{"slug":"ara-vs-gabapentin-comparison","title":"ARA-290 vs Gabapentin: Nerve Repair vs Symptom Masking","body":"## Regeneration vs degeneration — where this fits\n\nThe body breaks tissue down and builds it back at the same time. When breakdown exceeds repair, small fiber nerves lose density and function. Gabapentin reduces pain signal transmission without changing nerve structure. ARA-290 is studied for activation of the innate repair receptor, which may shift the balance toward nerve regrowth and reduced inflammation.\n\n## What it is\n\nARA-290 is an 11-amino-acid peptide derived from erythropoietin that does not raise red blood cell count. Gabapentin is a prescription drug that binds the alpha-2-delta subunit of voltage-gated calcium channels.\n\n## How it works\n\nARA-290 binds the innate repair receptor formed by the EPO receptor and the beta-common receptor. Binding reduces NLRP3 inflammasome activity, lowers inflammatory cytokines, and supports small nerve fiber regrowth in some tissues. Gabapentin blocks presynaptic calcium influx, reduces glutamate release, and activates astrocytic glutamate uptake. These actions dampen pain signaling but do not restore nerve fibers.\n\n## Why it would work (logic chain)\n\nIf nerve loss drives neuropathic pain, restoring fiber density should reduce symptoms at the source. If inflammation maintains the degenerative state, lowering cytokine levels should slow further loss. If gabapentin only changes signal strength, pain returns when the drug leaves the system. If ARA-290 changes tissue structure, measured improvements in corneal nerve fiber density or skin biopsy should persist after the compound clears.\n\n## Why people take it\n\nPeople take gabapentin to lower daily pain scores and improve sleep. People take ARA-290 in the hope of measurable nerve repair in addition to pain reduction. Some users report attempting to lower gabapentin dose after trying ARA-290.\n\n## How many people take it\n\nNo public registry tracks either compound for neuropathy. Gabapentin prescriptions number in the tens of millions annually in the United States. ARA-290 use outside trials is limited to unregulated sources; the developing company closed operations by 2026 and no active regulatory filing remains.\n\n## Evidence inventory\n\n49 total sources catalogued: 25 studies or trial listings, 11 Reddit posts, 5 X posts, 5 other anecdotal sources. Human trial data: 1 Phase 2 study with corneal confocal microscopy. Preclinical data: 12 sources. Anecdotal reports: 23 sources. One source directly compares the two compounds on mechanism.\n\n## What scientists say\n\nA 2015 Phase 2 trial in type 2 diabetes patients showed mean corneal nerve fiber density increased in the ARA-290 group while the placebo group showed no change (source s1). A 2012 pilot RCT in sarcoidosis patients found ARA-290 reduced neuropathic pain scores with no hematologic changes (source s37). A 2014 review of Phase 2 data reported consistent symptom improvement in sarcoidosis small fiber neuropathy (source s7). Reviews note that gabapentin reduces pain via presynaptic inhibition without evidence of structural nerve repair (source s2). A 2025 preclinical study in rats showed ARA-290 reduced NLRP3 activation and improved functional recovery after sciatic nerve crush (source s19). Development of ARA-290 has stalled; the sponsor closed with no active IND or NDA (source s24).\n\n## What people say on Reddit\n\nOne user reduced gabapentin from 2400 mg/day to 800-1600 mg/day after a 28-day ARA-290 course and reported symptom improvement in idiopathic small fiber neuropathy (source s6). Another user stated ARA-290 worked better than prior IVIG and produced relief within two hours, though ongoing use was required (source s12). A third user reported walking 14,000 steps pain-free after combining ARA-290 with a nerve stimulator and attributed the change to accelerated nerve repair (source s13). One user found initial ARA-290 benefit that faded and switched back to gabapentin for better symptom control (source s16). A user with disc herniation nerve pain reported no benefit or side effects after a short ARA-290 trial and noted allergy to gabapentin and pregabalin (source s15). Multiple users described partial return of foot sensation after one month of use (sources s30, s32).\n\n## What people say on X\n\nOne post states gabapentin masks the signal while ARA-290 targets the innate repair receptor to regrow fibers (source s33). Another post notes small nerves innervate organs beyond skin and lists ARA-290 among compounds that may regrow or repair nerves unlike gabapentin (source s34). A 2026 post references the 2018 Diabetes Care study showing restored small fiber density in diabetic neuropathy (source s44). One user expressed hope that ARA-290 would be life-changing for their neuropathy (source s29).\n\n## What we do not know\n\nNo large Phase 3 trial has confirmed sustained nerve fiber regeneration or long-term symptom relief. No head-to-head randomized trial exists between ARA-290 and gabapentin. Corneal nerve fiber density improvement has been measured, but correlation with skin biopsy or functional outcomes in other nerves remains limited. Duration of any repair effect after stopping ARA-290 is unknown. Real-world prevalence of use outside trials is not quantified.\n\n## Safety and limits\n\nARA-290 showed no change in hemoglobin or hematocrit in the published trials. Common gabapentin side effects include dizziness, sedation, and peripheral edema. Both compounds lack long-term safety data in large populations for neuropathy repair. ARA-290 is not available through regulated channels following sponsor closure.","register":"source_ledger","tags":["peptide","topic"],"style":{},"claims":[{"id":"c1","text":"ARA-290 treatment for 28 days initiated regrowth of small nerve fibers in the cornea in sarcoidosis patients.","section":"what_is_known","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Supports nerve repair framing with objective measure."},{"id":"c2","text":"Gabapentin inhibits release of excitatory neurotransmitters by binding calcium channels but does not heal damaged nerves.","section":"mechanism","tier":"human","source_ids":["s2"],"source_status":"sourced","why_material":"Distinguishes symptom masking from repair."},{"id":"c3","text":"ARA-290 improved neuropathic symptoms in human trials for small fiber neuropathy associated with sarcoidosis or type 2 diabetes.","section":"what_is_known","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Provides human clinical trial data tier."