{"slug":"dihexa","title":"dihexa","body":"## Overview\nEvidence is being populated by Grok web search.","register":"standard","tags":[],"category":null,"style":{},"claims":[{"id":"c1","text":"2026 review discusses dihexa among neuroactive peptides for potential neuroplasticity benefits via HGF/c-Met and BDNF pathways, noting promising preclinical data but absence of clinical trials.","section":"mechanism","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Materialized from orphan source s1 by ledger repair"},{"id":"c2","text":"2024 preclinical study examining Dihexa (as PNB-0408) in a rat model of 3-nitropropionic acid-induced neurotoxicity modeling Huntington’s disease, highlighting its neuroprotective properties.","section":"what_is_known","tier":"preclinical","source_ids":["s2"],"source_status":"sourced","why_material":"Materialized from orphan source s2 by ledger repair"}],"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions","quote":"neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity. Although preclinical studies are promising, there is a current lack of clinical trials.","summary":"2026 review discusses dihexa among neuroactive peptides for potential neuroplasticity benefits via HGF/c-Met and BDNF pathways, noting promising preclinical data but absence of clinical trials.","author":"","publisher":"","date":"","claim_ids":["c1"]},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38489193/","title":"Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Neurotoxicity in Rats","quote":"N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (PNB-0408), also known as Dihexa , has been shown to have neuroprotective and procognitive properties in animal models of Alzheimer's and Parkinson's diseases.","summary":"2024 preclinical study examining Dihexa (as PNB-0408) in a rat model of 3-nitropropionic acid-induced neurotoxicity modeling Huntington’s disease, highlighting its neuroprotective properties.","author":"","publisher":"","date":"","claim_ids":["c2"]}],"prov":{"model":"grok/grok-4.3","action":"write"}}