{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_bundle","feature":"bundle","name":"LLM article bundle","what":"Portable reference package: body + claims + sources + voxels + provenance + manifest + constitution.","contains":"body, claims, sources, voxels, provenance, question graph, constitution, llm_manifest","slug":"ara-290-post-surgical-nerve","urls":{"read":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle?format=markdown"},"how_to_use":"Reference bundle for an LLM or reader. §SELF explains the surface; ingest and claim endpoints in llm_manifest are the write-back routes.","write":null,"imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"topology","name":"Article topology","what":"Claims, sources, anecdotes, user reports, related embeds, question graph slice — for ask/ROUTER.","urls":{"read":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/topology"}},{"id":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). 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Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions."},{"id":"c41","tier":"human","status":"active","text":"There is a lack of data on the comparative efficacy of ARA-290 against standard treatments for post-surgical nerve damage."}],"standing_objections":{"open":0,"strongest_open":null,"link":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/discourse"},"verbs":{"read":"GET https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/voxels — DIVs + hashes + chains (free)","read_claims":"GET https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/claims — every formal claim as claim:<id> with current hash, thread, stable link, and exact contribution/edit bodies","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {slug, expected_thread_head, target_div?, expected_hash?, body, actor} — read /discourse first; no key needed; returns the stable widget link","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {slug, outcome, content_hash, actor} — close your read with one of four outcomes","mutate":"voxel-edit / voxel-move / voxel-consolidate — CAS-gated, needs a key scoped rows:VOXEL_* from the owner"},"reads_next":["https://miscsubjects.com/a/philosophy","https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/discourse","https://miscsubjects.com/api/protocol"]},"bundle_version":1,"generated_at":"2026-07-30T03:40:04.263Z","slug":"ara-290-post-surgical-nerve","title":"ARA-290 for Post-Surgical Nerve Damage: Evidence Review","url":"https://miscsubjects.com/a/ara-290-post-surgical-nerve","register":"source_ledger","tags":["peptide","topic"],"posted_at":"2026-06-29 08:23:19","updated_at":"2026-07-17T02:38:15.458Z","body":"## Regeneration vs degeneration — where this fits\nThe body breaks down tissue and builds it back at the same time. When breakdown outruns repair after surgery, nerves can stay damaged and signals stay active. ARA-290 is studied for the repair side of this balance in nerve tissue.\n\n## What it is\nARA-290 is a short chain of amino acids. It comes from the structure of erythropoietin but does not raise red blood cells. Research focuses on its effect on small nerve fibers and neuropathic pain after injury.\n\n## How it works\nIt binds a receptor called the innate repair receptor. Binding turns on signals that lower inflammation in nerve-support cells. It also reduces activation of NLRP3 inflammasome in Schwann cells after nerve crush. These steps are shown in rat models.\n\n## Why it would work (logic chain)\nIf nerve injury causes ongoing inflammation, then lowering that inflammation could allow regrowth signals to dominate. If regrowth signals dominate, then small nerve fiber density can rise and pain sensitivity can fall. Rat studies test this chain after surgical-type nerve cuts. Human sarcoidosis trials test the same chain in small fiber loss.\n\n## Why people take it\nPeople with ongoing nerve pain after surgery or with small fiber neuropathy look for options that target repair rather than only masking pain. They read trial summaries and animal data that show reduced allodynia and increased corneal nerve fiber density.\n\n## How many people take it\nNo public count exists. The ledger records ten Reddit posts, one X post, and one Instagram source. Human trial data cover two conditions: sarcoidosis small fiber neuropathy and type 2 diabetes neuropathy.\n\n## Evidence inventory\n32 total sources.  \n18 studies catalogued.  \n10 Reddit posts.  \n1 X post.  \n1 other anecdote source.  \nHuman claims: 2.  \nPreclinical claims: 11.  \nAnecdotal claims: 15.  \n\nHuman data come from sarcoidosis and diabetes trials. Preclinical data come from spared nerve injury, sciatic crush, and diabetic mouse models. Anecdote sources are self-reports on forums and social media.\n\n## What scientists say\nSource s2: 28 days of daily use in sarcoidosis patients improved neuropathic symptoms and raised corneal small nerve fiber density.  \nSource s3: In type 2 diabetes, neuropathic symptoms on the PainDetect scale improved and a subgroup showed higher corneal nerve fiber density.  \nSource s7: In rats with spared nerve injury, ARA-290 given on days 1, 3, 6, 8, and 10 produced dose-dependent, long-term relief of mechanical and cold pain. The effect lasted weeks after the last dose.  \nSource s22: In rats after sciatic nerve crush, ARA-290 reduced NLRP3 inflammasome activity in Schwann cells and supported functional recovery.  \nSource s6: The same spared nerve injury model showed ARA-290 prevented neuropathic pain development when started early.  \nThese studies prove short-term symptom change and some fiber density increase in the tested groups. They do not prove the same results occur after every type of surgery or in every patient.\n\n## What people say on Reddit\nSource s10: User followed the 28-day sarcoidosis protocol and reported definite benefit after 12 days with slight improvement in numbness.  \nSource s14: User at day 8 reported walking over 14,000 steps pain free after titrating to the trial amount.  \nSource s15: User said feeling started to come back in areas that had been numb.  \nSource s16: Post-surgical back patient with peripheral neuropathy started ARA-290 and reported no side effects after two injections.  \nSource s17: User after one month called it the most helpful option tried and noted significant improvement in severe neuropathy.  \nSource s18: User developed painful tingling at 2 mg and stopped; pain eased after stopping.  \nSource s19: User said pain relief was temporary and required repeated courses.  \nSource s20: User with disc-related nerve pain reported no benefit or side effects after less than one week.  \nThese posts are real user reports. They are not controlled trials.\n\n## What people say on X\nSource s21: One user stated ARA-290 is amazing for nerve pain in neck and shoulders.\n\n## What we do not know\nNo completed human trial tests ARA-290 specifically for post-surgical nerve damage. Long-term safety data beyond 28 days are absent. It is unknown whether increased corneal nerve fiber density in sarcoidosis patients predicts repair in surgical nerve injury. The 2025 rat study on NLRP3 shows one mechanism but does not confirm the same pathway works in humans after surgery. How long any reported benefit lasts after stopping is not measured in controlled settings.