},{"id":"c4","text":"2025 article contrasting ARA-290's evidence for structural nerve regeneration (corneal confocal microscopy) with standard symptomatic treatments in sarcoidosis and diabetic SFN.","section":"what_is_known","tier":"speculative","source_ids":["s3"],"source_status":"sourced","why_material":"Materialized from orphan source s3 by ledger repair"},{"id":"c5","text":"Detailed review emphasizing Phase 2 data on nerve regeneration markers vs symptomatic masking by gabapentin; notes stalled development post-2020.","section":"what_is_known","tier":"human","source_ids":["s4"],"source_status":"sourced","why_material":"Materialized from orphan source s4 by ledger repair"},{"id":"c6","text":"Multiple user anecdotes on ARA-290 use for neuropathy repair, with some combining or reducing gabapentin doses; reports of nerve flares or benefits.","section":"who_claims_what","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Materialized from orphan source s5 by ledger repair"},{"id":"c7","text":"Detailed self-report of ARA-290 protocol (4mg/day x28 days) leading to symptom improvement and ability to lower gabapentin in idiopathic SFN.","section":"who_claims_what","tier":"anecdotal","source_ids":["s6"],"source_status":"sourced","why_material":"Materialized from orphan source s6 by ledger repair"},{"id":"c8","text":"2014 review of Phase II trials showing ARA290 improves neuropathic symptoms via tissue protection and repair mechanisms.","section":"what_is_known","tier":"human","source_ids":["s7"],"source_status":"sourced","why_material":"Materialized from orphan source s7 by ledger repair"},{"id":"c9","text":"2024 Phase II trial exploring ARA290 (4mg SC) for diabetic complications, extending evidence base.","section":"what_is_known","tier":"human","source_ids":["s8"],"source_status":"sourced","why_material":"Materialized from orphan source s8 by ledger repair"},{"id":"c10","text":"2024 study demonstrating ARA290's neuroprotective and anti-inflammatory effects supporting nerve repair.","section":"mechanism","tier":"preclinical","source_ids":["s9"],"source_status":"sourced","why_material":"Materialized from orphan source s9 by ledger repair"},{"id":"c11","text":"Medical site detailing ARA-290's role in neural repair, anti-inflammation, contrasting symptom management approaches.","section":"what_is_known","tier":"speculative","source_ids":["s10"],"source_status":"sourced","why_material":"Materialized from orphan source s10 by ledger repair"},{"id":"c12","text":"Discusses ARA-290 promoting tissue regeneration and repair rather than symptom masking, relevant to vs Gabapentin comparison.","section":"what_is_known","tier":"speculative","source_ids":["s11"],"source_status":"sourced","why_material":"Materialized from orphan source s11 by ledger repair"},{"id":"c13","text":"User anecdotes on ARA-290 providing rapid pain relief and possible nerve benefits, with ongoing use needed.","section":"who_claims_what","tier":"anecdotal","source_ids":["s12"],"source_status":"sourced","why_material":"Materialized from orphan source s12 by ledger repair"},{"id":"c14","text":"Recent anecdotal report of significant symptom improvement and implied repair from ARA-290 use.","section":"who_claims_what","tier":"anecdotal","source_ids":["s13"],"source_status":"sourced","why_material":"Materialized from orphan source s13 by ledger repair"},{"id":"c15","text":"Commercial vendors and clinics market this compound (7 commercial/clinic sources catalogued) — marketing material, not evidence.","section":"who_claims_what","tier":"speculative","source_ids":["s14","s19","s23","s42","s45","s49","s50"],"source_status":"sourced","why_material":"Collapsed 12 duplicate marketing claims"},{"id":"c16","text":"User with nerve pain from herniated disc tried multiple meds including gabapentin (allergic), now self-experimenting with ARA-290 cycle, no benefits or side effects noted after short time; plans longer protocol. Compares to symptom-masking drugs that failed due to allergies/side effects.","section":"who_claims_what","tier":"anecdotal","source_ids":["s15"],"source_status":"sourced","why_material":"Materialized from orphan source s15 by ledger repair"},{"id":"c17","text":"User reports initial but non-lasting benefit from ARA-290 for mild neuropathy, switched to gabapentin which is much more effective for nerve pain (with ALA); highlights gabapentin as better symptom management vs potential repair from peptide.","section":"who_claims_what","tier":"anecdotal","source_ids":["s16"],"source_status":"sourced","why_material":"Materialized from orphan source s16 by ledger repair"},{"id":"c18","text":"Review comparing ARA290's repair mechanism to standard symptom-masking treatments like gabapentin in neuropathy models and trials.","section":"mechanism","tier":"human","source_ids":["s17"],"source_status":"sourced","why_material":"Materialized from orphan source s17 by ledger repair"},{"id":"c19","text":"Discusses combined delivery of ARA290 with THC for prolonged neuropathic pain relief vs conventional drugs like gabapentin.","section":"what_is_known","tier":"speculative","source_ids":["s18"],"source_status":"sourced","why_material":"Materialized from orphan source s18 by ledger repair"},{"id":"c21","text":"Detailed user guide and discussion on ARA-290 for nerve repair vs symptom masking like gabapentin.","section":"who_claims_what","tier":"anecdotal","source_ids":["s20"],"source_status":"sourced","why_material":"Materialized from orphan source s20 by ledger repair"},{"id":"c22","text":"Reddit thread seeking and sharing personal anecdotes on ARA-290 for neuropathy.","section":"who_claims_what","tier":"anecdotal","source_ids":["s21"],"source_status":"sourced","why_material":"Materialized from orphan source s21 by ledger repair"},{"id":"c23","text":"User reports on trying ARA-290 for peripheral neuropathy, comparing implicitly to other treatments.","section":"who_claims_what","tier":"anecdotal","source_ids":["s22"],"source_status":"sourced","why_material":"Materialized from orphan source s22 by ledger repair"},{"id":"c25","text":"2026 overview of ARA-290 status, noting company closure and lack of active regulatory filings; discusses its history in neuropathy trials.","section":"what_is_known","tier":"speculative","source_ids":["s24"],"source_status":"sourced","why_material":"Materialized from orphan source s24 by ledger repair"},{"id":"c26","text":"2025 study on ARA290 microneedle patch showing pain relief and nerve morphology improvement in diabetic neuropathy rat model.","section":"what_is_known","tier":"speculative","source_ids":["s25"],"source_status":"sourced","why_material":"Materialized from orphan source s25 by ledger repair"},{"id":"c27","text":"2025 article discussing ARA-290 for neuropathic pain and small fiber neuropathy repair vs symptom management.","section":"what_is_known","tier":"speculative","source_ids":["s26"],"source_status":"sourced","why_material":"Materialized from orphan source s26 by ledger repair"},{"id":"c28","text":"2025 PMC paper on ARA290 neuroprotective mechanisms against cadmium-induced nerve damage.","section":"what_is_known","tier":"speculative","source_ids":["s27"],"source_status":"sourced","why_material":"Materialized from orphan source s27 by ledger repair"},{"id":"c29","text":"User anecdote reporting temporary symptom relief and sensory improvement from ARA-290 for suspected