{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_topology","feature":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","contains":"claims, sources, anecdotes, question_graph slice","slug":"bpc-ara-post-surgical-nerve","urls":{"read":"https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/topology"},"how_to_use":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"graph_topology","name":"Cross-article graph","what":"Merged claims/sources across condition+stack slugs for one question.","urls":{"read":"https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/graph-topology?question=..."}},{"id":"question_graph","name":"Question graph","what":"Ask nodes (questions + gaps) and evidence_ingest nodes (pasted model output).","urls":{"read":"https://miscsubjects.com/api/articles/bpc-ara-post-surgical-nerve/question-graph","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). 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Per-claim provenance."}],"not_medical_advice":true},"slug":"bpc-ara-post-surgical-nerve","title":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary","register":"source_ledger","tags":["peptide","topic"],"updated_at":"2026-07-17T02:38:41.467Z","body_excerpt":"## Regeneration vs degeneration — where this fits\nThe body breaks down tissue and builds it back at the same time. When breakdown outruns repair after surgery, nerve damage can stay. Most drugs reduce pain signals without fixing the nerve itself. BPC-157 and ARA-290 are studied for repair steps: new blood vessels, cell migration to the injury, and nerve fiber regrowth.\n\n## What it is\nBPC-157 is a peptide studied in rat nerve injury models. ARA-290 is a peptide studied in human small fiber neuropathy trials. The ledger covers their separate use and reported stacking for post-surgical nerve damage.\n\n## How it works\nBPC-157 is linked to angiogenesis and cytoprotection at the injury site in rat models. ARA-290 binds the innate repair receptor on nerve tissue and immune cells. Binding reduces neuroinflammation and supports nerve fiber regrowth.\n\n## Why it would work (logic chain)\nIf surgery cuts or stretches a nerve, then axons and myelin break down. If new blood vessels form and repair cells reach the site, then axons can regrow. If inflammation stays high, then regrowth slows. BPC-157 is proposed to aid the vessel and repair-cell steps. ARA-290 is proposed to lower inflammation and signal regrowth through the innate repair receptor. If both pathways run, then repair might increase.\n\n## Why people take it\nPeople report post-surgical nerve pain or numbness that does not resolve. They look for options that target repair instead of only symptom relief.\n\n## How many people take it\nUnknown. The ledger shows 8 Reddit posts, 5 X posts, and 3 other anecdote sources. No population count exists.\n\n## Evidence inventory\nSources total 28. Studies catalogued 11. Reddit posts 8. X posts 5. Other anecdote sources 3. Human claims 3. Preclinical claims 8. Anecdotal claims 17. Human data come from ARA-290 sarcoidosis trials. BPC-157 data are rat sciatic nerve transection studies. No human trial tests either compound or the combination for post-surgical nerve damage.\n\n## What scientists say\nRat study s1 showed BPC-157 improved axonal regeneration, myelin thickness, and motor function after sciatic nerve transection. Human trial s2 found ARA-290 improved SFNSL scores and increased corneal nerve fiber density after 28 days in sarcoidosis patients. Review s8 states ARA-290 reprograms a proinflammatory state toward healing. Review s18 states BPC-157 has the strongest preclinical evidence for peripheral nerve regeneration while ARA-290 has the strongest clinical evidence for small fiber neuropathy. No study tests the combination for post-surgical nerve damage.\n\n## What people say on Reddit\nReddit post s11 states: “I got a neuropathic pain due to nerve damage after surgery.” The user reports stacking BPC-157, TB-500, and ARA-290. Post s4 states the user added ARA-290 to BPC-157/TB-500 and saw symptom changes. Post s14 reports reduced nerve cracking after two months of ARA-290 but increased twitching after starting BPC-157. Post s15 states BPC-157 plus TB-500 produced no benefit during a flare, while ARA-290 gave roughly 50 percent improvement. Post s17 states ARA-290 gave temporary relief that lasted about two months after a one-month course. These are single-person reports, not controlled data.\n\n## What people say on X\nX post s24 states ARA-290 at 2-4 mg daily paired with BPC-157 plus TB-500 for nerve repair and that results build over 3-4 weeks. Post s25 states ARA-290 reduces inflammation and supports nerve repair when paired with BPC-157. Post s26 states the stack of ARA-290, TB-500, and BPC-157 improved nerve function and mobility after soft-tissue healing. Post s27 states the user added ARA-290 to an existing TB-500 and BPC-157 cycle for nerve repair. These are individual accounts of perceived change.\n\n## What we do not know\nNo human clinical trial tests BPC-157 or the BPC-157 plus ARA-290 combination for post-surgical nerve damage. Long-term effects and safety in this setting are unknown. Species differences mean rat nerve data may not translate to ","ranking":"safety-first (interaction_risk/limitations), then quote-gated effective_weight","claims":[{"id":"c64","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tier":"mechanistic","weight":0.3,"section":"limitations","slot":"limitations","interaction_risk":false,"status":"active","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: limitations","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.3,"quote_gated":false},{"id":"c35","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tier":"human","weight":0.8,"section":"disclaimer","slot":"disclaimer","interaction_risk":false,"status":"active","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: disclaimer","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.8,"quote_gated":false},{"id":"c63","text":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tier":"system","weight":0.35,"section":"what_it_is","slot":"what_it_is","interaction_risk":false,"status":"active","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: what_it_is","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.35,"quote_gated":false},{"id":"c7","text":"Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including BPC-157 contexts.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s5"],"source_status":"sourced","why_material":"Materialized from orphan source s5 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.3,"quote_gated":false},{"id":"c27","text":"Anecdotal report of ARA-290 stacked with BPC-157 aiding nerve repair and recovery.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s25"],"source_status":"sourced","why_material":"Materialized from orphan source s25 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.3,"quote_gated":false},{"id":"c30","text":"User discusses potential benefits of ARA-290 for nerve regeneration/damage (drop foot), mentions BPC/TB stack positively for back pain.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s28"],"source_status":"sourced","why_material":"Materialized from orphan source s28 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.3,"quote_gated":false},{"id":"c37","text":"Anecdotal reports from users on platforms like Reddit and Instagram suggest that BPC-157 and ARA-290 may help with post-surgical nerve pain, but these claims lack rigorous scientific validation.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s4","s5"],"source_status":"sourced","why_material":"This claim names specific anecdotal claimants from social media platforms, providing a more detailed view of who is making these claims and from where, which is important for assessing the credibility and context of anecdotal evidence.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.3,"quote_gated":false},{"id":"c2","text":"ARA-290 treatment for 28 days in sarcoidosis patients with small fiber neuropathy improved neuropathic symptoms and increased corneal nerve fiber density.","tier":"human","weight":0.8,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s2"],"source_status":"sourced","why_material":"Provides the only cited human trial evidence for nerve fiber regrowth.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c8","text":"Compares ARA-290 (nerve-specific) with BPC-157 (broad repair) for post-surgical nerve pain; supports potential stacking.","tier":"human","weight":0.8,"section":"what_is_unknown","slot":"what_is_unknown","interaction_risk":false,"status":"active","source_ids":["s6"],"source_status":"sourced","why_material":"Materialized from orphan source s6 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c9","text":"Phase II trial data on ARA-290 improving neuropathic symptoms and nerve fibers in sarcoidosis; relevant to nerve damage repair (no BPC-157).","tier":"human","weight":0.8,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s7"],"source_status":"sourced","why_material":"Materialized from orphan source s7 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c40","text":"A medical resource characterizes ARA-290 as a tissue-protective peptide for nerve pain.","tier":"human","weight":0.8,"section":"what_is_unknown","slot":"what_is_unknown","interaction_risk":false,"status":"active","source_ids":["s3"],"source_status":"sourced","why_material":"This claim materializes information from an orphan source (s3) and provides context on how ARA-290 is described in some medical literature, enriching the 'who_claims_what' section.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c41","text":"A review article discusses ARA-290 in the context of neuropathic pain and nerve repair.","tier":"human","weight":0.8,"section":"what_is_unknown","slot":"what_is_unknown","interaction_risk":false,"status":"active","source_ids":["s6"],"source_status":"sourced","why_material":"This claim materializes information from an orphan source (s6), indicating the scope of discussion for ARA-290 in a review, which is relevant to understanding the broader literature landscape.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c1","text":"BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.","tier":"preclinical","weight":0.22,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"downweighted","source_ids":["s1"],"source_status":"sourced","why_material":"Documents rat-specific evidence for peripheral nerve healing separate from human data.","retracted_at":null,"retraction_reason":null,"challenged_by":["c38"],"effective_weight":0.22,"quote_gated":true},{"id":"c4","text":"BPC-157 effects in rat nerve models involve angiogenesis and cytoprotection at the injury site.","tier":"preclinical","weight":0.22,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s1"],"source_status":"sourced","why_material":"Links given peptide definition to observed rat outcomes.