\n\n## Safety and limits\nSource s18 reports one case of increased painful tingling that resolved after stopping. Other Reddit users report no side effects. Human trials up to 28 days did not list major adverse events in the summaries. No long-term human safety data exist for repeated or extended use. The ledger contains no dose information.","claims":[{"id":"c59","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tier":"mechanistic","weight":0.3,"effective_weight":0.22,"slot":"limitations","source_ids":[],"who_claims":"miscsubjects protocol","status":"active"},{"id":"c31","text":"Blog post on ARA-290 for peripheral nerve damage including injury-related, referencing sarcoidosis studies.","tier":"human","weight":0.8,"effective_weight":0.8,"slot":"what_is_known","source_ids":["s31"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c7","text":"Details dose-dependent long-term relief of neuropathic pain in spared nerve injury rat model.","tier":"preclinical","weight":0.5,"effective_weight":0.5,"slot":"what_is_known","source_ids":["s7"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c_map_ara-290-post-surgical-ne","text":"Combinatorial mapping (transparent): ara-290 vs post-surgical-nerve — regen=0.888, degen=0.83, Δ=0.057. Method: layer_relevance(0.95) × evidence_factor(0.85); catalog.degen_score for Post-surgical nerve injury.","tier":"system","weight":0.35,"effective_weight":0.35,"slot":"what_is_known","source_ids":[],"who_claims":"grok/4.3-populate"},{"id":"c58","text":"ARA-290 for Post-Surgical Nerve Damage: Evidence Review is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tier":"system","weight":0.35,"effective_weight":0.35,"slot":"what_it_is","source_ids":[],"who_claims":"miscsubjects protocol","status":"active"},{"id":"c1","text":"Human trials in sarcoidosis SFN showed symptom improvement and increased corneal nerve fiber density after 28 days of ARA-290.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"mechanism","source_ids":["s1","s2"],"who_claims":"grok/4.3-populate","status":"downweighted"},{"id":"c2","text":"Human trial in type 2 diabetes neuropathy showed improved neuropathic symptoms and CNFD increase in subgroup.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s3"],"who_claims":"grok/4.3-populate","status":"downweighted"},{"id":"c5","text":"ARA-290 activates IRR to promote anti-inflammatory and repair pathways rather than symptomatic pain masking.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"mechanism","source_ids":["s1"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c6","text":"Commercial vendors and clinics market this compound (9 commercial/clinic sources catalogued) — marketing material, not evidence.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","source_ids":["s6","s24","s26","s27","s28","s29","s30","s1","s8"],"who_claims":"commercial vendors","status":"active"},{"id":"c8","text":"Ongoing or completed trial on ARA 290 for sarcoid-associated small fiber neuropathy and nerve fiber regeneration.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s8"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c12","text":"2024 review detailing EPO, ARA290, and CHBP mechanisms and protective effects in peripheral nerve injury models, noting ARA290's neuroprotective role despite short half-life limitations.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_known","source_ids":["s12"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c37","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"disclaimer","source_ids":[],"who_claims":"system/protocol","status":"active"},{"id":"c41","text":"There is a lack of data on the comparative efficacy of ARA-290 against standard treatments for post-surgical nerve damage.","tier":"human","weight":0.8,"effective_weight":0.22,"slot":"what_is_unknown","source_ids":["s1"],"who_claims":"kimi-collaborator","status":"active"},{"id":"c9","text":"Shows ARA290 benefits in diabetic neuropathy model, relevant to nerve damage repair.","tier":"preclinical","weight":0.5,"effective_weight":0.22,"slot":"what_is_known","source_ids":["s9"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c22","text":"2025 study showing ARA290 (and EPO) inhibits NLRP3 inflammasome in Schwann cells post-sciatic nerve crush injury in rats, promoting repair and functional recovery.","tier":"preclinical","weight":0.5,"effective_weight":0.22,"slot":"mechanism","source_ids":["s22"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c4","text":"Rat models of sciatic nerve injury show reduced allodynia and nerve repair effects with ARA-290.","tier":"mechanistic","weight":0.3,"effective_weight":0.22,"slot":"what_is_known","quote_gated":true,"source_ids":["s5"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c40","text":"While the study mentioned in claim c1 shows increased corneal nerve fiber density, it does not necessarily imply direct nerve repair in the context of post-surgical nerve damage, as the study was conducted in sarcoidosis patients, which may have different underlying mechanisms.","tier":"mechanistic","weight":0.4,"effective_weight":0.22,"slot":null,"source_ids":[],"who_claims":"kimi/moonshot-v1-8k (adversary)","status":"active"},{"id":"c43","text":"While the human trial mentioned in claim c2 showed improved neuropathic symptoms and CNFD increase in a subgroup, the applicability of these findings to post-surgical nerve damage specifically is uncertain due to differences in patient populations and study context.","tier":"mechanistic","weight":0.4,"effective_weight":0.22,"slot":null,"source_ids":[],"who_claims":"kimi/moonshot-v1-8k (adversary)","status":"active"},{"id":"c10","text":"User anecdote of self-experimenting with ARA-290 for SFN/neuropathy, reporting symptom improvement and nerve healing hints.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s10"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c11","text":"Reddit discussion thread with user experiences trying ARA-290 for neuropathy symptoms.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s11"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c14","text":"User anecdote reporting significant pain relief and improved mobility from ARA-290 for chronic neuropathy symptoms after 8 days of use.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s14"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c15","text":"Anecdotal report of temporary symptom improvement (tingling, temperature awareness) from short-term ARA-290 use for suspected small fiber neuropathy.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s15"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c16","text":"Post-surgical (back surgery) neuropathy patient reports starting ARA-290 protocol with no side effects so far and optimism based on studies.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s16"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c17","text":"Positive user report of significant improvement in severe neuropathy after 1 month of ARA-290.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s17"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c18","text":"Negative experience: painful tingling side effect leading to stopping ARA-290; pain subsided after discontinuation.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s18"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c19","text":"User reports temporary pain relief from ARA-290 requiring ongoing use.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s19"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c20","text":"User with post-disc herniation (surgical context implied) nerve pain reports no benefits or side effects after short use of ARA-290; planning longer cycle.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s20"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c21","text":"Positive anecdotal report of ARA-290 helping nerve pain in neck and shoulders.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s21"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c32","text":"Instagram reel by foot/ankle surgeon recommending ARA-290 specifically for post-operative nerve pain and nerve injury.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s32"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c39","text":"Anecdotal reports of ARA-290's effectiveness come from various individuals on platforms like Reddit.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s10"],"who_claims":"kimi-collaborator","status":"active"},{"id":"c42","text":"Anecdotal reports from patients on online forums suggest ARA-290 may provide relief for post-surgical nerve pain, but these are not systematically collected or verified.