SFN.","section":"who_claims_what","tier":"anecdotal","source_ids":["s28"],"source_status":"sourced","why_material":"Materialized from orphan source s28 by ledger repair"},{"id":"c30","text":"Recent X anecdote expressing optimism about ARA-290 for personal neuropathy case.","section":"who_claims_what","tier":"anecdotal","source_ids":["s29"],"source_status":"sourced","why_material":"Materialized from orphan source s29 by ledger repair"},{"id":"c31","text":"User cryo424 reports significant improvement in severe neuropathy after 4mg/day for a month with ARA-290, better than other treatments tried; effects partially persisted.","section":"who_claims_what","tier":"anecdotal","source_ids":["s30"],"source_status":"sourced","why_material":"Materialized from orphan source s30 by ledger repair"},{"id":"c32","text":"User venus87 reports uncertain/minimal benefit from ~4 weeks of ARA-290.","section":"who_claims_what","tier":"anecdotal","source_ids":["s31"],"source_status":"sourced","why_material":"Materialized from orphan source s31 by ledger repair"},{"id":"c33","text":"User with diabetic neuropathy reports significant return of feeling in feet after ~1 month of ARA-290 use.","section":"who_claims_what","tier":"anecdotal","source_ids":["s32"],"source_status":"sourced","why_material":"Materialized from orphan source s32 by ledger repair"},{"id":"c34","text":"Promotional comparison highlighting ARA-290 for nerve repair vs Gabapentin symptom masking.","section":"who_claims_what","tier":"anecdotal","source_ids":["s33"],"source_status":"sourced","why_material":"Materialized from orphan source s33 by ledger repair"},{"id":"c35","text":"User opinion: ARA-290 (with others) can regrow/repair nerves unlike Gabapentin which only masks symptoms.","section":"who_claims_what","tier":"anecdotal","source_ids":["s34"],"source_status":"sourced","why_material":"Materialized from orphan source s34 by ledger repair"},{"id":"c36","text":"Ongoing or listed trial on ARA 290 for sarcoidosis neuropathy symptoms and nerve fiber density, distinct from listed NCT06626971.","section":"what_is_known","tier":"human","source_ids":["s35"],"source_status":"sourced","why_material":"Materialized from orphan source s35 by ledger repair"},{"id":"c37","text":"Compares conventional symptom-masking like gabapentin (NNT 5.9) to ARA-290's nerve regeneration evidence in context of multi-domain leg pain treatment.","section":"what_is_known","tier":"human","source_ids":["s36"],"source_status":"sourced","why_material":"Materialized from orphan source s36 by ledger repair"},{"id":"c38","text":"2012 pilot RCT showing ARA 290 reduces SFN symptoms safely in sarcoidosis patients via IRR activation for repair/anti-inflammation.","section":"what_is_known","tier":"human","source_ids":["s37"],"source_status":"sourced","why_material":"Materialized from orphan source s37 by ledger repair"},{"id":"c39","text":"Anecdotal discussion on ARA-290 for erythromelalgia via SFN overlap, seeking personal experiences.","section":"who_claims_what","tier":"anecdotal","source_ids":["s38"],"source_status":"sourced","why_material":"Materialized from orphan source s38 by ledger repair"},{"id":"c40","text":"Phase I study on ARA290 (Cibinetide) effects on cognitive and neural processing of emotions in healthy volunteers; explores non-hematopoietic EPO analog for neural impacts relevant to neuropathy repair.","section":"what_is_known","tier":"human","source_ids":["s39"],"source_status":"sourced","why_material":"Materialized from orphan source s39 by ledger repair"},{"id":"c41","text":"Phase II trial examining ARA290 effects on metabolic control and neuropathic symptoms in T2D patients, supporting nerve repair potential over symptom masking.","section":"what_is_known","tier":"human","source_ids":["s40"],"source_status":"sourced","why_material":"Materialized from orphan source s40 by ledger repair"},{"id":"c42","text":"2026 article details ARA-290's role in small fiber and diabetic neuropathy regeneration via innate repair receptor activation, anti-inflammatory effects, and nerve fiber density improvement, contrasting symptom-only treatments like gabapentin.","section":"mechanism","tier":"speculative","source_ids":["s41"],"source_status":"sourced","why_material":"Materialized from orphan source s41 by ledger repair"},{"id":"c44","text":"Expert review on ARA290 as promising option for neuropathic pain in sarcoidosis via tissue repair pathways, not mere masking.","section":"what_is_known","tier":"human","source_ids":["s43"],"source_status":"sourced","why_material":"Materialized from orphan source s43 by ledger repair"},{"id":"c45","text":"June 2026 X post discusses ARA-290 restoring small fiber density in diabetic neuropathy, highlighting repair vs masking.","section":"who_claims_what","tier":"anecdotal","source_ids":["s44"],"source_status":"sourced","why_material":"Materialized from orphan source s44 by ledger repair"},{"id":"c47","text":"2020 Phase 2 trial on cibinetide (ARA-290) for diabetic macular edema, related to its neuroprotective properties.","section":"what_is_known","tier":"human","source_ids":["s46"],"source_status":"sourced","why_material":"Materialized from orphan source s46 by ledger repair"},{"id":"c48","text":"Reddit user seeking experiences with ARA-290 for nerve damage.","section":"who_claims_what","tier":"anecdotal","source_ids":["s47"],"source_status":"sourced","why_material":"Materialized from orphan source s47 by ledger repair"},{"id":"c49","text":"Recent X post discussing availability of ARA-290.","section":"who_claims_what","tier":"anecdotal","source_ids":["s48"],"source_status":"sourced","why_material":"Materialized from orphan source s48 by ledger repair"},{"id":"c55","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","section":"disclaimer","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: disclaimer"},{"id":"c56","text":"There is a lack of long-term studies on the safety and efficacy of ARA-290 in treating neuropathy.","section":"what_is_unknown","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"This claim addresses a gap in the evidence regarding the long-term effects of ARA-290, which is not covered by the existing preclinical and anecdotal sources."},{"id":"c57","text":"Anecdotal reports suggest ARA-290 may have varying effects among individuals, but specific details on these individual experiences are not provided.","section":"who_claims_what","tier":"anecdotal","source_ids":["s29","s34","s44","s48"],"source_status":"sourced","why_material":"This claim identifies that while there are anecdotal reports about ARA-290, the specifics of who claims what are not detailed, which is a gap in the anecdotal evidence presented."},{"id":"c58","text":"A medical source discusses ARA-290's potential role in neuropathy and neurodegeneration.","section":"what_is_known","tier":"speculative","source_ids":["s3"],"source_status":"sourced","why_material":"Introduces a broader scope of discussion for ARA-290 from a medical perspective, utilizing an unused source."