{"slug":"bpc-ara-post-surgical-nerve","verification":{"valid":true,"entries":21,"head":"d9bcca3c84ace95ce8b4cfea14043ae73780ff26abec6bb7bc8e561746683e2f"},"count":21,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","fill-slots"],"yield":{"passes":21,"energy_spent_rows":0,"total_cost_usd":0.012806,"waste_cost_usd":0,"total_tokens":15713,"material_outputs":6,"usd_per_output":0.002134,"models":[{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000372,"tokens_total":3465,"outputs":3,"waste_passes":0,"usd_per_output":0.000124},{"model":"kimi/moonshot-v1-8k","passes":1,"cost_usd":0.000551,"tokens_total":3671,"outputs":3,"waste_passes":0,"usd_per_output":0.000184},{"model":"grok-4.3","passes":10,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.011883,"tokens_total":8577,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:57:07.238Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary","register":"source_ledger","body":"## BPC-157 Preclinical Data on Nerve Injury\n\nBPC-157 is derived from gastric juice. Rat studies show effects on peripheral and central nerve recovery after transection or spinal injury.\n\n## ARA-290 Human Clinical Data on Small Fiber Neuropathy\n\nARA-290 has been tested in randomized trials for small fiber neuropathy symptoms and corneal nerve fiber density.\n\n## Absence of Direct Data on Post-Surgical Nerve Damage Stack\n\nNo human trials exist for the BPC-157 + ARA-290 combination or either peptide specifically in post-surgical nerve damage models.\n\n## Mechanistic Mapping\n\nBPC-157 data describe local angiogenesis and tissue repair in animal models. ARA-290 activates innate repair receptor pathways in human neuropathy studies.","claims":[{"id":"c1","text":"BPC-157 improved axonal regeneration, myelin thickness, and motor function in rat sciatic nerve transection models.","section":"BPC-157 Preclinical Data on Nerve Injury","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Documents rat-specific evidence for peripheral nerve healing separate from human data.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"ARA-290 treatment for 28 days in sarcoidosis patients with small fiber neuropathy improved neuropathic symptoms and increased corneal nerve fiber density.","section":"ARA-290 Human Clinical Data on Small Fiber Neuropathy","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Provides the only cited human trial evidence for nerve fiber regrowth.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No published human clinical trials evaluate BPC-157 or the BPC-157 + ARA-290 combination for post-surgical nerve damage.","section":"Absence of Direct Data on Post-Surgical Nerve Damage Stack","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"States the explicit lack of human data as required.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"BPC-157 effects in rat nerve models involve angiogenesis and cytoprotection at the injury site.","section":"Mechanistic Mapping","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Links given peptide definition to observed rat outcomes.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://link.springer.com/article/10.1186/s13018-019-1242-6","title":"Stable gastric pentadecapeptide BPC 157 can improve the healing of transected sciatic nerve in rats","quote":"BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers...)","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3563705/","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy","quote":"The ARA 290 group showed significant (p < 0.05) improvement at wk 4 in SFNSL score compared with placebo... In addition, ARA290 treatment for 28 days initiated a regrowth of small nerve fibers in the cornea...","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"1140bdf3b64c56e733f548e18b6e00aac2d8cf70c7a6d49a68fdccde7e1c5e15"},{"seq":1,"id":"k2","ts":"2026-06-29T10:40:17.366Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s3","type":"medical","url":"https://peptidefox.com/content/ara-290","title":"ARA-290: Tissue-Protective Peptide for Nerve Pain","quote":"The reason to think it would help here is preclinical. The closest evidence is a rat study of a surgical nerve injury, where ARA-290 relieved touch and cold hypersensitivity and the effect vanished without the receptor³. That is a strong