{"slug":"dsip-adderall-insomnia","verification":{"valid":true,"entries":13,"head":"fa790faee386d91f93e09f038247956e7d86c7cca76895fa35247dfbde2febf7"},"count":13,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","fill-slots"],"yield":{"passes":13,"energy_spent_rows":0,"total_cost_usd":0.000515,"waste_cost_usd":0,"total_tokens":3435,"material_outputs":2,"usd_per_output":0.000258,"models":[{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000515,"tokens_total":3435,"outputs":2,"waste_passes":0,"usd_per_output":0.000258},{"model":"grok/grok-4.3","passes":1,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok-4.3","passes":4,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T09:24:07.737Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"DSIP Peptide and Sleep Regulation: Evidence on Delta Sleep-Inducing Peptide","register":"source_ledger","body":"## Overview of DSIP\nDelta Sleep-Inducing Peptide (DSIP) is a 9-amino-acid neuropeptide first identified in the 1970s. It has been investigated for effects on sleep architecture, primarily in animal models and limited human studies.\n\n## Human Data on Sleep\nSmall clinical investigations from the 1980s reported objective improvements in sleep parameters with intravenous DSIP in chronic insomniacs. One double-blind study of 16 patients found higher sleep efficiency and shorter latency versus placebo (human tier). Another trial in 6 middle-aged insomniacs noted longer sleep duration and fewer interruptions (human tier). A 1992 double-blind study concluded short-term treatment is unlikely to provide major therapeutic benefit despite objective changes, with no subjective improvements (human tier). No large-scale, recent randomized controlled trials exist.\n\nNo human data address DSIP specifically in the context of stimulant-induced insomnia such as that associated with Adderall use.\n\n## Preclinical and Mechanistic Findings\nAnimal studies have explored DSIP's role in promoting delta-wave sleep and modulating stress responses (preclinical tier). DSIP is described in research as a sleep-promoting factor rather than a sedative, with effects potentially involving normalization of sleep regulation (mechanistic tier).\n\n## Relation to Stimulants\nOne preclinical study in mice examined DSIP's effect on amphetamine-induced hyperthermia (preclinical tier). No human studies link DSIP to stimulant-related sleep disruption.\n\n## User Reports\nAnecdotal accounts on platforms such as YouTube describe subjective improvements in sleep quality with DSIP use, but these remain unverified and outside controlled settings (anecdotal tier).\n\n## Framing of Action\nResearch characterizes DSIP in terms of supporting endogenous sleep processes rather than pharmacological suppression of wakefulness.\n\n## Limitations\nAvailable human evidence is limited to small samples from decades ago with inconsistent replication. Larger, modern trials are absent. Claims of dependency avoidance or absence of hangover effects lack direct comparative human data against agents such as zolpidem.","claims":[{"id":"c1","text":"A 1992 double-blind study of 16 chronic insomniac patients found higher sleep efficiency and shorter sleep latency with DSIP versus placebo, but no changes in subjective measures and concluded short-term treatment is unlikely to be of major therapeutic benefit.","section":"Human Data on Sleep","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Provides direct evidence from controlled human trial on objective sleep parameters.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"A 1981 study in 6 middle-aged chronic insomniacs reported longer sleep duration, higher quality, fewer interruptions, and normalizing influence on sleep regulation after intravenous DSIP.","section":"Human Data on Sleep","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Documents early human evidence of objective sleep improvements.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No human data specifically examine DSIP in Adderall-induced or stimulant-related insomnia.","section":"Relation to Stimulants","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"States absence of targeted evidence plainly.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Preclinical research in mice showed DSIP reduced amphetamine-induced hyperthermia at certain doses.","section":"Relation to Stimulants","tier":"preclinical","source_ids":["s3"],"source_status":"sourced","why_material":"Only available link between DSIP and amphetamine effects.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Anecdotal user reports describe subjective sleep quality improvements with DSIP.","section":"User Reports","tier":"anecdotal","source_ids":["s4"],"source_status":"sourced","why_material":"Captures non-clinical observations for completeness.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo... it was concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of major therapeutic benefit.","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep","quote":"The results were: longer sleep duration and a higher quality of sleep with fewer interruptions... The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/6548818/","title":"DSIP reduces amphetamine-induced hyperthermia in mice","quote":"A reduction of the increased temperature was observed in mice but not in rats.","link_status":"ok","quote_status":"verified"},{"id":"s4","type":"youtube","url":"https://www.youtube.com/watch?v=grwWLZedRQQ","title":"DSIP Peptide: Revolutionizing Sleep, Stress, and Pain ...","quote":"My personal experience-after 10 years of insomnia and trying SO many things, I'm finding great success with 100 mcg DSIP 30-60 min before bed.","link_status":"http_429","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"05620bcae5a9f0d4a9d77255f020993eadbaa53bed433ed1ffc10aaf44a5c7f6"},{"seq":1,"id":"k2","ts":"2026-06-29T11:23:18.167Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39444618/","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models","quote":"The study underscores DSIP-CBBBP potential in correcting neurotransmitter dysregulation and promoting sleep, hinting at its utility in sleep-related therapies.","link_status":"ok","quote_status":"verified"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/ADHDers/comments/1shiytb/delta_sleepinducing_peptide_dsip_did_it_affect/","title":"Delta Sleep-Inducing Peptide (DSIP) — did it affect your prescription stimulants?","quote":"When pathways healed, strat an hour after I took it would decrease Adderall effect, which I took Adderall ...","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1qk6n6v/sleep_issues_with_dextroamphetamine/","title":"Sleep Issues with Dextroamphetamine","quote":"you can try DSIP peptide 30 min before you want to fall asleep ... Fellow ADHD'er here, adderall , lfetime sleep issues.