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s10"],"who_claims":"kimi-collaborator","status":"active"},{"id":"c44","text":"A Reddit user provides their personal assessment regarding the effectiveness of ARA-290.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s10"],"who_claims":"gemini-collaborator","status":"active"},{"id":"c46","text":"Positive anecdotal report of significant nerve damage area reduction and symptom improvement from ARA-290 use post-vein ablation procedure (saphenous nerve axonal damage).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s33"],"who_claims":"grok-4.3","status":"active"},{"id":"c47","text":"Negative user experience reporting no pain relief or symptom improvement after 14 days of ARA-290 (user continued briefly but later discontinued without benefit).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s34"],"who_claims":"grok-4.3","status":"active"},{"id":"c48","text":"User reports no effect from 4mg/day ARA-290 for 8 weeks on neuropathy (anecdotal, not advice). Another similar negative report for 60 days.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s35"],"who_claims":"grok-4.3","status":"active"},{"id":"c49","text":"User tried ARA290 but stopped due to insufficient relief and cost (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s36"],"who_claims":"grok-4.3","status":"active"},{"id":"c50","text":"Mixed anecdotal outcome: limited overall effect from 2 months ARA290 but some reduction in nerve overfiring symptoms (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s37"],"who_claims":"grok-4.3","status":"active"},{"id":"c51","text":"Positive anecdotal report of ARA-290 helping post-back surgery nerve issues (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s38"],"who_claims":"grok-4.3","status":"active"},{"id":"c52","text":"Anecdotal dosing and stacking advice for nerve repair (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s39"],"who_claims":"grok-4.3","status":"active"},{"id":"c53","text":"Positive anecdotal report on ARA-290 for nerve repair and inflammation (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s40"],"who_claims":"grok-4.3","status":"active"},{"id":"c54","text":"User reports trying 4mg daily ARA-290 (anecdotal) with uncertain effects on neuropathy alongside other treatments; no clear positive or negative outcome detailed for post-surgical nerve issues.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","quote_gated":true,"source_ids":["s41"],"who_claims":"grok-4.3","status":"active"},{"id":"c55","text":"Anecdotal comment on ARA-290 for SFN/EM (related nerve pain): temporary relief in some, loses efficacy, best for central sensitization; suggests short trial from peptide sources (anecdotal, not advice).","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s42"],"who_claims":"grok-4.3","status":"active"},{"id":"c56","text":"Discussion of ARA-290 for neuropathic pain including potential nerve support; general positive research mention but no specific user outcomes or post-surgical anecdotes here.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s43"],"who_claims":"grok-4.3","status":"active"},{"id":"c57","text":"User considering ARA-290 for personal nerve damage (anecdotal intent); no outcome reported.","tier":"anecdotal","weight":0.3,"effective_weight":0.22,"slot":"who_claims_what","source_ids":["s44"],"who_claims":"grok-4.3","status":"active"},{"id":"c3","text":"No human trials have tested ARA-290 in post-surgical nerve damage.","tier":"speculative","weight":0.12,"effective_weight":0.12,"slot":"what_is_unknown","source_ids":["s4"],"who_claims":"grok/4.3-populate","status":"active"},{"id":"c13","text":"Blog post discussing ARA-290 for peripheral nerve regeneration, including post-surgical nerve damage recovery in combination with BPC-157.","tier":"speculative","weight":0.12,"effective_weight":0.12,"slot":"what_is_known","quote_gated":true,"source_ids":["s13"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c23","text":"Research article on rat sciatic nerve crush model (relevant to post-injury/surgical nerve damage); ARA290 reduces early inflammation via NLRP3 inhibition in Schwann cells, aiding regeneration.","tier":"speculative","weight":0.12,"effective_weight":0.12,"slot":"mechanism","source_ids":["s23"],"who_claims":"grok/grok-4.3","status":"active"},{"id":"c25","text":"2016 review discussing ARA290 (targeting innate repair receptor) in post-surgical neuropathic pain models like spared nerve injury (SNI) and sciatic nerve injury, showing long-term relief of allodynia.","tier":"speculative","weight":0.12,"effective_weight":0.12,"slot":"mechanism","source_ids":["s25"],"who_claims":"grok/grok-4.3","status":"active"}],"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5741312/","title":"Targeting the innate repair receptor to treat neuropathy","summary":"Review summarizing human sarcoidosis and T2D trials plus preclinical data.","quote":"In patients with sarcoidosis, ARA290 significantly improved neuropathic and autonomic symptoms... In addition, ARA290 treatment for 28 days initiated a regrowth of small nerve fibers in the cornea...","quote_status":"unverified","link_status":"ok","claim_ids":["c1","c5","c41","c6"],"hash":"3f27e6e11408236a"},{"id":"s2","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24136731/","title":"ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density","summary":"Primary sarcoidosis SFN trial results.","quote":"28 d of daily subcutaneous administration of ARA 290... significantly improves neuropathic symptoms... significant increase in corneal small nerve fiber density","quote_status":"unverified","link_status":"ok","claim_ids":["c1"],"hash":"5fec5a49d472937a"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290... Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes","summary":"T2D neuropathy phase 2 trial.","quote":"Neuropathic symptoms as assessed by the PainDetect questionnaire improved significantly... subjects with a mean CNFD >1 standard deviation from normal showed a significant increase in CNFD","quote_status":"unverified","link_status":"ok","claim_ids":["c2"],"hash":"e5babafece44e9b9"},{"id":"s4","type":"other","url":"https://www.truehealwellness.com/peptides-research/ara-290","title":"ARA-290: Neuropathic Pain & Nerve Repair","summary":"Explicit statement of evidence gap.","quote":"For post-surgical nerve pain, the rationale is preclinical (an animal surgical-nerve-injury study); no human trial has tested it.","quote_status":"verified","link_status":"ok","claim_ids":["c3"],"hash":"fe67582a75ebdca7"},{"id":"s5","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/25549226/","title":"Discovery of a master regulator of injury and healing","summary":"Preclinical nerve injury models referenced.","quote":"ARA 290 has effective and prolonged (up to 20 weeks) anti-allodynic effects... after nerve injury","quote_status":"unverified","link_status":"ok","claim_ids":["c4"],"hash":"44da2cc99c0817a5"},{"id":"s6","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/21873879/","title":"ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response","summary":"Preclinical study on spared nerve injury (post-surgical model) showing ARA290 prevents and relieves neuropathic pain long-term.","quote":"ARA290 is a promising new drug in the prevention of peripheral nerve injury -induced neuropathic pain in humans.","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"e39739e51f5a0571"},{"id":"s7","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24529189/","title":"ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response","summary":"Details dose-dependent long-term relief of neuropathic pain in spared nerve injury rat model.","quote":"Following a spared nerve injury in rats, vehicle or ARA290 (administered in either one of 4 doses: 3, 10, 30 and 60 μg/kg) was administered on days 1, 3, 6, 8 and 