{"slug":"ara-290-post-surgical-nerve","verification":{"valid":true,"entries":44,"head":"47a68756fca878246ddad29ab683479a0a6d11b57d147cb5d03e4784625b3d0b"},"count":44,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","quote":"In patients with sarcoidosis, ARA290 significantly improved neuropathic and autonomic symptoms... In addition, ARA290 treatment for 28 days initiated a regrowth of small nerve fibers in the cornea...","summary":"Review summarizing human sarcoidosis and T2D trials plus preclinical data.","claim_ids":["c1","c5","c41","c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:55:09.574Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"3f27e6e11408236af7ff77ceec270961dc9a901bd802ba0c37b2ef0b64e692c9","source_role":"adjacent_context"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24136731/","title":"ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density","quote":"28 d of daily subcutaneous administration of ARA 290... significantly improves neuropathic symptoms... significant increase in corneal small nerve fiber density","summary":"Primary sarcoidosis SFN trial results.","claim_ids":["c1"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:55:09.574Z","link_status":"ok","quote_status":"unverified","prev":"3f27e6e11408236af7ff77ceec270961dc9a901bd802ba0c37b2ef0b64e692c9","hash":"5fec5a49d472937a24bce4c8dcdb4989cf92135655fc2d5502f2db739d6f9759","source_role":"cycle_background"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290... Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes","quote":"Neuropathic symptoms as assessed by the PainDetect questionnaire improved significantly... subjects with a mean CNFD >1 standard deviation from normal showed a significant increase in CNFD","summary":"T2D neuropathy phase 2 trial.","claim_ids":["c2"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:55:09.574Z","link_status":"ok","quote_status":"unverified","prev":"5fec5a49d472937a24bce4c8dcdb4989cf92135655fc2d5502f2db739d6f9759","hash":"e5babafece44e9b9b84054329a7b75f66eb1e1c40cd76698ddc67ccf1e66aa3c","source_role":"cycle_background"},{"id":"s4","type":"other","url":"https://www.truehealwellness.com/peptides-research/ara-290","title":"ARA-290: Neuropathic Pain & Nerve Repair","quote":"For post-surgical nerve pain, the rationale is preclinical (an animal surgical-nerve-injury study); no human trial has tested it.","summary":"Explicit statement of evidence gap.","claim_ids":["c3"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:55:09.574Z","link_status":"ok","quote_status":"verified","prev":"e5babafece44e9b9b84054329a7b75f66eb1e1c40cd76698ddc67ccf1e66aa3c","hash":"fe67582a75ebdca77fb81ada31f295f3611d180f6aef65fb884268f9b9dc11f7","source_role":"mechanism_support"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25549226/","title":"Discovery of a master regulator of injury and healing","quote":"ARA 290 has effective and prolonged (up to 20 weeks) anti-allodynic effects... after nerve injury","summary":"Preclinical nerve injury models referenced.","claim_ids":["c4"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:55:09.574Z","link_status":"ok","quote_status":"unverified","prev":"fe67582a75ebdca77fb81ada31f295f3611d180f6aef65fb884268f9b9dc11f7","hash":"44da2cc99c0817a552bef4c742c8c00d9be1da056d86b7d1973e880b50a31050","source_role":"cycle_background"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/21873879/","title":"ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response","quote":"ARA290 is a promising new drug in the prevention of peripheral nerve injury -induced neuropathic pain in humans.","summary":"Preclinical study on spared nerve injury (post-surgical model) showing ARA290 prevents and relieves neuropathic pain long-term.