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c36","text":"There is no information on the long-term effects or safety of using BPC-157 or ARA-290 for post-surgical nerve damage in humans.","tier":"preclinical","weight":0.22,"section":"what_is_unknown","slot":"what_is_unknown","interaction_risk":false,"status":"active","source_ids":["s1"],"source_status":"sourced","why_material":"This claim addresses an explicit gap in the evidence regarding long-term safety and effects, which is crucial for understanding the complete picture of these treatments.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c39","text":"The efficacy and safety of BPC-157, or the combination of BPC-157 and ARA-290, specifically for post-surgical nerve damage in humans, remain unknown.","tier":"preclinical","weight":0.22,"section":"what_is_unknown","slot":"what_is_unknown","interaction_risk":false,"status":"active","source_ids":["s1","s2","s7","s10"],"source_status":"sourced","why_material":"This claim explicitly states a critical gap in human clinical evidence for the specific condition and combination, which is central to the ledger's topic. It uses existing sources to frame what has been studied to emphasize what has not.","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c6","text":"User anecdotes on stacking ARA-290 with BPC-157 for neuropathy pain relief and nerve healing; reports of symptom improvement and flares.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s4"],"source_status":"sourced","why_material":"Materialized from orphan source s4 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c13","text":"User anecdote on stacking BPC-157, TB-500, and ARA-290 specifically for post-surgical neuropathic pain.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s11"],"source_status":"sourced","why_material":"Materialized from orphan source s11 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c15","text":"Mentions BPC-157 and ARA-290 peptide therapy for residual nerve pain after surgery.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s13"],"source_status":"sourced","why_material":"Materialized from orphan source s13 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c16","text":"User reports partial positive effect from 2 months ARA-290 (reduced nerve cracking and myoclonus) but negative reaction to BPC-157 (increased twitching), planning lower dose retry; context is SFN from toxic insult, considering stack for nerve repair.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s14"],"source_status":"sourced","why_material":"Materialized from orphan source s14 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c17","text":"User reports BPC-157 + TB-500 as ineffective/waste for neuropathy flare-up, leading to trying ARA-290 instead (which provided ~50% symptom improvement).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s15"],"source_status":"sourced","why_material":"Materialized from orphan source s15 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c18","text":"User mentions using ARA-290 (4mg cycle) after major back surgery in context of nerve/pain management and peptide stacking.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s16"],"source_status":"sourced","why_material":"Materialized from orphan source s16 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c19","text":"User reports ARA-290 provides temporary pain relief for neuropathy (relief lasting ~2 months after 1-month course) but requires ongoing/periodic use and is costly.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s17"],"source_status":"sourced","why_material":"Materialized from orphan source s17 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c22","text":"Reddit post (anecdotal/user guide) on ARA-290 for neuropathic pain and nerve regeneration, explicitly recommending stacking with BPC-157 for neuroprotection and tissue repair in nerve damage scenarios.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s20"],"source_status":"sourced","why_material":"Materialized from orphan source s20 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c25","text":"Reddit thread on BPC-157 for chronic/long-term nerve damage (feet pain), with context of neuropathy management.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s23"],"source_status":"sourced","why_material":"Materialized from orphan source s23 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c26","text":"User reports positive pairing of ARA-290 with BPC-157 (and TB-500) for nerve repair, with dosing and timeline advice.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s24"],"source_status":"sourced","why_material":"Materialized from orphan source s24 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c28","text":"User reports improved nerve function and mobility after stacking ARA-290 with BPC-157 and TB-500 for injury-related nerve issues.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s26"],"source_status":"sourced","why_material":"Materialized from orphan source s26 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c29","text":"User describes adding ARA-290 to BPC-157/TB-500 stack specifically for nerve repair post-injury.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s27"],"source_status":"sourced","why_material":"Materialized from orphan source s27 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c42","text":"OP discusses positive anecdotal results with BPC-157 for back pain (possibly post-surgical/nerve related) and interest in stacking/adding ARA-290; comments report no effect from ARA-290 at 4mg/day for 8-60 days (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s29"],"source_status":"sourced","why_material":"Materialized from orphan source s29 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c43","text":"User with severe neuropathy reports negative outcome from BPC-157 (flare); plans to try ARA-290 (anecdotal experiences shared, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s30"],"source_status":"sourced","why_material":"Materialized from orphan source s30 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c44","text":"Post-surgical nerve damage patient starting BPC-157; comment recommends ARA-290 or PEG-MGF as better for nerves, with one positive anecdotal BPC story for femoral nerve recovery (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s31"],"source_status":"sourced","why_material":"Materialized from orphan source s31 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c45","text":"Discussion of stacking ARA-290 and BPC-157 for nerve issues/muscle twitching/tingling; mixed anecdotal mentions of BPC side effects (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s32"],"source_status":"sourced","why_material":"Materialized from orphan source s32 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c47","text":"Anecdotal guide suggesting stack of ARA-290 with BPC-157 for post-trauma/surgery nerve damage; labels as research only, not advice. Good outcomes implied for nerve regeneration.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s34"],"source_status":"sourced","why_material":"Materialized from orphan source s34 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c48","text":"Anecdotal explanation of stacking ARA-290 with BPC-157 for nerve issues; no specific side effects mentioned, focuses on complementary repair.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s35"],"source_status":"sourced","why_material":"Materialized from orphan source s35 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c49","text":"Anecdotal post discussing BPC-157 for nerve healing alongside ARA-290 mentions; rat study reference, positive for recovery.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s36"],"source_status":"sourced","why_material":"Materialized from orphan source s36 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c50","text":"Anecdotal X post recommending ARA-290 stack with BPC-157 for nerve pain (including disc-related); dosing anecdote 1-4mg, positive for chronic nerve issues.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s37"],"source_status":"sourced","why_material":"Materialized from orphan source s37 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c51","text":"Anecdotal reply on X about BPC-157 + ARA-290 for nerve condition (CRPS, post-injury like); mixed outcomes with BPC helping some, overall positive stack mention.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s38"],"source_status":"sourced","why_material":"Materialized from orphan source s38 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c52","text":"User reports dramatic improvement in allodynia and neuropathy symptoms after 8 days of ARA-290 (titrated to 4mg), combined with electrical stimulator; mentions prior severe nerve pain post unknown trigger, anecdotal positive outcome with no side effects noted.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s39"],"source_status":"sourced","why_material":"Materialized from orphan source s39 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c53","text":"User with disc herniation, peripheral neuropathy, nerve damage post fusions/knee issues starting ARA-290 protocol (up to 6mg); no benefits/side effects in first week, anecdotal dosing report for post-surgical nerve pain context.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s40"],"source_status":"sourced","why_material":"Materialized from orphan source s40 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c54","text":"Comment mentions ARA-290 for long-term nerve damage from TBI; positive anecdotal outcome, pairs with discussions of BPC in broader peptide contexts for nerve issues.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s41"],"source_status":"sourced","why_material":"Materialized from orphan source s41 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c55","text":"User stacks ARA-290 + BPC-157 + TB-500 for sciatica/nerve pain (post-surgical nerve compression context); anecdotal positive for healing/nerve pain relief, no dosing or side effects detailed.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s42"],"source_status":"sourced","why_material":"Materialized from orphan source s42 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c56","text":"Post promotes ARA-290 for nerve damage repair; mentions studies on small fiber restoration, relevant to post-surgical contexts; anecdotal endorsement of use (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s43"],"source_status":"sourced","why_material":"Materialized from orphan source s43 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c57","text":"Discussion of BPC-157 and other peptides including mentions of ARA-290 for nerve issues and chronic pain, anecdotal experiences with nerve repair.