{"slug":"ll-37","verification":{"valid":true,"entries":4,"head":"e12aa5abf713aa0178309a7d76bb43878588dc742cc90b67791b33c36f73baef"},"count":4,"models":["grok-4.3"],"yield":{"passes":4,"energy_spent_rows":0,"total_cost_usd":0,"waste_cost_usd":0,"total_tokens":0,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok-4.3","passes":4,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST 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LL-37: Structure and antimicrobial mechanisms ...","quote":"LL-37 effectively combats over 38 bacteria, 16 fungi, and 16 viruses through various mechanisms, including membrane rupture, targeting, and ...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41544412/","title":"LL-37 antimicrobial peptide: Molecular characterisation ...","quote":"LL-37 plays a multifaceted role in oral immunity by integrating antimicrobial, immunomodulatory, and tissue-regenerative functions.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40869425/","title":"Antimicrobial Peptides of the Cathelicidin Family: Focus on ...","quote":"LL-37-based analogs represent promising candidates for the development of next-generation antimicrobial and immunomodulatory therapies.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40960088/","title":"Significance of the LL-37 Peptide Delivered from Human ...","quote":"One approach to develop new treatments for patients with sepsis is to better understand the pleiotropic function of the human LL-37 peptide that ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39837472/","title":"Human cathelicidin LL-37 rapidly disrupted colonic ...","quote":"LL-37 increases epithelial cell permeability by degrading TJ proteins occludin and claudin-2 through endocytosis and lysosomal degradation.","link_status":"ok","quote_status":"verified"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40063262/","title":"Human antimicrobial/host defense peptide LL-37 may ...","quote":"LL-37 may prevent the spread of a local infection through multiple mechanisms: an update","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39643165/","title":"LL-37, the master antimicrobial peptide, its multifaceted ...","quote":"LL-37 has emerged as a significant player, demonstrating its multifaceted roles during bacterial, fungal, and viral infections, as well as exhibiting ...","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40612001/","title":"Antimicrobial peptide LL-37 increases rhinovirus-induced ...","quote":"The human cathelicidin LL-37 is active against both bacteria and viruses , but it also shows immunomodulatory properties.","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39873762/","title":"Study of cathelicidin (LL-37) immunoexpression in the skin ...","quote":"The present work aimed to study the immunoexpression of cathelicidin in the vitiligo patients' skin to elucidate its possible role in vitiligo pathogenesis.","link_status":"ok","quote_status":"verified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40410820/","title":"LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated ...","quote":"Overall, our findings showed that LL-37 and citLL-37 can selectively suppress the abundance of IL-17A/F-mediated LCN-2, a protein that is ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"db58ae5f3164cc50e60a2cea21d4ca74a5a15d8a06d4e66906102a039744d256","hash":"65d203578c55b0b10a636fddd71f23f1412b53c3c546950c8a15e95bb2159afd"},{"seq":2,"id":"k3","ts":"2026-06-29T16:52:36.332Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39954662/","title":"Cathelicidin LL-37 in periodontitis: current research progress and prospects","quote":"This review summarizes the expression and roles of LL-37 in periodontitis, providing new perspectives and insights into its pathogenesis and treatment.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41791569/","title":"Exploring the Role of Cathelicidin LL-37 and Ceragenins in Wound Healing","quote":"This work reviews literature describing the role of AMPs, particularly LL-37 and synthetic ceragenins, in wound healing.","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41064641/","title":"Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike, ORF7a, and ORF8 proteins and inhibits viral replication","quote":"LL-37 disrupts key viral-host interactions by binding to Spike, ORF7a, and ORF8, thereby reducing SARS-CoV-2 infectivity.","link_status":"ok","quote_status":"verified"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41862276/","title":"LL-37 and bacterial DNA complexes in dental plaque","quote":"This review summarizes current knowledge of the molecular mechanisms and immunological consequences of LL-37-bacterial DNA interactions in dental plaque.","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883500/","title":"Vicenin-2 attenuates rosacea-like inflammation by targeting the IL-17RA/NF-κB pathway","quote":"Vicenin-2 alleviates LL-37-induced rosacea-like inflammation by regulating the IL-17RA/NF-κB pathway.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"65d203578c55b0b10a636fddd71f23f1412b53c3c546950c8a15e95bb2159afd","hash":"db954139d2a02efda61bc04827c233cf12e62ba565fae8bda20e8a0ae2c78320"},{"seq":3,"id":"k4","ts":"2026-06-29T16:52:59.852Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s16","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41485275/","title":"LL-37-derived peptide shows promising antimicrobial ...","quote":"In this study, we designed a series of antimicrobial peptides by fusing the two fragments of antimicrobial peptides Cathelicidin-BF (1-9) and LL-37 (17-29), and ...","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41654238/","title":"CRISPR/Cas9-engineered Salmonella phage displaying ...","quote":"LL-37 -engineered bacteriophages demonstrated improved antibacterial activity and intracellular infection control against S. Typhimurium.","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41674152/","title":"Structural determinants of glycosaminoglycan ...","quote":"The human antimicrobial peptide LL-37 exerts a dual role in cancer, promoting tumor progression in breast carcinoma by stimulating calcium influx and enhancing ...","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41941993/","title":"Antimicrobial peptide WK-13-3D inhibits Japanese ...","quote":"In this study, we found that the synthetic LL-37 analogue peptide WK-13-3D has strong antiviral activity against JEV. Notably, pre-treatment or co-incubation ...","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42295538/","title":"Salivary antimicrobial peptides histatin-5, beta defensins ...","quote":"Salivary antimicrobial peptides histatin-5, beta defensins, human neutrophilic peptides, LL-37 , and calprotectin in severe dental caries, with a focus on early ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"db954139d2a02efda61bc04827c233cf12e62ba565fae8bda20e8a0ae2c78320","hash":"e12aa5abf713aa0178309a7d76bb43878588dc742cc90b67791b33c36f73baef"}]}