{"slug":"humanin","title":"humanin","body":"## Overview\nEvidence is being populated by Grok web search.","register":"standard","tags":[],"style":{},"claims":[{"id":"c1","text":"2025 review on Humanin (HN) as autophagy inducer for metabolic disorders therapy.","section":"what_is_known","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Materialized from orphan source s1 by ledger repair"},{"id":"c2","text":"2025 review detailing Humanin's molecular neuroprotective effects in AD.","section":"what_is_known","tier":"preclinical","source_ids":["s2"],"source_status":"sourced","why_material":"Materialized from orphan source s2 by ledger repair"},{"id":"c3","text":"2026 study showing Humanin (HNG) prevents glucocorticoid-induced bone issues in mice.","section":"what_is_known","tier":"preclinical","source_ids":["s3"],"source_status":"sourced","why_material":"Materialized from orphan source s3 by ledger repair"},{"id":"c4","text":"2025 study on Humanin reducing neuropathic pain via oxidative stress protection in mice.","section":"what_is_known","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Materialized from orphan source s4 by ledger repair"},{"id":"c5","text":"2024 study linking Humanin variant P3S to longevity in APOE4 carriers.","section":"what_is_known","tier":"preclinical","source_ids":["s5"],"source_status":"sourced","why_material":"Materialized from orphan source s5 by ledger repair"},{"id":"c6","text":"Discusses humanin variants and their aggregation into fibrils with varying cytotoxicity.","section":"limitations","tier":"preclinical","source_ids":["s6"],"source_status":"sourced","why_material":"Materialized from orphan source s6 by ledger repair"},{"id":"c7","text":"Reviews biomarker potential of humanin and MOTS-c in diseases.","section":"what_is_known","tier":"preclinical","source_ids":["s7"],"source_status":"sourced","why_material":"Materialized from orphan source s7 by ledger repair"},{"id":"c8","text":"Shows humanin produced by macrophages has pro-resolving properties.","section":"what_is_known","tier":"preclinical","source_ids":["s8"],"source_status":"sourced","why_material":"Materialized from orphan source s8 by ledger repair"},{"id":"c9","text":"Links humanin to benefits of antioxidants in T2DM.","section":"what_is_known","tier":"preclinical","source_ids":["s9"],"source_status":"sourced","why_material":"Materialized from orphan source s9 by ledger repair"},{"id":"c10","text":"Humanin attenuates atrial fibrillation via anti-fibrotic and mitochondrial effects.","section":"what_is_known","tier":"preclinical","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair"},{"id":"c11","text":"Associates humanin levels with Mediterranean diet adherence and cardioprotection.","section":"what_is_known","tier":"preclinical","source_ids":["s11"],"source_status":"sourced","why_material":"Materialized from orphan source s11 by ledger repair"},{"id":"c12","text":"Humanin as prognostic biomarker for cardiovascular outcomes.","section":"what_is_known","tier":"preclinical","source_ids":["s12"],"source_status":"sourced","why_material":"Materialized from orphan source s12 by ledger repair"},{"id":"c13","text":"Humanin and MOTS-c protect against glucocorticoid-induced muscle wasting.","section":"what_is_known","tier":"preclinical","source_ids":["s13"],"source_status":"sourced","why_material":"Materialized from orphan source s13 by ledger repair"},{"id":"c14","text":"Examines humanin levels in PCOS patients.","section":"what_is_known","tier":"human","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair"},{"id":"c15","text":"Review on humanin as therapeutic and biomarker in vascular disease.","section":"what_is_known","tier":"preclinical","source_ids":["s15"],"source_status":"sourced","why_material":"Materialized from orphan source s15 by ledger repair"}],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39950467/","title":"A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders","quote":"The review primarily highlights that HN is an autophagy inducer, which can promote cell survival in the presence of metabolic and oxidative stress, ...","summary":"2025 review on Humanin (HN) as autophagy inducer for metabolic disorders therapy.","author":"","publisher":"","date":"","claim_ids":["c1"]},{"id":"s2","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/40090538/","title":"The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects","quote":"It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine.","summary":"2025 review detailing Humanin's molecular neuroprotective effects in AD.","author":"","publisher":"","date":"","claim_ids":["c2"]},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41550496/","title":"Humanin improves bone health in a glucocorticoid-treated mouse model","quote":"We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of ...","summary":"2026 study showing Humanin (HNG) prevents glucocorticoid-induced bone issues in