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s44"],"source_status":"sourced","why_material":"Materialized from orphan source s44 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c58","text":"Anecdotal inquiry about BPC-157 for post-GBS nerve damage recovery; users discuss potential for nerve repair (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s45"],"source_status":"sourced","why_material":"Materialized from orphan source s45 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c59","text":"User planning to try ARA-290 for facial neuropathy post issues, mentions stacking or combining with others; anecdotal dosing and expectations.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s46"],"source_status":"sourced","why_material":"Materialized from orphan source s46 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c60","text":"Anecdotal discussion recommending ARA-290 and BPC-157 for nerve damage from herniated disk; good outcomes noted in similar cases.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s47"],"source_status":"sourced","why_material":"Materialized from orphan source s47 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c61","text":"Positive anecdotal outcome with ARA-290 for nerve regeneration and symptom relief in SFN-like symptoms; no bad outcomes or sides mentioned here.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s48"],"source_status":"sourced","why_material":"Materialized from orphan source s48 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c62","text":"Anecdotal and research-based discussion of ARA-290 for nerve conditions, potential stacking with BPC-157 implied; mixed user experiences on efficacy.","tier":"anecdotal","weight":0.3,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s49"],"source_status":"sourced","why_material":"Materialized from orphan source s49 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.22,"quote_gated":true},{"id":"c3","text":"Commercial vendors and clinics market this compound (8 commercial/clinic sources catalogued) — marketing material, not evidence.","tier":"speculative","weight":0.12,"section":"who_claims_what","slot":"who_claims_what","interaction_risk":false,"status":"active","source_ids":["s3","s9","s10","s12","s18","s19","s22","s33"],"source_status":"sourced","why_material":"Collapsed 14 duplicate marketing claims","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.12,"quote_gated":false},{"id":"c10","text":"Reviews ARA290 (ARA-290) mechanism and evidence for neuropathy treatment via innate repair receptor, including nerve repair effects.","tier":"speculative","weight":0.12,"section":"mechanism","slot":"mechanism","interaction_risk":false,"status":"active","source_ids":["s8"],"source_status":"sourced","why_material":"Materialized from orphan source s8 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.12,"quote_gated":false},{"id":"c23","text":"Medical blog on ARA-290 for nerve conditions, mentions pairing with BPC-157 in regenerative protocols for inflammation and nerve issues.","tier":"speculative","weight":0.12,"section":"what_is_known","slot":"what_is_known","interaction_risk":false,"status":"active","source_ids":["s21"],"source_status":"sourced","why_material":"Materialized from orphan source s21 by ledger repair","retracted_at":null,"retraction_reason":null,"challenged_by":[],"effective_weight":0.12,"quote_gated":true}],"sources":[{"id":"s1","type":"pubmed","url":"https://link.springer.com/article/10.1186/s13018-019-1242-6","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing of transected sciatic nerve in rats","quote":"BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers...)","summary":"Rat sciatic nerve transection study showing BPC-157 improved regeneration metrics versus controls.","claim_ids":["c1","c4","c36","c39"],"link_status":"ok","quote_status":"unverified","hash":"5c797f94cb8a337ae3a6bb27dd3bf78f41a015c93847c41506688f3ef9f9f145"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3563705/","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy","quote":"The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in SFNSL score compared with placebo... In addition, ARA290 treatment for 28 days initiated a regrowth of small nerve fibers in the cornea...","summary":"Double-blind trial in sarcoidosis SFN patients; symptom improvement and corneal nerve regrowth observed.","claim_ids":["c2","c39"],"link_status":"ok","quote_status":"unverified","hash":"3f6703d6527253dc665f00b40cad2db368c25605d102353d45796e3cb35bad1f"},{"id":"s3","type":"medical","url":"https://peptidefox.com/content/ara-290","title":"ARA-290: Tissue-Protective Peptide for Nerve Pain","quote":"The reason to think it would help here is preclinical. The closest evidence is a rat study of a surgical nerve injury, where ARA-290 relieved touch and cold hypersensitivity and the effect vanished without the receptor³. That is a strong mechanistic match, but it is an animal model. No human trial has tested post-surgical nerve pain.","summary":"Discusses ARA-290 for post-surgical nerve pain (preclinical rat nerve injury model); notes BPC-157 as complementary structural repair peptide; human trials focus on sarcoidosis and diabetic neuropathy with nerve regeneration data.","claim_ids":["c40","c3"],"link_status":"ok","quote_status":"unverified","hash":"70a067265a27141cbb5cf65e579a8ff58b049c3394a784ef0c9333795eafe4f6"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"I’ve been on BPC157/TB 500 for a month or so now doing fine. Just added in ARA290 last week... The second cycle I did it I also stacked BPC-157/TB500. That seemed to help a lot.","summary":"User anecdotes on stacking ARA-290 with BPC-157 for neuropathy pain relief and nerve healing; reports of symptom improvement and flares.","claim_ids":["c6","c37"],"link_status":"ok","quote_status":"unverified","hash":"dd6a431b38eb364fe7d86a0441113175c635c8984c0e447f343108fcca51e0fa"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment with peptides","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy, tarsal tunnel, nerve injury or post operative nerve pain.","summary":"Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including BPC-157 contexts.","claim_ids":["c7","c37"],"link_status":"ok","quote_status":"verified","hash":"d85835f3c80b3cb4a28281baafbcfa1cf5c20c3361dafe6475f28450f841c295"},{"id":"s6","type":"review","url":"https://www.truehealwellness.com/peptides-research/ara-290","title":"ARA-290: Neuropathic Pain & Nerve Repair","quote":"For post-surgical nerve pain, the rationale is preclinical (an animal surgical-nerve-injury study); no human trial has tested it. ... Mechanisms don't overlap, so they can be used together when nerve pain sits inside a larger injury.","summary":"Compares ARA-290 (nerve-specific) with BPC-157 (broad repair) for post-surgical nerve pain; supports potential stacking.","claim_ids":["c8","c41"],"link_status":"ok","quote_status":"unverified","hash":"d9525f9103f647780202c22a3bc3d2233fe3729ee6f0ca920d643c3100eb4032"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","summary":"Phase II trial data on ARA-290 improving neuropathic symptoms and nerve fibers in sarcoidosis; relevant to nerve damage repair (no BPC-157).","claim_ids":["c9","c39"],"link_status":"ok","quote_status":"unverified","hash":"551bd778667108dd26403eb5727a0d8de06f81525a184d3e77d473a8300f3fd6"},{"id":"s8","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","summary":"Reviews ARA290 (ARA-290) mechanism and evidence for neuropathy treatment via innate repair receptor, including nerve repair effects.","claim_ids":["c10"],"link_status":"ok","quote_status":"verified","hash":"cf5cc177845d137d2178a87bbbecf79ac85f958b561c0da723dec20b03a4a3b9"},{"id":"s9","type":"other","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"Discover how combining ARA-290 and BPC-157 can accelerate peripheral nerve regeneration.","summary":"Discusses synergistic potential of ARA-290 and BPC-157 for peripheral nerve regeneration and neuropathic pain.","claim_ids":["c3"],"link_status":"ok","quote_status":"verified","hash":"2f38aaf002b2e603163fd885795455365ab2335a9b4b19353426cc2eb4deaefb"},{"id":"s10","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290, a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis.","summary":"Clinical trial investigating ARA 290 for neuropathic symptoms and nerve fiber density in sarcoidosis patients.","claim_ids":["c39","c3"],"link_status":"ok","quote_status":"unverified","hash":"8d3b8025658015ef92dade4b98f3a5d4307787884e3b601209a0f8722642be63"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/v4sj4d/bpc157_tb500_and_ara290_stack/","title":"BPC-157, TB-500, and ARA-290 stack","quote":"I got a neuropathic pain due to nerve damage after surgery.","summary":"User anecdote on stacking BPC-157, TB-500, and ARA-290 specifically for post-surgical neuropathic pain.","claim_ids":["c13"],"link_status":"ok","quote_status":"unverified","hash":"2809be7f3c503b51cee734087a42a61feb6afd687b08d5d1a221f277d229e29d"},{"id":"s12","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term functional improvement in this condition.","summary":"Video discussing ARA-290 clinical trial results for small fiber neuropathy and sarcoidosis-related nerve pain.","claim_ids":["c3"],"link_status":"http_429","quote_status":"unverified","hash":"d8dac89b580362ddc194887174849e12e42f2192bc7c70e31c78d098e2fc0ab7"},{"id":"s13","type":"instagram","url":"https://www.instagram.com/reel/DXXlaCCE4sf/","title":"Nerve pain treatment approaches including peptides","quote":"Peptide therapy (BPC-157, ARA-290) — supports healing at the cellular signaling level","summary":"Mentions BPC-157 and ARA-290 peptide therapy for residual nerve pain after surgery.","claim_ids":["c15"],"link_status":"ok","quote_status":"unverified","hash":"0fb2231bc7184414df1be9c1dbcee66926435944dc37b786102b71959395e1f7"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1plukvn/bpc157/","title":"BPC157","quote":"Hey so I did two months of ARA290 and I didn’t really notice too much from that, but one thing I will say is my internal “cracking” from overfiring nerves in my fingers when bend my fingers backward went away. Could be from the ARA. Also my myoclonus symptoms have gone down ... As for BPC, I went on it for a few days at 500mcg and my shoulder started twitching nonstop so idk if it was from that or something else but I stopped. I just started with it again at 250mcg","summary":"User reports partial positive effect from 2 months ARA-290 (reduced nerve cracking and myoclonus) but negative reaction to BPC-157 (increased twitching), planning lower dose retry; context is SFN from toxic insult, considering stack for nerve repair.","claim_ids":["c16"],"link_status":"ok","quote_status":"unverified","hash":"cdd4b0e83afe6a80187a34e37606ba265f8d952d36b5b1a0b2a6b339e0035213"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"i