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"unverified","prev":"44da2cc99c0817a552bef4c742c8c00d9be1da056d86b7d1973e880b50a31050","hash":"e39739e51f5a05719bb2c39c2ce9856dcfa6a07aa8e3e28d23f7a489a25ed89e","source_role":"adjacent_context"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24529189/","title":"ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response","quote":"Following a spared nerve injury in rats, vehicle or ARA290 (administered in either one of 4 doses: 3, 10, 30 and 60 μg/kg) was administered on days 1, 3, 6, 8 and 10.","summary":"Details dose-dependent long-term relief of neuropathic pain in spared nerve injury rat model.","author":"","publisher":"","date":"","claim_ids":["c7"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"verified","prev":"e39739e51f5a05719bb2c39c2ce9856dcfa6a07aa8e3e28d23f7a489a25ed89e","hash":"91f2d1d2744fb42c0659093b96b255cf9e20b1ada6828c3ee988f8680526c8b3","source_role":"cycle_background"},{"id":"s8","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Abundance in Patients With Sarcoidosis","quote":"The purpose of this study is to determine whether ARA 290 , a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis ...","summary":"Ongoing or completed trial on ARA 290 for sarcoid-associated small fiber neuropathy and nerve fiber regeneration.","author":"","publisher":"","date":"","claim_ids":["c8","c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"unverified","prev":"91f2d1d2744fb42c0659093b96b255cf9e20b1ada6828c3ee988f8680526c8b3","hash":"f7dfd894e38451011512e26643f2dc2446dd823fbb5f5530c775edfcf5ab2b75","source_role":"cycle_background"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23262243/","title":"The erythropoietin-derived peptide ARA290 reverses established neuritic dystrophy in Akita (Ins2Akita) diabetic mouse sympathetic ganglia","quote":"ARA290 may be beneficial in the treatment of neuropathic pain symptoms where signs of nerve injury are absent on clinical assessment.","summary":"Shows ARA290 benefits in diabetic neuropathy model, relevant to nerve damage repair.","author":"","publisher":"","date":"","claim_ids":["c9"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"verified","prev":"f7dfd894e38451011512e26643f2dc2446dd823fbb5f5530c775edfcf5ab2b75","hash":"8ab1f09b374f525d2be8be264a6645d64b2a9ffc6f483320cc9759a6ec65d1c3","source_role":"adjacent_context"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"I followed the clinical phase II protocol from 2017. 28 days, 4mg/day... Definite benefit, although it took12 days for it to start working... Slight improvement in numbness.","summary":"User anecdote of self-experimenting with ARA-290 for SFN/neuropathy, reporting symptom improvement and nerve healing hints.","author":"","publisher":"","date":"","claim_ids":["c10","c39","c42","c44"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"unverified","prev":"8ab1f09b374f525d2be8be264a6645d64b2a9ffc6f483320cc9759a6ec65d1c3","hash":"9e752736f03df50f2a7d898f2c5481d53ac1b9a5006c81723df87bfa82088d53","source_role":"adjacent_context"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"Has anyone tried the peptide ARA-290. It has clinical evidence of helping to slow or stop neuropathy and allow nerves to heal.","summary":"Reddit discussion thread with user experiences trying ARA-290 for neuropathy symptoms.","author":"","publisher":"","date":"","claim_ids":["c11"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:16.953Z","link_status":"ok","quote_status":"unverified","prev":"9e752736f03df50f2a7d898f2c5481d53ac1b9a5006c81723df87bfa82088d53","hash":"1393304c499d39d242fcd877a44b35f2ed6b8da910134487bdd04ee13a622653","source_role":"adjacent_context"},{"id":"s12","type":"review","url":"https://www.sciencedirect.com/science/article/abs/pii/S1567576924009731","title":"The protective effect of erythropoietin and its novel derived peptides in peripheral nerve injury","quote":"This review summarizes for the first time the role of ARA290 and CHBP, derivatives of EPO in peripheral nerve injury.","summary":"2024 review detailing EPO, ARA290, and CHBP mechanisms and protective effects in peripheral nerve injury models, noting ARA290's neuroprotective role despite short half-life limitations.","author":"","publisher":"","date":"","claim_ids":["c12"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:41.203Z","link_status":"http_403","quote_status":"unverified","prev":"1393304c499d39d242fcd877a44b35f2ed6b8da910134487bdd04ee13a622653","hash":"9b5e7898a793927b56c40f71e73056a9eb389f51a13636c7b194d3e34b16a46e","source_role":"adjacent_context"},{"id":"s13","type":"medical","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"Post-Surgical