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"05620bcae5a9f0d4a9d77255f020993eadbaa53bed433ed1ffc10aaf44a5c7f6","hash":"225ea7b5a790fb7c07353e80b39bd2a8cf763bd84b72929a0c9aeca4a4107fc0"},{"seq":2,"id":"k3","ts":"2026-06-29T12:08:53.213Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"I'm taking a break after a month of using DSIP every other day at 125 mg. I have severe insomnia, but I think that DSIP is giving me deeper sleep. It just doesn't help me fall asleep.","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"The first day using DSIP in this manner made me sleep about 10 hours, a 2 hour nap in the afternoon followed by a solid 8 hours during the night with little to no wake-up, something I haven't had in about 30 years.","link_status":"ok","quote_status":"unverified"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1rgdoj8/sleep_support_for_narcolepsy/","title":"Sleep support for Narcolepsy","quote":"I do take adderall 30mg Ir x2 so that could be affecting sleep. ... I have heard of DSIP and that looks promising especially as a nasal spray","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"x","url":"https://x.com/AntiDoc/status/1904576757568545067","title":"X post by @AntiDoc on DSIP sleep benefits","quote":"More/better sleep means more/dramatically better gains. That’s why DSIP is quickly becoming one of my favorite peptides. Ridiculous sleep every night. Ridiculous energy every morning.","link_status":"ok","quote_status":"verified"},{"id":"s12","type":"x","url":"https://x.com/troywhiteyyc/status/2069118587764453799","title":"X post by @troywhiteyyc on DSIP dosing for insomnia","quote":"I started testing out DSIP for sleep management. First night 1mg- no real major difference - 4 hours Second night 1mg - same amount of sleep Third night 1.5mg - 9 hours","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","quote":"Unfortunately, dsip lost its effect (I took it for about 3 months and the last month it wasn’t working). Tried from two different sources and still nada.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"225ea7b5a790fb7c07353e80b39bd2a8cf763bd84b72929a0c9aeca4a4107fc0","hash":"35457521c4b4710f98143ee6b75a1ccee3d2af254e01c49526ae1b6250b3925a"},{"seq":3,"id":"k4","ts":"2026-06-29T12:09:09.861Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s14","type":"clinical_trial","url":"https://pubmed.ncbi.nlm.nih.gov/3622582/","title":"Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia","quote":"The treatment substantially improved night sleep with the first and additionally with repeated doses. These effects were maintained for the first posttreatment (placebo) night. Efficiency of night sleep and daytime rest reached the levels of normal controls. Alertness and performance at daytime increased significantly. The study demonstrates the efficacy of DSIP for the treatment of impaired sleep and daytime functions as well.","link_status":"ok","quote_status":"verified"},{"id":"s15","type":"review","url":"https://www.innerbody.com/dsip-delta-sleep-inducing-peptide","title":"DSIP (Delta Sleep-Inducing Peptide) | Full Rundown [2026]","quote":"In 1981, for example, a paper published in the International Journal of Clinical Pharmacology, Therapy, and Toxicology described a trial with six volunteers who experienced immediate sleep pressure after intravenous DSIP infusion, as well as increased sleep time, decreased sleep onset, and better sleep efficiency without any sedative effects.","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"medical","url":"https://drlewis.com/dsip-delta-sleep-inducing-peptide/","title":"DSIP Peptide: Research, Benefits, Dosage & Sleep Studies","quote":"One of the most frequently cited human studies evaluated DSIP in patients with chronic insomnia and found modest improvements in sleep ...","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1rj4824/dsip_the_overlooked_peptide_for_deep_sleep/","title":"The Overlooked Peptide for Deep Sleep & Chronic Fatigue","quote":"If deep sleep is compromised, no amount of stimulants will fix that. 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Normalize stress ...","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"youtube","url":"https://www.youtube.com/watch?v=dz6vYHXE3Yc","title":"How does the Peptide DSIP Work?","quote":"Delta Sleep‑Inducing Peptide (DSIP) is a neuropeptide studied for its potential involvement in sleep regulation , stress responses, and ...","link_status":"http_429","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"35457521c4b4710f98143ee6b75a1ccee3d2af254e01c49526ae1b6250b3925a","hash":"9b48ed5a49c73b51d031ab04f2d6dcc09482f468ebc6e0452cdb7c8eb1742e7a"},{"seq":4,"id":"k5","ts":"2026-06-29T12:45:09.734Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c20","tier":"system","text":"DSIP Peptide and Sleep Regulation: Evidence on Delta Sleep-Inducing Peptide is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). 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I struggled with bouts of insomnia, waking up +/- 2 times a night and bedtime anxiety but now I’m actually seeing a pay off. Cannot wait to see how well my sleep progresses with time and DSIP ... I’ve been on DSIP for three weeks now. 5 on 2 off. ... Typically my whoop would show me in light sleeping stage for about 3 hrs with that amount of sleep but I was maxing about 3.5 hrs of deep sleep. ... waking up feeling fine and restful even though I’m fighting a tiny bit of jet lag.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"2399748dfae6d64086d29d2e082a773183286be8a103f532567ac9762939c87f","hash":"9e40b83db31d93f509624fe1973cab02b01c635558386cd915283a94b18a7490"},{"seq":11,"id":"k12","ts":"2026-06-29T21:18:05.939Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c28","tier":"system","text":"DSIP Peptide and Sleep Regulation: Evidence on Delta Sleep-Inducing Peptide is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). 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