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Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions."},{"id":"c25","tier":"human","status":"active","text":"There is no specific information on the long-term effects of DSIP on sleep patterns or potential dependency issues."},{"id":"c6","tier":"preclinical","status":"active","text":"2024 study on DSIP fusion peptide showing efficacy in mouse insomnia model via neurotransmitter balancing and sleep promotion."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/dsip-adderall-insomnia/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/dsip-adderall-insomnia/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/dsip-adderall-insomnia/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-29T21:23:31.747Z","slug":"dsip-adderall-insomnia","title":"DSIP Peptide and Sleep Regulation: Evidence on Delta Sleep-Inducing Peptide","url":"https://miscsubjects.com/a/dsip-adderall-insomnia","register":"source_ledger","tags":["peptide","topic"],"posted_at":"2026-06-29 08:23:19","updated_at":"2026-07-17T02:39:01.448Z","body":"## Overview of DSIP\nDelta Sleep-Inducing Peptide (DSIP) is a 9-amino-acid neuropeptide first identified in the 1970s. It has been investigated for effects on sleep architecture, primarily in animal models and limited human studies.\n\n## Human Data on Sleep\nSmall clinical investigations from the 1980s reported objective improvements in sleep parameters with intravenous DSIP in chronic insomniacs. One double-blind study of 16 patients found higher sleep efficiency and shorter latency versus placebo (human tier). Another trial in 6 middle-aged insomniacs noted longer sleep duration and fewer interruptions (human tier). A 1992 double-blind study concluded short-term treatment is unlikely to provide major therapeutic benefit despite objective changes, with no subjective improvements (human tier). No large-scale, recent randomized controlled trials exist.\n\nNo human data address DSIP specifically in the context of stimulant-induced insomnia such as that associated with Adderall use.\n\n## Preclinical and Mechanistic Findings\nAnimal studies have explored DSIP's role in promoting delta-wave sleep and modulating stress responses (preclinical tier). DSIP is described in research as a sleep-promoting factor rather than a sedative, with effects potentially involving normalization of sleep regulation (mechanistic tier).\n\n## Relation to Stimulants\nOne preclinical study in mice examined DSIP's effect on amphetamine-induced hyperthermia (preclinical tier). No human studies link DSIP to stimulant-related sleep disruption.\n\n## User Reports\nAnecdotal accounts on platforms such as YouTube describe subjective improvements in sleep quality with DSIP use, but these remain unverified and outside controlled settings (anecdotal tier).\n\n## Framing of Action\nResearch characterizes DSIP in terms of supporting endogenous sleep processes rather than pharmacological suppression of wakefulness.\n\n## Limitations\nAvailable human evidence is limited to small samples from decades ago with inconsistent replication. Larger, modern trials are absent. Claims of dependency avoidance or absence of hangover effects lack direct comparative human data against agents such as zolpidem.\n\n---\n\nRelated:\n[DSIP](/a/dsip)\n\n[[embed:dsip]]","claims":[{"id":"c29","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tier":"mechanistic","weight":0.3,"effective_weight":0.3,"slot":"limitations","source_ids":[],"who_claims":"miscsubjects protocol","status":"active"},{"id":"c3","text":"No human data specifically examine DSIP in Adderall-induced or stimulant-related insomnia.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":null,"source_ids":[],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c6","text":"2024 study on DSIP fusion peptide showing efficacy in mouse insomnia model via neurotransmitter balancing and sleep promotion.","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":"what_is_known","source_ids":["s5"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c_map_dsip-adderall-insomnia","text":"Combinatorial mapping (transparent): dsip vs adderall-insomnia — regen=0.717, degen=0.75, Δ=-0.033. Method: layer_relevance(0.75) × evidence_factor(0.85); catalog.degen_score for Stimulant-driven insomnia.","tier":"system","weight":0.35,"effective_weight":0.35,"slot":"what_is_known","source_ids":[],"who_claims":"grok/4.3-populate"},{"id":"c28","text":"DSIP Peptide and Sleep Regulation: Evidence on Delta Sleep-Inducing Peptide is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tier":"system","weight":0.35,"effective_weight":0.35,"slot":"what_it_is","source_ids":[],"who_claims":"miscsubjects