{"slug":"ara-290-sciatica","verification":{"valid":true,"entries":22,"head":"ee3cc4f5df2a00b6c08e529186078191ef407fda08d7e713b5b6d7dd4f5101c2"},"count":22,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","fill-slots"],"yield":{"passes":22,"energy_spent_rows":0,"total_cost_usd":0.013522,"waste_cost_usd":0,"total_tokens":18641,"material_outputs":10,"usd_per_output":0.001352,"models":[{"model":"kimi/moonshot-v1-8k","passes":2,"cost_usd":0.000959,"tokens_total":6392,"outputs":6,"waste_passes":0,"usd_per_output":0.00016},{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000418,"tokens_total":3574,"outputs":4,"waste_passes":0,"usd_per_output":0.000105},{"model":"grok-4.3","passes":10,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":5,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.012145,"tokens_total":8675,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:51:10.867Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"ARA-290 for Sciatica: Evidence-Graded Review","register":"source_ledger","body":"## Overview\nSciatica involves compression of nerves in the lower back leading to leg pain. ARA-290 (cibinetide) is described as activating the innate repair receptor to support nerve repair and reduce inflammation without erythropoietic effects.\n\n## Preclinical Data on Sciatic Nerve Injury\nNo direct mapping to human sciatica exists. In rat and mouse models of sciatic nerve injury or spared nerve injury, ARA-290 administration produced long-term relief of mechanical and cold allodynia and delayed pain development (preclinical tier).\n\n## Human Clinical Trials\nNo human trials specifically for sciatica or lumbar radiculopathy were identified. Phase II randomized controlled trials in sarcoidosis-associated small fiber neuropathy (n=22–64) and type 2 diabetes with painful neuropathy (n=48) reported improvements in neuropathic symptom scores, quality of life, and corneal nerve fiber density/regrowth after 28 days of daily subcutaneous dosing (human tier). Pain reduction averaged ~40% in some reports; effects distinguished from symptom masking by observed structural nerve changes. No epidermal nerve regrowth noted in one trial. Metabolic improvements (HbA1c, lipids) observed in T2D cohort.\n\nNo human data exist for sciatica.\n\n## User Reports\nAnecdotal reports on forums describe self-administration protocols modeled on trials (e.g., 4 mg daily for 28 days) with subjective reductions in neuropathic symptoms; one mention of combined use with other peptides for sciatica-like pain (anecdotal tier). No controlled verification.\n\n## Safety and Status\nShort-term tolerability reported as good in trials, with no hematologic changes. No active Phase III trials or regulatory approval for neuropathy indications as of 2026.\n\n## Mechanism Framing\nARA-290 targets repair pathways via innate repair receptor rather than suppressing pain signaling alone (mechanistic tier).","claims":[{"id":"c1","text":"In rat and mouse models of sciatic nerve injury, ARA-290 produced long-term relief of allodynia and delayed pain development.","section":"Preclinical Data on Sciatic Nerve Injury","tier":"preclinical","source_ids":["s1","s2"],"source_status":"sourced","why_material":"Separates animal data from human evidence; no human sciatica trials exist.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"Phase II RCTs in sarcoidosis SFN and T2D neuropathy showed improved neuropathic symptoms and corneal nerve fiber regrowth after 28 days.","section":"Human Clinical Trials","tier":"human","source_ids":["s3","s4","s5"],"source_status":"sourced","why_material":"Core human evidence; repair (regrowth) vs suppression distinction.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No human trials exist for sciatica or radiculopathy.","section":"Human Clinical Trials","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"Plain statement of evidence gap as required.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Forum users reported subjective symptom relief with trial-modeled self-dosing protocols.","section":"User Reports","tier":"anecdotal","source_ids":["s6"],"source_status":"sourced","why_material":"Distinguishes user reports from trials.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice...","link_status":"ok","quote_status":"unverified"},{"id":"s2","type":"pubmed","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925003644","title":"ARA290... after sciatic nerve injury","quote":"both EPO and ARA290... promote functional recovery after sciatic nerve crush injury in rat models.","link_status":"http_403","quote_status":"unverified"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290... in type 2 diabetes","quote":"Neuropathic symptoms... improved significantly... mean corneal nerve fiber density... significant increase...","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://www.stopsarcoidosis.org/wp-content/uploads/ARAIM-DOSARA-Press-Release.pdf","title":"Cibinetide Regenerates Small Nerve Fibers...","quote":"significant increase in corneal nerve fiber area versus placebo... reductions in