mice.","author":"","publisher":"","date":"","claim_ids":["c3"]},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39510375/","title":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","quote":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","summary":"2025 study on Humanin reducing neuropathic pain via oxidative stress protection in mice.","author":"","publisher":"","date":"","claim_ids":["c4"]},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38520065/","title":"Humanin variant P3S is associated with longevity in APOE4 carriers","quote":"Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.","summary":"2024 study linking Humanin variant P3S to longevity in APOE4 carriers.","author":"","publisher":"","date":"","claim_ids":["c5"]},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40543583/","title":"Humanin variants aggregate to produce different fibril structures with distinct cytotoxicity","quote":"Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX.","summary":"Discusses humanin variants and their aggregation into fibrils with varying cytotoxicity.","author":"","publisher":"","date":"","claim_ids":["c6"]},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41303353/","title":"Insights into the Biomarker Potential of Humanin and Mots-c in Metabolic and Neurodegenerative Diseases","quote":"Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels...","summary":"Reviews biomarker potential of humanin and MOTS-c in diseases.","author":"","publisher":"","date":"","claim_ids":["c7"]},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40877234/","title":"HUMANIN produced by human efferocytic macrophages promotes inflammation resolution","quote":"Mainly known for its antioxidant and neuroprotective effects, we found that HUMANIN was also associated with pro-resolving properties in human and mouse models.","summary":"Shows humanin produced by macrophages has pro-resolving properties.","author":"","publisher":"","date":"","claim_ids":["c8"]},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41249265/","title":"Redox-sensitive miRNAs and Humanin could mediate the metabolic benefits of crocin and astaxanthin in type 2 diabetes","quote":"The metabolic and anti-inflammatory benefits of CT and AST in T2DM may mediated by the effects of HN on mitochondrial function and insulin signaling...","summary":"Links humanin to benefits of antioxidants in T2DM.","author":"","publisher":"","date":"","claim_ids":["c9"]},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42193373/","title":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","quote":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","summary":"Humanin attenuates atrial fibrillation via anti-fibrotic and mitochondrial effects.","author":"","publisher":"","date":"","claim_ids":["c10"]},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883858/","title":"Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE","quote":"To investigate Humanin and SHMOOSE... as potential mitochondrial biomarkers of Med-Diet adherence and their associations with markers of oxidative stress.","summary":"Associates humanin levels with Mediterranean diet adherence and cardioprotection.","author":"","publisher":"","date":"","claim_ids":["c11"]},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41849628/","title":"Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Mortality and Morbidity Prediction","quote":"In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondrial dysfunction, could refine CVMM prediction...","summary":"Humanin as prognostic biomarker for cardiovascular outcomes.","author":"","publisher":"","date":"","claim_ids":["c12"]},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41732124/","title":"Mitochondrial-derived peptides MOTS-c and humanin attenuate glucocorticoid-induced muscle atrophy","quote":"Glucocorticoids... cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising...","summary":"Humanin and MOTS-c protect against glucocorticoid-induced muscle wasting.","author":"","publisher":"","date":"","claim_ids":["c13"]},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41186863/","title":"Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome","quote":"Keywords: Androgen excess; Humanin; Insulin resistance; Mitochondrial dysfunction; Mitokine; PCOS.","summary":"Examines humanin levels in PCOS patients.","author":"","publisher":"","date":"","claim_ids":["c14"]},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40574402/","title":"Mitochondrial-Derived Peptides as Therapeutics and Biomarkers in Vascular Diseases","quote":"This review examines the protective roles of mitochondrial-derived peptides such as humanin, MOTS-c, and small humanin-like peptides in mitigating vascular...","summary":"Review on humanin as therapeutic and biomarker in vascular disease.","author":"","publisher":"","date":"","claim_ids":["c15"]}],"prov":{"model":"grok/grok-4.3","action":"write"}}