{"slug":"epitalon","verification":{"valid":true,"entries":7,"head":"1a9fbfd8f54ae67e9e864e6f7e22c080268ff7051a9a7a6aec4a0a4b374f1eaf"},"count":7,"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/40141333/","title":"Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties","quote":"Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptide complex solution. During the last 25 years, this compound has been extensively studied using in vitro, in vivo, and in silico methods. The results of these studies indicate significant geroprotective and neuroendocrine effects of Epitalone, resulting from its antioxidant, neuro-protective, and antimutagenic effects, originating from both specific and nonspecific mechanisms.","summary":"2025 review summarizing 25 years of Epitalon research showing geroprotective, antioxidant, neuroprotective effects via in vitro/in vivo studies; notes limited physico-chemical data.","author":"","publisher":"","date":"","claim_ids":["c1"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:15.494Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"9a9574559d7d8fd6c39094404f914bfff9e2ea377f14b7a0fd5d7d8c8cf63735","source_role":"mechanism_support"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40908429/","title":"Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity","quote":"Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. ... Our data suggests that epitalon can extend telomere length in normal healthy mammalian cells through the upregulation of hTERT mRNA expression and telomerase enzyme activity.","summary":"2025 study on human cell lines (normal and cancer) showing Epitalon extends telomeres dose-dependently via telomerase/hTERT in normal cells and ALT in cancer cells.","author":"","publisher":"","date":"","claim_ids":["c2"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:15.494Z","link_status":"ok","quote_status":"verified","prev":"9a9574559d7d8fd6c39094404f914bfff9e2ea377f14b7a0fd5d7d8c8cf63735","hash":"f31e92aac0c7313b51d4b3927e205c76fd264a6075358beba650215a219690a8","source_role":"mechanism_support"},{"id":"s3","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/42021992/","title":"Therapeutic peptides in gerontology: mechanisms and applications for healthy aging","quote":"Nine peptides were identified spanning diverse aging interventions: metabolic restoration (tirzepatide), telomere biology (epitalon), dermal regeneration (GHK-Cu), tissue repair (BPC-157, TB-500), neuroprotection (Semax), growth hormone modulation (CJC-1295, ipamorelin), and sexual function (bremelanotide).","summary":"2026 narrative review discussing Epitalon in context of telomere biology and healthy aging interventions, based on searches through Jan 2026.","author":"","publisher":"","date":"","claim_ids":["c3"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:36.647Z","link_status":"ok","quote_status":"verified","prev":"f31e92aac0c7313b51d4b3927e205c76fd264a6075358beba650215a219690a8","hash":"0ea8d3ce74b863960ff55c584b0a974ebc4c781ec7e711a0c8759265649d1762","source_role":"mechanism_support"},{"id":"s4","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions","quote":"Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity.","summary":"2026 review on peptides in orthopaedics, briefly covering epithalon for recovery and circadian regulation.","author":"","publisher":"","date":"","claim_ids":["c4"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:36.647Z","link_status":"ok","quote_status":"verified","prev":"0ea8d3ce74b863960ff55c584b0a974ebc4c781ec7e711a0c8759265649d1762","hash":"023e6342b456d684b489ff6b989f688a4f130b5a508a77cb76e0c85e11d592da","source_role":"mechanism_support"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40493162/","title":"The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy","quote":"This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG ( Ala-Glu-Asp-Gly , Epitalon ) improves the delayed ...","summary":"2025 study on Epitalon (AEDG) antioxidant effects improving wound healing in diabetic retinopathy cell model.","author":"","publisher":"","date":"","claim_ids":["c5"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:55.813Z","link_status":"ok","quote_status":"unverified","prev":"023e6342b456d684b489ff6b989f688a4f130b5a508a77cb76e0c85e11d592da","hash":"62e3f2891fddff7bb3dc116632444868bbdce076ce0774eb231db36a86d0b983","source_role":"mechanism_support"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39788414/","title":"Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development","quote":"Epitalon highly enhances the quality and health of the oocyte, cumulus cell, and post-thawed blastocyst.","summary":"2025 research showing Epitalon improves bovine oocyte maturation, embryo development via telomerase activation.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:55.813Z","link_status":"ok","quote_status":"verified","prev":"62e3f2891fddff7bb3dc116632444868bbdce076ce0774eb231db36a86d0b983","hash":"77601874111be2108bd84624ba44da8b402cadf5e401a4fc4c5f43355e984953","source_role":"mechanism_support"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39518916/","title":"Short Peptides Protect Fibroblast-Derived Induced Pluripotent Stem Cell-Derived Neural Stem Cells from Amyloid-Beta Toxicity","quote":"Glu-Asp-Arg (EDR) and Lys-Glu-Asp (KED), and Ala-Glu-Asp-Gly (AEDG) peptides have previously demonstrated neuroprotective effects in various models of ...","summary":"2024 paper discussing AEDG (Epitalon) peptide neuroprotective effects in stem cell models.","author":"","publisher":"","date":"","claim_ids":["c7"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:51:55.813Z","link_status":"ok","quote_status":"unverified","prev":"77601874111be2108bd84624ba44da8b402cadf5e401a4fc4c5f43355e984953","hash":"1a9fbfd8f54ae67e9e864e6f7e22c080268ff7051a9a7a6aec4a0a4b374f1eaf","source_role":"mechanism_support"}]}