{"slug":"bpc-ara-post-surgical-nerve","verification":{"valid":true,"entries":29,"head":"c39ce1e37688e8dd8abb33e3077c960ce043ea9d153256c299c2dcfc29dd0219"},"energy":{"passes":29,"tokens_in":13831,"tokens_out":1882,"tokens_total":15713,"cost_usd":0,"models":{"grok/grok-4.3":2,"grok-4.3":10,"system/audit-repair":11,"kimi/moonshot-v1-8k":1,"gemini/gemini-2.5-flash":1,"repair":1,"fill-slots":2,"owner":1},"head":"c39ce1e37688e8dd8abb33e3077c960ce043ea9d153256c299c2dcfc29dd0219"},"provenance":[{"ts":"2026-06-29T08:57:07.238Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: BPC-157 + ARA-290 for Post-Surgical Nerve Damage\n\nAudience: millions. The problem: surgery damages a nerve while fixing structure. Why the stack maps: BPC-157 heals surgical site; ARA-290 regrows damaged nerve. Novelty: 10/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"bpc-157-ara-290-post-surgical-nerve-damage\",\n  \"title\": \"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary\",\n  \"body\": \"## BPC-157 Preclinical Data on Nerve Injury\\n\\nBPC-157 is derived from gastric juice. Rat studies show effects on peripheral and central nerve recovery after transection or spinal injury.\\n\\n## ARA-290 Human Clinical Data on Small Fiber Neuropathy\\n\\nARA-290 has been tested in randomized trials for small fiber neuropathy symptoms and corneal nerve fiber density.\\n\\n## Absence of Direct Data on Post-Surgical Nerve Damage Stack\\n\\nNo human trials exist for the BPC-157 + ARA-290 combination or either peptide specifically in post-surgical nerve damage models.\\n\\n## Mechanistic Mapping\\n\\nBPC-157 data describe local angiogenesis and tissue repair in animal models. ARA-290 activates innate repair receptor pathways in human neuropathy studies.\",\n  \"register\": \"source_ledger\",\n  \"claims\": [\n    {\n      \"id\": \"c1\",\n      \"text\": \"BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.\",\n      \"section\": \"BPC-157 Preclinical Data on Nerve Injury\",\n      \"tier\": \"preclinical\",\n      \"source_ids\": [\"s1\"],\n      \"source_status\": \"sourced\",\n      \"why_material\": \"Documents rat-specific evidence for peripheral nerve healing separate from human data.\"\n    },\n    {\n      \"id\": \"c2\",\n      \"text\": \"ARA-290 treatment for 28 days in sarcoidosis patients with small fiber neuropathy improved neuropathic symptoms and increased corneal nerve fiber density.\",\n      \"section\": \"ARA-290 Human Clinical Data on Small Fiber Neuropathy\",\n      \"tier\": \"human\",\n      \"source_ids\": [\"s2\"],\n      \"source_status\": \"sourced\",\n      \"why_material\": \"Provides the only cited human trial evidence for nerve fiber regrowth.\"\n    },\n    {\n      \"id\": \"c3\",\n      \"text\": \"No published human clinical trials evaluate BPC-157 or the BPC-157 + ARA-290 combination for post-surgical nerve damage.\",\n      \"s","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"9cb428ac344950f417d11500c4cc6ce719f40f7e1517af63ee26de463f6db4b0"},{"ts":"2026-06-29T10:40:17.366Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"9cb428ac344950f417d11500c4cc6ce719f40f7e1517af63ee26de463f6db4b0","hash":"b6af7a742ffdbe71428d1d82cfa60bfac6f54c7de9e155e396d0726e5e9fd36c"},{"ts":"2026-06-29T10:40:45.674Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b6af7a742ffdbe71428d1d82cfa60bfac6f54c7de9e155e396d0726e5e9fd36c","hash":"4ae1bbce6e52fb450c150783af8f4c373efdbaf0141e94902978f51fb31e987e"},{"ts":"2026-06-29T10:41:09.904Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4ae1bbce6e52fb450c150783af8f4c373efdbaf0141e94902978f51fb31e987e","hash":"3fbc181f1622ae0e143df52d6ec09d89f042a29db2fbcadf5ea939b379cc88d2"},{"ts":"2026-06-29T10:42:22.029Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"3fbc181f1622ae0e143df52d6ec09d89f042a29db2fbcadf5ea939b379cc88d2","hash":"5f325c18dcaaf83c79df24319e2003b718817a86fc3446c28cabbcafdc4552e8"},{"ts":"2026-06-29T10:42:48.657Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"2 