Recovery. Surgery inevitably cuts through nerves.","summary":"Blog post discussing ARA-290 for peripheral nerve regeneration, including post-surgical nerve damage recovery in combination with BPC-157.","author":"","publisher":"","date":"","claim_ids":["c13"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:41.203Z","link_status":"ok","quote_status":"unverified","prev":"9b5e7898a793927b56c40f71e73056a9eb389f51a13636c7b194d3e34b16a46e","hash":"c0b11c83d8c3ab61782023070bf7a38cfc02aaefe3f5bbaaa4744d0923c44773","source_role":"mechanism_support"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months! I walked over 14,000 steps pain free!","summary":"User anecdote reporting significant pain relief and improved mobility from ARA-290 for chronic neuropathy symptoms after 8 days of use.","author":"","publisher":"","date":"","claim_ids":["c14"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:41.203Z","link_status":"ok","quote_status":"unverified","prev":"c0b11c83d8c3ab61782023070bf7a38cfc02aaefe3f5bbaaa4744d0923c44773","hash":"256080897ea7eb1af9a2f4693a95bb291fe453b80d8a345acb9fd8a346936526","source_role":"adjacent_context"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back...","summary":"Anecdotal report of temporary symptom improvement (tingling, temperature awareness) from short-term ARA-290 use for suspected small fiber neuropathy.","author":"","publisher":"","date":"","claim_ids":["c15"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:37:41.203Z","link_status":"ok","quote_status":"unverified","prev":"256080897ea7eb1af9a2f4693a95bb291fe453b80d8a345acb9fd8a346936526","hash":"960167d9ccd16b39876e011f6fbeafb9c01460f24ffed50eaf8563328b6302dd","source_role":"adjacent_context"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I am 55 years old ... I had L5/S1 anterior back surgery about 4 yrs ago. Unfortunately, one of the side effects to my surgery was the potential non-diabetic peripheral neuropathy which I ended up getting. ... I started doing research and I learned about ARA 290 which I purchased through Peptides Sciences ... I'm on my second shot so far so perhaps it's too soon to opine. ... So far so good! ... I have no side effects, such as headaches, itchiness on the injection site or any ","summary":"Post-surgical (back surgery) neuropathy patient reports starting ARA-290 protocol with no side effects so far and optimism based on studies.","author":"","publisher":"","date":"","claim_ids":["c16"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"unverified","prev":"960167d9ccd16b39876e011f6fbeafb9c01460f24ffed50eaf8563328b6302dd","hash":"2110dc5fe9f95ec545a26ab3c748251ba77608f53c995091c58d84e4aba0e2c2","source_role":"anecdotal_report"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I am almost done with a month of ara 290. ... It’s not cheap. I have seen really great results. My neuropathy was very bad and it has improved significantly. I have tried almost everything and this was the most helpful by far. Whether it lasts I’ll have to see.","summary":"Positive user report of significant improvement in severe neuropathy after 1 month of ARA-290.","author":"","publisher":"","date":"","claim_ids":["c17"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"unverified","prev":"2110dc5fe9f95ec545a26ab3c748251ba77608f53c995091c58d84e4aba0e2c2","hash":"035d26cc061d6b5629bc5d14164d6c92c861bf28bfb9fb3997ddda7a13167fc4","source_role":"anecdotal_report"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","quote":"I began last week at .5 mg, then 1, then 2, then 3 and finally 4 mg. ... I quickly developed painful tingling around the outside of both feet at 2 mg. Those last 3 days were very painful. ... I have been off the peptide for 2 days now and the pain is mostly gone.","summary":"Negative experience: painful tingling side effect leading to stopping ARA-290; pain subsided after