protocol","status":"active"},{"id":"c12","text":"Positive user experience: DSIP provides excellent nightly sleep and morning energy, cheap and effective for recovery/gains.","tier":"anecdotal","weight":0.3,"effective_weight":0.3,"slot":"who_claims_what","source_ids":["s11"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c13","text":"User with decades of insomnia reports dose-dependent improvement with DSIP, achieving 9 hours sleep at 1.5mg.","tier":"anecdotal","weight":0.3,"effective_weight":0.3,"slot":"who_claims_what","source_ids":["s12"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c1","text":"A 1992 double-blind study of 16 chronic insomniac patients found higher sleep efficiency and shorter sleep latency with DSIP versus placebo, but no changes in subjective measures and concluded short-term treatment is unlikely to be of major therapeutic benefit.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s1"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c2","text":"A 1981 study in 6 middle-aged chronic insomniacs reported longer sleep duration, higher quality, fewer interruptions, and normalizing influence on sleep regulation after intravenous DSIP.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s2"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c16","text":"2026 review summarizing DSIP research on sleep, mood, and other effects, including human trials for insomnia.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s15"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c17","text":"Medical site overview of DSIP research and sleep studies published Jan 2026.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s16"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c24","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"disclaimer","source_ids":[],"who_claims":"system/protocol","status":"active"},{"id":"c25","text":"There is no specific information on the long-term effects of DSIP on sleep patterns or potential dependency issues.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_unknown","quote_gated":true,"source_ids":["s1"],"who_claims":"kimi/moonshot-v1-8k","status":"active"},{"id":"c5","text":"Anecdotal user reports describe subjective sleep quality improvements with DSIP.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s4"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c7","text":"Reddit discussion on DSIP potentially interacting with or affecting Adderall/stimulant effects in ADHD users, in context of sleep.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s6"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c8","text":"Users suggest DSIP for sleep issues caused by dextroamphetamine/Adderall in ADHD context.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s7"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c9","text":"User reports DSIP improves deep sleep quality for severe insomnia but does not aid falling asleep; mixed with other peptides in comments for better results.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s8"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c10","text":"Positive report of dramatic sleep improvement (10+ hours deep sleep) via continuous low-dose DSIP via insulin pump; reduced benzo use, but later tolerance noted in follow-up.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s9"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c11","text":"User with narcolepsy/OSA on Adderall notes stimulant likely worsens sleep initiation and considers DSIP as promising option for deep sleep support.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s10"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c14","text":"Negative long-term outcome: initial strong benefits faded after ~2 months, leading to tolerance and return to other sleep aids.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s13"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c18","text":"Reddit anecdote and discussion on DSIP for sleep issues potentially related to stimulants.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s17"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c19","text":"YouTube video explaining DSIP mechanisms for sleep and related effects.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s18"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c27","text":"User on 20mg Adderall XR reports prior insomnia, multiple awakenings, and bedtime anxiety; after 3 weeks DSIP (5 on/2 off, subq ~1hr before bed) notes improved deep sleep (up to 3.5 hrs), feeling rested despite shorter sleep or jet lag, and overall payoff for stimulant-related sleep issues.