dd064c4631ff8947f82c1cad1c2fce4eda862c0451312517df3dfedcb8a5f4a4"},{"id":"s17","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41654238/","title":"CRISPR/Cas9-engineered Salmonella phage displaying ...","quote":"LL-37 -engineered bacteriophages demonstrated improved antibacterial activity and intracellular infection control against S. Typhimurium.","summary":"Research on LL-37 engineered phages for antibacterial effects.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:59.261Z","link_status":"ok","quote_status":"unverified","prev":"dd064c4631ff8947f82c1cad1c2fce4eda862c0451312517df3dfedcb8a5f4a4","hash":"6c2f579a8e359a2f5fa5daf2b1294b9a38ff7dc78509dce2b3b9aa0e5a00bd5a"},{"id":"s18","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41674152/","title":"Structural determinants of glycosaminoglycan ...","quote":"The human antimicrobial peptide LL-37 exerts a dual role in cancer, promoting tumor progression in breast carcinoma by stimulating calcium influx and enhancing ...","summary":"LL-37's role in cancer and glycosaminoglycan interactions.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:59.261Z","link_status":"ok","quote_status":"unverified","prev":"6c2f579a8e359a2f5fa5daf2b1294b9a38ff7dc78509dce2b3b9aa0e5a00bd5a","hash":"13b4267b3fe98c044df28e04ce63cf9ad29fe40de663c3697af2d849176d2c63"},{"id":"s19","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41941993/","title":"Antimicrobial peptide WK-13-3D inhibits Japanese ...","quote":"In this study, we found that the synthetic LL-37 analogue peptide WK-13-3D has strong antiviral activity against JEV. Notably, pre-treatment or co-incubation ...","summary":"LL-37 analogue with antiviral activity against JEV.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:59.261Z","link_status":"ok","quote_status":"unverified","prev":"13b4267b3fe98c044df28e04ce63cf9ad29fe40de663c3697af2d849176d2c63","hash":"0f59fe86dcdd1eee398626b104c00232b7ca4ec721768f4628099e18911875a5"},{"id":"s20","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42295538/","title":"Salivary antimicrobial peptides histatin-5, beta defensins ...","quote":"Salivary antimicrobial peptides histatin-5, beta defensins, human neutrophilic peptides, LL-37 , and calprotectin in severe dental caries, with a focus on early ...","summary":"Systematic review on salivary LL-37 and other peptides in dental caries.","author":"","publisher":"","date":"","claim_ids":[],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:52:59.261Z","link_status":"ok","quote_status":"unverified","prev":"0f59fe86dcdd1eee398626b104c00232b7ca4ec721768f4628099e18911875a5","hash":"4ebbcbd468bc167d08330bb40e297ce263e49cd370a58e1094e11135242b47da"}]}