{"slug":"humanin","verification":{"valid":true,"entries":15,"head":"e3eb7b1148024b1bbd152cc03c6208ecaab7533120712d3480167467369c0f33"},"count":15,"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39950467/","title":"A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders","quote":"The review primarily highlights that HN is an autophagy inducer, which can promote cell survival in the presence of metabolic and oxidative stress, ...","summary":"2025 review on Humanin (HN) as autophagy inducer for metabolic disorders therapy.","author":"","publisher":"","date":"","claim_ids":["c1"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:13.710Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"89cd0091646160b8a353cf0e24364edf00be97b002ceffce65dea493b9e97149"},{"id":"s2","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/40090538/","title":"The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects","quote":"It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine.","summary":"2025 review detailing Humanin's molecular neuroprotective effects in AD.","author":"","publisher":"","date":"","claim_ids":["c2"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:13.710Z","link_status":"ok","quote_status":"unverified","prev":"89cd0091646160b8a353cf0e24364edf00be97b002ceffce65dea493b9e97149","hash":"69727ba8b1708e5e0a8e0e300b7a2962437c7a6897f2c3e5a10373fef5684c40"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41550496/","title":"Humanin improves bone health in a glucocorticoid-treated mouse model","quote":"We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of ...","summary":"2026 study showing Humanin (HNG) prevents glucocorticoid-induced bone issues in mice.","author":"","publisher":"","date":"","claim_ids":["c3"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:13.710Z","link_status":"ok","quote_status":"unverified","prev":"69727ba8b1708e5e0a8e0e300b7a2962437c7a6897f2c3e5a10373fef5684c40","hash":"75cc86befed22788703496e9876c7ec031f033ec722fc557b7b50e3715c4a1d6"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39510375/","title":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","quote":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","summary":"2025 study on Humanin reducing neuropathic pain via oxidative stress protection in mice.","author":"","publisher":"","date":"","claim_ids":["c4"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:13.710Z","link_status":"ok","quote_status":"unverified","prev":"75cc86befed22788703496e9876c7ec031f033ec722fc557b7b50e3715c4a1d6","hash":"40e83724b2b27c2cc1678c8e4e7ea0fe9499cc2ff060d4cc3e5e6dcd25615b67"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38520065/","title":"Humanin variant P3S is associated with longevity in APOE4 carriers","quote":"Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.","summary":"2024 study linking Humanin variant P3S to longevity in APOE4 carriers.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:13.710Z","link_status":"ok","quote_status":"verified","prev":"40e83724b2b27c2cc1678c8e4e7ea0fe9499cc2ff060d4cc3e5e6dcd25615b67","hash":"a8db43b048caa6385eba8d1f9634726b317ac572f5f80f84b81e2ce0046a2630"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40543583/","title":"Humanin variants aggregate to produce different fibril structures with distinct cytotoxicity","quote":"Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX.","summary":"Discusses humanin variants and their aggregation into fibrils with varying cytotoxicity.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"verified","prev":"a8db43b048caa6385eba8d1f9634726b317ac572f5f80f84b81e2ce0046a2630","hash":"526368c54debce53547a5779b2fb889833e8e6b434088a2bfa90988c670c57fc"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41303353/","title":"Insights into the Biomarker Potential of Humanin and Mots-c in Metabolic and Neurodegenerative Diseases","quote":"Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels...","summary":"Reviews biomarker potential of humanin and MOTS-c in diseases.","author":"","publisher":"","date":"","claim_ids":["c7"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"526368c54debce53547a5779b2fb889833e8e6b434088a2bfa90988c670c57fc","hash":"471a121b0d78a5bb22bb3f81a644bd393359366928c55910a55e6309f80e5306"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40877234/","title":"HUMANIN produced by human efferocytic macrophages promotes inflammation resolution","quote":"Mainly known for its antioxidant and neuroprotective effects, we found that HUMANIN was also associated with pro-resolving properties in human and mouse models.","summary":"Shows humanin produced