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s19"],"who_claims":"grok-4.3","status":"active"},{"id":"c4","text":"Commercial vendors and clinics market this compound (4 commercial/clinic sources catalogued) — marketing material, not evidence.","tier":"speculative","weight":0.12,"effective_weight":0.12,"slot":"who_claims_what","source_ids":["s3","s14","s6","s7"],"who_claims":"commercial vendors","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/1299794/","title":"Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study","summary":"Double-blind study (n=16) showing limited objective benefits without subjective or major clinical impact.","quote":"The results for objective sleep quality indicated higher sleep efficiency and shorter sleep latency with DSIP as compared to placebo... it was concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of major therapeutic benefit.","quote_status":"unverified","link_status":"ok","claim_ids":["c1","c25"],"hash":"b7cd2e6d39446f11"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/7028502/","title":"The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep","summary":"Small study (n=6) reporting sleep normalization effects.","quote":"The results were: longer sleep duration and a higher quality of sleep with fewer interruptions... The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.","quote_status":"unverified","link_status":"ok","claim_ids":["c2"],"hash":"65f9bb15fd04be6a"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/6548818/","title":"DSIP reduces amphetamine-induced hyperthermia in mice","summary":"Preclinical thermoregulatory study with amphetamine.","quote":"A reduction of the increased temperature was observed in mice but not in rats.","quote_status":"verified","link_status":"ok","claim_ids":["c4"],"hash":"58815c2eb807d7c9"},{"id":"s4","type":"youtube","url":"https://www.youtube.com/watch?v=grwWLZedRQQ","title":"DSIP Peptide: Revolutionizing Sleep, Stress, and Pain ...","summary":"User testimonial excerpt on subjective sleep effects.","quote":"My personal experience-after 10 years of insomnia and trying SO many things, I'm finding great success with 100 mcg DSIP 30-60 min before bed.","quote_status":"unverified","link_status":"http_429","claim_ids":["c5"],"hash":"f85ce16a3d52a394"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/39444618/","title":"Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models","summary":"2024 study on DSIP fusion peptide showing efficacy in mouse insomnia model via neurotransmitter balancing and sleep promotion.","quote":"The study underscores DSIP-CBBBP potential in correcting neurotransmitter dysregulation and promoting sleep, hinting at its utility in sleep-related therapies.","quote_status":"verified","link_status":"ok","claim_ids":["c6"],"hash":"077639f2ae74c4de"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/ADHDers/comments/1shiytb/delta_sleepinducing_peptide_dsip_did_it_affect/","title":"Delta Sleep-Inducing Peptide (DSIP) — did it affect your prescription stimulants?","summary":"Reddit discussion on DSIP potentially interacting with or affecting Adderall/stimulant effects in ADHD users, in context of sleep.","quote":"When pathways healed, strat an hour after I took it would decrease Adderall effect, which I took Adderall ...","quote_status":"unverified","link_status":"ok","claim_ids":["c7","c4"],"hash":"4060a44108d7dc7d"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/Nootropics/comments/1qk6n6v/sleep_issues_with_dextroamphetamine/","title":"Sleep Issues with Dextroamphetamine","summary":"Users suggest DSIP for sleep issues caused by dextroamphetamine/Adderall in ADHD context.","quote":"you can try DSIP peptide 30 min before you want to fall asleep ... Fellow ADHD'er here, adderall , lfetime sleep issues.","quote_status":"unverified","link_status":"ok","claim_ids":["c8","c4"],"hash":"2487c092c8b77535"},{"id":"s8","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","summary":"User reports DSIP improves deep sleep quality for severe insomnia but does not aid falling asleep; mixed with other peptides in comments for better results.","quote":"I'm taking a break after a month of using DSIP every other day at 125 mg. I have severe insomnia, but I think that DSIP is giving me deeper sleep. It just doesn't help me fall asleep.","quote_status":"unverified","link_status":"ok","claim_ids":["c9"],"hash":"e76582bff875a9b7"},{"id":"s9","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","summary":"Positive report of dramatic sleep improvement (10+ hours deep sleep) via