mechanistic match, but it is an animal model. No human trial has tested post-surgical nerve pain.","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"I’ve been on BPC157/TB 500 for a month or so now doing fine. Just added in ARA290 last week... The second cycle I did it I also stacked BPC-157/TB500. That seemed to help a lot.","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment with peptides","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy, tarsal tunnel, nerve injury or post operative nerve pain.","link_status":"ok","quote_status":"verified"},{"id":"s6","type":"review","url":"https://www.truehealwellness.com/peptides-research/ara-290","title":"ARA-290: Neuropathic Pain & Nerve Repair","quote":"For post-surgical nerve pain, the rationale is preclinical (an animal surgical-nerve-injury study); no human trial has tested it. ... Mechanisms don't overlap, so they can be used together when nerve pain sits inside a larger injury.","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"1140bdf3b64c56e733f548e18b6e00aac2d8cf70c7a6d49a68fdccde7e1c5e15","hash":"504cd5124b7cc0c08c8bcd394a428530c20bfa98fcd91b8094ab0b833b23ebe9"},{"seq":2,"id":"k3","ts":"2026-06-29T10:40:45.674Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","link_status":"ok","quote_status":"verified"},{"id":"s9","type":"other","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"Discover how combining ARA-290 and BPC-157 can accelerate peripheral nerve regeneration.","link_status":"ok","quote_status":"verified"},{"id":"s10","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290, a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/v4sj4d/bpc157_tb500_and_ara290_stack/","title":"BPC-157, TB-500, and ARA-290 stack","quote":"I got a neuropathic pain due to nerve damage after surgery.","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term functional improvement in this condition.","link_status":"http_429","quote_status":"unverified"},{"id":"s13","type":"instagram","url":"https://www.instagram.com/reel/DXXlaCCE4sf/","title":"Nerve pain treatment approaches including peptides","quote":"Peptide therapy (BPC-157, ARA-290) — supports healing at the cellular signaling level","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"504cd5124b7cc0c08c8bcd394a428530c20bfa98fcd91b8094ab0b833b23ebe9","hash":"d858d76300035af5e23d8f22d7ce83ab28d21180b1b6e5166cfada720c086a8e"},{"seq":3,"id":"k4","ts":"2026-06-29T10:41:09.904Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1plukvn/bpc157/","title":"BPC157","quote":"Hey so I did two months of ARA290 and I didn’t really notice too much from that, but one thing I will say is my internal “cracking” from overfiring nerves in my fingers when bend my fingers backward went away. Could be from the ARA. Also my myoclonus symptoms have gone down ... As for BPC, I went on it for a few days at 500mcg and my shoulder started twitching nonstop so idk if it was from that or something else but I stopped. I just started with it again at 250mcg","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"i was on bpc-157 and tb-500 when i experienced my flare-up progression that led me to seek out ara-290 in the 1st place. they're a waste of money, imo.","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"Using after major back surgery. Lots of chatter. Have a huge supply of 30+ peptides so I am good with cycling stacks.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive. ... I think like a month of it gives prob 2 months of relief","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"d858d76300035af5e23d8f22d7ce83ab28d21180b1b6e5166cfada720c086a8e","hash":"c8d79cdd6544f7d0d105ce6a02ab4b9a8949b783ce05d97dc9eba2ba0b3db84a"},{"seq":4,"id":"k5","ts":"2026-06-29T10:42:22.029Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s18","type":"review","url":"https://www.seekpeptides.com/blog/articles/peptides-for-neuropathy","title":"Peptides for neuropathy: the complete guide to nerve repair and pain relief","quote":"BPC-157 stands as arguably the most researched peptide for peripheral nerve regeneration, with a body of preclinical evidence that spans multiple nerve injury models... If BPC-157 represents the strongest preclinical evidence for peptide-based nerve repair, ARA-290 represents the strongest clinical evidence.