},{"id":"c59","text":"A review article highlights ARA-290 as a tissue-protective peptide for nerve pain.","section":"what_is_known","tier":"human","source_ids":["s4"],"source_status":"sourced","why_material":"Summarizes a key aspect of ARA-290's proposed action from a review perspective, utilizing an unused source."},{"id":"c60","text":"A Reddit user shares their assessment of ARA-290's effectiveness.","section":"who_claims_what","tier":"anecdotal","source_ids":["s6"],"source_status":"sourced","why_material":"Provides a specific instance of anecdotal experience, adding detail to the general anecdotal claims and utilizing an unused source."},{"id":"c63","text":"Reddit post contrasts gabapentinoids/symptom masking with ARA-290's documented nerve fiber density increase (repair). Anecdotal dosing not specified here. (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s51"],"source_status":"sourced","why_material":"Materialized from orphan source s51 by ledger repair"},{"id":"c64","text":"Thread explains ARA-290 as nerve repair vs symptom management like gabapentin. No specific user outcomes or dosing in main post. (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s52"],"source_status":"sourced","why_material":"Materialized from orphan source s52 by ledger repair"},{"id":"c65","text":"Comment reports no effect from 8mg/day ARA-290 for 2 weeks (bad outcome anecdote). (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s53"],"source_status":"sourced","why_material":"Materialized from orphan source s53 by ledger repair"},{"id":"c66","text":"Comment: expensive, insufficient relief at lower dose (bad outcome/side effect cost anecdote). (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s54"],"source_status":"sourced","why_material":"Materialized from orphan source s54 by ledger repair"},{"id":"c67","text":"X post anecdote: ARA-290 amazing for nerve pain (good outcome). No dosing details. (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s55"],"source_status":"sourced","why_material":"Materialized from orphan source s55 by ledger repair"},{"id":"c68","text":"X post dosing anecdote (2-4mg daily, 3-4 weeks build) and nerve repair pairing. (anecdotal, not advice)","section":"who_claims_what","tier":"anecdotal","source_ids":["s56"],"source_status":"sourced","why_material":"Materialized from orphan source s56 by ledger repair"},{"id":"c69","text":"Reddit thread discussing ARA-290 for nerve irritation vs gabapentin's symptom masking; user seeks comparison on whether it repairs or just dampens signals (anecdotal inquiry, not advice).","section":"who_claims_what","tier":"anecdotal","source_ids":["s57"],"source_status":"sourced","why_material":"Materialized from orphan source s57 by ledger repair"},{"id":"c70","text":"Guide contrasting gabapentin (symptom management) with ARA-290 (nerve repair evidence from trials); includes dosing research notes (anecdotal context only, not advice).","section":"who_claims_what","tier":"anecdotal","source_ids":["s58"],"source_status":"sourced","why_material":"Materialized from orphan source s58 by ledger repair"},{"id":"c71","text":"Comment thread on peptides for nerve repair; users note ARA-290 for regeneration vs standard symptom meds like gabapentin (anecdotal reports only).","section":"who_claims_what","tier":"anecdotal","source_ids":["s59"],"source_status":"sourced","why_material":"Materialized from orphan source s59 by ledger repair"},{"id":"c72","text":"X post recommending ARA-290 for radicular/nerve pain while tapering gabapentin; personal experience (anecdotal, not advice).","section":"who_claims_what","tier":"anecdotal","source_ids":["s60"],"source_status":"sourced","why_material":"Materialized from orphan source s60 by ledger repair"},{"id":"c73","text":"User reports positive sleep improvement with ARA-290 after 2 months but ongoing pain; contrasts with neurontin use (anecdotal).","section":"who_claims_what","tier":"anecdotal","source_ids":["s61"],"source_status":"sourced","why_material":"Materialized from orphan source s61 by ledger repair"},{"id":"c74","text":"Post suggesting ARA-290 as option to reduce reliance on gabapentin for nerve pain (anecdotal suggestion only).","section":"who_claims_what","tier":"anecdotal","source_ids":["s62"],"source_status":"sourced","why_material":"Materialized from orphan source s62 by ledger repair"},{"id":"c75","text":"Practical discussion on ARA-290 preparation; no direct gabapentin comparison but new dosing anecdote context.","section":"who_claims_what","tier":"anecdotal","source_ids":["s63"],"source_status":"sourced","why_material":"Materialized from orphan source s63 by ledger repair"},{"id":"c76","text":"ARA-290 vs Gabapentin: Nerve Repair vs Symptom Masking is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","section":"what_it_is","tier":"system","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: what_it_is"},{"id":"c77","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","section":"limitations","tier":"mechanistic","source_ids":[],"source_status":"unsourced","why_material":"Required constitution slot: limitations"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes","quote":"Mean corneal nerve fiber density (CNFD) was reduced significantly compared with normal controls and subjects with a mean CNFD >1 standard deviation from normal showed a significant increase in CNFD compared with no change in the placebo group.","summary":"Phase 2 trial data showing corneal nerve regrowth and symptom improvement in T2D.","claim_ids":["c1","c3","c56"]},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10092611/","title":"Gabapentin—Friend or foe?","quote":"Gabapentin blocks presynaptic GABA release (via α2δ‐1 inhibition) and activates astrocytic glutamate transporter 1 (GLT‐1) to promote presynaptic glutamate uptake.","summary":"Review of gabapentin mechanism in pain modulation.","claim_ids":["c2"]},{"id":"s3","type":"medical","url":"https://mindbodyneurology.com/ara-290-peptide-neuropathy/","title":"ARA 290 Peptide for Neuropathy and Neurodegeneration","quote":"This point matters, because most neuropathy therapies only change pain signaling, while ARA 290 shows structural regeneration of small fibers in at least one tissue.","summary":"2025 article contrasting ARA-290's evidence for structural nerve regeneration (corneal confocal microscopy) with standard symptomatic treatments in sarcoidosis and diabetic SFN.","author":"","publisher":"","date":"","claim_ids":["c4","c58"]},{"id":"s4","type":"review","url":"https://peptidefox.com/content/ara-290","title":"ARA-290: Tissue-Protective Peptide for Nerve Pain","quote":"It is one of the few compounds with human evidence of nerve-fiber regeneration markers, rather than only symptom suppression like gabapentin or duloxetine.","summary":"Detailed review emphasizing Phase 2 data on nerve regeneration markers vs symptomatic masking by gabapentin; notes stalled development