{"slug":"ara-290","verification":{"valid":true,"entries":28,"head":"7c99040abc32be4c067faed6a408c8081947882aab5c8eef25f1545e2eea5168"},"count":28,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","fill-slots"],"yield":{"passes":28,"energy_spent_rows":0,"total_cost_usd":0.013595,"waste_cost_usd":0,"total_tokens":19362,"material_outputs":10,"usd_per_output":0.001359,"models":[{"model":"kimi/moonshot-v1-8k","passes":2,"cost_usd":0.001084,"tokens_total":7224,"outputs":6,"waste_passes":0,"usd_per_output":0.000181},{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000382,"tokens_total":3457,"outputs":4,"waste_passes":0,"usd_per_output":0.000096},{"model":"grok-4.3","passes":16,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.012129,"tokens_total":8681,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:31:56.109Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"ARA-290: Nerve Repair Peptide","register":"source_ledger","body":"## Overview\nARA-290 is an 11-amino-acid peptide engineered from erythropoietin that selectively activates the innate repair receptor (IRR).\n\n## Mechanism\nARA-290 targets the IRR (heteromer of EPO receptor and β-common receptor) to promote anti-inflammatory and tissue-repair pathways without hematopoietic effects (mechanistic). Activation reprograms proinflammatory environments toward healing (mechanistic).\n\n## Human Clinical Data\nIn phase 2 trials, subcutaneous ARA-290 (4 mg daily for 28 days) reduced neuropathic symptoms and improved quality of life in sarcoidosis-associated small fiber neuropathy (human). Treatment increased corneal nerve fiber density in patients with initial reductions (human). Similar symptom improvements and metabolic benefits (HbA1c, lipids) occurred in type 2 diabetes patients with small fiber neuropathy (human). No significant adverse effects reported in these trials (human).\n\n## Preclinical Data\nIn rodent models of sciatic nerve injury and spared nerve injury, ARA-290 reduced mechanical and cold allodynia in a β-common receptor-dependent manner (preclinical). Effects observed after peripheral nerve damage include rapid and sustained relief without requiring peripheral TNF-α suppression (preclinical).\n\n## Evidence Gaps\nNo large phase 3 human trials or long-term follow-up data identified. Absence of published user reports or anecdotal data in available sources.","claims":[{"id":"c1","text":"ARA-290 is an 11-amino-acid peptide engineered from erythropoietin that selectively activates the innate repair receptor (IRR).","section":"Mechanism","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Core definition and selectivity for repair vs erythropoiesis.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"In phase 2 trials, ARA-290 reduced neuropathic symptoms and improved quality of life in sarcoidosis small fiber neuropathy patients.","section":"Human Clinical Data","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Direct evidence from randomized controlled trials separating human data.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"ARA-290 treatment increased corneal nerve fiber density in sarcoidosis patients with initial reductions.","section":"Human Clinical Data","tier":"human","source_ids":["s1"],"source_status":"sourced","why_material":"Indicates nerve regrowth rather than symptom masking.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"In rodent sciatic and spared nerve injury models, ARA-290 reduced allodynia in a β-common receptor-dependent manner.","section":"Preclinical Data","tier":"preclinical","source_ids":["s1"],"source_status":"sourced","why_material":"Separates animal evidence from human trials.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","link_status":"ok","quote_status":"verified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"2cedf09b343c470a1325be15ec7184f64bc1b657942cd721d06e9ee14ac139bf"},{"seq":1,"id":"k2","ts":"2026-06-29T09:39:03.111Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s2","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT06626971","title":"The Use of ARA290 for the Treatment of Diabetic Macular Edema","quote":"The aim or primary objective of the study was to determine whether ARA 290 administered at a daily dose of 4mg subcutaneously for 12 weeks to patients with ...","link_status":"ok","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/36085231/","title":"Mechanistic Approach for Protective Effect of ARA290, a Non-Hematopoietic Peptide Derived from Erythropoietin, on Doxorubicin-Induced Genotoxicity and Oxidative Stress","quote":"ARA 290 , an 11-amino acid linear nonhematopoietic peptide derived from the three-dimensional structure of helix B of the erythropoietin (EPO) ...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density in Patients With Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290 , a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis ...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"RE: ARA-290 . It is quite effective, at least for the length-dependent variety of SFN. My experience jives w/ the phase II study . Unfortunately, ...","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis, as well as its potential for disease modification and long-term functional improvement in this condition.","link_status":"http_429","quote_status":"unverified"},{"id":"s7","type":"medical","url":"https://mindbodyneurology.com/ara-290-peptide-neuropathy/","title":"ARA 290 Peptide for Neuropathy and Neurodegeneration","quote":"A 2025 study using an ARA 290 microneedle patch in a diabetic peripheral neuropathy rat model showed relief of mechanical pain and improved ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"2cedf09b343c470a1325be15ec7184f64bc1b657942cd721d06e9ee14ac139bf","hash":"e05303a30fd24f6de4e59ef6cc8178048710d5e6316a94466e132ea781c6f1ad"},{"seq":2,"id":"k3","ts":"2026-06-29T09:39:20.421Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s8","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/38488446/","title":"Erythropoietin-derived peptide ARA290 mediates brain protection through βCR in cerebral ischemic mice","quote":"ARA290 provided a neuroprotective effect via βCR in cerebral ischemic mice without causing erythropoiesis. This study provides novel insights into the role ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation ...","quote":"EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","link_status":"ok","quote_status":"verified"},{"id":"s10","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02070783","title":"NCT02070783 | Cognitive and Neural Effects of ARA290","quote":"ARA290 is a peptide that does not have the effects of EPO on blood cells but may still have its effect on brain function . In an attempt to replicate previous ...","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT01933529","title":"ARA290 in T2D (Effects of ARA 290, an Erythropoietin ...","quote":"The purpose of this study is to determine whether a non-hematopoietic erythropoietin analogue, ARA 290 , exerts beneficial effects on blood ...","link_status":"ok","quote_status":"unverified"},{"id":"s12","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25387363/","title":"ARA 290, a nonerythropoietic peptide engineered from ...","quote":"ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"Has anyone tried the peptide ARA-290 . It has clinical evidence of helping to slow or stop neuropathy and allow nerves to heal.","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide ...","quote":"ARA-290 is an 11-amino acid synthetic peptide derived from the helix-B region of erythropoietin (EPO) ... Human Phase II clinical trial data for neuropathic pain - unusually strong evidence base","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","quote":"ARA-290 represents a promising therapeutic peptide with demonstrated benefits in clinical studies of diabetic neuropathy and chronic neuropathic pain. Its ...","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in ...","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"e05303a30fd24f6de4e59ef6cc8178048710d5e6316a94466e132ea781c6f1ad","hash":"81d70fc9c3e558c58b1611aa89db889e05326dfba493979712eda540e9076c51"},{"seq":3,"id":"k4","ts":"2026-06-29T09:39:45.709Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive.","link_status":"ok","quote_status":"unverified"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too -- I guess you don't notice when you lose awareness of temperature. Since then (I ran out -- it was $90 for four days of ARA-290), the symptoms returned quickly.","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I am almost done with a month of ara 290. I’m not part of a trial but I am using it. It’s not cheap. I have seen really great results. My neuropathy was very bad and it has improved significantly. I have tried almost everything and this was the most helpful by far.","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months! I walked over 14,000 steps pain free! Not totally symptom free, but pain free.","link_status":"ok","quote_status":"unverified"},{"id":"s22","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/zy6z6u/ara_290_14_days_in_no_relief/","title":"ARA 290 14 days in, no relief.","quote":"14 days into ARA 290 and zero relief. Losing my mind in pain. Home bound/bed bound for years now.","link_status":"ok","quote_status":"unverified"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1lhvdnl/has_anyone_tried_ara_290_for_6_months/","title":"Has anyone tried ARA 290 for 6+ months?","quote":"I took 8mg daily for 4-5 months, unfortunately I didn't notice any positive effects. I also have quite severe autonomic symptoms......","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"81d70fc9c3e558c58b1611aa89db889e05326dfba493979712eda540e9076c51","hash":"32f532a5788a5fd8ed5746d3325fd61d382a8e1ecf08f29add15baf0312bf44b"},{"seq":4,"id":"k5","ts":"2026-06-29T09:40:10.431Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s24","type":"medical","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925003644","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","quote":"In our study, we demonstrated that both EPO and [pyroglutamic acid] helix B surface peptide (pHBSP, also known as