discontinuation.","author":"","publisher":"","date":"","claim_ids":["c18"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"unverified","prev":"035d26cc061d6b5629bc5d14164d6c92c861bf28bfb9fb3997ddda7a13167fc4","hash":"b3034ca690ce289ca11172647d0e5e3ec60e75d57c6f5d5c12d34e7fc27047ed","source_role":"adjacent_context"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive.","summary":"User reports temporary pain relief from ARA-290 requiring ongoing use.","author":"","publisher":"","date":"","claim_ids":["c19"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"unverified","prev":"b3034ca690ce289ca11172647d0e5e3ec60e75d57c6f5d5c12d34e7fc27047ed","hash":"6d3b5116bdf449c9da4dbf40106146d32dd71999deab3c22c4f00f8505046980","source_role":"adjacent_context"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I’ve been dealing with pretty annoying nerve pain from a herniated disc at C6–C7 ... I’ve started ARA-290 ... UPDATE (07.06.2026) I had to take 2 days off from it as I was abroad ... I was on it for less than a week and didn't notice any benefits nor side effects.","summary":"User with post-disc herniation (surgical context implied) nerve pain reports no benefits or side effects after short use of ARA-290; planning longer cycle.","author":"","publisher":"","date":"","claim_ids":["c20"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"unverified","prev":"6d3b5116bdf449c9da4dbf40106146d32dd71999deab3c22c4f00f8505046980","hash":"6ec12979c54a1f37b138442add0dda917233e494c51168af6cf614832a046fc1","source_role":"adjacent_context"},{"id":"s21","type":"x","url":"https://x.com/RickWingfield5/status/2070195807316246840","title":"X post on ARA-290 for nerve pain","quote":"PEG-MGF has been incredible with healing my mid sixties muscles and ARA-290 is amazing for nerve pain in neck and shoulders.","summary":"Positive anecdotal report of ARA-290 helping nerve pain in neck and shoulders.","author":"","publisher":"","date":"","claim_ids":["c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:05.151Z","link_status":"ok","quote_status":"verified","prev":"6ec12979c54a1f37b138442add0dda917233e494c51168af6cf614832a046fc1","hash":"475ee96f38d1d692ee06940905fc4e3eb63f990249fc18671a5b0ada26a35917","source_role":"adjacent_context"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","quote":"EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","summary":"2025 study showing ARA290 (and EPO) inhibits NLRP3 inflammasome in Schwann cells post-sciatic nerve crush injury in rats, promoting repair and functional recovery.","author":"","publisher":"","date":"","claim_ids":["c22"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:30.014Z","link_status":"ok","quote_status":"verified","prev":"475ee96f38d1d692ee06940905fc4e3eb63f990249fc18671a5b0ada26a35917","hash":"1f54fd3bb24ce5e444702c58f7be6f8d8fdb8e6a1b66349ae96ce8fab1bff926","source_role":"adjacent_context"},{"id":"s23","type":"medical","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925003644","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","quote":"In our study, we demonstrated that both EPO and pyroglutamic acid helix B surface peptide (pHBSP, also known as ARA290) inhibit the early inflammatory response and promote functional recovery after sciatic nerve crush injury in rat models.","summary":"Research article on rat sciatic nerve crush model (relevant to post-injury/surgical nerve damage); ARA290 reduces early inflammation via NLRP3 inhibition in Schwann cells, aiding regeneration.","author":"","publisher":"","date":"","claim_ids":["c23"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:30.014Z","link_status":"http_403","quote_status":"unverified","prev":"1f54fd3bb24ce5e444702c58f7be6f8d8fdb8e6a1b66349ae96ce8fab1bff926","hash":"99ff6fd53f52c614e0d545f19912b5d0937cd6709fd762ce7e93a9dd6f7026fb","source_role":"adjacent_context"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide Targeting Neuropathic Pain and Tissue Protection","quote":"It has entered Phase I and Phase II human clinical trials for neuropathic pain (specifically in sarcoidosis patients), diabetic neuropathy, and critical limb ischemia","summary":"Detailed user guide post discussing ARA-290 mechanisms, clinical trial history, dosing, and nerve repair potential (anecdotal/educational