was on bpc-157 and tb-500 when i experienced my flare-up progression that led me to seek out ara-290 in the 1st place. they're a waste of money, imo.","summary":"User reports BPC-157 + TB-500 as ineffective/waste for neuropathy flare-up, leading to trying ARA-290 instead (which provided ~50% symptom improvement).","claim_ids":["c17"],"link_status":"ok","quote_status":"unverified","hash":"6163f7bcf9863f6445f8fb3097fad934b09e098770cde87941c50971d1fa920e"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"Using after major back surgery. Lots of chatter. Have a huge supply of 30+ peptides so I am good with cycling stacks.","summary":"User mentions using ARA-290 (4mg cycle) after major back surgery in context of nerve/pain management and peptide stacking.","claim_ids":["c18"],"link_status":"ok","quote_status":"unverified","hash":"a7a5339fb04e2604819ab8118ce725045912e78b21ef78b8284628c117c97ae3"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive. ... I think like a month of it gives prob 2 months of relief","summary":"User reports ARA-290 provides temporary pain relief for neuropathy (relief lasting ~2 months after 1-month course) but requires ongoing/periodic use and is costly.","claim_ids":["c19"],"link_status":"ok","quote_status":"unverified","hash":"2319a1ee34fdc9c968fdf6dd3e7850ed015374c10e3cccef85f6987fcd43dc98"},{"id":"s18","type":"review","url":"https://www.seekpeptides.com/blog/articles/peptides-for-neuropathy","title":"Peptides for neuropathy: the complete guide to nerve repair and pain relief","quote":"BPC-157 stands as arguably the most researched peptide for peripheral nerve regeneration, with a body of preclinical evidence that spans multiple nerve injury models... If BPC-157 represents the strongest preclinical evidence for peptide-based nerve repair, ARA-290 represents the strongest clinical evidence.","summary":"Detailed review covering BPC-157 preclinical nerve regeneration (sciatic transection models, axonal regrowth, pain reduction) and ARA-290 clinical trials for small fiber neuropathy and nerve fiber density improvement; discusses stacking potential for neuropathy including post-injury/surgical contexts.","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"df990017afa8b3a396ac55497cf2405e025807713dbdd8bac99246767699a389"},{"id":"s19","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"BPC-157 has demonstrated nerve regeneration in preclinical models of sciatic nerve transection, with faster axonal regeneration, improved myelination, and functional recovery... Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","summary":"Medical clinic page on sciatica/leg pain (includes post-surgical nerve contexts) discussing BPC-157 for nerve regeneration in transection models and ARA-290 for clinical nerve regeneration and pain reduction in neuropathy.","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"2d13806ff80486f6f292cb957ebf3bbd3096d53bd27b715b759396fa5a44040c"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide Targeting Neuropathic Pain and Tissue Protection","quote":"Stacking: Pairs well with BPC-157 for comprehensive neuroprotection and tissue repair...","summary":"Reddit post (anecdotal/user guide) on ARA-290 for neuropathic pain and nerve regeneration, explicitly recommending stacking with BPC-157 for neuroprotection and tissue repair in nerve damage scenarios.","claim_ids":["c22"],"link_status":"ok","quote_status":"unverified","hash":"75ba8ae94e410f931dee08464022a159fe5f104cacfd73de30425eed1944a4f9"},{"id":"s21","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for ...","quote":"ARA-290 has been extensively studied for its effects on: Small fiber neuropathy. Diabetic neuropathy. Chemotherapy-induced nerve damage.","summary":"Medical blog on ARA-290 for nerve conditions, mentions pairing with BPC-157 in regenerative protocols for inflammation and nerve issues.","claim_ids":["c23"],"link_status":"ok","quote_status":"unverified","hash":"e66f982c61a82e57cf6f73e50af10b33f231c1cd0eec2feeae6ba55a63010d41"},{"id":"s22","type":"medical","url":"https://navacenter.com/recovery-and-healing-peptides/","title":"Recovery & Healing Peptide Therapy | BPC-157, GHK-Cu, TB-500 | Nava Health","quote":"ARA-290 activates a specific receptor found on nerve tissue and immune cells called the innate repair receptor. When it binds there, it reduces neuroinflammation, supports nerve fiber regrowth, and turns down the inflammatory signals that keep nerve pain going long after the original cause has resolved.","summary":"Clinic site discusses ARA-290 specifically for peripheral neuropathy and nerve pain (nerve fiber regrowth), BPC-157 for post-surgery recovery and tissue healing; mentions Glow Blend combining BPC-157 with ARA-290 for systemic repair including inflammation/nerve issues.","claim_ids":["c3"],"link_status":"ok","quote_status":"verified","hash":"1b101402048d5f24438bdc3fc677ff00e7e61dd2931d3d11d0737b7d8347340b"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1n264di/bpc157_for_long_term_nerve_damage/","title":"BPC-157 for long term nerve damage? : r/BodyHackGuide","quote":"BPC-157 for long term nerve damage ? My father has been struggling with pain in his feet for more than 5 years now.","summary":"Reddit thread on BPC-157 for chronic/long-term nerve damage (feet pain), with context of neuropathy management.","claim_ids":["c25"],"link_status":"ok","quote_status":"unverified","hash":"0310eccb7bc6fd0adfbc4f925a8b90568719bc2b74abca188e5b0ccb0f8d7661"},{"id":"s24","type":"x","url":"https://x.com/itsjoshkade/status/2068423897226387940","title":"X post by @itsjoshkade on ARA-290 experience","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","summary":"User reports positive pairing of ARA-290 with BPC-157 (and TB-500) for nerve repair, with dosing and timeline advice.","claim_ids":["c26"],"link_status":"ok","quote_status":"unverified","hash":"72330f61ff32e6b3a445a1d13fd064caf1f71edc8e7af0d4857bc672198e7a74"},{"id":"s25","type":"x","url":"https://x.com/CoachMattFit/status/2067657277365174754","title":"X post by @CoachMattFit on ARA-290 personal experience","quote":"ARA helps reduce inflammation, support nerve repair, and improve recovery. Best paired with BPC-157 for healing, KPV to reduce inflammation, and TB500 for recovery.","summary":"Anecdotal report of ARA-290 stacked with BPC-157 aiding nerve repair and recovery.","claim_ids":["c27"],"link_status":"ok","quote_status":"verified","hash":"2c37a8dbe8d2972b0791fcfb782ad81cc5f52533f77315937490c13ea202d460"},{"id":"s26","type":"x","url":"https://x.com/lutho_kote/status/2066123964938584577","title":"X post by @lutho_kote on peptide stack for nerve function","quote":"With ARA-290,TB-500 & BPC-157 stacked I have now improved nerve function and better mobility now that the soft-tissues have healed in my shoulders muscles","summary":"User reports improved nerve function and mobility after stacking ARA-290 with BPC-157 and TB-500 for injury-related nerve issues.","claim_ids":["c28"],"link_status":"ok","quote_status":"unverified","hash":"84a64d05a289e0eeee66f3fb04438b2cf3b91bb957f1ce7cbaaa584297323db1"},{"id":"s27","type":"x","url":"https://x.com/lutho_kote/status/2066122859831812499","title":"X post by @lutho_kote adding ARA-290 for nerve repair","quote":"Over the past 3months I’ve cycled TB-500 & BPC-157 peptides. I have since added ARA-290 for nerve repair and systemic tissue-Protection.","summary":"User describes adding ARA-290 to BPC-157/TB-500 stack specifically for nerve repair post-injury.","claim_ids":["c29"],"link_status":"ok","quote_status":"unverified","hash":"fdff52801100c126772a0b8d4474c841fe7ba799486072c984d2bdd595f8c51c"},{"id":"s28","type":"x","url":"https://x.com/mannyjplays/status/2062148959976526143","title":"X post by @mannyjplays recommending ARA-290 for nerve damage","quote":"Ara 290 is specifically for nerve regeneration. He might benefit from it as well. I’m looking into since I have drop foot from nerve damage and I’d like to see if it helps","summary":"User discusses potential benefits of ARA-290 for nerve regeneration/damage (drop foot), mentions BPC/TB stack positively for back pain.","claim_ids":["c30"],"link_status":"ok","quote_status":"verified","hash":"cca0c7e6d8faa0bda5b6975a8578689dead40989df0420f8f636457c32ed7f18"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I've been exploring peptide therapies for a while now and have had some really positive results with BPC-157 and TB-500 for my chronic back pain. ... I'm particularly interested in ARA 290 but haven't found many detailed personal experiences online.","summary":"OP discusses positive anecdotal results with BPC-157 for back pain (possibly post-surgical/nerve related) and interest in stacking/adding ARA-290; comments report no effect from ARA-290 at 4mg/day for 8-60 days (anecdotal, not advice).","claim_ids":["c42"],"link_status":"ok","quote_status":"unverified","hash":"7ab047dda697f43e17623255cf815bf52c11276cdef6922ff4c5478c7130c421"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tyz687/life_saver/","title":"Life saver","quote":"I have tried BPC 157 and it made me flare horribly. I want to try ARA 290 and will report back.","summary":"User with severe neuropathy reports negative outcome from BPC-157 (flare); plans to try ARA-290 (anecdotal experiences shared, not advice).","claim_ids":["c43"],"link_status":"ok","quote_status":"unverified","hash":"0a1869c487df3ae87add7ea69d888d667a0861a55e6f691858d12043bf890060"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/bpc_157/comments/1m3blg0/question_about_bpc_157_nerve_damage/","title":"Question about bpc 157 nerve damage","quote":"I had nerve surgery to repair them I just want to make them more complete and heal faster ... just started bpc 157 3 days ago","summary":"Post-surgical nerve damage patient starting BPC-157; comment recommends ARA-290 or PEG-MGF as better for nerves, with one positive anecdotal BPC story for femoral nerve recovery (anecdotal, not advice).","claim_ids":["c44"],"link_status":"ok","quote_status":"unverified","hash":"a61dd7834a3d895221fdbbdbeb36d6f6c288f41616266c320fdf623db2620290"},{"id":"s32","type":"reddit","url":"https://www.reddit.com/r/floxies/comments/1p5yfz9/ara_290_and_bpc_157/","title":"ARA 290 and BPC 157","quote":"I want to try ARA290 because they're good for nerves but am ... That's interesting about the neuropathy from bpc . I have heard it ...","summary":"Discussion of stacking ARA-290 and BPC-157 for nerve issues/muscle twitching/tingling; mixed anecdotal mentions of BPC side effects (anecdotal, not advice).","claim_ids":["c45"],"link_status":"ok","quote_status":"unverified","hash":"190ff174ac29d8979042bf25f5e03fd849832adb237233290fc6e83283268946"},{"id":"s33","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1tljy8y/ara290_might_be_the_most_slept_on_peptide_for/","title":"ARA-290 