continuous low-dose DSIP via insulin pump; reduced benzo use, but later tolerance noted in follow-up.","quote":"The first day using DSIP in this manner made me sleep about 10 hours, a 2 hour nap in the afternoon followed by a solid 8 hours during the night with little to no wake-up, something I haven't had in about 30 years.","quote_status":"unverified","link_status":"ok","claim_ids":["c10"],"hash":"505c0949ede90b77"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1rgdoj8/sleep_support_for_narcolepsy/","title":"Sleep support for Narcolepsy","summary":"User with narcolepsy/OSA on Adderall notes stimulant likely worsens sleep initiation and considers DSIP as promising option for deep sleep support.","quote":"I do take adderall 30mg Ir x2 so that could be affecting sleep. ... I have heard of DSIP and that looks promising especially as a nasal spray","quote_status":"unverified","link_status":"ok","claim_ids":["c11"],"hash":"62cabe0a9fdd681a"},{"id":"s11","type":"x","url":"https://x.com/AntiDoc/status/1904576757568545067","title":"X post by @AntiDoc on DSIP sleep benefits","summary":"Positive user experience: DSIP provides excellent nightly sleep and morning energy, cheap and effective for recovery/gains.","quote":"More/better sleep means more/dramatically better gains. That’s why DSIP is quickly becoming one of my favorite peptides. Ridiculous sleep every night. Ridiculous energy every morning.","quote_status":"verified","link_status":"ok","claim_ids":["c12"],"hash":"9cce755a7bfe9d29"},{"id":"s12","type":"x","url":"https://x.com/troywhiteyyc/status/2069118587764453799","title":"X post by @troywhiteyyc on DSIP dosing for insomnia","summary":"User with decades of insomnia reports dose-dependent improvement with DSIP, achieving 9 hours sleep at 1.5mg.","quote":"I started testing out DSIP for sleep management. First night 1mg- no real major difference - 4 hours Second night 1mg - same amount of sleep Third night 1.5mg - 9 hours","quote_status":"verified","link_status":"ok","claim_ids":["c13"],"hash":"8ff41e681a1cc9ed"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1afsuih/any_personal_experience_with_dsip_delta/","title":"any personal experience with DSIP (Delta Sleep-Inducing Peptide)?","summary":"Negative long-term outcome: initial strong benefits faded after ~2 months, leading to tolerance and return to other sleep aids.","quote":"Unfortunately, dsip lost its effect (I took it for about 3 months and the last month it wasn’t working). Tried from two different sources and still nada.","quote_status":"unverified","link_status":"ok","claim_ids":["c14"],"hash":"7bff73ef6e6520cb"},{"id":"s14","type":"clinical_trial","url":"https://pubmed.ncbi.nlm.nih.gov/3622582/","title":"Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia","summary":"Double-blind placebo-controlled clinical trial showing DSIP improves sleep and daytime function in chronic insomniacs.","quote":"The treatment substantially improved night sleep with the first and additionally with repeated doses. These effects were maintained for the first posttreatment (placebo) night. Efficiency of night sleep and daytime rest reached the levels of normal controls. Alertness and performance at daytime increased significantly. The study demonstrates the efficacy of DSIP for the treatment of impaired sleep and daytime functions as well.","quote_status":"verified","link_status":"ok","claim_ids":["c4"],"hash":"82fc43eabdef9579"},{"id":"s15","type":"review","url":"https://www.innerbody.com/dsip-delta-sleep-inducing-peptide","title":"DSIP (Delta Sleep-Inducing Peptide) | Full Rundown [2026]","summary":"2026 review summarizing DSIP research on sleep, mood, and other effects, including human trials for insomnia.","quote":"In 1981, for example, a paper published in the International Journal of Clinical Pharmacology, Therapy, and Toxicology described a trial with six volunteers who experienced immediate sleep pressure after intravenous DSIP infusion, as well as increased sleep time, decreased sleep onset, and better sleep efficiency without any sedative effects.","quote_status":"unverified","link_status":"ok","claim_ids":["c16"],"hash":"97beb1a9e7e46af4"},{"id":"s16","type":"medical","url":"https://drlewis.com/dsip-delta-sleep-inducing-peptide/","title":"DSIP Peptide: Research, Benefits, Dosage & Sleep Studies","summary":"Medical site overview of DSIP research and sleep studies published Jan 2026.","quote":"One of the most frequently cited human studies evaluated DSIP in patients with chronic insomnia and found modest improvements in sleep ...","quote_status":"unverified","link_status":"ok","claim_ids":["c17"],"hash":"2fde569b22673a4e"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1rj4824/dsip_the_overlooked_peptide_for_deep_sleep/","title":"The Overlooked Peptide for Deep Sleep & Chronic Fatigue","summary":"Reddit anecdote and discussion on DSIP for sleep issues potentially related to stimulants.","quote":"If deep sleep is compromised, no amount of stimulants will fix that. DSIP was studied as a way to: Restore deeper sleep phases. Normalize stress ...","quote_status":"unverified","link_status":"ok","claim_ids":["c18"],"hash":"1cd400bbe177bb70"},{"id":"s18","type":"youtube","url":"https://www.youtube.com/watch?v=dz6vYHXE3Yc","title":"How does the Peptide DSIP Work?","summary":"YouTube video explaining DSIP mechanisms for sleep and related effects.","quote":"Delta Sleep‑Inducing Peptide (DSIP) is a neuropeptide studied for its potential involvement in sleep regulation , stress responses, and ...","quote_status":"unverified","link_status":"http_429","claim_ids":["c19"],"hash":"d75ac9a2814b498a"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/PeptideDiscussion/comments/1k74ddg/doctor_offering_dsip_deltasleepinducing_peptide/","title":"Doctor offering DSIP (Delta-sleep-inducing peptide), worth getting?","summary":"User on 20mg Adderall XR reports prior insomnia, multiple awakenings, and bedtime anxiety; after 3 weeks DSIP (5 on/2 off, subq ~1hr before bed) notes improved deep sleep (up to 3.5 hrs), feeling rested despite shorter sleep or jet lag, and overall payoff for stimulant-related sleep issues.","quote":"20mg of adderall xr daily had me struggling to find sleep at 10pm. I struggled with bouts of insomnia, waking up +/- 2 times a night and bedtime anxiety but now I’m actually seeing a pay off. Cannot wait to see how well my sleep progresses with time and DSIP ... I’ve been on DSIP for three weeks now. 5 on 2 off. ... Typically my whoop would show me in light sleeping stage for about 3 hrs with that amount of sleep but I was maxing about 3.5 hrs of deep sleep. ... waking up fee","quote_status":"unverified","link_status":"ok","claim_ids":["c27"],"hash":"b8deaca6136f4ae1"}],"voxels":{"slug":"dsip-adderall-insomnia","counts":{"divs":18,"voxels":24,"sources":19,"edges":46},"note":"slim bundle — full voxels at /api/articles/dsip-adderall-insomnia/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"collaborate","model":"kimi/moonshot-v1-8k","ts":"2026-06-29T13:45:41.971Z","hash":"40c2b52be2571d23","tokens_in":3142,"tokens_out":293},{"action":"repair","model":"system/audit-repair","ts":"2026-06-29T13:53:56.977Z","hash":"8e643a985c53d1a7","tokens_in":0,"tokens_out":0},{"action":"repair","model":"system/audit-repair","ts":"2026-06-29T13:53:58.271Z","hash":"1d8c498d962b7713","tokens_in":0,"tokens_out":0},{"action":"sources","model":"grok-4.3","ts":"2026-06-29T16:37:30.239Z","hash":"6e33598dfeab2e45","tokens_in":0,"tokens_out":0},{"action":"repair","model":"repair","ts":"2026-06-29T20:07:01.849Z","hash":"bef461b21eca46fb","tokens_in":0,"tokens_out":0},{"action":"claim","model":"fill-slots","ts":"2026-06-29T21:18:05.939Z","hash":"750d946c041a874c","tokens_in":0,"tokens_out":0},{"action":"claim","model":"fill-slots","ts":"2026-06-29T21:18:07.327Z","hash":"3fe5ac8a545cf5dd","tokens_in":0,"tokens_out":0},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:39:01.448Z","hash":"342e0c8ecbb3e23e","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T09:24:07.737Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"05620bcae5a9f0d4a9d77255f020993eadbaa53bed433ed1ffc10aaf44a5c7f6"},{"id":"k2","ts":"2026-06-29T11:23:18.167Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"225ea7b5a790fb7c07353e80b39bd2a8cf763bd84b72929a0c9aeca4a4107fc0"},{"id":"k3","ts":"2026-06-29T12:08:53.213Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"35457521c4b4710f98143ee6b75a1ccee3d2af254e01c49526ae1b6250b3925a"},{"id":"k4","ts":"2026-06-29T12:09:09.861Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 2","hash":"9b48ed5a49c73b51d031ab04f2d6dcc09482f468ebc6e0452cdb7c8eb1742e7a"},{"id":"k5","ts":"2026-06-29T12:45:09.734Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"104ba7da9f1dee97e05ce82f58b4d70422c82f216ef9311b316aa3bf0573072e"},{"id":"k6","ts":"2026-06-29T12:45:09.772Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"fc5500908b5cb804aaf3509bffa692a7d417f81ef720fdebdf10d889177e1774"},{"id":"k7","ts":"2026-06-29T12:45:09.817Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"48fac2c46f8104d14967b15a803651488e9e3dac505b66305c6f08dc05aac2a2"},{"id":"k8","ts":"2026-06-29T12:45:09.860Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"c0088042b4b08acab0ef078bd488f38fb21def22657347cb675c123c88227955"},{"id":"k9","ts":"2026-06-29T12:45:09.907Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"7324e4cbd8e509824543d0223e78f79fd148f71c8ffd8f8faf2942ab5a45872e"},{"id":"k10","ts":"2026-06-29T13:45:41.971Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","rationale":"I