ARA290) inhibit the early inflammatory response and promote functional recovery after [sciatic nerve] [crush injury] in rat models.","link_status":"http_403","quote_status":"unverified"},{"id":"s25","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"The winter months are coming up quickly for me here in Buffalo, NY and I am destined to have another miserable few months ahead. I have been dealing with ...","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1tljy8y/ara290_might_be_the_most_slept_on_peptide_for/","title":"ARA-290 Might Be the Most Slept On Peptide for Nerve ...","quote":"ARA-290 is a synthetic peptide built from the tissue protective part of erythropoietin, the hormone that stimulates red blood cell production.","link_status":"ok","quote_status":"unverified"},{"id":"s27","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I've been exploring peptide therapies for a while now and have had some really positive results with BPC-157 and TB-500 for my chronic back pain. ... I'm particularly interested in ARA 290 but haven't found many detailed personal experiences online.","link_status":"ok","quote_status":"unverified"},{"id":"s28","type":"other","url":"https://superpower.com/guides/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid ...","quote":"As of April 2026, no active clinical trials are registered on ClinicalTrials.gov for ARA-290 or cibinetide ... A Phase 2 Clinical Trial on the Use of Cibinetide ...","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for ...","quote":"ARA-290 ( cibinetide ) is a non-erythropoietic peptide that reduces inflammation, protects nerves, and supports tissue repair.","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"other","url":"https://preferredregen.com/blog/benefits-of-ara290-peptide-a-simple-guide","title":"Benefits of ARA290 Peptide: A Simple Guide","quote":"ARA-290 targets healing at the cellular level: This peptide activates your body's innate repair system to calm inflammation and encourage tissue regeneration, ...","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment is also possible with peptides. ARA ...","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy , tarsal tunnel, nerve injury or post operative nerve pain. # ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"32f532a5788a5fd8ed5746d3325fd61d382a8e1ecf08f29add15baf0312bf44b","hash":"fdbd4ba8d7a1610a8de868bb3c883cce80bd08a5a3f8f83e2d30ba9ac753f5ec"},{"seq":5,"id":"k6","ts":"2026-06-29T09:41:08.499Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s32","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/32674280/","title":"A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema","quote":"A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema","link_status":"ok","quote_status":"verified"},{"id":"s33","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/28475703/","title":"Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain","quote":"Cibinetide significantly increased small nerve fiber abundance in the cornea and skin, consistent with a disease modifying effect.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"fdbd4ba8d7a1610a8de868bb3c883cce80bd08a5a3f8f83e2d30ba9ac753f5ec","hash":"7a1cd25886d86a61caeb0d5d698613d10df6c8ab685a2a4d135b34c821e08bb5"},{"seq":6,"id":"k7","ts":"2026-06-29T12:46:26.375Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c37","tier":"system","text":"ARA-290: Nerve Repair Peptide is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:46:26.375Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"7a1cd25886d86a61caeb0d5d698613d10df6c8ab685a2a4d135b34c821e08bb5","hash":"be0ff6023211420a271f75581f0f128a45013de8e032205b39aa8d7264c5d778"},{"seq":7,"id":"k8","ts":"2026-06-29T12:46:26.484Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c38","tier":"preclinical","text":"Per this ledger on ARA-290: Nerve Repair Peptide: 17 scientific and 14 anecdotal sources are catalogued; 15 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:46:26.484Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"be0ff6023211420a271f75581f0f128a45013de8e032205b39aa8d7264c5d778","hash":"d85f0502e9ca6de97d65f8d44d711706dc1ab9c3cc951b0f74678f87f5248fc1"},{"seq":8,"id":"k9","ts":"2026-06-29T12:46:26.540Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c39","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:46:26.540Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"d85f0502e9ca6de97d65f8d44d711706dc1ab9c3cc951b0f74678f87f5248fc1","hash":"24e0f6cfde85f9022ecea44e0a4c087ab799c057d783bc5771597a9800123e4f"},{"seq":9,"id":"k10","ts":"2026-06-29T12:46:26.601Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c40","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:46:26.601Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"24e0f6cfde85f9022ecea44e0a4c087ab799c057d783bc5771597a9800123e4f","hash":"1d88fc2b0cfa43e9aeb25e1030976f2b90e43b11aa8a178b24df0e497fbc90ae"},{"seq":10,"id":"k11","ts":"2026-06-29T12:46:26.684Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c41","tier":"human","text":"Not medical advice. 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