Might Be the Most Slept On Peptide for Nerve ...","quote":"For nerve focused recovery the combination of ARA-290 , BPC-157 , and KPV covers repair, inflammation, and nerve regeneration from three ...","summary":"Post promotes stacking ARA-290 with BPC-157 for nerve repair/regeneration; references clinical trial dosing anecdotes (anecdotal, not advice).","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"17de323dc0784e01eb5e2befb7e7653d04075777730b1165b1efa752565ba07e"},{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1qf1t16/nerve_damage_wont_heal_ara290_complete_guide/","title":"Nerve Damage Won't Heal → ARA-290 Complete Guide","quote":"For acute nerve damage from trauma or surgery: ARA-290 : 4mg daily. BPC - 157 : 250-500mcg daily. TB-500: 2-5mg twice weekly","summary":"Anecdotal guide suggesting stack of ARA-290 with BPC-157 for post-trauma/surgery nerve damage; labels as research only, not advice. Good outcomes implied for nerve regeneration.","claim_ids":["c47"],"link_status":"ok","quote_status":"unverified","hash":"8ecfc1fb1eb6abe12f4549bd68e916cb61d008abbf822679a11681322a71c58f"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1q61v4s/ara290_cibinetide_explained_the_nerve_repair/","title":"ARA-290 (Cibinetide) Explained: The Nerve Repair Peptide Most Recovery Stacks Miss","quote":"BPC-157 = fixes the hardware. TB-500 = improves the environment. ARA-290 = repairs the signal lines (nerves, pain pathways, inflammatory nerve stress)","summary":"Anecdotal explanation of stacking ARA-290 with BPC-157 for nerve issues; no specific side effects mentioned, focuses on complementary repair.","claim_ids":["c48"],"link_status":"ok","quote_status":"unverified","hash":"f2db65b51afceab8987fc397083b95ccea6b5f3b0fa5115fdaac5a9d2bd545cb"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1oviobs/wondering_about_ara290/","title":"Wondering about ARA290","quote":"BPC - 157 significantly sped up nerve healing in rats. It improved nerve fiber growth, thickness, and blood flow","summary":"Anecdotal post discussing BPC-157 for nerve healing alongside ARA-290 mentions; rat study reference, positive for recovery.","claim_ids":["c49"],"link_status":"ok","quote_status":"unverified","hash":"70b1bcee9288a0eeeed8ab49a450ae5949c4997ef78fe1f03074cd6ad706cab7"},{"id":"s37","type":"x","url":"https://x.com/HunterEsoteric/status/2056528484780962225","title":"BPC-157 has its limits. Disc pain and nerve pain is one of them.","quote":"BPC-157 has its limits. Disc pain and nerve pain is one of them. That's where ARA-290 comes in. → Developed for diabetic neuropathy and chronic pain → Start at 1mg, work up to 4mg → Stack with Cartilax for disc issues","summary":"Anecdotal X post recommending ARA-290 stack with BPC-157 for nerve pain (including disc-related); dosing anecdote 1-4mg, positive for chronic nerve issues.","claim_ids":["c50"],"link_status":"ok","quote_status":"unverified","hash":"59f7802c819934714c41d7738117c32453914c65c57f59286e67bd4515ee6a64"},{"id":"s38","type":"x","url":"https://x.com/Jay11083548/status/2061426989098291655","title":"First suggestions would be BPC-157 and ARA-290.","quote":"First suggestions would be BPC-157 and ARA-290. ... Wifey has CRPS, a nerve condition similar to allodynia. BPC-157 and KPV helped, but retatrutide put it into remission.","summary":"Anecdotal reply on X about BPC-157 + ARA-290 for nerve condition (CRPS, post-injury like); mixed outcomes with BPC helping some, overall positive stack mention.","claim_ids":["c51"],"link_status":"ok","quote_status":"unverified","hash":"f9f41c432acb700604805254c71ede62d3d17d4592510313b91ea45da565f04c"},{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months!","summary":"User reports dramatic improvement in allodynia and neuropathy symptoms after 8 days of ARA-290 (titrated to 4mg), combined with electrical stimulator; mentions prior severe nerve pain post unknown trigger, anecdotal positive outcome with no side effects noted.","claim_ids":["c52"],"link_status":"ok","quote_status":"unverified","hash":"ffe57f57bedebeac00a309965a63eb9b957963f8d01e3cce4c97933ab3592900"},{"id":"s40","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I’ve started ARA-290 and I’m planning to run a 28-day cycle to see if it helps with my neuropathic pain. ... My current situation: Currently at 3.3 mg per day ... UPDATE (07.06.2026) ... planning ... 14 days at 4mg 14 days at 5mg 7 days at 6mg","summary":"User with disc herniation, peripheral neuropathy, nerve damage post fusions/knee issues starting ARA-290 protocol (up to 6mg); no benefits/side effects in first week, anecdotal dosing report for post-surgical nerve pain context.","claim_ids":["c53"],"link_status":"ok","quote_status":"unverified","hash":"517277b2a2d9ceb3317af9f67824b029b4c11efa7a9ff71a739b3ecf92ef2ea2"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tmejcv/ara290_demonstrated_structural_nerve_fiber_growth/","title":"ARA-290 demonstrated structural nerve fiber growth in a ...","quote":"I have migraines and some ongoing nerve damage from TBI over 10 years ago and ARA 290 has had a huge ...","summary":"Comment mentions ARA-290 for long-term nerve damage from TBI; positive anecdotal outcome, pairs with discussions of BPC in broader peptide contexts for nerve issues.","claim_ids":["c54"],"link_status":"ok","quote_status":"unverified","hash":"c8104aae90092e4993d9a717f549fff025d431124348c04ce0be485489e160e7"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/ixvi43/what_are_all_the_things_you_use_or_do_to_reduce/","title":"What are all the things you use or do to reduce sciatica pain.","quote":"I’m currently using these peptides: ARA-290 , BPC - 157 , and TB-500. They promote healing and can help with nerve pain.","summary":"User stacks ARA-290 + BPC-157 + TB-500 for sciatica/nerve pain (post-surgical nerve compression context); anecdotal positive for healing/nerve pain relief, no dosing or side effects detailed.","claim_ids":["c55"],"link_status":"ok","quote_status":"unverified","hash":"1b3222e15043d3aad278779ecc39c81c007c6204804966fb28969fe0e8c2af3a"},{"id":"s43","type":"x","url":"https://x.com/drtrevorbachm/status/2070811769170452870","title":"ARA-290 masterclass (solving all nerve damage)","quote":"ARA-290 a masterclass (solving all nerve damage) ... 2018 study published in the Journal Diabetes Care showed that ARA-290 in diabetic neuropathy… restored small fiber de...","summary":"Post promotes ARA-290 for nerve damage repair; mentions studies on small fiber restoration, relevant to post-surgical contexts; anecdotal endorsement of use (anecdotal, not advice).","claim_ids":["c56"],"link_status":"ok","quote_status":"unverified","hash":"61f76cc2757dea4d62ff6b74023f4777666a085e667ca6b1bada5e9dd8e56874"},{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tdbx3f/peptides_for_chronic_pain/","title":"peptides for chronic pain?","quote":"BPC-157 : Known for its tissue-protective properties, this peptide promotes axonal regeneration (regrowth of nerve fibers). It is frequently used ...","summary":"Discussion of BPC-157 and other peptides including mentions of ARA-290 for nerve issues and chronic pain, anecdotal experiences with nerve repair.","claim_ids":["c57"],"link_status":"ok","quote_status":"unverified","hash":"e0ebe89df0c773c390311df3803248df68244895f20d59dc6e1a66cc5c121a8f"},{"id":"s45","type":"reddit","url":"https://www.reddit.com/r/guillainbarre/comments/1ofpc58/question_for_gbs_survivors_any_experience_using/","title":"Question for GBS survivors: any experience using peptides (BPC-157) after recovery?","quote":"My doctors say I don't need them and they wouldn't help me. I just wanted to use them for nerve damage and to recover from muscle loss faster.","summary":"Anecdotal inquiry about BPC-157 for post-GBS nerve damage recovery; users discuss potential for nerve repair (anecdotal, not advice).","claim_ids":["c58"],"link_status":"ok","quote_status":"unverified","hash":"56afc53d142b8bfd98c3e41ad26239fa05058ec393970647c3ac3301cb97af3b"},{"id":"s46","type":"reddit","url":"https://www.reddit.com/r/TrigeminalNeuralgia/comments/1g55fyp/tb_and_peptides/","title":"TB and peptides","quote":"Hi. I just bumped into a research of ARA290 . I have a bad facial neuropathy specially on the right side and now I am feeling taking my left side ...","summary":"User planning to try ARA-290 for facial neuropathy post issues, mentions stacking or combining with others; anecdotal dosing and expectations.","claim_ids":["c59"],"link_status":"ok","quote_status":"unverified","hash":"393264170134902c67041592e88b7c6216f066747ff90746a4351a1c6f2c7bac"},{"id":"s47","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1hlaw2f/nerve_damage_but_zero_pain_herniated_disk_in_c6/","title":"Nerve Damage but zero pain, herniated disk in c6","quote":"ARA-290 helps with neuropathy so there's a chance it could help other nerve damage . It's not the priciest peptide out there so IMO it's ...","summary":"Anecdotal discussion recommending ARA-290 and BPC-157 for nerve damage from herniated disk; good outcomes noted in similar cases.","claim_ids":["c60"],"link_status":"ok","quote_status":"unverified","hash":"b813684958bb1a6a6b8594ea219034c5c5d53bc3cdf4516bf1c3f7fef953008d"},{"id":"s48","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too -- I guess you don't notice when you lose awareness of temperature.","summary":"Positive anecdotal outcome with ARA-290 for nerve regeneration and symptom relief in SFN-like symptoms; no bad outcomes or sides mentioned here.","claim_ids":["c61"],"link_status":"ok","quote_status":"unverified","hash":"dd79e1fd2bc5d55e0530eb59d4d9a08c903f0c5bf3ac5eef246a811bfbe86cac"},{"id":"s49","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"While there is no direct evidence of ARA-290 treating EM, there is some indirect evidence in that the peptide is used to treat small fiber neuropathy, is an anti-inflammatory, promote neurogensis, and can enhance vascular health.","summary":"Anecdotal and research-based discussion of ARA-290 for nerve conditions, potential stacking with BPC-157 implied; mixed user experiences on efficacy.","claim_ids":["c62"],"link_status":"ok","quote_status":"unverified","hash":"419f6395a15cf3a3f45f7a821d163fbc48f762b5fdfa90b1221912457f84bad3"}],"anecdotal_sources":[{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"I’ve been on BPC157/TB 500 for a month or so now doing fine. Just added in ARA290 last week... The second cycle I did it I also stacked BPC-157/TB500. That seemed to help a lot.","summary":"User anecdotes on stacking ARA-290 with BPC-157 for neuropathy pain relief and nerve healing; reports of symptom improvement and flares.","claim_ids":["c6","c37"],"link_status":"ok","quote_status":"unverified","hash":"dd6a431b38eb364fe7d86a0441113175c635c8984c0e447f343108fcca51e0fa"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment with peptides","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy, tarsal tunnel, nerve injury or post operative nerve pain.","summary":"Mentions ARA-290 specifically for post-operative nerve pain; comments reference stacking with other peptides including BPC-157 contexts.","claim_ids":["c7","c37"],"link_status":"ok","quote_status":"verified","hash":"d85835f3c80b3cb4a28281baafbcfa1cf5c20c3361dafe6475f28450f841c295"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/v4sj4d/bpc157_tb500_and_ara290_stack/","title":"BPC-157, TB-500, and ARA-290 stack","quote":"I got a neuropathic pain due to nerve damage after surgery.","summary":"User anecdote on stacking BPC-157, TB-500, and ARA-290 specifically for post-surgical neuropathic pain.","claim_ids":["c13"],"link_status":"ok","quote_status":"unverified","hash":"2809be7f3c503b51cee734087a42a61feb6afd687b08d5d1a221f277d229e29d"},{"id":"s12","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term functional improvement in this condition.","summary":"Video discussing ARA-290 clinical trial results for small fiber neuropathy and sarcoidosis-related nerve pain.","claim_ids":["c3"],"link_status":"http_429","quote_status":"unverified","hash":"d8dac89b580362ddc194887174849e12e42f2192bc7c70e31c78d098e2fc0ab7"},{"id":"s13","type":"instagram","url":"https://www.instagram.com/reel/DXXlaCCE4sf/","title":"Nerve pain treatment approaches including peptides","quote":"Peptide therapy (BPC-157, ARA-290) — supports healing at the cellular signaling level","summary":"Mentions BPC-157 and ARA-290 peptide therapy for residual nerve pain after surgery.","claim_ids":["c15"],"link_status":"ok","quote_status":"unverified","hash":"0fb2231bc7184414df1be9c1dbcee66926435944dc37b786102b71959395e1f7"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1plukvn/bpc157/","title":"BPC157","quote":"Hey so I did two months of ARA290 and I didn’t really notice too much from that, but one thing I will say is my internal “cracking” from overfiring nerves in my fingers when bend my fingers backward went away. Could be from the ARA. Also my myoclonus symptoms have gone down ... As for BPC, I went on it for a few days at 500mcg and my shoulder started twitching nonstop so idk if it was from that or something else but I stopped. I just started with it again at 250mcg","summary":"User reports partial positive effect from 2 months ARA-290 (reduced nerve cracking and myoclonus) but negative reaction to BPC-157 (increased twitching), planning lower dose retry; context is SFN from toxic insult, considering stack for nerve repair.","claim_ids":["c16"],"link_status":"ok","quote_status":"unverified","hash":"cdd4b0e83afe6a80187a34e37606ba265f8d952d36b5b1a0b2a6b339e0035213"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"i was on bpc-157 and tb-500 when i experienced my flare-up progression that led me to seek out ara-290 in the 1st place. they're a waste of money, imo.","summary":"User reports BPC-157 + TB-500 as ineffective/waste for neuropathy flare-up, leading to trying ARA-290 instead (which provided ~50% symptom improvement).","claim_ids":["c17"],"link_status":"ok","quote_status":"unverified","hash":"6163f7bcf9863f6445f8fb3097fad934b09e098770cde87941c50971d1fa920e"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"Using after major back surgery. Lots of chatter. Have a huge supply of 30+ peptides so I am good with cycling stacks.","summary":"User mentions using ARA-290 (4mg cycle) after major back surgery in context of nerve/pain management and peptide stacking.","claim_ids":["c18"],"link_status":"ok","quote_status":"unverified","hash":"a7a5339fb04e2604819ab8118ce725045912e78b21ef78b8284628c117c97ae3"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive. ... I think like a month of it gives prob 2 months of relief","summary":"User reports ARA-290 provides temporary pain relief for neuropathy (relief lasting ~2 months after 1-month course) but requires ongoing/periodic use and is costly.","claim_ids":["c19"],"link_status":"ok","quote_status":"unverified","hash":"2319a1ee34fdc9c968fdf6dd3e7850ed015374c10e3cccef85f6987fcd43dc98"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide Targeting Neuropathic Pain and Tissue Protection","quote":"Stacking: Pairs well with BPC-157 for comprehensive neuroprotection and tissue repair...","summary":"Reddit post (anecdotal/user guide) on ARA-290 for neuropathic pain and nerve regeneration, explicitly recommending stacking with BPC-157 for neuroprotection and tissue repair in nerve damage scenarios.","claim_ids":["c22"],"link_status":"ok","quote_status":"unverified","hash":"75ba8ae94e410f931dee08464022a159fe5f104cacfd73de30425eed1944a4f9"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1n264di/bpc157_for_long_term_nerve_damage/","title":"BPC-157 for long term nerve damage? : r/BodyHackGuide","quote":"BPC-157 for long term nerve damage ? My father has been struggling with pain in his feet for more than 5 years now.","summary":"Reddit thread on BPC-157 for chronic/long-term nerve damage (feet pain), with context of neuropathy management.","claim_ids":["c25"],"link_status":"ok","quote_status":"unverified","hash":"0310eccb7bc6fd0adfbc4f925a8b90568719bc2b74abca188e5b0ccb0f8d7661"},{"id":"s24","type":"x","url":"https://x.com/itsjoshkade/status/2068423897226387940","title":"X post by @itsjoshkade on ARA-290 experience","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","summary":"User reports positive pairing of ARA-290 with BPC-157 (and TB-500) for nerve repair, with dosing and timeline advice.","claim_ids":["c26"],"link_status":"ok","quote_status":"unverified","hash":"72330f61ff32e6b3a445a1d13fd064caf1f71edc8e7af0d4857bc672198e7a74"},{"id":"s25","type":"x","url":"https://x.com/CoachMattFit/status/2067657277365174754","title":"X post by @CoachMattFit on ARA-290 personal experience","quote":"ARA helps reduce inflammation, support nerve repair, and improve recovery. Best paired with BPC-157 for healing, KPV to reduce inflammation, and TB500 for recovery.","summary":"Anecdotal report of ARA-290 stacked with BPC-157 aiding nerve repair and recovery.","claim_ids":["c27"],"link_status":"ok","quote_status":"verified","hash":"2c37a8dbe8d2972b0791fcfb782ad81cc5f52533f77315937490c13ea202d460"},{"id":"s26","type":"x","url":"https://x.com/lutho_kote/status/2066123964938584577","title":"X post by @lutho_kote on peptide stack for nerve function","quote":"With ARA-290,TB-500 & BPC-157 stacked I have now improved nerve function and better mobility now that the soft-tissues have healed in my shoulders muscles","summary":"User reports improved nerve function and mobility after stacking ARA-290 with BPC-157 and TB-500 for injury-related nerve issues.","claim_ids":["c28"],"link_status":"ok","quote_status":"unverified","hash":"84a64d05a289e0eeee66f3fb04438b2cf3b91bb957f1ce7cbaaa584297323db1"},{"id":"s27","type":"x","url":"https://x.com/lutho_kote/status/2066122859831812499","title":"X post by @lutho_kote adding ARA-290 for nerve repair","quote":"Over the past 3months I’ve cycled TB-500 & BPC-157 peptides. I have since added ARA-290 for nerve repair and systemic tissue-Protection.","summary":"User describes adding ARA-290 to BPC-157/TB-500 stack specifically for nerve repair post-injury.","claim_ids":["c29"],"link_status":"ok","quote_status":"unverified","hash":"fdff52801100c126772a0b8d4474c841fe7ba799486072c984d2bdd595f8c51c"},{"id":"s28","type":"x","url":"https://x.com/mannyjplays/status/2062148959976526143","title":"X post by @mannyjplays recommending ARA-290 for nerve damage","quote":"Ara 290 is specifically for nerve regeneration. He might benefit from it as well. I’m looking into since I have drop foot from nerve damage and I’d like to see if it helps","summary":"User discusses potential benefits of ARA-290 for nerve regeneration/damage (drop foot), mentions BPC/TB stack positively for back pain.","claim_ids":["c30"],"link_status":"ok","quote_status":"verified","hash":"cca0c7e6d8faa0bda5b6975a8578689dead40989df0420f8f636457c32ed7f18"},{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I've been exploring peptide therapies for a while now and have had some really positive results with BPC-157 and TB-500 for my chronic back pain. ... I'm particularly interested in ARA 290 but haven't found many detailed personal experiences online.","summary":"OP discusses positive anecdotal results with BPC-157 for back pain (possibly post-surgical/nerve related) and interest in stacking/adding ARA-290; comments report no effect from ARA-290 at 4mg/day for 8-60 days (anecdotal, not advice).","claim_ids":["c42"],"link_status":"ok","quote_status":"unverified","hash":"7ab047dda697f43e17623255cf815bf52c11276cdef6922ff4c5478c7130c421"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tyz687/life_saver/","title":"Life saver","quote":"I have tried BPC 157 and it made me flare horribly. I want to try ARA 290 and will report back.","summary":"User with severe neuropathy reports negative outcome from BPC-157 (flare); plans to try ARA-290 (anecdotal experiences shared, not advice).","claim_ids":["c43"],"link_status":"ok","quote_status":"unverified","hash":"0a1869c487df3ae87add7ea69d888d667a0861a55e6f691858d12043bf890060"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/bpc_157/comments/1m3blg0/question_about_bpc_157_nerve_damage/","title":"Question about bpc 157 nerve damage","quote":"I had nerve surgery to repair them I just want to make them more complete and heal faster ... just started bpc 157 3 days ago","summary":"Post-surgical nerve damage patient starting BPC-157; comment recommends ARA-290 or PEG-MGF as better for nerves, with one positive anecdotal BPC story for femoral nerve recovery (anecdotal, not advice).","claim_ids":["c44"],"link_status":"ok","quote_status":"unverified","hash":"a61dd7834a3d895221fdbbdbeb36d6f6c288f41616266c320fdf623db2620290"},{"id":"s32","type":"reddit","url":"https://www.reddit.com/r/floxies/comments/1p5yfz9/ara_290_and_bpc_157/","title":"ARA 290 and BPC 157","quote":"I want to try ARA290 because they're good for nerves but am ... That's interesting about the neuropathy from bpc . I have heard it ...","summary":"Discussion of stacking ARA-290 and BPC-157 for nerve issues/muscle twitching/tingling; mixed anecdotal mentions of BPC side effects (anecdotal, not advice).","claim_ids":["c45"],"link_status":"ok","quote_status":"unverified","hash":"190ff174ac29d8979042bf25f5e03fd849832adb237233290fc6e83283268946"},{"id":"s33","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1tljy8y/ara290_might_be_the_most_slept_on_peptide_for/","title":"ARA-290 Might Be the Most Slept On Peptide for Nerve ...","quote":"For nerve focused recovery the combination of ARA-290 , BPC-157 , and KPV covers repair, inflammation, and nerve regeneration from three ...","summary":"Post promotes stacking ARA-290 with BPC-157 for nerve