context).","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:38:30.014Z","link_status":"ok","quote_status":"unverified","prev":"99ff6fd53f52c614e0d545f19912b5d0937cd6709fd762ce7e93a9dd6f7026fb","hash":"bbfcbaa28a0bcc8e66ee1e0119b21ad44e115111466e697c5ac0c3e850db4e0d","source_role":"adjacent_context"},{"id":"s25","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in animals with a β-common receptor knockout phenotype. ... We tested ARA290 in the spared nerve injury (SNI) model in mice and rats. ... Animals were sham operated (blue) or received SNI and vehicle (grey) or SNI and 60 µg/kg ARA290 (red), both administered on days 1, 3, 6, 8, and 10 postsurgery (*P* < 0.0001 compared with vehicle).","summary":"2016 review discussing ARA290 (targeting innate repair receptor) in post-surgical neuropathic pain models like spared nerve injury (SNI) and sciatic nerve injury, showing long-term relief of allodynia.","author":"","publisher":"","date":"","claim_ids":["c25"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:18.044Z","link_status":"ok","quote_status":"verified","prev":"bbfcbaa28a0bcc8e66ee1e0119b21ad44e115111466e697c5ac0c3e850db4e0d","hash":"3751d7e3ba4e0e1aa72602e77e5b2c72abbf5bde10eab5895f9bf6585a9fea0e","source_role":"adjacent_context"},{"id":"s26","type":"medical","url":"https://peptidefox.com/content/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid Peptide","quote":"The reason to think it would help here is preclinical. The closest evidence is a rat study of a surgical nerve injury, where ARA-290 relieved touch and cold hypersensitivity and the effect vanished without the receptor. ... Could ARA-290 help lingering nerve pain after surgery, like after an ACL reconstruction? Possibly, if the pain is genuinely from a nerve (tingling, touch sensitivity), which is common after knee surgery. But be clear on the evidence: the reason to expect b","summary":"Medical overview noting preclinical evidence from surgical nerve injury rat models (e.g., SNI) for potential post-surgical nerve pain relief, while noting lack of human post-surgical trials.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:18.044Z","link_status":"ok","quote_status":"unverified","prev":"3751d7e3ba4e0e1aa72602e77e5b2c72abbf5bde10eab5895f9bf6585a9fea0e","hash":"10366db3f51fdfe58f016916c4aeaaceb180c6a4ae1bd24acc1668f9fd25aeb4","source_role":"mechanism_support"},{"id":"s27","type":"medical","url":"https://mindbodyneurology.com/ara-290-peptide-neuropathy/","title":"ARA 290 Peptide for Neuropathy and Neurodegeneration","quote":"A 2025 study using an ARA 290 microneedle patch in a diabetic peripheral neuropathy rat model showed relief of mechanical pain and improved nerve structure... Several key studies focus on ARA 290 in this group. ... A randomized, double-blind pilot trial in sarcoidosis with SFN symptoms...","summary":"2025 article summarizing ARA-290 evidence including a new 2025 rat study on microneedle delivery for neuropathy and referencing surgical/preclinical models indirectly via broader neuropathy data.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:18.044Z","link_status":"ok","quote_status":"unverified","prev":"10366db3f51fdfe58f016916c4aeaaceb180c6a4ae1bd24acc1668f9fd25aeb4","hash":"2b76803186000f314e4b36b2ff8aeb248efa9fce305664341b1cb142222990e1","source_role":"core_stack_evidence"},{"id":"s28","type":"other","url":"https://www.renewyouth.com/ara-290-a-new-frontier-in-pain-relief-and-healing/","title":"ARA 290: A New Frontier in Pain Relief and Healing","quote":"Neuropathic Pain: This type of pain is caused by nerve damage... Research suggests ARA 290 can reduce these painful sensations... Small Fiber Neuropathy: ... ARA 290 may help to repair these small nerve fibers...","summary":"2025 clinic/blog post on ARA-290 for neuropathic pain and small fiber neuropathy from nerve damage (context includes post-surgical potential).","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:18.044Z","link_status":"ok","quote_status":"unverified","prev":"2b76803186000f314e4b36b2ff8aeb248efa9fce305664341b1cb142222990e1","hash":"b10572af7bde1a48d1f0c8afa2226db38984e2f1661e22d87fb274caa83a67c4","source_role":"core_stack_evidence"},{"id":"s29","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","quote":"The peptide has gained significant attention in regenerative medicine and neurology due to its demonstrated efficacy in treating diabetic neuropathy, chronic neuropathic pain, and inflammatory conditions through its unique mechanism of promoting neural repair and reducing inflammation. ... Application Diabetic Neuropathy Neuropathic Pain","summary":"Clinic medical resource on ARA-290 mechanisms and applications for neuropathic pain and nerve regeneration.