pain...","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density...","quote":"determine whether ARA 290... is effective in the treatment of the neuropathic symptoms of sarcoidosis","link_status":"ok","quote_status":"unverified"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"Definite benefit, although it took 12 days... Slight improvement in numbness... no noticeable side effects.","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"54cc2fd6da5d16c2119e3f6cdd6571277faacd4251df3da7f97cf0f4980230a2"},{"seq":1,"id":"k2","ts":"2026-06-29T10:30:08.930Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/PeptideDiscussion/comments/1s5wtsl/peptides_and_sciatica_my_success_story/","title":"Peptides and Sciatica, My Success Story","quote":"Have had an amazing experience using ARA290 for my sciatica. ... As a last ditch attempt before cortisone and surgery I stopped Monic and started 2mg ARA-290 with maybe some small improvements over the first 3 days. I decided to run 8mg of ara290 and the next morning instantly felt 10-15 percent better. Across the next 10 days at 8mg I could see a significant improvement every day. ... Between day 3 and day 10 my straight leg raise went from 20 degrees to 50 degrees... the numbness has completely gone from my foot. It’s been absolutely life changing.","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"Just started ARA290 about 4mg per day. It's been 10 days and sciatica from sitting has improved drastically . I am also taking Alpha lipoic acid.","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention. ... ARA-290 has the most advanced clinical evidence of any peptide for neuropathic pain.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"54cc2fd6da5d16c2119e3f6cdd6571277faacd4251df3da7f97cf0f4980230a2","hash":"a242f38ca675c84fbff149b6e658f191f9f5b371e59ecb2a08e4ddb128eccce3"},{"seq":2,"id":"k3","ts":"2026-06-29T10:30:36.966Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","quote":"In summary, EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","link_status":"ok","quote_status":"verified"},{"id":"s11","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in animals with a β-common receptor knockout phenotype.","link_status":"ok","quote_status":"verified"},{"id":"s12","type":"medical","url":"https://www.renewyouth.com/ara-290-a-new-frontier-in-pain-relief-and-healing/","title":"ARA 290: A New Frontier in Pain Relief and Healing","quote":"Research suggests ARA 290 can reduce these painful sensations and improve quality of life for patients who experience them. ... ARA 290 may help to repair these small nerve fibers and restore normal function over time.","link_status":"ok","quote_status":"unverified"},{"id":"s13","type":"other","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"Cibinetide (ARA 290) for the treatment of small fiber neuropathy in sarcoidosis.","link_status":"ok","quote_status":"verified"},{"id":"s14","type":"other","url":"https://superpower.com/guides/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid Peptide","quote":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"a242f38ca675c84fbff149b6e658f191f9f5b371e59ecb2a08e4ddb128eccce3","hash":"f8d34f03feb50484db1d08e37f5a4dca9bed022a398498d8e0caa7609248eedf"},{"seq":3,"id":"k4","ts":"2026-06-29T10:31:04.962Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/ixvi43/what_are_all_the_things_you_use_or_do_to_reduce/","title":"What are all the things you use or do to reduce sciatica pain.","quote":"I'm currently using these peptides: ARA-290, BPC-157, and TB-500. They promote healing and can help with nerve pain.","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/zy6z6u/ara_290_14_days_in_no_relief/","title":"ARA 290 14 days in, no relief.","quote":"14 days into ARA 290 and zero relief. Losing my mind in pain.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1krtzg2/peptide_therapy_for_sciatica_np1_bpc157_or_other/","title":"Peptide Therapy for Sciatica – NP-1, BPC-157, or Other ...","quote":"For neuropathic pain relief, the dose is 1.32 mg per day for a total of 30 days (per /jaycampbell.com/peptides/ ara-290 -the- pain - relief -peptide/).","link_status":"ok","quote_status":"unverified"},{"id":"s18","type":"anecdotal","url":"https://www.tiktok.com/@hackiebackup/video/7643927944624082190","title":"ARA-290 Results: Why this peptide surprised me","quote":"I've been having some sciatic nerve issue that started like a week ago, and I was like, limping hard and it has been bothering me. ... it is making a huge difference with how it feels right now.