10.","quote_status":"verified","link_status":"ok","claim_ids":["c7"],"hash":"91f2d1d2744fb42c"},{"id":"s8","type":"clinical_trial","url":"https://clinicaltrials.gov/study/NCT02039687","title":"Study of Efficacy of ARA 290 on Corneal Nerve Fiber Abundance in Patients With Sarcoidosis","summary":"Ongoing or completed trial on ARA 290 for sarcoid-associated small fiber neuropathy and nerve fiber regeneration.","quote":"The purpose of this study is to determine whether ARA 290 , a new class of compound, is effective in the treatment of the neuropathic symptoms of sarcoidosis ...","quote_status":"unverified","link_status":"ok","claim_ids":["c8","c6"],"hash":"f7dfd894e3845101"},{"id":"s9","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/23262243/","title":"The erythropoietin-derived peptide ARA290 reverses established neuritic dystrophy in Akita (Ins2Akita) diabetic mouse sympathetic ganglia","summary":"Shows ARA290 benefits in diabetic neuropathy model, relevant to nerve damage repair.","quote":"ARA290 may be beneficial in the treatment of neuropathic pain symptoms where signs of nerve injury are absent on clinical assessment.","quote_status":"verified","link_status":"ok","claim_ids":["c9"],"hash":"8ab1f09b374f525d"},{"id":"s10","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","summary":"User anecdote of self-experimenting with ARA-290 for SFN/neuropathy, reporting symptom improvement and nerve healing hints.","quote":"I followed the clinical phase II protocol from 2017. 28 days, 4mg/day... Definite benefit, although it took12 days for it to start working... Slight improvement in numbness.","quote_status":"unverified","link_status":"ok","claim_ids":["c10","c39","c42","c44"],"hash":"9e752736f03df50f"},{"id":"s11","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","summary":"Reddit discussion thread with user experiences trying ARA-290 for neuropathy symptoms.","quote":"Has anyone tried the peptide ARA-290. It has clinical evidence of helping to slow or stop neuropathy and allow nerves to heal.","quote_status":"unverified","link_status":"ok","claim_ids":["c11"],"hash":"1393304c499d39d2"},{"id":"s12","type":"review","url":"https://www.sciencedirect.com/science/article/abs/pii/S1567576924009731","title":"The protective effect of erythropoietin and its novel derived peptides in peripheral nerve injury","summary":"2024 review detailing EPO, ARA290, and CHBP mechanisms and protective effects in peripheral nerve injury models, noting ARA290's neuroprotective role despite short half-life limitations.","quote":"This review summarizes for the first time the role of ARA290 and CHBP, derivatives of EPO in peripheral nerve injury.","quote_status":"unverified","link_status":"http_403","claim_ids":["c12"],"hash":"9b5e7898a793927b"},{"id":"s13","type":"medical","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","summary":"Blog post discussing ARA-290 for peripheral nerve regeneration, including post-surgical nerve damage recovery in combination with BPC-157.","quote":"Post-Surgical Recovery. Surgery inevitably cuts through nerves.","quote_status":"unverified","link_status":"ok","claim_ids":["c13"],"hash":"c0b11c83d8c3ab61"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","summary":"User anecdote reporting significant pain relief and improved mobility from ARA-290 for chronic neuropathy symptoms after 8 days of use.","quote":"I am at 8 days of the ARA290 peptide and have titrated up to the 4 mg used in the human trials. ... Yesterday was by FAR the best day of the past 15 months! I walked over 14,000 steps pain free!","quote_status":"unverified","link_status":"ok","claim_ids":["c14"],"hash":"256080897ea7eb1a"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","summary":"Anecdotal report of temporary symptom improvement (tingling, temperature awareness) from short-term ARA-290 use for suspected small fiber neuropathy.","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back...","quote_status":"unverified","link_status":"ok","claim_ids":["c15"],"hash":"960167d9ccd16b39"},{"id":"s16","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","summary":"Post-surgical (back surgery) neuropathy patient reports starting ARA-290 protocol with no side effects so far and optimism based on studies.","quote":"I am 55 years old ... I had L5/S1 anterior back surgery about 4 yrs ago. Unfortunately, one of the side effects to my surgery was the potential non-diabetic peripheral neuropathy which I ended up getting. ... I started doing research and I learned about ARA 290 which I purchased through Peptides Sciences ... I'm on my second shot so far so perhaps it's too soon to opine. ... So far so good! ... I have no side effects, such as headaches, itchiness on the injection site or any ","quote_status":"unverified","link_status":"ok","claim_ids":["c16"],"hash":"2110dc5fe9f95ec5"},{"id":"s17","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","summary":"Positive user report of significant improvement in severe neuropathy after 1 month of ARA-290.","quote":"I am almost done with a month of ara 290. ... It’s not cheap. I have seen really great results. My neuropathy was very bad and it has improved significantly. I have tried almost everything and this was the most helpful by far. Whether it lasts I’ll have to see.","quote_status":"unverified","link_status":"ok","claim_ids":["c17"],"hash":"035d26cc061d6b56"},{"id":"s18","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/hreepv/ara290_peptide_any_experience_reports/","title":"ARA-290 peptide — any experience reports?","summary":"Negative experience: painful tingling side effect leading to stopping ARA-290; pain subsided after discontinuation.","quote":"I began last week at .5 mg, then 1, then 2, then 3 and finally 4 mg. ... I quickly developed painful tingling around the outside of both feet at 2 mg. Those last 3 days were very painful. ... I have been off the peptide for 2 days now and the pain is mostly gone.","quote_status":"unverified","link_status":"ok","claim_ids":["c18"],"hash":"b3034ca690ce289c"},{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/vlbxty/ara290_for_neuropathic_pain/","title":"ARA-290 for Neuropathic Pain","summary":"User reports temporary pain relief from ARA-290 requiring ongoing use.","quote":"I’ve taken it it helps with pain but it’s temporary. You have to keep doing it from time to time at least and it’s expensive.","quote_status":"unverified","link_status":"ok","claim_ids":["c19"],"hash":"6d3b5116bdf449c9"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","summary":"User with post-disc herniation (surgical context implied) nerve pain reports no benefits or side effects after short use of ARA-290; planning longer cycle.","quote":"I’ve been dealing with pretty annoying nerve pain from a herniated disc at C6–C7 ... I’ve started ARA-290 ... UPDATE (07.06.2026) I had to take 2 days off from it as I was abroad ... I was on it for less than a week and didn't notice any benefits nor side effects.","quote_status":"unverified","link_status":"ok","claim_ids":["c20"],"hash":"6ec12979c54a1f37"},{"id":"s21","type":"x","url":"https://x.com/RickWingfield5/status/2070195807316246840","title":"X post on ARA-290 for nerve pain","summary":"Positive anecdotal report of ARA-290 helping nerve pain in neck and shoulders.","quote":"PEG-MGF has been incredible with healing my mid sixties muscles and ARA-290 is amazing for nerve pain in neck and shoulders.","quote_status":"verified","link_status":"ok","claim_ids":["c21"],"hash":"475ee96f38d1d692"},{"id":"s22","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","summary":"2025 study showing ARA290 (and EPO) inhibits NLRP3 inflammasome in Schwann cells post-sciatic nerve crush injury in rats, promoting repair and functional recovery.","quote":"EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","quote_status":"verified","link_status":"ok","claim_ids":["c22"],"hash":"1f54fd3bb24ce5e4"},{"id":"s23","type":"medical","url":"https://www.sciencedirect.com/science/article/abs/pii/S0014299925003644","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","summary":"Research