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"BPC-157 has demonstrated nerve regeneration in preclinical models of sciatic nerve transection, with faster axonal regeneration, improved myelination, and functional recovery... Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide Targeting Neuropathic Pain and Tissue Protection","quote":"Stacking: Pairs well with BPC-157 for comprehensive neuroprotection and tissue repair...","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for ...","quote":"ARA-290 has been extensively studied for its effects on: Small fiber neuropathy. Diabetic neuropathy. Chemotherapy-induced nerve damage.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"c8d79cdd6544f7d0d105ce6a02ab4b9a8949b783ce05d97dc9eba2ba0b3db84a","hash":"5eb76b0456da5bad632765a131ee7d985d8095beda90bf19f163890856f7bf89"},{"seq":5,"id":"k6","ts":"2026-06-29T10:42:48.657Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s22","type":"medical","url":"https://navacenter.com/recovery-and-healing-peptides/","title":"Recovery & Healing Peptide Therapy | BPC-157, GHK-Cu, TB-500 | Nava Health","quote":"ARA-290 activates a specific receptor found on nerve tissue and immune cells called the innate repair receptor. When it binds there, it reduces neuroinflammation, supports nerve fiber regrowth, and turns down the inflammatory signals that keep nerve pain going long after the original cause has resolved.","link_status":"ok","quote_status":"verified"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/BodyHackGuide/comments/1n264di/bpc157_for_long_term_nerve_damage/","title":"BPC-157 for long term nerve damage? : r/BodyHackGuide","quote":"BPC-157 for long term nerve damage ? My father has been struggling with pain in his feet for more than 5 years now.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"5eb76b0456da5bad632765a131ee7d985d8095beda90bf19f163890856f7bf89","hash":"3893b69f5185bbf212bf969b2d9a129d3ce05fc96999422b9d9a10bec23d23d7"},{"seq":6,"id":"k7","ts":"2026-06-29T10:43:11.742Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s24","type":"x","url":"https://x.com/itsjoshkade/status/2068423897226387940","title":"X post by @itsjoshkade on ARA-290 experience","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","link_status":"ok","quote_status":"unverified"},{"id":"s25","type":"x","url":"https://x.com/CoachMattFit/status/2067657277365174754","title":"X post by @CoachMattFit on ARA-290 personal experience","quote":"ARA helps reduce inflammation, support nerve repair, and improve recovery. Best paired with BPC-157 for healing, KPV to reduce inflammation, and TB500 for recovery.","link_status":"ok","quote_status":"verified"},{"id":"s26","type":"x","url":"https://x.com/lutho_kote/status/2066123964938584577","title":"X post by @lutho_kote on peptide stack for nerve function","quote":"With ARA-290,TB-500 & BPC-157 stacked I have now improved nerve function and better mobility now that the soft-tissues have healed in my shoulders muscles","link_status":"ok","quote_status":"unverified"},{"id":"s27","type":"x","url":"https://x.com/lutho_kote/status/2066122859831812499","title":"X post by @lutho_kote adding ARA-290 for nerve repair","quote":"Over the past 3months I’ve cycled TB-500 & BPC-157 peptides. I have since added ARA-290 for nerve repair and systemic tissue-Protection.","link_status":"ok","quote_status":"unverified"},{"id":"s28","type":"x","url":"https://x.com/mannyjplays/status/2062148959976526143","title":"X post by @mannyjplays recommending ARA-290 for nerve damage","quote":"Ara 290 is specifically for nerve regeneration. He might benefit from it as well. I’m looking into since I have drop foot from nerve damage and I’d like to see if it helps","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"3893b69f5185bbf212bf969b2d9a129d3ce05fc96999422b9d9a10bec23d23d7","hash":"13ee46091ac626f2ba42970cccebd8b6088a8ae2e3f2558664868e8eb2384229"},{"seq":7,"id":"k8","ts":"2026-06-29T12:48:17.000Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c31","tier":"system","text":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:17.000Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"13ee46091ac626f2ba42970cccebd8b6088a8ae2e3f2558664868e8eb2384229","hash":"21e15d86302cb324cd0693a00883945358562361d84ad6895d2fcaac7c3ac076"},{"seq":8,"id":"k9","ts":"2026-06-29T12:48:18.877Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c32","tier":"preclinical","text":"Per