am adding claims to fill explicit gaps in the ledger as per the instructions. I am not Grok because I am focusing on adding new claims to the ledger rather than challenging existing ones.","hash":"2399748dfae6d64086d29d2e082a773183286be8a103f532567ac9762939c87f"},{"id":"k11","ts":"2026-06-29T16:37:30.239Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"9e40b83db31d93f509624fe1973cab02b01c635558386cd915283a94b18a7490"},{"id":"k12","ts":"2026-06-29T21:18:05.939Z","model":"fill-slots","role":"claim_post","action":"claim","rationale":"","hash":"ce42d9dd341b5ef0d4293953c1f1c99ad6a123604c8e16b7db173927c2f64bcb"},{"id":"k13","ts":"2026-06-29T21:18:07.327Z","model":"fill-slots","role":"claim_post","action":"claim","rationale":"","hash":"fa790faee386d91f93e09f038247956e7d86c7cca76895fa35247dfbde2febf7"}],"topology":null,"slim":true,"ledger_totals":{"claims":24,"sources":19,"exported_claims":24,"exported_sources":19},"question_graph":{"slug":"dsip-adderall-insomnia","questions":[],"evidence":[{"ingest_id":"ev_351ae3c3a012","ts":"2026-06-29T13:45:41.971Z","slug":"dsip-adderall-insomnia","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I am adding claims to fill explicit gaps in the ledger as per the instructions. I am not Grok because I am focusing on adding new claims to the ledger rather than challenging existing ones.","source_ids":[],"claim_ids":["c25","c26"],"model":"kimi/moonshot-v1-8k","hash":"3db97cb342b260c6853fcd2ae591def21d1a61a114fcbd825b0457d69a12caa4","status":"promoted"}],"edges":[],"counts":{"questions":0,"evidence":1,"edges":0}},"verification":{"provenance":{"valid":true,"entries":23,"head":"342e0c8ecbb3e23e5f0331eaa4a03c1a8aa7095552767e39d0340b090e0fbc5c"},"sources":{"valid":true,"entries":19,"head":"b8deaca6136f4ae18b485b1d5a1967cb1e3aeca2fd995824c8a0a88c17cca796"}},"counts":{"claims":24,"sources":19,"provenance":23,"contributions":13,"questions":0,"evidence_ingests":1,"voxel_edges":46},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/dsip-adderall-insomnia","bundle_json":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/topology","question_graph":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/question-graph","sources":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/sources","provenance":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/provenance","contributions":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/contributions","graph_topology":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=dsip-adderall-insomnia","graph_yield":"https://miscsubjects.com/api/graph?slugs=dsip-adderall-insomnia&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=dsip-adderall-insomnia","graph_query":"https://miscsubjects.com/api/v1/query?from=dsip-adderall-insomnia&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"dsip-adderall-insomnia|your question","router_tag":"[ARTICLE_ASK]dsip-adderall-insomnia|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest dsip-adderall-insomnia|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]dsip-adderall-insomnia|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim dsip-adderall-insomnia|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]dsip-adderall-insomnia|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"dsip-adderall-insomnia","url":"https://miscsubjects.com/a/dsip-adderall-insomnia","bundle_url":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/dsip-adderall-insomnia) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"dsip-adderall-insomnia\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"dsip-adderall-insomnia\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"dsip-adderall-insomnia\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"dsip-adderall-insomnia\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"dsip-adderall-insomnia\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"dsip-adderall-insomnia\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/dsip-adderall-insomnia/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/dsip-adderall-insomnia/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/dsip-adderall-insomnia#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/topology","voxels":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/dsip-adderall-insomnia/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}