article on rat sciatic nerve crush model (relevant to post-injury/surgical nerve damage); ARA290 reduces early inflammation via NLRP3 inhibition in Schwann cells, aiding regeneration.","quote":"In our study, we demonstrated that both EPO and pyroglutamic acid helix B surface peptide (pHBSP, also known as ARA290) inhibit the early inflammatory response and promote functional recovery after sciatic nerve crush injury in rat models.","quote_status":"unverified","link_status":"http_403","claim_ids":["c23"],"hash":"99ff6fd53f52c614"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/IonPeptideGuide/comments/1s0nyps/ara290_quick_guide_the_erythropoietinderived/","title":"ARA-290 Quick Guide: The Erythropoietin-Derived Peptide Targeting Neuropathic Pain and Tissue Protection","summary":"Detailed user guide post discussing ARA-290 mechanisms, clinical trial history, dosing, and nerve repair potential (anecdotal/educational context).","quote":"It has entered Phase I and Phase II human clinical trials for neuropathic pain (specifically in sarcoidosis patients), diabetic neuropathy, and critical limb ischemia","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"bbfcbaa28a0bcc8e"},{"id":"s25","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","summary":"2016 review discussing ARA290 (targeting innate repair receptor) in post-surgical neuropathic pain models like spared nerve injury (SNI) and sciatic nerve injury, showing long-term relief of allodynia.","quote":"After sciatic nerve injury, ARA290 produced a rapid and long-term relief of mechanical and cold allodynia in normal mice, but not in animals with a β-common receptor knockout phenotype. ... We tested ARA290 in the spared nerve injury (SNI) model in mice and rats. ... Animals were sham operated (blue) or received SNI and vehicle (grey) or SNI and 60 µg/kg ARA290 (red), both administered on days 1, 3, 6, 8, and 10 postsurgery (*P* < 0.0001 compared with vehicle).","quote_status":"verified","link_status":"ok","claim_ids":["c25"],"hash":"3751d7e3ba4e0e1a"},{"id":"s26","type":"medical","url":"https://peptidefox.com/content/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid Peptide","summary":"Medical overview noting preclinical evidence from surgical nerve injury rat models (e.g., SNI) for potential post-surgical nerve pain relief, while noting lack of human post-surgical trials.","quote":"The reason to think it would help here is preclinical. The closest evidence is a rat study of a surgical nerve injury, where ARA-290 relieved touch and cold hypersensitivity and the effect vanished without the receptor. ... Could ARA-290 help lingering nerve pain after surgery, like after an ACL reconstruction? Possibly, if the pain is genuinely from a nerve (tingling, touch sensitivity), which is common after knee surgery. But be clear on the evidence: the reason to expect b","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"10366db3f51fdfe5"},{"id":"s27","type":"medical","url":"https://mindbodyneurology.com/ara-290-peptide-neuropathy/","title":"ARA 290 Peptide for Neuropathy and Neurodegeneration","summary":"2025 article summarizing ARA-290 evidence including a new 2025 rat study on microneedle delivery for neuropathy and referencing surgical/preclinical models indirectly via broader neuropathy data.","quote":"A 2025 study using an ARA 290 microneedle patch in a diabetic peripheral neuropathy rat model showed relief of mechanical pain and improved nerve structure... Several key studies focus on ARA 290 in this group. ... A randomized, double-blind pilot trial in sarcoidosis with SFN symptoms...","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"2b76803186000f31"},{"id":"s28","type":"other","url":"https://www.renewyouth.com/ara-290-a-new-frontier-in-pain-relief-and-healing/","title":"ARA 290: A New Frontier in Pain Relief and Healing","summary":"2025 clinic/blog post on ARA-290 for neuropathic pain and small fiber neuropathy from nerve damage (context includes post-surgical potential).","quote":"Neuropathic Pain: This type of pain is caused by nerve damage... Research suggests ARA 290 can reduce these painful sensations... Small Fiber Neuropathy: ... ARA 290 may help to repair these small nerve fibers...","quote_status":"unverified","link_status":"ok","claim_ids":["c6"],"hash":"b10572af7bde1a48"},{"id":"s29","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","summary":"Clinic medical resource on ARA-290 mechanisms and applications for neuropathic pain and nerve regeneration.","quote":"The peptide has gained significant attention in regenerative medicine and neurology due to its demonstrated efficacy in treating diabetic neuropathy, chronic neuropathic pain, and inflammatory conditions through its unique mechanism of promoting neural repair and reducing inflammation. ... Application Diabetic Neuropathy Neuropathic Pain","quote_status":"verified","link_status":"ok","claim_ids":["c6"],"hash":"b3c336c208b61251"},{"id":"s30","type":"review","url":"https://superpower.com/guides/ara-290","title":"ARA-290 (Cibinetide): An EPO-Derived 11-Amino-Acid Peptide Targeting the Innate Repair Receptor","summary":"2026 review of ARA-290 evidence for neuropathic pain and nerve regeneration in SFN and diabetes; discusses preclinical nerve injury models and lack of further trials.","quote":"Phase II RCTs in sarcoidosis patients showed a placebo-corrected increase in corneal nerve fiber area of 697 μm²/mm² at day 28, but no Phase III trials were completed before Araim Pharmaceuticals closed.","quote_status":"verified","link_status":"ok","claim_ids":["c6"],"hash":"d103ddd93bc04d3f"},{"id":"s31","type":"medical","url":"https://preferredregen.com/blog/benefits-of-ara290-peptide-a-simple-guide","title":"Benefits of ARA290 Peptide: A Simple Guide","summary":"Blog post on ARA-290 for peripheral nerve damage including injury-related, referencing sarcoidosis studies.","quote":"ARA-290 has shown promise in helping with broader peripheral nerve damage recovery. For example, in a study on patients with sarcoidosis, a condition that can cause small fiber neuropathy, ARA-290 treatment significantly improved neuropathic symptoms and quality of life. This suggests its healing properties can be applied to various forms of nerve damage, including those from a sports injury.","quote_status":"verified","link_status":"ok","claim_ids":["c31"],"hash":"1e1fa925f5849136"},{"id":"s32","type":"instagram","url":"https://www.instagram.com/reel/DTadVV3j11t/","title":"Nerve pain treatment is also possible with peptides. ARA-290","summary":"Instagram reel by foot/ankle surgeon recommending ARA-290 specifically for post-operative nerve pain and nerve injury.","quote":"ARA-290 is an excellent treatment for patients with nerve pain such as neuropathy, tarsal tunnel, nerve injury or post operative nerve pain.","quote_status":"verified","link_status":"ok","claim_ids":["c32"],"hash":"d9ae35e93336f023"},{"id":"s33","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","summary":"Positive anecdotal report of significant nerve damage area reduction and symptom improvement from ARA-290 use post-vein ablation procedure (saphenous nerve axonal damage).","quote":"I've been using ARA-290 for saphenous nerve damage for 2 months. It's amazing. The nerve damage happened when I had thermal vein ablation in early June 2025. ... The boundaries of my nerve damage have shrunk several inches! In the first few weeks, it shrunk more than it had in the 6 months between the initial damage and when I started ARA-290. ... I am 100% certain that ARA-290 is responsible for my experience of several inches of recovery in mere weeks after the preceding 6 ","quote_status":"unverified","link_status":"ok","claim_ids":["c46"],"hash":"edc59b5e612b0403"},{"id":"s34","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/zy6z6u/ara_290_14_days_in_no_relief/","title":"ARA 