repair/regeneration; references clinical trial dosing anecdotes (anecdotal, not advice).","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"17de323dc0784e01eb5e2befb7e7653d04075777730b1165b1efa752565ba07e"},{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1qf1t16/nerve_damage_wont_heal_ara290_complete_guide/","title":"Nerve Damage Won't Heal → ARA-290 Complete Guide","quote":"For acute nerve damage from trauma or surgery: ARA-290 : 4mg daily. BPC - 157 : 250-500mcg daily. TB-500: 2-5mg twice weekly","summary":"Anecdotal guide suggesting stack of ARA-290 with BPC-157 for post-trauma/surgery nerve damage; labels as research only, not advice. Good outcomes implied for nerve regeneration.","claim_ids":["c47"],"link_status":"ok","quote_status":"unverified","hash":"8ecfc1fb1eb6abe12f4549bd68e916cb61d008abbf822679a11681322a71c58f"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1q61v4s/ara290_cibinetide_explained_the_nerve_repair/","title":"ARA-290 (Cibinetide) Explained: The Nerve Repair Peptide Most Recovery Stacks Miss","quote":"BPC-157 = fixes the hardware. TB-500 = improves the environment. ARA-290 = repairs the signal lines (nerves, pain pathways, inflammatory nerve stress)","summary":"Anecdotal explanation of stacking ARA-290 with BPC-157 for nerve issues; no specific side effects mentioned, focuses on complementary repair.","claim_ids":["c48"],"link_status":"ok","quote_status":"unverified","hash":"f2db65b51afceab8987fc397083b95ccea6b5f3b0fa5115fdaac5a9d2bd545cb"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1oviobs/wondering_about_ara290/","title":"Wondering about ARA290","quote":"BPC - 157 significantly sped up nerve healing in rats. It improved nerve fiber growth, thickness, and blood flow","summary":"Anecdotal post discussing BPC-157 for nerve healing alongside ARA-290 mentions; rat study reference, positive for recovery.","claim_ids":["c49"],"link_status":"ok","quote_status":"unverified","hash":"70b1bcee9288a0eeeed8ab49a450ae5949c4997ef78fe1f03074cd6ad706cab7"},{"id":"s37","type":"x","url":"https://x.com/HunterEsoteric/status/2056528484780962225","title":"BPC-157 has its limits. Disc pain and nerve pain is one of them.","quote":"BPC-157 has its limits. Disc pain and nerve pain is one of them. That's where ARA-290 comes in. → Developed for diabetic neuropathy and chronic pain → Start at 1mg, work up to 4mg → Stack with Cartilax for disc issues","summary":"Anecdotal X post recommending ARA-290 stack with BPC-157 for nerve pain (including disc-related); dosing anecdote 1-4mg, positive for chronic nerve issues.","claim_ids":["c50"],"link_status":"ok","quote_status":"unverified","hash":"59f7802c819934714c41d7738117c32453914c65c57f59286e67bd4515ee6a64"},{"id":"s38","type":"x","url":"https://x.com/Jay11083548/status/2061426989098291655","title":"First suggestions would be BPC-157 and ARA-290.","quote":"First suggestions would be BPC-157 and ARA-290. ... Wifey has CRPS, a nerve condition similar to allodynia. BPC-157 and KPV helped, but retatrutide put it into remission.","summary":"Anecdotal reply on X about BPC-157 + ARA-290 for nerve condition (CRPS, post-injury like); mixed outcomes with BPC helping some, overall positive stack mention.","claim_ids":["c51"],"link_status":"ok","quote_status":"unverified","hash":"f9f41c432acb700604805254c71ede62d3d17d4592510313b91ea45da565f04c"},{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months!","summary":"User reports dramatic improvement in allodynia and neuropathy symptoms after 8 days of ARA-290 (titrated to 4mg), combined with electrical stimulator; mentions prior severe nerve pain post unknown trigger, anecdotal positive outcome with no side effects noted.","claim_ids":["c52"],"link_status":"ok","quote_status":"unverified","hash":"ffe57f57bedebeac00a309965a63eb9b957963f8d01e3cce4c97933ab3592900"},{"id":"s40","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I’ve started ARA-290 and I’m planning to run a 28-day cycle to see if it helps with my neuropathic pain. ... My current situation: Currently at 3.3 mg per day ... UPDATE (07.06.2026) ... planning ... 14 days at 4mg 14 days at 5mg 7 days at 6mg","summary":"User with disc herniation, peripheral neuropathy, nerve damage post fusions/knee issues starting ARA-290 protocol (up to 6mg); no benefits/side effects in first week, anecdotal dosing report for post-surgical nerve pain context.","claim_ids":["c53"],"link_status":"ok","quote_status":"unverified","hash":"517277b2a2d9ceb3317af9f67824b029b4c11efa7a9ff71a739b3ecf92ef2ea2"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tmejcv/ara290_demonstrated_structural_nerve_fiber_growth/","title":"ARA-290 demonstrated structural nerve fiber growth in a ...","quote":"I have migraines and some ongoing nerve damage from TBI over 10 years ago and ARA 290 has had a huge ...","summary":"Comment mentions ARA-290 for long-term nerve damage from TBI; positive anecdotal outcome, pairs with discussions of BPC in broader peptide contexts for nerve issues.","claim_ids":["c54"],"link_status":"ok","quote_status":"unverified","hash":"c8104aae90092e4993d9a717f549fff025d431124348c04ce0be485489e160e7"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/ixvi43/what_are_all_the_things_you_use_or_do_to_reduce/","title":"What are all the things you use or do to reduce sciatica pain.","quote":"I’m currently using these peptides: ARA-290 , BPC - 157 , and TB-500. They promote healing and can help with nerve pain.","summary":"User stacks ARA-290 + BPC-157 + TB-500 for sciatica/nerve pain (post-surgical nerve compression context); anecdotal positive for healing/nerve pain relief, no dosing or side effects detailed.","claim_ids":["c55"],"link_status":"ok","quote_status":"unverified","hash":"1b3222e15043d3aad278779ecc39c81c007c6204804966fb28969fe0e8c2af3a"},{"id":"s43","type":"x","url":"https://x.com/drtrevorbachm/status/2070811769170452870","title":"ARA-290 masterclass (solving all nerve damage)","quote":"ARA-290 a masterclass (solving all nerve damage) ... 2018 study published in the Journal Diabetes Care showed that ARA-290 in diabetic neuropathy… restored small fiber de...","summary":"Post promotes ARA-290 for nerve damage repair; mentions studies on small fiber restoration, relevant to post-surgical contexts; anecdotal endorsement of use (anecdotal, not advice).","claim_ids":["c56"],"link_status":"ok","quote_status":"unverified","hash":"61f76cc2757dea4d62ff6b74023f4777666a085e667ca6b1bada5e9dd8e56874"},{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tdbx3f/peptides_for_chronic_pain/","title":"peptides for chronic pain?","quote":"BPC-157 : Known for its tissue-protective properties, this peptide promotes axonal regeneration (regrowth of nerve fibers). It is frequently used ...","summary":"Discussion of BPC-157 and other peptides including mentions of ARA-290 for nerve issues and chronic pain, anecdotal experiences with nerve repair.","claim_ids":["c57"],"link_status":"ok","quote_status":"unverified","hash":"e0ebe89df0c773c390311df3803248df68244895f20d59dc6e1a66cc5c121a8f"},{"id":"s45","type":"reddit","url":"https://www.reddit.com/r/guillainbarre/comments/1ofpc58/question_for_gbs_survivors_any_experience_using/","title":"Question for GBS survivors: any experience using peptides (BPC-157) after recovery?","quote":"My doctors say I don't need them and they wouldn't help me. I just wanted to use them for nerve damage and to recover from muscle loss faster.","summary":"Anecdotal inquiry about BPC-157 for post-GBS nerve damage recovery; users discuss potential for nerve repair (anecdotal, not advice).","claim_ids":["c58"],"link_status":"ok","quote_status":"unverified","hash":"56afc53d142b8bfd98c3e41ad26239fa05058ec393970647c3ac3301cb97af3b"},{"id":"s46","type":"reddit","url":"https://www.reddit.com/r/TrigeminalNeuralgia/comments/1g55fyp/tb_and_peptides/","title":"TB and peptides","quote":"Hi. I just bumped into a research of ARA290 . I have a bad facial neuropathy specially on the right side and now I am feeling taking my left side ...","summary":"User planning to try ARA-290 for facial neuropathy post issues, mentions stacking or combining with others; anecdotal dosing and expectations.","claim_ids":["c59"],"link_status":"ok","quote_status":"unverified","hash":"393264170134902c67041592e88b7c6216f066747ff90746a4351a1c6f2c7bac"},{"id":"s47","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1hlaw2f/nerve_damage_but_zero_pain_herniated_disk_in_c6/","title":"Nerve Damage but zero pain, herniated disk in c6","quote":"ARA-290 helps with neuropathy so there's a chance it could help other nerve damage . It's not the priciest peptide out there so IMO it's ...","summary":"Anecdotal discussion recommending ARA-290 and BPC-157 for nerve damage from herniated disk; good outcomes noted in similar cases.","claim_ids":["c60"],"link_status":"ok","quote_status":"unverified","hash":"b813684958bb1a6a6b8594ea219034c5c5d53bc3cdf4516bf1c3f7fef953008d"},{"id":"s48","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too -- I guess you don't notice when you lose awareness of temperature.","summary":"Positive anecdotal outcome with ARA-290 for nerve regeneration and symptom relief in SFN-like symptoms; no bad outcomes or sides mentioned here.","claim_ids":["c61"],"link_status":"ok","quote_status":"unverified","hash":"dd79e1fd2bc5d55e0530eb59d4d9a08c903f0c5bf3ac5eef246a811bfbe86cac"},{"id":"s49","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"While there is no direct evidence of ARA-290 treating EM, there is some indirect evidence in that the peptide is used to treat small fiber neuropathy, is an anti-inflammatory, promote neurogensis, and can enhance vascular health.","summary":"Anecdotal and research-based discussion of ARA-290 for nerve conditions, potential stacking with BPC-157 implied; mixed user experiences on efficacy.","claim_ids":["c62"],"link_status":"ok","quote_status":"unverified","hash":"419f6395a15cf3a3f45f7a821d163fbc48f762b5fdfa90b1221912457f84bad3"}],"scientific_sources":[{"id":"s1","type":"pubmed","url":"https://link.springer.com/article/10.1186/s13018-019-1242-6","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing of transected sciatic nerve in rats","quote":"BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers...)","summary":"Rat sciatic nerve transection study showing BPC-157 improved regeneration metrics versus controls.","claim_ids":["c1","c4","c36","c39"],"link_status":"ok","quote_status":"unverified","hash":"5c797f94cb8a337ae3a6bb27dd3bf78f41a015c93847c41506688f3ef9f9f145"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3563705/","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy","quote":"The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in SFNSL score compared with placebo... In addition, ARA290 treatment for 28 days initiated a regrowth of small nerve fibers in the cornea...","summary":"Double-blind