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"prev_hash":"f8d34f03feb50484db1d08e37f5a4dca9bed022a398498d8e0caa7609248eedf","hash":"a7e91117b1e64b391e5d150dc78328075eeb5db7376849750d223cadd35015bc"},{"seq":4,"id":"k5","ts":"2026-06-29T10:31:31.552Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s19","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24529189/","title":"ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response","quote":"Following a spared nerve injury in rats, vehicle or ARA290 (administered in either one of 4 doses: 3, 10, 30 and 60 μg/kg) was administered on days 1, 3, 6, 8 and 10. ARA290 exerted a dose-response effect by significantly reducing mechanical allodynia up to 20 weeks when compared to vehicle.","link_status":"ok","quote_status":"verified"},{"id":"s20","type":"medical","url":"https://revolutionhealth.org/blogs/news/ara-290-cibinetide-peptide","title":"ARA-290 (Cibinetide): The Anti-Inflammatory Peptide for Nerve Repair and Chronic Disease","quote":"ARA-290 has been extensively studied for its effects on: Small fiber neuropathy, Diabetic neuropathy, Chemotherapy-induced nerve damage, Autonomic dysfunction.","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","quote":"The peptide has gained significant attention in regenerative medicine and neurology due to its demonstrated efficacy in treating diabetic neuropathy, chronic neuropathic pain, and inflammatory conditions through its unique mechanism of promoting neural repair and reducing inflammation.","link_status":"ok","quote_status":"verified"},{"id":"s22","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1srvqv4/thoughts_on_ara290/","title":"Thoughts on ara-290","quote":"Absolutely helps with sciatica, both myself and other people I know that have tried it. 4mg daily is the dose used in all the clinical ...","link_status":"ok","quote_status":"unverified"},{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I too developed severe sciatica post Covid which evolved to painful neuropathy.","link_status":"ok","quote_status":"unverified"},{"id":"s24","type":"instagram","url":"https://www.instagram.com/p/DaAxGSODFZx/","title":"ARA-290 peptide post","quote":"ARA-290 peptide is an amazing peptide especially for those dealing with neuropathy, sciatica , and inflammation.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 4","tokens_in":0,"tokens_out":0,"prev_hash":"a7e91117b1e64b391e5d150dc78328075eeb5db7376849750d223cadd35015bc","hash":"646807184124e4ed3ccbdc306e6305280f3e263c8dd28fef8089a1739e04deb6"},{"seq":5,"id":"k6","ts":"2026-06-29T10:32:18.044Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s25","type":"review","url":"https://pubmed.ncbi.nlm.nih.gov/24555851/","title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","quote":"ARA 290 treatment was consistently associated with a significant improvement of neuropathic pain symptoms in sarcoidosis patients.","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"medical","url":"https://www.sciencedirect.com/science/article/abs/pii/S0306452212012031","title":"The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model","quote":"Treatment with either 30 (n = 11) or 120 μg/kg ARA290 (n = 9) prevented the development of mechanical allodynia.","link_status":"http_403","quote_status":"unverified"},{"id":"s27","type":"youtube","url":"https://www.youtube.com/watch?v=xggIEy1ZfM8","title":"Small Fiber Neuropathy and ARA-290 Results","quote":"ARA 290 is a potential therapy currently being researched for its safety and efficacy for the treatment of neuropathic pain in patients with sarcoidosis.","link_status":"http_429","quote_status":"unverified"},{"id":"s28","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1u6zfcg/ara290_for_sciatica_and_nerve_pain_can_this/","title":"ARA-290 for Sciatica and Nerve Pain — Can This Peptide Help?","quote":"Studies show ARA-290 promotes nerve repair instead of just blocking pain signals. It reduces the burning and tingling that comes with irritated nerves.","link_status":"ok","quote_status":"unverified"},{"id":"s29","type":"x","url":"https://x.com/TestAlchemistx/status/2067363953991155869","title":"X post on ARA-290 for sciatica","quote":"My sciatica is back after 2-3 days of poor sleep, time to full send KLOW and ARA 290 for 15 -20 days.","link_status":"ok","quote_status":"verified"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/PeptidePathways/comments/1oviobs/wondering_about_ara290/","title":"Wondering about ARA-290","quote":"It improved nerve fiber growth, thickness, and blood flow, made the nerves function better, and reduced pain or injury-related behaviors.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"646807184124e4ed3ccbdc306e6305280f3e263c8dd28fef8089a1739e04deb6","hash":"9256922e37ec83126ac122e6808c46cd1aad7dc2e9e0b27548e137d8a5bc62b7"},{"seq":6,"id":"k7","ts":"2026-06-29T10:32:37.115Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s31","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/26774587/","title":"ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception","quote":"ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception","link_status":"ok","quote_status":"verified"},{"id":"s32","type":"medical","url":"https://mindbodyneurology.com/ara-290-peptide-neuropathy/","title":"ARA 290 Peptide for Neuropathy and Neurodegeneration","quote":"In a neuritis model, ARA 290 reversed mechanical allodynia and produced long-lasting relief from neuropathic pain with associated suppression of spinal inflammatory signaling.","link_status":"ok","quote_status":"unverified"},{"id":"s33","type":"medical","url":"https://thepeptidecatalog.com/articles/ara-290-benefits","title":"ARA-290 for Nerve Repair: What Trials Show (2026)","quote":"The 2013 sarcoidosis trial reported that 28 days of ARA 290 improved neuropathic symptoms and raised thresholds for painful thermal stimuli, with improvement sustained through 16 weeks of follow-up.