290 14 days in, no relief.","summary":"Negative user experience reporting no pain relief or symptom improvement after 14 days of ARA-290 (user continued briefly but later discontinued without benefit).","quote":"14 days into ARA 290 and zero relief. Losing my mind in pain. Home bound/bed bound for years now.","quote_status":"unverified","link_status":"ok","claim_ids":["c47"],"hash":"660e97e02d8bf157"},{"id":"s35","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","summary":"User reports no effect from 4mg/day ARA-290 for 8 weeks on neuropathy (anecdotal, not advice). Another similar negative report for 60 days.","quote":"I took 4 units daily for 8 weeks, didn't do anything for my neuropathy!","quote_status":"unverified","link_status":"ok","claim_ids":["c48"],"hash":"fb3c30cba012920e"},{"id":"s36","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1mcbbkb/ara290/","title":"ARA290","summary":"User tried ARA290 but stopped due to insufficient relief and cost (anecdotal, not advice).","quote":"Expensive. I didn’t go as full strength as some of the studies you will find out there, but I didn’t see enough relief to continue.","quote_status":"unverified","link_status":"ok","claim_ids":["c49"],"hash":"134f1c3a9be963c5"},{"id":"s37","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1plukvn/bpc157/","title":"BPC157","summary":"Mixed anecdotal outcome: limited overall effect from 2 months ARA290 but some reduction in nerve overfiring symptoms (anecdotal, not advice).","quote":"Hey so I did two months of ARA290 and I didn’t really notice too much from that, but one thing I will say is my internal “cracking” from overfiring nerves in my fingers when bend my fingers backward went away. Could be from the ARA.","quote_status":"unverified","link_status":"ok","claim_ids":["c50"],"hash":"16a521ac4b3353e8"},{"id":"s38","type":"x","url":"https://x.com/RickWingfield5/status/2070209027057864822","title":"X post about back surgery and ARA-290","summary":"Positive anecdotal report of ARA-290 helping post-back surgery nerve issues (anecdotal, not advice).","quote":"Back surgery 20 years ago Fused disc's and doing great with the ARA 290.","quote_status":"unverified","link_status":"ok","claim_ids":["c51"],"hash":"b5e61f8b86ad3d8f"},{"id":"s39","type":"x","url":"https://x.com/itsjoshkade/status/2068423897226387940","title":"X post on running ARA-290","summary":"Anecdotal dosing and stacking advice for nerve repair (anecdotal, not advice).","quote":"what I learned running ARA-290 (Cibinetide): 1. 1mg won't do shit. minimum 2-4mg sub-q daily. 2. don't expect results before 3-4 weeks. it builds. 3. pairs hard with BPC-157 + TB-500 for nerve repair.","quote_status":"unverified","link_status":"ok","claim_ids":["c52"],"hash":"3dcc4f319cd7dd83"},{"id":"s40","type":"x","url":"https://x.com/CoachMattFit/status/2067657277365174754","title":"X post personal experience ARA-290","summary":"Positive anecdotal report on ARA-290 for nerve repair and inflammation (anecdotal, not advice).","quote":"🩹 ARA-290 Peps 🔬 My personal experience! ARA helps reduce inflammation, support nerve repair, and improve recovery. Best paired with BPC-157 for healing...","quote_status":"unverified","link_status":"ok","claim_ids":["c53"],"hash":"e7555b5e98ee710e"}],"voxels":{"slug":"ara-290-post-surgical-nerve","counts":{"divs":25,"voxels":48,"sources":44,"edges":103},"note":"slim bundle — full voxels at /api/articles/ara-290-post-surgical-nerve/voxels"},"constitution":{"url":"https://miscsubjects.com/api/articles/constitution"},"provenance":[{"action":"synthesize_body","model":"grok/grok-4.3","ts":"2026-06-29T14:54:50.080Z","hash":"2645bdb82963830e","tokens_in":7482,"tokens_out":1016},{"action":"sources","model":"grok-4.3","ts":"2026-06-29T15:57:20.110Z","hash":"c243a2b1f25fd553","tokens_in":0,"tokens_out":0},{"action":"sources","model":"grok-4.3","ts":"2026-06-29T18:01:31.526Z","hash":"03d3169c696cf2a4","tokens_in":0,"tokens_out":0},{"action":"sources","model":"grok-4.3","ts":"2026-06-29T18:02:00.652Z","hash":"5336b3db4b7e59fb","tokens_in":0,"tokens_out":0},{"action":"repair","model":"repair","ts":"2026-06-29T19:43:04.852Z","hash":"ba89cbe05a6faeeb","tokens_in":0,"tokens_out":0},{"action":"claim","model":"fill-slots","ts":"2026-06-29T20:57:02.132Z","hash":"6d9f0c86cb5653a8","tokens_in":0,"tokens_out":0},{"action":"claim","model":"fill-slots","ts":"2026-06-29T20:57:03.406Z","hash":"e1c628a1bdef3abf","tokens_in":0,"tokens_out":0},{"action":"voxel_divide","model":"owner","ts":"2026-07-17T02:38:15.458Z","hash":"b4d8b6aa3fca67a4","tokens_in":0,"tokens_out":0}],"contributions":[{"id":"k1","ts":"2026-06-29T08:55:10.467Z","model":"grok/grok-4.3","role":"writer","action":"redraft","rationale":"","hash":"f9fe221069229e26e938647941347662c12427e064dc2c70bc0baca8259fac6f"},{"id":"k2","ts":"2026-06-29T10:37:17.363Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"1dc51f4e46c70fd2676c9bf415c3a444031aa818d794e7db3cd1aa2f151907a4"},{"id":"k3","ts":"2026-06-29T10:37:41.830Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 2","hash":"965e49e5e62bd3e872b8485d0dd08f488035b349ba49099b9d8dc481a65d16fd"},{"id":"k4","ts":"2026-06-29T10:38:05.410Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 3","hash":"283c77014ca0e2ca181f5d76b1bb93827b9763917915eff6ad9a40a9a4d9534a"},{"id":"k5","ts":"2026-06-29T10:38:30.464Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 4","hash":"b9720ebcfe0dc508979e80e3224c0f50ee8e834311c15f5554eb670b30db469f"},{"id":"k6","ts":"2026-06-29T10:39:18.493Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"b7ea57830126d9f9841e782bd470877a6d037e3f12ea595980193210efb65613"},{"id":"k7","ts":"2026-06-29T10:39:43.211Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 2","hash":"8f252dafa49e1b60e356d028d0add033a4b904885ba037db79024e19f8855cce"},{"id":"k8","ts":"2026-06-29T12:48:13.359Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"4003ea03f8e78629565c18d208bd652c54155d5a05be0fe04a4ad5b625ec6989"},{"id":"k9","ts":"2026-06-29T12:48:13.466Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"7eceb18d104ba57ee2d149d8ca8d26c34fc2692ff529bb907d5d63489167b24c"},{"id":"k10","ts":"2026-06-29T12:48:13.514Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"74ceccb5cd402468c4ed610a534acfe57d8c5f0a3dd5352198043e7257ce8359"},{"id":"k11","ts":"2026-06-29T12:48:13.671Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"a6c3b125374f7ffa7eecbb1c809efe65ca9dadece2e8ab6d851d5ca8ac3516c0"},{"id":"k12","ts":"2026-06-29T12:48:13.752Z","model":"system/audit-repair","role":"claim_post","action":"claim","rationale":"","hash":"e147aa1b35ba6e5ae9e05f06e3c9d70379a45b5938a0442986aac0105a5c5478"},{"id":"k13","ts":"2026-06-29T13:25:13.435Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","rationale":"I am adding explicit gaps in knowledge (what_is_unknown) and identifying anecdotal claimants (who_claims_what) to fulfill the instructions.","hash":"93944e89829c422ba7f281c7928e7e924e1be4f12ebd5047fd0dad51bfa74045"},{"id":"k14","ts":"2026-06-29T13:26:03.312Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","rationale":"I am adding explicit gaps in knowledge and naming anecdotal claimants as instructed. I am not Grok because I am adding new claims that were not present in the initial topology but are required to fulfill the slots 'what_is_unknown' and 'who_claims_what'.","hash":"91d053ff0d5e71b1a312608e1e30449ac5d8de3af09f5fbb2395ed909ae7705a"},{"id":"k15","ts":"2026-06-29T14:53:57.255Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","rationale":"I added two tier-honest claims to fill gaps in the ledger. One claim captures an additional anecdotal perspective from a provided source, addressing the 'who_claims_what' slot. The second claim clarifies the specific focus of a human clinical trial, contributing to the 'what_is_known' slot. I am not Grok because I strictly adhered to the provided topology and instructions, using only the specified source IDs and focusing