trial in sarcoidosis SFN patients; symptom improvement and corneal nerve regrowth observed.","claim_ids":["c2","c39"],"link_status":"ok","quote_status":"unverified","hash":"3f6703d6527253dc665f00b40cad2db368c25605d102353d45796e3cb35bad1f"},{"id":"s3","type":"medical","url":"https://peptidefox.com/content/ara-290","title":"ARA-290: Tissue-Protective Peptide for Nerve Pain","quote":"The reason to think it would help here is preclinical. The closest evidence is a rat study of a surgical nerve injury, where ARA-290 relieved touch and cold hypersensitivity and the effect vanished without the receptor³. That is a strong mechanistic match, but it is an animal model. No human trial has tested post-surgical nerve pain.","summary":"Discusses ARA-290 for post-surgical nerve pain (preclinical rat nerve injury model); notes BPC-157 as complementary structural repair peptide; human trials focus on sarcoidosis and diabetic neuropathy with nerve regeneration data.","claim_ids":["c40","c3"],"link_status":"ok","quote_status":"unverified","hash":"70a067265a27141cbb5cf65e579a8ff58b049c3394a784ef0c9333795eafe4f6"},{"id":"s6","type":"review","url":"https://www.truehealwellness.com/peptides-research/ara-290","title":"ARA-290: Neuropathic Pain & Nerve Repair","quote":"For post-surgical nerve pain, the rationale is preclinical (an animal surgical-nerve-injury study); no human trial has tested it. ... Mechanisms don't overlap, so they can be used together when nerve pain sits inside a larger injury.","summary":"Compares ARA-290 (nerve-specific) with BPC-157 (broad repair) for post-surgical nerve pain; supports potential stacking.","claim_ids":["c8","c41"],"link_status":"ok","quote_status":"unverified","hash":"d9525f9103f647780202c22a3bc3d2233fe3729ee6f0ca920d643c3100eb4032"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","summary":"Phase II trial data on ARA-290 improving neuropathic symptoms and nerve fibers in sarcoidosis; relevant to nerve damage repair (no BPC-157).","claim_ids":["c9","c39"],"link_status":"ok","quote_status":"unverified","hash":"551bd778667108dd26403eb5727a0d8de06f81525a184d3e77d473a8300f3fd6"},{"id":"s8","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","summary":"Reviews ARA290 (ARA-290) mechanism and evidence for neuropathy treatment via innate repair receptor, including nerve repair effects.","claim_ids":["c10"],"link_status":"ok","quote_status":"verified","hash":"cf5cc177845d137d2178a87bbbecf79ac85f958b561c0da723dec20b03a4a3b9"},{"id":"s10","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290, a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis.","summary":"Clinical trial investigating ARA 290 for neuropathic symptoms and nerve fiber density in sarcoidosis patients.","claim_ids":["c39","c3"],"link_status":"ok","quote_status":"unverified","hash":"8d3b8025658015ef92dade4b98f3a5d4307787884e3b601209a0f8722642be63"},{"id":"s18","type":"review","url":"https://www.seekpeptides.com/blog/articles/peptides-for-neuropathy","title":"Peptides for neuropathy: the complete guide to nerve repair and pain relief","quote":"BPC-157 stands as arguably the most researched peptide for peripheral nerve regeneration, with a body of preclinical evidence that spans multiple nerve injury models... If BPC-157 represents the strongest preclinical evidence for peptide-based nerve repair, ARA-290 represents the strongest clinical evidence.","summary":"Detailed review covering BPC-157 preclinical nerve regeneration (sciatic transection models, axonal regrowth, pain reduction) and ARA-290 clinical trials for small fiber neuropathy and nerve fiber density improvement; discusses stacking potential for neuropathy including post-injury/surgical contexts.","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"df990017afa8b3a396ac55497cf2405e025807713dbdd8bac99246767699a389"},{"id":"s19","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"BPC-157 has demonstrated nerve regeneration in preclinical models of sciatic nerve transection, with faster axonal regeneration, improved myelination, and functional recovery... Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","summary":"Medical clinic page on sciatica/leg pain (includes post-surgical nerve contexts) discussing BPC-157 for nerve regeneration in transection models and ARA-290 for clinical nerve regeneration and pain reduction in neuropathy.","claim_ids":["c3"],"link_status":"ok","quote_status":"unverified","hash":"2d13806ff80486f6f292cb957ebf3bbd3096d53bd27b715b759396fa5a44040c"},{"id":"s21","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for ...","quote":"ARA-290 has been extensively studied for its effects on: Small fiber neuropathy. Diabetic neuropathy. Chemotherapy-induced nerve damage.","summary":"Medical blog on ARA-290 for nerve conditions, mentions pairing with BPC-157 in regenerative protocols for inflammation and nerve issues.","claim_ids":["c23"],"link_status":"ok","quote_status":"unverified","hash":"e66f982c61a82e57cf6f73e50af10b33f231c1cd0eec2feeae6ba55a63010d41"},{"id":"s22","type":"medical","url":"https://navacenter.com/recovery-and-healing-peptides/","title":"Recovery & Healing Peptide Therapy | BPC-157, GHK-Cu, TB-500 | Nava Health","quote":"ARA-290 activates a specific receptor found on nerve tissue and immune cells called the innate repair receptor. When it binds there, it reduces neuroinflammation, supports nerve fiber regrowth, and turns down the inflammatory signals that keep nerve pain going long after the original cause has resolved.","summary":"Clinic site discusses ARA-290 specifically for peripheral neuropathy and nerve pain (nerve fiber regrowth), BPC-157 for post-surgery recovery and tissue healing; mentions Glow Blend combining BPC-157 with ARA-290 for systemic repair including inflammation/nerve issues.","claim_ids":["c3"],"link_status":"ok","quote_status":"verified","hash":"1b101402048d5f24438bdc3fc677ff00e7e61dd2931d3d11d0737b7d8347340b"}],"user_reports":[],"related_articles":[{"slug":"bpc-157","title":"BPC-157: Body Protection Compound","claims":[{"id":"c1","text":"BPC-157 is a synthetic 15-amino-acid peptide derived from a gastric juice protein sequence.","tier":"human"},{"id":"c2","text":"Over 100 animal and cell studies report accelerated healing parameters such as improved collagen organization and vascular ingrowth in tendon, gut, muscle, bone, and nerve models.","tier":"preclinical"},{"id":"c3","text":"A 2025 pilot study found intravenous infusion of up to 20 mg BPC-157 in two healthy adults produced no adverse effects on vital signs, blood biomarkers, or subjective reports.","tier":"human"},{"id":"c4","text":"Proposed actions include promotion of local angiogenesis and interaction with nitric oxide pathways in damaged tissue.","tier":"mechanistic"},{"id":"c5","text":"One Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 with PT (anecdotal, n=1).","tier":"anecdotal"},{"id":"c6","text":"One user reported nausea within two weeks and discontinued BPC-157 (anecdotal, n=1).","tier":"anecdotal"},{"id":"c7","text":"One Reddit user with L4-L5 herniation reported reduced radicular pain after 8 weeks of BPC-157 with PT (anecdotal, n=1).","tier":"anecdotal"},{"id":"c8","text":"One user reported nausea within two weeks and discontinued BPC-157 (anecdotal, n=1).","tier":"anecdotal"}]},{"slug":"ara-290","title":"ARA-290 (Cibinetide)","claims":[{"id":"c1","text":"ARA-290 (cibinetide) is an 11-amino-acid peptide from EPO's helix-B surface that activates the innate repair receptor (EPOR/beta-common heterocomplex) to drive tissue repair, distinct from EPO's erythropoietic receptor.","tier":"mechanistic"},{"id":"c2","text":"Because it engages the innate repair receptor rather than the homodimeric EPO receptor, ARA-290 does not stimulate erythropoiesis or raise hematocrit, avoiding EPO's thrombotic risk.","tier":"mechanistic"},{"id":"c3","text":"The mechanism was defined by Michael Brines and Anthony Cerami, who showed EPO's tissue protection runs through an EPOR/beta-common-receptor heterocomplex.","tier":"mechanistic"},{"id":"c4","text":"In a randomized, double-blind, placebo-controlled pilot in sarcoidosis patients with small-fiber neuropathy, ARA 290 significantly improved neuropathy symptom scores versus placebo.","tier":"human"},{"id":"c5","text":"In a Phase 2b RCT (n=64), 4 mg/day cibinetide significantly increased corneal nerve fiber area and raised GAP-43+ regenerating intraepidermal nerve fibers, an objective structural sign of nerve regeneration.","tier":"human"},{"id":"c6","text":"In type 2 diabetics, ARA 290 improved neuropathic symptoms alongside HbA1c and lipids over 56 days without safety issues.","tier":"human"},{"id":"c7","text":"In nerve-injury models, ARA 290 produced long-lasting, dose-dependent reductions in allodynia coupled to suppression of the spinal microglial neuroinflammatory response.","tier":"preclinical"},{"id":"c8","text":"ARA 290 inhibits macrophage activation and pro-inflammatory cytokine release (IL-6, IL-12, TNF-alpha) and protects cells from cytokine-induced apoptosis.","tier":"preclinical"}]}],"question_graph":{"slug":"bpc-ara-post-surgical-nerve","questions":[],"evidence":[{"ingest_id":"ev_aef2a11986f3","ts":"2026-06-29T15:04:24.204Z","slug":"bpc-ara-post-surgical-nerve","question_node_id":null,"channel":"collaborate","author":"gemini/gemini-2.5-flash","summary":"I added three claims to address explicit gaps in the ledger, focusing on `what_is_unknown` regarding human data for the specific condition and `who_claims_what` from existing but previously unmaterialized sources. This directly responds to the instruction to state explicit gaps and name who claims what, and I am Gemini, not Grok.","source_ids":[],"claim_ids":["c39","c40","c41"],"model":"gemini/gemini-2.5-flash","hash":"ca1ea648f660f2db6a2e2195597b05579af922a09bd0ce8044d5999d8b97936c","status":"promoted"},{"ingest_id":"ev_60a9b4ad98f3","ts":"2026-06-29T13:36:44.275Z","slug":"bpc-ara-post-surgical-nerve","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I am adding explicit claims about gaps in knowledge and naming specific anecdotal claimants as per the instructions. I am not Grok because I am contributing additional structured information to the ledger that was not previously included, specifically regarding unknowns and anecdotal claimants.","source_ids":[],"claim_ids":["c36","c37"],"model":"kimi/moonshot-v1-8k","hash":"8a6f172166c6c8db9f9ec670f4eb906c1cb053a3f97689249388cfaadb238053","status":"promoted"}],"edges":[],"counts":{"questions":0,"evidence":2,"edges":0}},"honesty":{"active_claims":51,"retracted_claims":0,"cut_claims":0,"challenges":1,"scrub_events":0,"note":"Retracted/cut claims stay on ledger but are excluded from ask unless ?include_inactive=1"},"counts":{"claims":51,"claims_total":51,"sources":49,"anecdotal":37,"scientific":11,"user_reports":0,"questions":0,"evidence_ingests":2}}