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"9256922e37ec83126ac122e6808c46cd1aad7dc2e9e0b27548e137d8a5bc62b7","hash":"7dfd2200a50324a6d4e3c25ef84b243c838368e27e99517f77f8ac8191044806"},{"seq":7,"id":"k8","ts":"2026-06-29T12:48:03.749Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c32","tier":"system","text":"ARA-290 for Sciatica: Evidence-Graded Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:03.749Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"7dfd2200a50324a6d4e3c25ef84b243c838368e27e99517f77f8ac8191044806","hash":"e1b6ca0b3de595b44e1c7ae9739e27f7015c6d0e1b1648407294c5e4f785ed30"},{"seq":8,"id":"k9","ts":"2026-06-29T12:48:03.796Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c33","tier":"preclinical","text":"Per this ledger on ARA-290 for Sciatica: Evidence-Graded Review: 17 scientific and 14 anecdotal sources are catalogued; 6 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:03.796Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"e1b6ca0b3de595b44e1c7ae9739e27f7015c6d0e1b1648407294c5e4f785ed30","hash":"94535f014460148f136297996f33b0ce07d51d209fc51d668478416e3799cff1"},{"seq":9,"id":"k10","ts":"2026-06-29T12:48:03.923Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c34","tier":"speculative","text":"Not established in this ledger: large randomized human trials for common marketed uses; long-term human safety beyond small pilots; condition-specific efficacy where only anecdotal or preclinical sources exist (explicit gaps remain in question graph).","who_claims":"miscsubjects gap analysis","source_ids":[],"slot":"what_is_unknown","posted_by":{"actor":"miscsubjects gap analysis","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:03.923Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"94535f014460148f136297996f33b0ce07d51d209fc51d668478416e3799cff1","hash":"8500e8a04c77f7fdc2cd4432126fb2b8434184e18275dfb08056436862932cbc"},{"seq":10,"id":"k11","ts":"2026-06-29T12:48:04.055Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c35","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:04.055Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"8500e8a04c77f7fdc2cd4432126fb2b8434184e18275dfb08056436862932cbc","hash":"56fe1dc991bb0653d1bc016878bc410ea3f45a4f6e0a69edcdaf6e899914a42d"},{"seq":11,"id":"k12","ts":"2026-06-29T12:48:04.291Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c36","tier":"human","text":"Not medical advice. 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You have to keep doing it from time to time at least and it’s expensive. Check out sites on it for dosage duration etc. at a min do it for a 28 days at 4 mg","link_status":"ok","quote_status":"unverified"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1lercvh/possible_cidp_diagnosis_doctor_will_not_treat/","title":"Possible CIDP Diagnosis- Doctor will not treat","quote":"I’m considering trying ARA-290, as it not only has shown to heal nerves, but limit autoimmune issues as well.","link_status":"ok","quote_status":"unverified"},{"id":"s38","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/1qa6g93/some_anecdoteanecdata_from_my_recent_experience/","title":"some anecdote/anecdata from my recent experience with peptides","quote":"Give ARA 290 a shot. youll want to go through a wholesaler from china as it can get quite expensive through resellers","link_status":"ok","quote_status":"unverified"},{"id":"s39","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/1kkb0y7/is_chronic_sciatica_for_life/","title":"Is chronic sciatica for life?","quote":"Bpc 157, tb500, ghk cu and ara 290. 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I struggle some with it too so I am looking to snag a kit here soon to see if it actually does help.","link_status":"ok","quote_status":"verified"},{"id":"s43","type":"x","url":"https://x.com/mannyjplays/status/2061991252678086838","title":"ARA 290 for sciatic nerve pain","quote":"For all my peeps who have dealt with lower back issues, sciatic nerve pain, degenerated or bulged discs. Have you experimented with ARA 290? If so what was your experience on it?","link_status":"ok","quote_status":"verified"},{"id":"s44","type":"x","url":"https://x.com/GodsHand1972/status/2057447150464966793","title":"ARA 290 trial for sciatica","quote":"Since the topic of sciatica popped up.. any thoughts on giving ARA 290 a trial when nerve injury related pain (tingling, numbness, etc) arises? I’d love to hear about those who’ve tried stacking ARA 290 with the KLOW family in certain circumstances","link_status":"ok","quote_status":"verified"},{"id":"s45","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too -- I guess you don't notice when you lose awareness of temperature. 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