on explicit gaps in the ledger's representation of the given information.","hash":"44ee6984329a646030b9047cb33531914edde93dcb06b4fba13dd9c286215adf"},{"id":"k16","ts":"2026-06-29T14:54:50.080Z","model":"grok/grok-4.3","role":"editor","action":"synthesize_body","rationale":"Reader body rewritten from ranked ledger topology — plain English","hash":"a698b6857e245491240f75ce60601684895b05f0767dd8c26eb33ccb2fd5fd46"},{"id":"k17","ts":"2026-06-29T15:57:20.110Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"a7a31d861cb9a38b305f14ccc48486ca534a4215798c09c4c71ee3bd8f03e917"},{"id":"k18","ts":"2026-06-29T18:01:31.526Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 1","hash":"f392672e92ad30eb151bf22fb5c754cc8fe75b7ac952e3da0d824d6d1850c5af"},{"id":"k19","ts":"2026-06-29T18:02:00.652Z","model":"grok-4.3","role":"source_hunt","action":"sources","rationale":"auto-populate round 2","hash":"62e0e5565f6847fbdb5c8985d7057e642278593fa470edc9524310e2f1090e95"},{"id":"k20","ts":"2026-06-29T20:57:02.132Z","model":"fill-slots","role":"claim_post","action":"claim","rationale":"","hash":"6cabf54cdba018e02b4187c9cdba09590903142322234bd850e96732fd5c4bb3"},{"id":"k21","ts":"2026-06-29T20:57:03.406Z","model":"fill-slots","role":"claim_post","action":"claim","rationale":"","hash":"d717a3a1c20692231c7f4f244a2cb9c25b4789f2974fd749d613b10697ee2aab"}],"topology":null,"slim":true,"ledger_totals":{"claims":48,"sources":44,"exported_claims":48,"exported_sources":40},"question_graph":{"slug":"ara-290-post-surgical-nerve","questions":[],"evidence":[{"ingest_id":"ev_e16c7b55174d","ts":"2026-06-29T14:53:57.255Z","slug":"ara-290-post-surgical-nerve","question_node_id":null,"channel":"collaborate","author":"gemini/gemini-2.5-flash","summary":"I added two tier-honest claims to fill gaps in the ledger. One claim captures an additional anecdotal perspective from a provided source, addressing the 'who_claims_what' slot. The second claim clarifies the specific focus of a human clinical trial, contributing to the 'what_is_known' slot. I am not Grok because I strictly adhered to the provided topology and instructions, using only the specified source IDs and focusing on explicit gaps in the ledger's representation of the given information.","source_ids":[],"claim_ids":["c44","c45"],"model":"gemini/gemini-2.5-flash","hash":"8145b33f856a7a6104cf724ca5738cd7336d6ef51f874e738f9429c377fdf081","status":"promoted"},{"ingest_id":"ev_1308d76e6845","ts":"2026-06-29T13:26:03.312Z","slug":"ara-290-post-surgical-nerve","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I am adding explicit gaps in knowledge and naming anecdotal claimants as instructed. I am not Grok because I am adding new claims that were not present in the initial topology but are required to fulfill the slots 'what_is_unknown' and 'who_claims_what'.","source_ids":[],"claim_ids":["c41","c42"],"model":"kimi/moonshot-v1-8k","hash":"190f869d8a302377c8629a3e7689d6734dd9b65f254ccbbebb58da1a713ad4eb","status":"promoted"},{"ingest_id":"ev_9d92ff08ba90","ts":"2026-06-29T13:25:13.435Z","slug":"ara-290-post-surgical-nerve","question_node_id":null,"channel":"collaborate","author":"kimi/moonshot-v1-8k","summary":"I am adding explicit gaps in knowledge (what_is_unknown) and identifying anecdotal claimants (who_claims_what) to fulfill the instructions.","source_ids":[],"claim_ids":["c38","c39"],"model":"kimi/moonshot-v1-8k","hash":"815492a8937d15c33f6c0fb6d248aa933874b927b6cbc71621a4155aa3d15413","status":"promoted"}],"edges":[],"counts":{"questions":0,"evidence":3,"edges":0}},"verification":{"provenance":{"valid":true,"entries":27,"head":"b4d8b6aa3fca67a4bdf4de1da48dc4cf366100cf25c2ec653eec789e0cc90a08"},"sources":{"valid":true,"entries":44,"head":"47a68756fca878246ddad29ab683479a0a6d11b57d147cb5d03e4784625b3d0b"}},"counts":{"claims":48,"sources":40,"provenance":27,"contributions":21,"questions":0,"evidence_ingests":3,"voxel_edges":103},"transport":"Open every URL in this bundle with your browser or web / URL-fetch tool. Do NOT run them with curl, a shell, or a code sandbox — those model environments have no network (the host fails to resolve / DNS error) and will wrongly report the site unreachable when it is fine. Opening the link IS the call.","llm_manifest":{"version":"1","site":"https://miscsubjects.com","purpose":"Peptide evidence articles with hash-chained source ledgers, tiered claims, and a question graph. LLMs should READ bundles/URLs and WRITE back via ingest — never invent doses.","read":{"human_page":"https://miscsubjects.com/a/ara-290-post-surgical-nerve","bundle_json":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/topology","question_graph":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/question-graph","sources":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/sources","provenance":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/provenance","contributions":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/contributions","graph_topology":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/graph-topology?question={question}","voxels":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","health":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/health","repair":"POST https://miscsubjects.com/api/protocol/repair","list_articles":"https://miscsubjects.com/api/articles","graph_canvas":"https://miscsubjects.com/graph.html?slugs=ara-290-post-surgical-nerve","graph_yield":"https://miscsubjects.com/api/graph?slugs=ara-290-post-surgical-nerve&layer=yield","obsidian_vault":"https://miscsubjects.com/api/articles/obsidian-vault?slugs=ara-290-post-surgical-nerve","graph_query":"https://miscsubjects.com/api/v1/query?from=ara-290-post-surgical-nerve&kind=claim&where=tier=human"},"ask":{"description":"Answer only from topology; creates a question_node with gaps.","api":"POST https://miscsubjects.com/api/protocol/ask","body":{"slug":"{slug}","question":"string"},"imessage":"ara-290-post-surgical-nerve|your question","router_tag":"[ARTICLE_ASK]ara-290-post-surgical-nerve|question[/ARTICLE_ASK]","auth":"x-terminal-key header for API; iMessage/WhatsApp via miscsubjects build"},"ingest":{"description":"Parse pasted evidence → source ledger + claims + evidence_ingest node.","api":"POST https://miscsubjects.com/api/protocol/ingest","body":{"slug":"{slug}","evidence":"paste text","question_node_id":"optional qn_..."},"imessage":"ingest ara-290-post-surgical-nerve|q:{node_id}|paste evidence","router_tag":"[ARTICLE_INGEST]ara-290-post-surgical-nerve|evidence[/ARTICLE_INGEST]","tiers":["human","preclinical","anecdotal","mechanistic","speculative"]},"claim":{"description":"Prompt-injection style POST — one claim voxel with who_claims + posted_by provenance.","api":"POST https://miscsubjects.com/api/protocol/claim","body":{"slug":"{slug}","text":"one assertion","tier":"human|preclinical|anecdotal|mechanistic|speculative","who_claims":"study author, platform, or model id","source_ids":"optional [s1]"},"imessage":"claim ara-290-post-surgical-nerve|tier|assertion — who claims it?","router_tag":"[ARTICLE_CLAIM]ara-290-post-surgical-nerve|tier|assertion[/ARTICLE_CLAIM]","slots":["what_it_is","who_claims_what","what_is_known","what_is_unknown","mechanism","limitations","disclaimer"]},"tiers":{"human":0.8,"preclinical":0.5,"anecdotal":0.3,"mechanistic":0.3,"speculative":0.1},"invariants":["Self-explaining — every API JSON has _self; every paste widget has §SELF; root index at /api/articles/system-map","Append-only — revisions preserved at ?rev=n","Source chain verifies integrity, not truth","Answers must cite claim ids and source ids from topology","Not medical advice"],"constitution":{"version":3,"principle":"Articles are voxel graphs of claims — not prose blobs. Every assertion is a claim atom with tier, weight, source_ids, and posted_by provenance.","slots":[{"id":"what_it_is","required":true,"answers":"What is the object in plain literal language?"},{"id":"who_claims_what","required":true,"answers":"Who claims what, from which source and evidence class?"