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:18.044Z","link_status":"ok","quote_status":"verified","prev":"b10572af7bde1a48d1f0c8afa2226db38984e2f1661e22d87fb274caa83a67c4","hash":"b3c336c208b61251d07c9ff9732cf5457a21e5c58488ac3971cc125cab610f79","source_role":"mechanism_support"},{"id":"s30","type":"review","url":"https://superpower.com/guides/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid Peptide Targeting the Innate Repair Receptor","quote":"Phase II RCTs in sarcoidosis patients showed a placebo-corrected increase in corneal nerve fiber area of 697 μm²/mm² at day 28, but no Phase III trials were completed before Araim Pharmaceuticals closed.","summary":"2026 review of ARA-290 evidence for neuropathic pain and nerve regeneration in SFN and diabetes; discusses preclinical nerve injury models and lack of further trials.","author":"","publisher":"","date":"","claim_ids":["c6"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:42.429Z","link_status":"ok","quote_status":"verified","prev":"b3c336c208b61251d07c9ff9732cf5457a21e5c58488ac3971cc125cab610f79","hash":"d103ddd93bc04d3f7949d2277eda62158b482408246c914b678f91ce49de42f4","source_role":"mechanism_support"},{"id":"s31","type":"medical","url":"https://preferredregen.com/blog/benefits-of-ara290-peptide-a-simple-guide","title":"Benefits of ARA290 Peptide: A Simple Guide","quote":"ARA-290 has shown promise in helping with broader peripheral nerve damage recovery. For example, in a study on patients with sarcoidosis, a condition that can cause small fiber neuropathy, ARA-290 treatment significantly improved neuropathic symptoms and quality of life. This suggests its healing properties can be applied to various forms of nerve damage, including those from a sports injury.","summary":"Blog post on ARA-290 for peripheral nerve damage including injury-related, referencing sarcoidosis studies.","author":"","publisher":"","date":"","claim_ids":["c31"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:42.429Z","link_status":"ok","quote_status":"verified","prev":"d103ddd93bc04d3f7949d2277eda62158b482408246c914b678f91ce49de42f4","hash":"1e1fa925f584913617404b5d4f94d6c4ef276a0b85c6b81150a42b47bdb956e3","source_role":"mechanism_support"},{"id":"s32","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment is also possible with peptides. ARA-290","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy, tarsal tunnel, nerve injury or post operative nerve pain.","summary":"Instagram reel by foot/ankle surgeon recommending ARA-290 specifically for post-operative nerve pain and nerve injury.","author":"","publisher":"","date":"","claim_ids":["c32"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T10:39:42.429Z","link_status":"ok","quote_status":"verified","prev":"1e1fa925f584913617404b5d4f94d6c4ef276a0b85c6b81150a42b47bdb956e3","hash":"d9ae35e93336f0234fdb42bcb883bc1a9cbb235d88ffeaee05b40a77076bbf0f","source_role":"adjacent_context"},{"id":"s33","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","quote":"I've been using ARA-290 for saphenous nerve damage for 2 months. It's amazing. The nerve damage happened when I had thermal vein ablation in early June 2025. ... The boundaries of my nerve damage have shrunk several inches! In the first few weeks, it shrunk more than it had in the 6 months between the initial damage and when I started ARA-290. ... I am 100% certain that ARA-290 is responsible for my experience of several inches of recovery in mere weeks after the preceding 6 ","summary":"Positive anecdotal report of significant nerve damage area reduction and symptom improvement from ARA-290 use post-vein ablation