this ledger on BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary: 11 scientific and 16 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:18.877Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"21e15d86302cb324cd0693a00883945358562361d84ad6895d2fcaac7c3ac076","hash":"af9942c8ae6e5143d35f88854a304b46039155cd6f161eee3a52acf8b4b42a11"},{"seq":9,"id":"k10","ts":"2026-06-29T12:48:18.927Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c33","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:18.927Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"af9942c8ae6e5143d35f88854a304b46039155cd6f161eee3a52acf8b4b42a11","hash":"e70047418272a8c9e6643f4264ed7fa33f1a7d0844cceecdf738e5403828c9a9"},{"seq":10,"id":"k11","ts":"2026-06-29T12:48:18.977Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c34","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:18.977Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"e70047418272a8c9e6643f4264ed7fa33f1a7d0844cceecdf738e5403828c9a9","hash":"1aa0e1836c54aa74ed2ef8baa3c123b34c1c115525105be8adf7740195848512"},{"seq":11,"id":"k12","ts":"2026-06-29T12:48:19.067Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c35","tier":"human","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"disclaimer","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:19.067Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"1aa0e1836c54aa74ed2ef8baa3c123b34c1c115525105be8adf7740195848512","hash":"c581938f1efed1322174dc9a06ce65a21cb9d5022ce918a4b94786e0f28c1741"},{"seq":12,"id":"k13","ts":"2026-06-29T13:36:44.275Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c36","c37"],"challenge_id":"c38","rationale":"I am adding explicit claims about gaps in knowledge and naming specific anecdotal claimants as per the instructions. I am not Grok because I am contributing additional structured information to the ledger that was not previously included, specifically regarding unknowns and anecdotal claimants."},"rationale":"I am adding explicit claims about gaps in knowledge and naming specific anecdotal claimants as per the instructions. I am not Grok because I am contributing additional structured information to the ledger that was not previously included, specifically regarding unknowns and anecdotal claimants.","tokens_in":3218,"tokens_out":453,"cost":0.00055065,"prev_hash":"c581938f1efed1322174dc9a06ce65a21cb9d5022ce918a4b94786e0f28c1741","hash":"81839456c22361f644013274c36de42cc09bead50cc08445bd35e106b98eb19b"},{"seq":13,"id":"k14","ts":"2026-06-29T15:04:24.204Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","payload":{"claims_added":["c39","c40","c41"],"challenge_id":null,"rationale":"I added three claims to address explicit gaps in the ledger, focusing on `what_is_unknown` regarding human data for the specific condition and `who_claims_what` from existing but previously unmaterialized sources. This directly responds to the instruction to state explicit gaps and name who claims what, and I am Gemini, not Grok."},"rationale":"I added three claims to address explicit gaps in the ledger, focusing on `what_is_unknown` regarding human data for the specific condition and `who_claims_what` from existing but previously unmaterialized sources. This directly responds to the instruction to state explicit gaps and name who claims what, and I am Gemini, not Grok.","tokens_in":2965,"tokens_out":500,"cost":0.000372375,"prev_hash":"81839456c22361f644013274c36de42cc09bead50cc08445bd35e106b98eb19b","hash":"29b494ed84f72c4c7fec30bc6c0462f866afcdd6ef55f4b45caa389ae6332a06"},{"seq":14,"id":"k15","ts":"2026-06-29T15:09:49.857Z","model":"grok/grok-4.3","role":"editor","action":"synthesize_body","payload":{"chars":4262,"claims_used":31,"legibility":{"pass":true,"reasons":[]}},"rationale":"Reader body rewritten from ranked ledger topology — plain English","tokens_in":7648,"tokens_out":929,"cost":0.0118825,"prev_hash":"29b494ed84f72c4c7fec30bc6c0462f866afcdd6ef55f4b45caa389ae6332a06","hash":"18cb85506c2bbb841d919a5e5f27dcec8234b88ac87ff690700b6d9bbb7dce80"},{"seq":15,"id":"k16","ts":"2026-06-29T18:02:32.787Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I've been exploring