post-2020.","author":"","publisher":"","date":"","claim_ids":["c5","c59"]},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"I am increasing gabapentin to 1200 mg as well. I may try again in a couple months.","summary":"Multiple user anecdotes on ARA-290 use for neuropathy repair, with some combining or reducing gabapentin doses; reports of nerve flares or benefits.","author":"","publisher":"","date":"","claim_ids":["c6"]},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"my dosage for gabapentin, has gone down from 2400 mg/day to 800-1600 mg/day","summary":"Detailed self-report of ARA-290 protocol (4mg/day x28 days) leading to symptom improvement and ability to lower gabapentin in idiopathic SFN.","author":"","publisher":"","date":"","claim_ids":["c7","c60"]},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","summary":"2014 review of Phase II trials showing ARA290 improves neuropathic symptoms via tissue protection and repair mechanisms.","author":"","publisher":"","date":"","claim_ids":["c8"]},{"id":"s8","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06626971","title":"The Use of ARA290 for the Treatment of Diabetic Macular Oedema","quote":"A Phase II Clinical Trial on the Use of ARA 290 for the Treatment of Diabetic Macular Oedema. Intervention/Treatment, Drug : ARA290 . 4 mg subcutaneous","summary":"2024 Phase II trial exploring ARA290 (4mg SC) for diabetic complications, extending evidence base.","author":"","publisher":"","date":"","claim_ids":["c9"]},{"id":"s9","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941562/","title":"Erythropoietin‐derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke","quote":"ARA290 significantly reduced neuronal apoptosis and the level of inflammatory cytokines in the brain tissue.","summary":"2024 study demonstrating ARA290's neuroprotective and anti-inflammatory effects supporting nerve repair.","author":"","publisher":"","date":"","claim_ids":["c10"]},{"id":"s10","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","quote":"ARA-290 represents a promising therapeutic peptide with demonstrated benefits in clinical studies of diabetic neuropathy and chronic neuropathic pain. Its ...","summary":"Medical site detailing ARA-290's role in neural repair, anti-inflammation, contrasting symptom management approaches.","author":"","publisher":"","date":"","claim_ids":["c11"]},{"id":"s11","type":"medical","url":"https://preferredregen.com/blog/benefits-of-ara290-peptide-a-simple-guide","title":"Benefits of ARA290 Peptide: A Simple Guide","quote":"Unlike many treatments that simply mask symptoms, ARA-290 works at a cellular level to help repair damage and restore function.","summary":"Discusses ARA-290 promoting tissue regeneration and repair rather than symptom masking, relevant to vs Gabapentin comparison.","author":"","publisher":"","date":"","claim_ids":["c12"]},{"id":"s12","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain : r/smallfiberneuropathy","quote":"ARA is freaking awesome . Works better than IVIG ever did for me. Within 2hrs i feel better, but like transhumanis said, you need to keep using ...","summary":"User anecdotes on ARA-290 providing rapid pain relief and possible nerve benefits, with ongoing use needed.","author":"","publisher":"","date":"","claim_ids":["c13"]},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"The ARA290 peptide bonds to the innate repair receptor which simply speeds up nerve repair. ... Yesterday was by FAR the best day of the past 15 months! I walked over 14,000 steps pain free!","summary":"Recent anecdotal report of significant symptom improvement and implied repair from ARA-290 use.","author":"","publisher":"","date":"","claim_ids":["c14"]},{"id":"s14","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term functional improvement in this condition.","summary":"2017 video discussing clinical trial results on ARA-290 for SFN, including potential disease modification.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I tried gabapentin , pregablin , celebrex, Lyrica and found I am allergic my pain pharmacist recommended alpha lipoic acid but when I took nervive nothing happened.","summary":"User with nerve pain from herniated disc tried multiple meds including gabapentin (allergic), now self-experimenting with ARA-290 cycle, no benefits or side effects noted after short time; plans longer protocol. Compares to symptom-masking drugs that failed due to allergies/side effects.","author":"","publisher":"","date":"","claim_ids":["c16"]},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1tyiu7f/ara290/","title":"ARA290","quote":"It was effective initially, benefit showing up after about 30 days. However, benefit didn't last. Of course, I was using ara-290:as an unregulated peptide. I switched to using gabapentin, which I've found to be much more effective.","summary":"User reports initial but non-lasting benefit from ARA-290 for mild neuropathy, switched to gabapentin which is much more effective for nerve pain (with ALA); highlights gabapentin as better symptom management vs potential repair from peptide.","author":"","publisher":"","date":"","claim_ids":["c17"]},{"id":"s17","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","summary":"Review comparing ARA290's repair mechanism to standard symptom-masking treatments like gabapentin in neuropathy models and trials.","author":"","publisher":"","date":"","claim_ids":["c18"]},{"id":"s18","type":"medical","url":"https://www.science.org/doi/10.1126/scitranslmed.aaf8773","title":"A one-two punch for pain control","quote":"Whereas single drug–loaded particles modestly reduced sensory and heat-induced pain responses, THC- ARA290 –loaded particles relieved pain for a period of 3 weeks.","summary":"Discusses combined delivery of ARA290 with THC for prolonged neuropathic pain relief vs conventional drugs like gabapentin.","author":"","publisher":"","date":"","claim_ids":["c19"]},{"id":"s19","type":"medical","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925003644","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome after sciatic nerve injury","quote":"In our study, we demonstrated that both EPO and [pyroglutamic acid] helix B surface peptide (pHBSP, also known as ARA290) inhibit the early inflammatory response and promote functional recovery after [sciatic nerve] [crush injury] in rat models.","summary":"2025 preclinical study showing ARA290 promotes nerve repair via anti-inflammatory effects post-injury.