procedure (saphenous nerve axonal damage).","author":"","publisher":"","date":"","claim_ids":["c46"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:57:20.094Z","link_status":"ok","quote_status":"unverified","prev":"d9ae35e93336f0234fdb42bcb883bc1a9cbb235d88ffeaee05b40a77076bbf0f","hash":"edc59b5e612b04035ec91266d55247878ace20a707c211398c7cc5d1a24f5e46","source_role":"adjacent_context"},{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/zy6z6u/ara_290_14_days_in_no_relief/","title":"ARA 290 14 days in, no relief.","quote":"14 days into ARA 290 and zero relief. Losing my mind in pain. Home bound/bed bound for years now.","summary":"Negative user experience reporting no pain relief or symptom improvement after 14 days of ARA-290 (user continued briefly but later discontinued without benefit).","author":"","publisher":"","date":"","claim_ids":["c47"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T15:57:20.094Z","link_status":"ok","quote_status":"unverified","prev":"edc59b5e612b04035ec91266d55247878ace20a707c211398c7cc5d1a24f5e46","hash":"660e97e02d8bf157a66eece042d4869f7755b73d7225bade282e9218130b3e8e","source_role":"anecdotal_report"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I took 4 units daily for 8 weeks, didn't do anything for my neuropathy!","summary":"User reports no effect from 4mg/day ARA-290 for 8 weeks on neuropathy (anecdotal, not advice). Another similar negative report for 60 days.","author":"","publisher":"","date":"","claim_ids":["c48"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"660e97e02d8bf157a66eece042d4869f7755b73d7225bade282e9218130b3e8e","hash":"fb3c30cba012920ea541e956cddcc4f1bbb9d254c467c7aa9485af3832f53dd1","source_role":"adjacent_context"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1mcbbkb/ara290/","title":"ARA290","quote":"Expensive. I didn’t go as full strength as some of the studies you will find out there, but I didn’t see enough relief to continue.","summary":"User tried ARA290 but stopped due to insufficient relief and cost (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c49"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"fb3c30cba012920ea541e956cddcc4f1bbb9d254c467c7aa9485af3832f53dd1","hash":"134f1c3a9be963c5e1dc39bf9332e95d2854c7df3c864069209c38d5c29dc9f7","source_role":"adjacent_context"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1plukvn/bpc157/","title":"BPC157","quote":"Hey so I did two months of ARA290 and I didn’t really notice too much from that, but one thing I will say is my internal “cracking” from overfiring nerves in my fingers when bend my fingers backward went away. Could be from the ARA.","summary":"Mixed anecdotal outcome: limited overall effect from 2 months ARA290 but some reduction in nerve overfiring symptoms (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c50"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"134f1c3a9be963c5e1dc39bf9332e95d2854c7df3c864069209c38d5c29dc9f7","hash":"16a521ac4b3353e80d738b8871ac1c96420a0ebf8daa5b4c5a86fab6a667cc8b","source_role":"adjacent_context"},{"id":"s38","type":"x","url":"https://x.com/RickWingfield5/status/2070209027057864822","title":"X post about back surgery and ARA-290","quote":"Back surgery 20 years ago Fused disc's and doing great with the ARA 290.","summary":"Positive anecdotal report of ARA-290 helping post-back surgery nerve issues (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c51"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"16a521ac4b3353e80d738b8871ac1c96420a0ebf8daa5b4c5a86fab6a667cc8b","hash":"b5e61f8b86ad3d8f03eac9393070f3f269e3a333fd56dd3fba5479539d4c569b","source_role":"anecdotal_report"},{"id":"s39","type":"x","url":"https://x.com/itsjoshkade/status/2068423897226387940","title":"X post on running ARA-290","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","summary":"Anecdotal dosing and stacking advice for nerve repair (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c52"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"b5e61f8b86ad3d8f03eac9393070f3f269e3a333fd56dd3fba5479539d4c569b","hash":"3dcc4f319cd7dd83b346b8af885c8ba957672846482b1c515ab5bedbfcfab4d2","source_role":"adjacent_context"},{"id":"s40","type":"x","url":"https://x.com/CoachMattFit/status/2067657277365174754","title":"X