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5f325c18dcaaf83c79df24319e2003b718817a86fc3446c28cabbcafdc4552e8","hash":"9ee735f7b540caf9dede0075b6fc939bd4d6a16d1f84fbbde75ac33f1bca9c1e"},{"ts":"2026-06-29T10:43:11.742Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"9ee735f7b540caf9dede0075b6fc939bd4d6a16d1f84fbbde75ac33f1bca9c1e","hash":"05765e7d9e844b9a3efec86911d753a7c22855222cf0e51dcd932f5ea988aaf9"},{"ts":"2026-06-29T12:48:16.400Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, what_is_unknown, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"05765e7d9e844b9a3efec86911d753a7c22855222cf0e51dcd932f5ea988aaf9","hash":"97cbac8fc16f9886e7808710a8e421c9c15e5fd22907ded5d8e792d567f8f948"},{"ts":"2026-06-29T12:48:17.000Z","model":"system/audit-repair","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c31","response":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"97cbac8fc16f9886e7808710a8e421c9c15e5fd22907ded5d8e792d567f8f948","hash":"434442857b1e89007ec6c2475f79bf2e117d9b12ac6b625e70262dfb74a9d94d"},{"ts":"2026-06-29T12:48:18.877Z","model":"system/audit-repair","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c32","response":"Per this ledger on BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary: 11 scientific and 16 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"434442857b1e89007ec6c2475f79bf2e117d9b12ac6b625e70262dfb74a9d94d","hash":"01fe22d80a135a45a8168c4ba7682d8358e457b9144177fc7bbb7021ec24a227"},{"ts":"2026-06-29T12:48:18.927Z","model":"system/audit-repair","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c33","response":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","tokens_in":0,"tokens_out":0,"cost":0,"prev":"01fe22d80a135a45a8168c4ba7682d8358e457b9144177fc7bbb7021ec24a227","hash":"63cea1cfe90a7475fc46c1f35f055591ad53d6555be10ab66e936053dee05d97"},{"ts":"2026-06-29T12:48:18.977Z","model":"system/audit-repair","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c34","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"63cea1cfe90a7475fc46c1f35f055591ad53d6555be10ab66e936053dee05d97","hash":"941e7e9238222a90c4b415dd0da1803f175d8b0f824803bc407510bff3e11be6"},{"ts":"2026-06-29T12:48:19.067Z","model":"system/audit-repair","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c35","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"941e7e9238222a90c4b415dd0da1803f175d8b0f824803bc407510bff3e11be6","hash":"296e72df0fa18e433c12e96f79f30222a89f24af2ffc9954323280dfc96c3a59"},{"ts":"2026-06-29T12:48:19.735Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"296e72df0fa18e433c12e96f79f30222a89f24af2ffc9954323280dfc96c3a59","hash":"68c299c4a3aa69fe47bc380024623255db881af24cc27447166b31099f3bb65a"},{"ts":"2026-06-29T13:23:53.881Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"68c299c4a3aa69fe47bc380024623255db881af24cc27447166b31099f3bb65a","hash":"044ab5c2ee1e5f04594caccd90b9c1ec963789065fe67d9bd470a3c45d9f0c76"},{"ts":"2026-06-29T13:23:55.169Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"044ab5c2ee1e5f04594caccd90b9c1ec963789065fe67d9bd470a3c45d9f0c76","hash":"a44328e908166af7f49445b4cc48211fd8df2e35daeb8e438934adb0ef91fa30"},{"ts":"2026-06-29T13:36:44.275Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"I am adding explicit claims about gaps in knowledge and naming specific anecdotal claimants as per the instructions. I am not Grok because I am contributing additional structured information to the ledger that was not previously included, specifically regarding unknowns and anecdotal claimants.","tokens_in":3218,"tokens_out":453,"cost":0,"prev":"a44328e908166af7f49445b4cc48211fd8df2e35daeb8e438934adb0ef91fa30","hash":"0f506c0f1c6ef2674045374742ca029183509515cd4ba1950e7c09d1480c501a"},{"ts":"2026-06-29T13:54:14.984Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0f506c0f1c6ef2674045374742ca029183509515cd4ba1950e7c09d1480c501a","hash":"512bf11bde3908f1af5c75e532a33d8c7e740aeb8934a4caf49de56f55ba31d5"},{"ts":"2026-06-29T13:54:16.172Z","model":"system/audit-repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"512bf11bde3908f1af5c75e532a33d8c7e740aeb8934a4caf49de56f55ba31d5","hash":"c79606a419fddf18372328fbb5ee6d8316f82ab1a3abd8ed17c57ef90c9ff422"},{"ts":"2026-06-29T15:04:24.204Z","model":"gemini/gemini-2.5-flash","action":"collaborate","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"I added three claims to address explicit gaps in the ledger, focusing on `what_is_unknown` regarding human data for the specific condition and `who_claims_what` from existing but previously unmaterialized sources. This directly responds to the instruction to state explicit gaps and name who claims what, and I am Gemini, not Grok.","tokens_in":2965,"tokens_out":500,"cost":0,"prev":"c79606a419fddf18372328fbb5ee6d8316f82ab1a3abd8ed17c57ef90c9ff422","hash":"60b6abaf07a181bea067e65a4d3affb3174ebceb7f22c3fb3bc0e78cb706b459"},{"ts":"2026-06-29T15:09:49.857Z","model":"grok/grok-4.3","action":"synthesize_body","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"## Regeneration vs degeneration — where this fits\nThe body breaks down tissue and builds it back at the same time. When breakdown outruns repair after surgery, nerve damage can stay. Most drugs reduce pain signals without fixing the nerve itself. BPC-157 and ARA-290 are studied for repair steps: new blood vessels, cell migration to the injury, and nerve fiber regrowth.