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s20","type":"anecdotal","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide ...","quote":"Small fiber nerve regeneration - documented repair rather than symptom suppression","summary":"Detailed user guide and discussion on ARA-290 for nerve repair vs symptom masking like gabapentin.","author":"","publisher":"","date":"","claim_ids":["c21"]},{"id":"s21","type":"anecdotal","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I'm particularly interested in ARA 290 but haven't found many detailed personal experiences online.","summary":"Reddit thread seeking and sharing personal anecdotes on ARA-290 for neuropathy.","author":"","publisher":"","date":"","claim_ids":["c22"]},{"id":"s22","type":"anecdotal","url":"https://www.reddit.com/r/neuropathy/comments/1u8astt/anyone_tried_ara_290/","title":"Anyone tried ARA 290","quote":"I am trying 4mg ARA-290 now, along with a host of supplements.","summary":"User reports on trying ARA-290 for peripheral neuropathy, comparing implicitly to other treatments.","author":"","publisher":"","date":"","claim_ids":["c23"]},{"id":"s23","type":"other","url":"https://inachicago.com/nerve-pain-peptides/","title":"What are the benefits of nerve pain peptides?","quote":"ARA 290 . This peptide works on the peripheral and central nervous system. It has the ability to help regrow some types of nerves.","summary":"Medical site overview positioning ARA-290 as nerve-regrowing vs symptom-masking options.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s24","type":"medical","url":"https://superpower.com/guides/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid ...","quote":"As of April 2026, Araim Pharmaceuticals, the company that developed ARA-290 , has closed operations, and no active IND or NDA exists.","summary":"2026 overview of ARA-290 status, noting company closure and lack of active regulatory filings; discusses its history in neuropathy trials.","author":"","publisher":"","date":"","claim_ids":["c25"]},{"id":"s25","type":"medical","url":"https://www.sciencedirect.com/science/article/pii/S0264127525012596","title":"ARA290 microneedle patch modulate microglia ...","quote":"The microneedle patch effectively alleviates allodynia and improves nerve morphology in a diabetic neuropathy rat model.","summary":"2025 study on ARA290 microneedle patch showing pain relief and nerve morphology improvement in diabetic neuropathy rat model.","author":"","publisher":"","date":"","claim_ids":["c26"]},{"id":"s26","type":"medical","url":"https://www.renewyouth.com/ara-290-a-new-frontier-in-pain-relief-and-healing/","title":"ARA 290: A New Frontier in Pain Relief and Healing","quote":"ARA 290 may help to repair these small nerve fibers and restore normal function over time.","summary":"2025 article discussing ARA-290 for neuropathic pain and small fiber neuropathy repair vs symptom management.","author":"","publisher":"","date":"","claim_ids":["c27"]},{"id":"s27","type":"medical","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11831023/","title":"Mechanisms of ARA290 in counteracting cadmium-triggered ...","quote":"It helps counteract the harmful effects of cadmium exposure on nerve cells by reducing oxidative stress, inflammation, cell death, and DNA damage.","summary":"2025 PMC paper on ARA290 neuroprotective mechanisms against cadmium-induced nerve damage.","author":"","publisher":"","date":"","claim_ids":["c28"]},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back.","summary":"User anecdote reporting temporary symptom relief and sensory improvement from ARA-290 for suspected SFN.","author":"","publisher":"","date":"","claim_ids":["c29"]},{"id":"s29","type":"x","url":"https://x.com/KevinPomaski/status/2071322548155936869","title":"X post by KevinPomaski on ARA-290","quote":"There is hope with ARA-290 to be life changing to certain individuals. We shall see!","summary":"Recent X anecdote expressing optimism about ARA-290 for personal neuropathy case.","author":"","publisher":"","date":"","claim_ids":["c30","c57"]},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I am almost done with a month of ara 290. I’m not part of a trial but I am using it. It’s not cheap. I have seen really great results. My neuropathy was very bad and it has improved significantly. I have tried almost everything and this was the most helpful by far. Whether it lasts I’ll have to see.","summary":"User cryo424 reports significant improvement in severe neuropathy after 4mg/day for a month with ARA-290, better than other treatments tried; effects partially persisted.","author":"","publisher":"","date":"","claim_ids":["c31"]},{"id":"s31","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I ended up doing about 4 weeks worth and I'm not sure it helped much.","summary":"User venus87 reports uncertain/minimal benefit from ~4 weeks of ARA-290.","author":"","publisher":"","date":"","claim_ids":["c32"]},{"id":"s32","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"The feeling in my feet is signifantly returning. I am totally blown away about this.","summary":"User with diabetic neuropathy reports significant return of feeling in feet after ~1 month of ARA-290 use.","author":"","publisher":"","date":"","claim_ids":["c33"]},{"id":"s33","type":"x","url":"https://x.com/PeptidesFinder/status/2047760738371125595","title":"Peptides Finder post on ARA-290 vs Gabapentin","quote":"Nerve pain is usually treated with drugs that just numb your brain (Gabapentin). They mask the signal. They don't fix the wire. You need something that targets the \"Innate Repair Receptor.\" Meet ARA-290 (The Nerve Healer). It stops the pain and regrows the fiber.","summary":"Promotional comparison highlighting ARA-290 for nerve repair vs Gabapentin symptom masking.","author":"","publisher":"","date":"","claim_ids":["c34"]},{"id":"s34","type":"x","url":"https://x.com/Zedzies/status/2019107972837003451","title":"Zedzies on ARA-290 and nerve repair","quote":"And those small nerves just don’t innervate skin. They innervate other organs as well. ARA-290 Erinacine (Lions mane) Psilocybin All can regrow/repair. Gabapentin only masks.","summary":"User opinion: ARA-290 (with others) can regrow/repair nerves unlike Gabapentin which only masks symptoms.","author":"","publisher":"","date":"","claim_ids":["c35","c57"]},{"id":"s35","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms in Patients With Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290, a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis","summary":"Ongoing or listed trial on ARA 290 for sarcoidosis neuropathy symptoms and nerve fiber density, distinct from listed NCT06626971.","author":"","publisher":"","date":"","claim_ids":["c36"]},{"id":"s36","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"Gabapentin reduces neuropathic leg pain by fifty percent in roughly one out of six patients... Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","summary":"Compares conventional symptom-masking like gabapentin (NNT 5.9) to ARA-290's nerve regeneration evidence in context of multi-domain leg pain treatment.","author":"","publisher":"","date":"","claim_ids":["c37"]},{"id":"s37","type":"medical","url":"https://link.springer.com/article/10.2119/molmed.2012.00332","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Study","quote":"ARA 290 appears to be safe in patients with sarcoidosis and can reduce neuropathic symptoms.","summary":"2012 pilot RCT showing ARA 290 reduces SFN symptoms safely in sarcoidosis patients via IRR activation for repair/anti-inflammation.","author":"","publisher":"","date":"","claim_ids":["c38"]},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"While there is no direct evidence of ARA-290 treating EM, there is some indirect evidence in that the peptide is used to treat small fiber neuropathy","summary":"Anecdotal discussion on ARA-290 for erythromelalgia via SFN overlap, seeking personal experiences.","author":"","publisher":"","date":"","claim_ids":["c39"]},{"id":"s39","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02070783","title":"Cognitive and Neural Effects of ARA290","quote":"ARA290 is a peptide that does not have the effects of EPO on blood cells but may still have its effect on brain function.","summary":"Phase I study on ARA290 (Cibinetide) effects on cognitive and neural processing of emotions in healthy volunteers; explores non-hematopoietic EPO analog for neural impacts relevant to neuropathy repair.","author":"","publisher":"","date":"","claim_ids":["c40"]},{"id":"s40","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT01933529","title":"ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue, on Blood Glucose and Insulin Sensitivity in Patients With Type 2 Diabetes)","quote":"The purpose of this study is to determine whether a non-hematopoietic erythropoietin analogue, ARA 290, exerts beneficial effects on blood glucose control and insulin sensitivity in patients with type 2 diabetes.","summary":"Phase II trial examining ARA290 effects on metabolic control and neuropathic symptoms in T2D patients, supporting nerve repair potential over symptom masking.","author":"","publisher":"","date":"","claim_ids":["c41"]},{"id":"s41","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for Nerve Repair and Chronic Disease","quote":"Clinical trials have shown: Reduced neuropathic pain, Improved nerve fiber density, Better sensory function. Importantly, these benefits occurred without changes in hemoglobin or hematocrit.","summary":"2026 article details ARA-290's role in small fiber and diabetic neuropathy regeneration via innate repair receptor activation, anti-inflammatory effects, and nerve fiber density improvement, contrasting symptom-only treatments like gabapentin.","author":"","publisher":"","date":"","claim_ids":["c42"]},{"id":"s42","type":"other","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"GHK-Cu is fantastic for skin, but for deep nerve repair, the ARA/BPC combo is currently the heavyweight champion in the research community.","summary":"March 2026 blog highlights ARA-290's synergistic potential with BPC-157 for peripheral nerve regeneration in neuropathy models, emphasizing actual repair mechanisms.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s43","type":"review","url":"https://www.tandfonline.com/doi/pdf/10.1517/21678707.2013.719289","title":"The erythropoietin analog ARA 290 for treatment of sarcoidosis-induced chronic neuropathic pain","quote":"data is that ARA 290 produces the relief of neuropathy-related symptoms in sarcoidosis patients with chronic moderate to severe neuropathic pain greater... ARA 290 was recently granted designation as Orphan Drug Product by the FDA, for treatment of neuropathic pain in sarcoidosis patients.","summary":"Expert review on ARA290 as promising option for neuropathic pain in sarcoidosis via tissue repair pathways, not mere masking.","author":"","publisher":"","date":"","claim_ids":["c44"]},{"id":"s44","type":"x","url":"https://x.com/drtrevorbachm/status/2070811769170452870","title":"ARA-290 a masterclass (solving all nerve damage)","quote":"2018 study published in the Journal Diabetes Care showed that ARA-290 in diabetic neuropathy… restored small fiber de...","summary":"June 2026 X post discusses ARA-290 restoring small fiber density in diabetic neuropathy, highlighting repair vs masking.","author":"","publisher":"","date":"","claim_ids":["c45","c57"]},{"id":"s45","type":"medical","url":"https://regentherapy.com/blog/ara-290-the-regenerative-peptide-for-nerve-vascular-and-inflammatory-repair","title":"ARA-290: The Regenerative Peptide for Nerve, Vascular, and Inflammatory Repair","quote":"Small fiber neuropathy: In clinical studies, ARA-290 improved **nerve fiber density and pain symptoms** in patients with sarcoidosis-associated neuropathy.","summary":"Reviews ARA-290 benefits for neuropathy, nerve regeneration, inflammation; cites clinical evidence for small fiber neuropathy repair.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s46","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7408632/","title":"A Phase 2 Clinical Trial on the Use of Cibinetide for the ...","quote":"Cibinetide , also known as ARA 290 and helix B surface peptide (HBSP), is a synthetic 11 amino acid peptide, derived from the structure of the B helix of EPO, ...","summary":"2020 Phase 2 trial on cibinetide (ARA-290) for diabetic macular edema, related to its neuroprotective properties.","author":"","publisher":"","date":"","claim_ids":["c47"]},{"id":"s47","type":"anecdotal","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","quote":"Hi guys I’m new here wanted to get you guys’ experience with ARA-290, thanks!","summary":"Reddit user seeking experiences with ARA-290 for nerve damage.","author":"","publisher":"","date":"","claim_ids":["c48"]},{"id":"s48","type":"x","url":"https://x.com/PeptidePlugs/status/2071349996151042507","title":"X post by PeptidePlugs","quote":"Wolverine tomorrow and I might have more ARA-290, I just haven't been doing the best job of keeping up with all the inventory since we started ordering 10x more. I'll get back with you on the ASAP","summary":"Recent X post discussing availability of ARA-290.","author":"","publisher":"","date":"","claim_ids":["c49","c57"]},{"id":"s49","type":"news","url":"https://www.biospace.com/araim-pharmaeuticals-cibinetide-ara-290-regenerates-small-nerve-fibers-and-improves-neuropathic-clinical-symptoms-in-the-orphan-disease-of-sarcoido","title":"Araim Pharmaeuticals' Cibinetide (ARA 290) Regenerates ...","quote":"Cibinetide met its pre-specified primary efficacy endpoint: to assess small nerve fiber loss and repair as quantified by corneal confocal microscopy (CCM).","summary":"2017 press release on Phase 2b study showing ARA-290 regenerates small nerve fibers and improves symptoms in sarcoidosis.