{"slug":"dihexa","verification":{"valid":true,"entries":2,"head":"31d58be61bffda04a2fe6771f696b7dc6dd1626dcc68b515ec5a1e13a305423d"},"count":2,"sources":[{"id":"s1","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/41490200/","title":"Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions","quote":"neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity. Although preclinical studies are promising, there is a current lack of clinical trials.","summary":"2026 review discusses dihexa among neuroactive peptides for potential neuroplasticity benefits via HGF/c-Met and BDNF pathways, noting promising preclinical data but absence of clinical trials.","author":"","publisher":"","date":"","claim_ids":["c1"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:53:09.676Z","link_status":"ok","quote_status":"verified","prev":"genesis","hash":"8ee34f83fc1f99b32a799222f7503e483e636ffece7f75898c770b7fbd071333"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38489193/","title":"Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Neurotoxicity in Rats","quote":"N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide (PNB-0408), also known as Dihexa , has been shown to have neuroprotective and procognitive properties in animal models of Alzheimer's and Parkinson's diseases.","summary":"2024 preclinical study examining Dihexa (as PNB-0408) in a rat model of 3-nitropropionic acid-induced neurotoxicity modeling Huntington’s disease, highlighting its neuroprotective properties.","author":"","publisher":"","date":"","claim_ids":["c2"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T16:53:26.273Z","link_status":"ok","quote_status":"unverified","prev":"8ee34f83fc1f99b32a799222f7503e483e636ffece7f75898c770b7fbd071333","hash":"31d58be61bffda04a2fe6771f696b7dc6dd1626dcc68b515ec5a1e13a305423d"}]}