post personal experience ARA-290","quote":"🩹 ARA-290 Peps 🔬 My personal experience! ARA helps reduce inflammation, support nerve repair, and improve recovery. Best paired with BPC-157 for healing...","summary":"Positive anecdotal report on ARA-290 for nerve repair and inflammation (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c53"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:01:31.071Z","link_status":"ok","quote_status":"unverified","prev":"3dcc4f319cd7dd83b346b8af885c8ba957672846482b1c515ab5bedbfcfab4d2","hash":"e7555b5e98ee710e14a6b64389b1d21fdedce57b18a4e31aba849480c057548b","source_role":"adjacent_context"},{"id":"s41","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1u8astt/anyone_tried_ara_290/","title":"Anyone tried ARA 290","quote":"I am trying 4mg ARA-290 now, along with a host of supplements. The major help for me was tirzepatide. I am unsure if ARA-290 is helping. I have injected 8 10mg vials so far.","summary":"User reports trying 4mg daily ARA-290 (anecdotal) with uncertain effects on neuropathy alongside other treatments; no clear positive or negative outcome detailed for post-surgical nerve issues.","author":"","publisher":"","date":"","claim_ids":["c54"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:02:00.273Z","link_status":"ok","quote_status":"unverified","prev":"e7555b5e98ee710e14a6b64389b1d21fdedce57b18a4e31aba849480c057548b","hash":"aadcad933a822caa125cc5d526069ae01813b5814d42a4855da816d04e398392","source_role":"anecdotal_report"},{"id":"s42","type":"reddit","url":"https://www.reddit.com/r/Erythromelalgia/comments/1n94gam/has_anyone_tried_ara290_or_any_other_peptides/","title":"Has anyone tried ARA-290 (or any other peptides)?","quote":"Doesn’t work for everyone and it’s not a cure, it also loses efficacy over time. But the first 7-10 days if you’re one of the ones it works for, is like a sigh of relief It seems to work best in those with a central sensitization component.","summary":"Anecdotal comment on ARA-290 for SFN/EM (related nerve pain): temporary relief in some, loses efficacy, best for central sensitization; suggests short trial from peptide sources (anecdotal, not advice).","author":"","publisher":"","date":"","claim_ids":["c55"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:02:00.273Z","link_status":"ok","quote_status":"unverified","prev":"aadcad933a822caa125cc5d526069ae01813b5814d42a4855da816d04e398392","hash":"131495544c52f50e88e72feb82083c6e58d6b26b812daf2d302ac05614a9fd68","source_role":"adjacent_context"},{"id":"s43","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tdbx3f/peptides_for_chronic_pain/","title":"peptides for chronic pain?","quote":"ARA-290 ... It is frequently used to treat diabetic nerve pain and chemotherapy-induced neuropathy by reducing inflammation and supporting nerve ...","summary":"Discussion of ARA-290 for neuropathic pain including potential nerve support; general positive research mention but no specific user outcomes or post-surgical anecdotes here.","author":"","publisher":"","date":"","claim_ids":["c56"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:02:00.273Z","link_status":"ok","quote_status":"unverified","prev":"131495544c52f50e88e72feb82083c6e58d6b26b812daf2d302ac05614a9fd68","hash":"cc64fbb100e99ace77ef0415ad34783aef355099170ecc1157ea6ab86ac14ed2","source_role":"adjacent_context"},{"id":"s44","type":"x","url":"https://x.com/peptidepirate/status/2070197012457271487","title":"X post by @peptidepirate","quote":"I have seen a few people talk about ARA-290 I was wanting to give it a go for some nerve damage I have","summary":"User considering ARA-290 for personal nerve damage (anecdotal intent); no outcome reported.","author":"","publisher":"","date":"","claim_ids":["c57"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T18:02:00.273Z","link_status":"ok","quote_status":"verified","prev":"cc64fbb100e99ace77ef0415ad34783aef355099170ecc1157ea6ab86ac14ed2","hash":"47a68756fca878246ddad29ab683479a0a6d11b57d147cb5d03e4784625b3d0b","source_role":"adjacent_context"}]}