peptide therapies for a while now and have had some really positive results with BPC-157 and TB-500 for my chronic back pain. ... I'm particularly interested in ARA 290 but haven't found many detailed personal experiences online.","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tyz687/life_saver/","title":"Life saver","quote":"I have tried BPC 157 and it made me flare horribly. I want to try ARA 290 and will report back.","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/bpc_157/comments/1m3blg0/question_about_bpc_157_nerve_damage/","title":"Question about bpc 157 nerve damage","quote":"I had nerve surgery to repair them I just want to make them more complete and heal faster ... just started bpc 157 3 days ago","link_status":"ok","quote_status":"unverified"},{"id":"s32","type":"reddit","url":"https://www.reddit.com/r/floxies/comments/1p5yfz9/ara_290_and_bpc_157/","title":"ARA 290 and BPC 157","quote":"I want to try ARA290 because they're good for nerves but am ... That's interesting about the neuropathy from bpc . I have heard it ...","link_status":"ok","quote_status":"unverified"},{"id":"s33","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1tljy8y/ara290_might_be_the_most_slept_on_peptide_for/","title":"ARA-290 Might Be the Most Slept On Peptide for Nerve ...","quote":"For nerve focused recovery the combination of ARA-290 , BPC-157 , and KPV covers repair, inflammation, and nerve regeneration from three ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"18cb85506c2bbb841d919a5e5f27dcec8234b88ac87ff690700b6d9bbb7dce80","hash":"b29f9439379564fe7b52931292467d795392806f6fbc8a7b48dd0f3d94c82947"},{"seq":16,"id":"k17","ts":"2026-06-29T18:03:04.847Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1qf1t16/nerve_damage_wont_heal_ara290_complete_guide/","title":"Nerve Damage Won't Heal → ARA-290 Complete Guide","quote":"For acute nerve damage from trauma or surgery: ARA-290 : 4mg daily. BPC - 157 : 250-500mcg daily. TB-500: 2-5mg twice weekly","link_status":"ok","quote_status":"unverified"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1q61v4s/ara290_cibinetide_explained_the_nerve_repair/","title":"ARA-290 (Cibinetide) Explained: The Nerve Repair Peptide Most Recovery Stacks Miss","quote":"BPC-157 = fixes the hardware. TB-500 = improves the environment. ARA-290 = repairs the signal lines (nerves, pain pathways, inflammatory nerve stress)","link_status":"ok","quote_status":"unverified"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1oviobs/wondering_about_ara290/","title":"Wondering about ARA290","quote":"BPC - 157 significantly sped up nerve healing in rats. It improved nerve fiber growth, thickness, and blood flow","link_status":"ok","quote_status":"unverified"},{"id":"s37","type":"x","url":"https://x.com/HunterEsoteric/status/2056528484780962225","title":"BPC-157 has its limits. Disc pain and nerve pain is one of them.","quote":"BPC-157 has its limits. Disc pain and nerve pain is one of them. That's where ARA-290 comes in. → Developed for diabetic neuropathy and chronic pain → Start at 1mg, work up to 4mg → Stack with Cartilax for disc issues","link_status":"ok","quote_status":"unverified"},{"id":"s38","type":"x","url":"https://x.com/Jay11083548/status/2061426989098291655","title":"First suggestions would be BPC-157 and ARA-290.","quote":"First suggestions would be BPC-157 and ARA-290. ... Wifey has CRPS, a nerve condition similar to allodynia. BPC-157 and KPV helped, but retatrutide put it into remission.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"b29f9439379564fe7b52931292467d795392806f6fbc8a7b48dd0f3d94c82947","hash":"d0fb72df27a4e73c6bb3b4622cf12c18082bffc00de2137ab1190e6a4c6b16a5"},{"seq":17,"id":"k18","ts":"2026-06-29T18:03:30.363Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months!","link_status":"ok","quote_status":"unverified"},{"id":"s40","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I’ve started ARA-290 and I’m planning to run a 28-day cycle to see if it helps with my neuropathic pain. ... My current situation: Currently at 3.3 mg per day ... UPDATE (07.06.2026) ... planning ... 