{"slug":"humanin","verification":{"valid":true,"entries":3,"head":"c7a26ee17678fcaa4d1acb398fd8bdfc699c4dc5c45ec538619ab5fb75911597"},"count":3,"models":["grok-4.3"],"yield":{"passes":3,"energy_spent_rows":0,"total_cost_usd":0,"waste_cost_usd":0,"total_tokens":0,"material_outputs":0,"usd_per_output":null,"models":[{"model":"grok-4.3","passes":3,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T16:57:57.473Z","model":"grok-4.3","role":"writer","action":"draft","payload":{"title":"humanin","register":"standard","body":"## Overview\nEvidence is being populated by Grok web search.","claims":[],"sources":[]},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"genesis","hash":"764fc61b3ab036a84d55d549f7d1b803509773c4b095a0a153b365c98beffb61"},{"seq":1,"id":"k2","ts":"2026-06-29T16:58:14.840Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/39950467/","title":"A Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders","quote":"The review primarily highlights that HN is an autophagy inducer, which can promote cell survival in the presence of metabolic and oxidative stress, ...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/40090538/","title":"The neuroprotective role of Humanin in Alzheimer's disease: The molecular effects","quote":"It has a neuroprotective effect against Alzheimer's disease (AD) and other neurodegenerative diseases by improving hippocampal acetylcholine.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41550496/","title":"Humanin improves bone health in a glucocorticoid-treated mouse model","quote":"We investigated whether the mitochondrial peptide humanin (HNG) could prevent GC-induced growth retardation and osteoporosis in mouse models of ...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39510375/","title":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","quote":"Humanin attenuates metabolic, toxic, and traumatic neuropathic pain in mice by protecting against oxidative stress and increasing inflammatory cytokine ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38520065/","title":"Humanin variant P3S is associated with longevity in APOE4 carriers","quote":"Our research uncovered a unique humanin variant, P3S, specifically enriched in centenarians with the APOE4 allele.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"764fc61b3ab036a84d55d549f7d1b803509773c4b095a0a153b365c98beffb61","hash":"8788e36adafe154e8effd0ccf5622ceefe2732059c500f08e2f0f25a27ec27f7"},{"seq":2,"id":"k3","ts":"2026-06-29T16:58:40.543Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40543583/","title":"Humanin variants aggregate to produce different fibril structures with distinct cytotoxicity","quote":"Humanin is an endogenous human peptide with cytoprotective effects, including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX.","link_status":"ok","quote_status":"verified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41303353/","title":"Insights into the Biomarker Potential of Humanin and Mots-c in Metabolic and Neurodegenerative Diseases","quote":"Humanin (HN) and MOTS-c are mitochondrial-derived peptides (MDPs) known for their neuroprotective and metabolic functions. Their circulating and tissue levels...","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40877234/","title":"HUMANIN produced by human efferocytic macrophages promotes inflammation resolution","quote":"Mainly known for its antioxidant and neuroprotective effects, we found that HUMANIN was also associated with pro-resolving properties in human and mouse models.","link_status":"ok","quote_status":"verified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41249265/","title":"Redox-sensitive miRNAs and Humanin could mediate the metabolic benefits of crocin and astaxanthin in type 2 diabetes","quote":"The metabolic and anti-inflammatory benefits of CT and AST in T2DM may mediated by the effects of HN on mitochondrial function and insulin signaling...","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/42193373/","title":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","quote":"Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction","link_status":"ok","quote_status":"verified"},{"id":"s11","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41883858/","title":"Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE","quote":"To investigate Humanin and SHMOOSE... as potential mitochondrial biomarkers of Med-Diet adherence and their associations with markers of oxidative stress.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41849628/","title":"Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Mortality and Morbidity Prediction","quote":"In this study, we evaluated whether circulating levels of Humanin, a micropeptide reflecting mitochondrial dysfunction, could refine CVMM prediction...","link_status":"ok","quote_status":"unverified"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41732124/","title":"Mitochondrial-derived peptides MOTS-c and humanin attenuate glucocorticoid-induced muscle atrophy","quote":"Glucocorticoids... cause severe muscle wasting. Mitochondrial-derived peptides (MDPs) are promising...","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/41186863/","title":"Assessment of mitochondrial peptide humanin in women with polycystic ovary syndrome","quote":"Keywords: Androgen excess; Humanin; Insulin resistance; Mitochondrial dysfunction; Mitokine; PCOS.","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40574402/","title":"Mitochondrial-Derived Peptides as Therapeutics and Biomarkers in Vascular Diseases","quote":"This review examines the protective roles of mitochondrial-derived peptides such as humanin, MOTS-c, and small humanin-like peptides in mitigating vascular...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"8788e36adafe154e8effd0ccf5622ceefe2732059c500f08e2f0f25a27ec27f7","hash":"c7a26ee17678fcaa4d1acb398fd8bdfc699c4dc5c45ec538619ab5fb75911597"}]}