\n\n## What it is\nBPC-157 is a peptide studied in rat nerve injury models. ARA-290 is a peptide studied in human small fiber neuropathy trials. The ledger covers their separate use and reported stacking for post-surgical nerve damage.\n\n## How it works\nBPC-157 is linked to angiogenesis and cytoprotection at the injury site in rat models. ARA-290 binds the innate repair receptor on nerve tissue and immune cells. Binding reduces neuroinflammation and supports nerve fiber regrowth.\n\n## Why it would work (logic chain)\nIf surgery cuts or stretches a nerve, then axons and myelin break down. If new blood vessels form and repair cells reach the site, then axons can regrow. If inflammation stays high, then regrowth slows. BPC-157 is proposed to aid the vessel and repair-cell steps. ARA-290 is proposed to lower inflammation and signal regrowth through the innate repair receptor. If both pathways run, then repair might increase.\n\n## Why people take it\nPeople report post-surgical nerve pain or numbness that does not resolve. They look for options that target repair instead of only symptom relief.\n\n## How many people take it\nUnknown. The ledger shows 8 Reddit posts, 5 X posts, and 3 other anecdote sources. No population count exists.\n\n## Evidence inventory\nSources total 28. Studies catalogued 11. Reddit posts 8. X posts 5. Other anecdote sources 3. Human claims 3. Preclinical claims 8. Anecdotal claims 17. Human data come from ARA-290 sarcoidosis trials. BPC-157 data are rat sciatic nerve transection studies. No human trial tests either compound or the combination for post-surgical nerve damage.\n\n## What scientists sa","tokens_in":7648,"tokens_out":929,"cost":0,"prev":"60b6abaf07a181bea067e65a4d3affb3174ebceb7f22c3fb3bc0e78cb706b459","hash":"b249fa479f6f015897126e8e8f336142770066d2eb72ba955accd3a4041689f5"},{"ts":"2026-06-29T18:02:32.787Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"b249fa479f6f015897126e8e8f336142770066d2eb72ba955accd3a4041689f5","hash":"5d89fd17720f193cb3dd1f529cb819e781b09f7f5543a77e40b9e47408bb6f7f"},{"ts":"2026-06-29T18:03:04.847Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"5d89fd17720f193cb3dd1f529cb819e781b09f7f5543a77e40b9e47408bb6f7f","hash":"7b72c373e928d5243a3a360d780525584b469b6b80dbc4d31f6c49d472c752db"},{"ts":"2026-06-29T18:03:30.363Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"7b72c373e928d5243a3a360d780525584b469b6b80dbc4d31f6c49d472c752db","hash":"0d469f22f2f57af9b453679aaa05949f0c3594dae081612a7be9fe5206fb1905"},{"ts":"2026-06-29T18:04:30.836Z","model":"grok-4.3","action":"sources","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0d469f22f2f57af9b453679aaa05949f0c3594dae081612a7be9fe5206fb1905","hash":"d4afc710588da15ce095f64b801748b90ed30c397fcbc26a49aea22d97d53954"},{"ts":"2026-06-29T19:44:04.091Z","model":"repair","action":"repair","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":0,\"cycle\":0,\"adjacent\":7}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d4afc710588da15ce095f64b801748b90ed30c397fcbc26a49aea22d97d53954","hash":"2f22e4f0ed9dbe32779d38514fee52c13655640ee1c1cc89929ce80c73f2b7de"},{"ts":"2026-06-29T20:57:27.393Z","model":"fill-slots","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c63","response":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"2f22e4f0ed9dbe32779d38514fee52c13655640ee1c1cc89929ce80c73f2b7de","hash":"6a118d563c99e7e7cfad344507278210133e5efd85db62e3736f87a3a5669dd9"},{"ts":"2026-06-29T20:57:27.586Z","model":"fill-slots","action":"claim","prompt":"","input":"bpc-ara-post-surgical-nerve c64","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6a118d563c99e7e7cfad344507278210133e5efd85db62e3736f87a3a5669dd9","hash":"6f1ea390e85292f9ed3ae4001831ff7aeb093f01a82dd506e1256ced808b017e"},{"ts":"2026-07-17T02:38:41.467Z","model":"owner","action":"voxel_divide","prompt":"","input":"bpc-ara-post-surgical-nerve","response":"24 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6f1ea390e85292f9ed3ae4001831ff7aeb093f01a82dd506e1256ced808b017e","hash":"c39ce1e37688e8dd8abb33e3077c960ce043ea9d153256c299c2dcfc29dd0219"}]}