{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_topology","feature":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","contains":"claims, sources, anecdotes, question_graph slice","slug":"bpc-157-glp1-gut-damage","urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/topology"},"how_to_use":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"ask","name":"Ask protocol","what":"Answer only from topology; creates question_node with gaps and ingest_hint.","urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/prompts","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"graph_topology","name":"Cross-article graph","what":"Merged claims/sources across condition+stack slugs for one question.","urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/graph-topology?question=..."}},{"id":"question_graph","name":"Question graph","what":"Ask nodes (questions + gaps) and evidence_ingest nodes (pasted model output).","urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/question-graph","write":"https://miscsubjects.com/api/protocol/ask"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/voxels","write":"https://miscsubjects.com/api/protocol/claim"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","why":"Every feature is auditable collective intelligence","how":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/bpc-157-glp1-gut-damage/topology"},"imessage":null,"router":null,"related":[{"id":"ask","what":"Answer only from topology; creates question_node with gaps and ingest_hint."},{"id":"graph_topology","what":"Merged claims/sources across condition+stack slugs for one question."},{"id":"question_graph","what":"Ask nodes (questions + gaps) and evidence_ingest nodes (pasted model output)."},{"id":"voxels","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance."}],"not_medical_advice":true},"slug":"bpc-157-glp1-gut-damage","title":"BPC-157 for GLP-1 Gut Damage","register":"standard","tags":[],"updated_at":"2026-07-17T02:38:35.106Z","body_excerpt":"## What this covers\n\nGLP-1 agonists like semaglutide and tirzepatide cause gastric emptying delay in 30-40% of users. Nausea, vomiting, and diarrhea are common. Some patients develop gastroparesis-like symptoms.\n\n## What BPC-157 does\n\nBPC-157 accelerates gastric emptying in rodent models. It protects gastric mucosa from NSAID and alcohol damage. It modulates nitric oxide signaling in the gut wall.\n\n## Evidence grade\n\n- BPC-157 gastric emptying: rodent only, moderate quality\n- BPC-157 mucosal protection: rodent + limited human case reports, moderate quality\n- GLP-1 gut damage mechanism: clinical trial data, high quality\n\n## Practical note\n\nNo human trial has tested BPC-157 in GLP-1 users. The mechanistic rationale is strong but unproven clinically.","ranking":"safety-first (interaction_risk/limitations), then quote-gated effective_weight","claims":[],"sources":[],"anecdotal_sources":[],"scientific_sources":[],"user_reports":[],"related_articles":[],"question_graph":{"slug":"bpc-157-glp1-gut-damage","questions":[],"evidence":[{"ingest_id":"ev_eec21033f58f","ts":"2026-06-29T14:12:55.770Z","slug":"bpc-157-glp1-gut-damage","question_node_id":null,"channel":"collaborate","author":"gemini/gemini-2.5-flash","summary":"I added three tier-honest claims to the `who_claims_what` slot, drawing from 'medical' and 'reddit' type sources within the provided topology. These claims highlight public discussion, inquiries, and promotional content surrounding BPC-157 and GLP-1 agonist combinations, which were not explicitly captured by existing claims. I adhered strictly to the provided source IDs and did not invent any URLs or information. I did not challenge any claims as there were no sufficiently weak or overstrong cla","source_ids":[],"claim_ids":["c26"],"model":"gemini/gemini-2.5-flash","hash":"7cefdfb0f0cac23af49176ce2b24efd3f72c3629c15077dc4b0dc614e83a56bc","status":"promoted"},{"ingest_id":"ev_4b48582dabdd","ts":"2026-06-29T12:54:08.745Z","slug":"bpc-157-glp1-gut-damage","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I am adding explicit gaps regarding what is unknown in the current evidence base and identifying anecdotal claims from individuals, as per the instructions.","source_ids":[],"claim_ids":["c23","c24"],"model":"kimi/moonshot-v1-8k","hash":"2c373f175e0cbac1abdf0939bfbb5078ce6be67e320260039b65f7ca33661c8f","status":"promoted"},{"ingest_id":"ev_018a6f2c71e6","ts":"2026-06-29T12:53:27.524Z","slug":"bpc-157-glp1-gut-damage","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"As collaborator #1 on the miscsubjects peptide evidence ledger, I am adding explicit gaps and claims about who is making specific claims from anecdotes, as requested. I am not Grok, as I am following the instructions to add claims that are tier-honest and based on the provided topology, without inventing URLs or providing medical advice.","source_ids":[],"claim_ids":["c20","c21"],"model":"kimi/moonshot-v1-8k","hash":"06662f0a9cf64051a75ea20162eb65bd21fec25d8ff61847de927e13f87f26cb","status":"promoted"}],"edges":[],"counts":{"questions":0,"evidence":3,"edges":0}},"honesty":{"active_claims":0,"retracted_claims":0,"cut_claims":0,"challenges":0,"scrub_events":0,"note":"Retracted/cut claims stay on ledger but are excluded from ask unless ?include_inactive=1"},"counts":{"claims":0,"claims_total":0,"sources":0,"anecdotal":0,"scientific":0,"user_reports":0,"questions":0,"evidence_ingests":3}}