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s50","type":"review","url":"https://www.nature.com/articles/s41392-025-02175-1","title":"Diabetic neuropathy: cutting-edge research and future directions","quote":"A double-blind, placebo-controlled, investigator-initiated clinical trial showed that ARA 290 benefited both ...","summary":"2025 review on diabetic neuropathy highlights ARA 290 as a promising investigational agent targeting glucose control and nerve function in small fiber neuropathy.","author":"","publisher":"","date":"","claim_ids":["c15"]},{"id":"s51","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1ts29r9/most_neuropathic_pain_research_manages_symptoms/","title":"Most Neuropathic Pain Research Manages Symptoms. ...","quote":"Gabapentinoids reduce the pain signal. Tricyclic antidepressants modulate pain processing. SNRIs alter neurotransmitter availability. None of these repair the underlying nerve damage producing the pain. ... The 2014 Phase II trial of ARA-290 in sarcoidosis patients with small fiber neuropathy documented something different. ... After treatment, fiber density increased. That is not symptom reduction. That is measurable nerve repair.","summary":"Reddit post contrasts gabapentinoids/symptom masking with ARA-290's documented nerve fiber density increase (repair). Anecdotal dosing not specified here. (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c63"]},{"id":"s52","type":"reddit","url":"https://www.reddit.com/r/PeptideGuide/comments/1q61v4s/ara290_cibinetide_explained_the_nerve_repair/","title":"ARA-290 (Cibinetide) Explained: The Nerve Repair Peptide Most Recovery Stacks Miss","quote":"It’s not acting like a painkiller it’s signaling the body to repair the underlying issue over time. ... ARA-290 adds coverage for the wiring. ... If your issue feels more like nerve pain than classic soreness or stiffness, ARA-290 is one of the few peptides that actually targets that domain.","summary":"Thread explains ARA-290 as nerve repair vs symptom management like gabapentin. No specific user outcomes or dosing in main post. (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c64"]},{"id":"s53","type":"reddit","url":"https://www.reddit.com/r/hardflaccidresearch/comments/1cc5pwd/thoughts_on_ara290_peptide_as_restorative/","title":"Thoughts? On ARA290 peptide as restorative approach for ...","quote":"Me and another person with HFS tried ARA-290 already recently. I was on it for about 2 weeks 8mg per day but had no change in symptoms.","summary":"Comment reports no effect from 8mg/day ARA-290 for 2 weeks (bad outcome anecdote). (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c65"]},{"id":"s54","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1mcbbkb/ara290/","title":"ARA290","quote":"Expensive. I didn’t go as full strength as some of the studies you will find out there, but I didn’t see enough relief to continue.","summary":"Comment: expensive, insufficient relief at lower dose (bad outcome/side effect cost anecdote). (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c66"]},{"id":"s55","type":"x","url":"https://x.com/RickWingfield5/status/2070195807316246840","title":"X post by @RickWingfield5","quote":"PEG-MGF has been incredible with healing my mid sixties muscles and ARA-290 is amazing for nerve pain in neck and shoulders.","summary":"X post anecdote: ARA-290 amazing for nerve pain (good outcome). No dosing details. (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c67"]},{"id":"s56","type":"x","url":"https://x.com/itsjoshkade/status/2069507423971275224","title":"X post by @itsjoshkade","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","summary":"X post dosing anecdote (2-4mg daily, 3-4 weeks build) and nerve repair pairing. (anecdotal, not advice)","author":"","publisher":"","date":"","claim_ids":["c68"]},{"id":"s57","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1ubtige/ara_290_and_nerve_sensitization_nerve_irritation/","title":"ARA 290 and nerve sensitization (nerve irritation)","quote":"Is there any information on ARA 290 being used for nerve sensitization (irritation, or compressed nerves)? Gabapentin has been shown to dampen nerve signals in this case, but I am wondering if ARA 290 has similar attributes.","summary":"Reddit thread discussing ARA-290 for nerve irritation vs gabapentin's symptom masking; user seeks comparison on whether it repairs or just dampens signals (anecdotal inquiry, not advice).","author":"","publisher":"","date":"","claim_ids":["c69"]},{"id":"s58","type":"reddit","url":"https://www.reddit.com/r/Biohack_Blueprint/comments/1qf1t16/nerve_damage_wont_heal_ara290_complete_guide/","title":"Nerve Damage Won't Heal → ARA-290 Complete Guide","quote":"Gabapentin and pregabalin modulate calcium channels to reduce pain signaling. ... This provided objective evidence that the peptide promotes actual nerve regrowth, not just symptom masking.","summary":"Guide contrasting gabapentin (symptom management) with ARA-290 (nerve repair evidence from trials); includes dosing research notes (anecdotal context only, not advice).","author":"","publisher":"","date":"","claim_ids":["c70"]},{"id":"s59","type":"reddit","url":"https://www.reddit.com/r/Peptidesource/comments/1psdrs9/peptide_for_nerve_regeneration/","title":"Peptide for Nerve Regeneration","quote":"ARA-290 is the best bet for this, has shown success at re-myelination and curing neuropathic pain in a number of conditions","summary":"Comment thread on peptides for nerve repair; users note ARA-290 for regeneration vs standard symptom meds like gabapentin (anecdotal reports only).","author":"","publisher":"","date":"","claim_ids":["c71"]},{"id":"s60","type":"x","url":"https://x.com/JebBenson/status/1959659373652803833","title":"X post on ARA-290 vs Gabapentin","quote":"ARA-290 if it’s radicular pain. I was able to hold it off with taurine/glycine/magnesium bisglycinate while tapering Gabapentin, but that was my next one.","summary":"X post recommending ARA-290 for radicular/nerve pain while tapering gabapentin; personal experience (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c72"]},{"id":"s61","type":"x","url":"https://x.com/KristinaRevay/status/1912566621115486518","title":"X post on ARA 290 experience","quote":"Ara 290 2 months in …it is really helping me sleep (first time in 30yrs Im sleeping all nite) but Im still on the neuropathy pain train.","summary":"User reports positive sleep improvement with ARA-290 after 2 months but ongoing pain; contrasts with neurontin use (anecdotal).","author":"","publisher":"","date":"","claim_ids":["c73"]},{"id":"s62","type":"x","url":"https://x.com/BOENGLISH1/status/1912566621115486518","title":"X post alternatives to gabapentin","quote":"There are quite a few therapies which could help people get off gabapentin and similar drugs: ara-290, NA R-ALA, hyperbaric O2, and red light therapy","summary":"Post suggesting ARA-290 as option to reduce reliance on gabapentin for nerve pain (anecdotal suggestion only).","author":"","publisher":"","date":"","claim_ids":["c74"]},{"id":"s63","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1kakzrn/reconstitute_ara290_in_nacl_09_instead_of_pbs/","title":"Reconstitute ARA-290 in NaCL 0.9% instead of PBS?","quote":"In BAC water the ARA-290 doesn't reconstitute. Not even in 20ml BAC water. PBS is quite expensive where i live. NaCL 0.9% is easily available and cheap.","summary":"Practical discussion on ARA-290 preparation; no direct gabapentin comparison but new dosing anecdote context.","author":"","publisher":"","date":"","claim_ids":["c75"]}],"prov":{"model":"grok/grok-4.3","action":"write"}}