by macrophages has pro-resolving properties.","author":"","publisher":"","date":"","claim_ids":["c8"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"verified","prev":"471a121b0d78a5bb22bb3f81a644bd393359366928c55910a55e6309f80e5306","hash":"d09383ea6e38f5e367e8f6065fb3e46af7bc5c861a6bf26dd3b0f31c22b17a66"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41249265/","title":"Redox-sensitive miRNAs and Humanin could mediate the metabolic benefits of crocin and astaxanthin in type 2 diabetes","quote":"The metabolic and anti-inflammatory benefits of CT and AST in T2DM may mediated by the effects of HN on mitochondrial function and insulin signaling...","summary":"Links humanin to benefits of antioxidants in T2DM.","author":"","publisher":"","date":"","claim_ids":["c9"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"d09383ea6e38f5e367e8f6065fb3e46af7bc5c861a6bf26dd3b0f31c22b17a66","hash":"cf5664f53827ef183f24196487cd4b1973e78aa424caa901ef435feade133b52"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42193373/","title":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","quote":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","summary":"Humanin attenuates atrial fibrillation via anti-fibrotic and mitochondrial effects.","author":"","publisher":"","date":"","claim_ids":["c10"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"verified","prev":"cf5664f53827ef183f24196487cd4b1973e78aa424caa901ef435feade133b52","hash":"706adde29fc3349e5c5ffca8b46bdc3bef32e417f62a85d9f280600b2129aece"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883858/","title":"Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE","quote":"To investigate Humanin and SHMOOSE... as potential mitochondrial biomarkers of Med-Diet adherence and their associations with markers of oxidative stress.","summary":"Associates humanin levels with Mediterranean diet adherence and cardioprotection.","author":"","publisher":"","date":"","claim_ids":["c11"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"706adde29fc3349e5c5ffca8b46bdc3bef32e417f62a85d9f280600b2129aece","hash":"b80a4edb25a02ca04ef094b4c8e2db4e0c52d7328579af2fafa1cab8608cc3e9"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41849628/","title":"Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Mortality and Morbidity Prediction","quote":"In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondrial dysfunction, could refine CVMM prediction...","summary":"Humanin as prognostic biomarker for cardiovascular outcomes.","author":"","publisher":"","date":"","claim_ids":["c12"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"b80a4edb25a02ca04ef094b4c8e2db4e0c52d7328579af2fafa1cab8608cc3e9","hash":"a0fa34b088154bc70a9bd8b4c97e88e423ca3b7e52ba0c157798e8fd6a7b5f4a"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41732124/","title":"Mitochondrial-derived peptides MOTS-c and humanin attenuate glucocorticoid-induced muscle atrophy","quote":"Glucocorticoids... cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising...","summary":"Humanin and MOTS-c protect against glucocorticoid-induced muscle wasting.","author":"","publisher":"","date":"","claim_ids":["c13"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"a0fa34b088154bc70a9bd8b4c97e88e423ca3b7e52ba0c157798e8fd6a7b5f4a","hash":"4feac49f3a19cedafdae083c80cc6d2c4bd635af942a35aa09b41522ac9ea07c"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41186863/","title":"Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome","quote":"Keywords: Androgen excess; Humanin; Insulin resistance; Mitochondrial dysfunction; Mitokine; PCOS.","summary":"Examines humanin levels in PCOS patients.","author":"","publisher":"","date":"","claim_ids":["c14"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"4feac49f3a19cedafdae083c80cc6d2c4bd635af942a35aa09b41522ac9ea07c","hash":"8a67eb2f2c2a0f2a806f695857ff22eef073c8f8a1220fba240a191f41523ddb"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40574402/","title":"Mitochondrial-Derived Peptides as Therapeutics and Biomarkers in Vascular Diseases","quote":"This review examines the protective roles of mitochondrial-derived peptides such as humanin, MOTS-c, and small humanin-like peptides in mitigating vascular...","summary":"Review on humanin as therapeutic and biomarker in vascular disease.","author":"","publisher":"","date":"","claim_ids":["c15"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:58:39.356Z","link_status":"ok","quote_status":"unverified","prev":"8a67eb2f2c2a0f2a806f695857ff22eef073c8f8a1220fba240a191f41523ddb","hash":"e3eb7b1148024b1bbd152cc03c6208ecaab7533120712d3480167467369c0f33"}]}