14 days at 4mg 14 days at 5mg 7 days at 6mg","link_status":"ok","quote_status":"unverified"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tmejcv/ara290_demonstrated_structural_nerve_fiber_growth/","title":"ARA-290 demonstrated structural nerve fiber growth in a ...","quote":"I have migraines and some ongoing nerve damage from TBI over 10 years ago and ARA 290 has had a huge ...","link_status":"ok","quote_status":"unverified"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/ixvi43/what_are_all_the_things_you_use_or_do_to_reduce/","title":"What are all the things you use or do to reduce sciatica pain.","quote":"I’m currently using these peptides: ARA-290 , BPC - 157 , and TB-500. They promote healing and can help with nerve pain.","link_status":"ok","quote_status":"unverified"},{"id":"s43","type":"x","url":"https://x.com/drtrevorbachm/status/2070811769170452870","title":"ARA-290 masterclass (solving all nerve damage)","quote":"ARA-290 a masterclass (solving all nerve damage) ... 2018 study published in the Journal Diabetes Care showed that ARA-290 in diabetic neuropathy… restored small fiber de...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d0fb72df27a4e73c6bb3b4622cf12c18082bffc00de2137ab1190e6a4c6b16a5","hash":"333622aaa15926d43bdae9bb96d413f517e3071e493aca2d9ca53da9dca1a29d"},{"seq":18,"id":"k19","ts":"2026-06-29T18:04:30.836Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s44","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tdbx3f/peptides_for_chronic_pain/","title":"peptides for chronic pain?","quote":"BPC-157 : Known for its tissue-protective properties, this peptide promotes axonal regeneration (regrowth of nerve fibers). It is frequently used ...","link_status":"ok","quote_status":"unverified"},{"id":"s45","type":"reddit","url":"https://www.reddit.com/r/guillainbarre/comments/1ofpc58/question_for_gbs_survivors_any_experience_using/","title":"Question for GBS survivors: any experience using peptides (BPC-157) after recovery?","quote":"My doctors say I don't need them and they wouldn't help me. I just wanted to use them for nerve damage and to recover from muscle loss faster.","link_status":"ok","quote_status":"unverified"},{"id":"s46","type":"reddit","url":"https://www.reddit.com/r/TrigeminalNeuralgia/comments/1g55fyp/tb_and_peptides/","title":"TB and peptides","quote":"Hi. I just bumped into a research of ARA290 . I have a bad facial neuropathy specially on the right side and now I am feeling taking my left side ...","link_status":"ok","quote_status":"unverified"},{"id":"s47","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1hlaw2f/nerve_damage_but_zero_pain_herniated_disk_in_c6/","title":"Nerve Damage but zero pain, herniated disk in c6","quote":"ARA-290 helps with neuropathy so there's a chance it could help other nerve damage . It's not the priciest peptide out there so IMO it's ...","link_status":"ok","quote_status":"unverified"},{"id":"s48","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too -- I guess you don't notice when you lose awareness of temperature.","link_status":"ok","quote_status":"unverified"},{"id":"s49","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"While there is no direct evidence of ARA-290 treating EM, there is some indirect evidence in that the peptide is used to treat small fiber neuropathy, is an anti-inflammatory, promote neurogensis, and can enhance vascular health.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"333622aaa15926d43bdae9bb96d413f517e3071e493aca2d9ca53da9dca1a29d","hash":"9c889cbb0db3c04542540470cb550a538e1072f6b5a0341417848bbb4fc9e7e6"},{"seq":19,"id":"k20","ts":"2026-06-29T20:57:27.393Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c63","tier":"system","text":"BPC-157 and ARA-290 for Post-Surgical Nerve Damage: Evidence Summary is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:57:27.393Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"9c889cbb0db3c04542540470cb550a538e1072f6b5a0341417848bbb4fc9e7e6","hash":"808ceaa8258ae3eda6fb115089632648f1a8bfba59936c063ca7d105fd4f94a8"},{"seq":20,"id":"k21","ts":"2026-06-29T20:57:27.586Z","model":"fill-slots","role":"claim_post","action":"claim","payload":{"claim_id":"c64","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T20:57:27.586Z","model":"fill-slots","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"808ceaa8258ae3eda6fb115089632648f1a8bfba59936c063ca7d105fd4f94a8","hash":"d9bcca3c84ace95ce8b4cfea14043ae73780ff26abec6bb7bc8e561746683e2f"}]}