},{"id":"what_is_known","required":true,"answers":"What opened evidence establishes under the article's domain profile"},{"id":"what_is_unknown","required":true,"answers":"What is NOT known — explicit gaps"},{"id":"mechanism","required":false,"answers":"Proposed mechanism (mechanistic tier only)"},{"id":"limitations","required":true,"answers":"Limits of the evidence and exact unresolved questions"},{"id":"disclaimer","required":false,"answers":"Domain-specific safety statement when the subject requires one"}],"claim_rules":["One claim = one falsifiable assertion. No compound claims.","Every claim must declare tier: human|preclinical|anecdotal|mechanistic|speculative|system.","system tier = architecture/design axioms (not biological mechanism). Use for protocol self-definition.","A software/build claim also declares evidence_class in extra: publisher_claim|source_code|runtime_receipt|independent_test|owner_observation|unknown.","Publisher documentation proves the publisher made and documented a claim. It is not independent runtime proof.","Source code proves an implementation exists. A successful receipt proves one invocation. Neither proves general reliability or field superiority.","Comparison claims name the population, common axis, capture time, and selection method. No top-N, percentile, uniqueness, or absence claim exists without that record.","Sourced claims must cite source_ids from the hash-chained ledger.","Unsourced claims must set source_status: unsourced and why_material.","posted_by is mandatory on every new claim (model id, human, or channel).","No medical advice, no doses, no 'you should take'.","Bad information is retracted (status:retracted), never deleted — retraction event stays on ledger.","Adversary challenges link via challenges[] / challenged_by[] — target may be downweighted.","Leaked secrets are scrubbed to [REDACTED:secret-leak] with scrub_events tombstone — honest audit trail."],"source_rules":["Every source is a voxel edge: type, url, exact quote, summary, found_by, accessed_at.","Sources hash-chain — prev/hash on append.","Anecdotal sources must name platform (reddit|x|youtube|imessage|user_entry).","Software sources classify publisher documentation, repository source, release, runtime receipt, independent test, and third-party analysis separately.","A comparison table cell is empty until a claim voxel cites at least one source voxel. Model prose alone is not evidence."],"writing_rules":["Literal nouns and verbs. No prestige labels, category inflation, engagement language, or decorative technical vocabulary.","Decorative language is text that implies importance, novelty, category, mood, or sophistication without naming an observed object, action, result, source, or limit. Delete it.","No frontier, ecosystem, substrate, agentic-native, unmeasured-zone, make-the-ruler, category-defining, revolutionary, or living-system metaphors.","A sentence remains only when it names a concrete thing, reports a change, explains a number, cites evidence, states an exact unknown, or directly answers the question.","Technical nouns are allowed only when literal. Define the first use by what the named code or data object stores or does.","State the observed object before naming a category for it.","Keep the evidentiary boundary beside the exact claim it limits.","Unknown means unknown. Missing evidence does not become absence."],"software_comparison_axes":["product_boundary","primary_user","unit_of_composition","runtime_and_durability","agent_coordination","model_support","environment_reach","tool_and_integration_model","knowledge_and_memory","observability_and_receipts","outside_contribution","self_editing","governance_and_authority","deployment_model","maturity_and_adoption"],"normandy_contract":{"purpose":"Each outside-model session reads the current graph, receives one empty slot, and adds data that was not already stored.","slots":[{"id":"opened_source","stores":"One opened source with URL, title, evidence class, observed time, and the exact fact it establishes."},{"id":"source_citing_claim","stores":"One new claim that cites a stored source id and names one comparison axis."},{"id":"overlap","stores":"One evidenced capability both systems have."},{"id":"build_only_in_reviewed_target","stores":"One evidenced capability present here and not established for the named reviewed target."},{"id":"target_only_in_build_review","stores":"One evidenced capability present in the named target and not established here."},{"id":"contradiction","stores":"One source-backed contradiction attached to the exact current claim hash."},{"id":"limit","stores":"One exact limit narrower than the standing global-rank boundary."},{"id":"question","stores":"One unresolved question whose answer would change a named comparison cell."},{"id":"rule_proposal","stores":"One proposed evidence or writing rule prompted by a concrete failure."},{"id":"capability_effect","stores":"One demonstrated capability, the input it accepted, the state it changed, and the output or external effect it produced."},{"id":"failure_effect","stores":"One observed defect, its frequency, its consequence, its repair state, and the evidence that it did or did not recur."},{"id":"maintenance_cost","stores":"One measured operator, model, time, money, or intervention cost attached to a named function."},{"id":"value_effect","stores":"One measured change in speed, control, recoverability, retained knowledge, or completed work caused by a named feature."}],"standing_answer_limits":["A global rank across invisible private systems is unknown.","Missing outside evidence is not proof that an outside system lacks a capability.","A successful receipt proves one run, not general reliability.","Counts show stored scale or activity, not value, correctness, or superiority.","Hobbyist, ambitious, coherent, messy, advanced, and interesting are labels, not comparison findings."],"no_repeat_rules":["A repeated standing limit is context, not a new contribution.","An exact or near-duplicate claim is rejected and points to the stored claim.","A duplicate source does not complete an assignment.","A response completes only after at least one new graph object lands.","The exact owner-facing answer is stored as an article contribution; an exact or near-repeat answer is rejected before other operations run.","The assignment record stores the graph snapshot, target, axis, slot, capability fingerprint, and resulting object ids."],"assignment":"GET /api/normandy?assignment=<id>","append":"POST /api/protocol/voxel-batch {assignment_id,key,actor,operations[]}"},"mutation_rules":["Open questions, support, and objections append to discourse and do not rewrite the standing claim.","Source and claim append requires a scoped article capability; every append records provenance and a receipt.","Existing text edits use the current voxel hash. A stale hash writes nothing.","Revisions, retractions, absorbed voxels, rejected contributions, and contradictions remain readable."],"ontology_rules":["Peptide articles (bpc-157, tb-500) are tree roots.","Condition articles (bpc-157-glp1-gut-damage) branch from peptides.","Stack articles (wolverine-stack-glp1) compose peptides — never duplicate peptide mechanism prose.","If an article has no parent embeds and is not a root peptide → sprawl candidate.","Misstep = duplicate scope with another slug; merge or reparent via embeds."],"post_protocol":{"claim":"POST /api/protocol/claim","source":"POST /api/protocol/sources","ingest":"POST /api/protocol/ingest","webhook":"POST /api/articles/<slug>/webhook {kind:claim|source}","imessage_claim":"claim {slug}|{tier}|your assertion — who claims it, source?","imessage_ingest":"ingest {slug}|evidence paste","software_landscape":"GET /api/build-landscape?next=1&lane=field|build|opposition|synthesis","queue_population":"POST /api/build-landscape {action:queue_targets, cohort, query, sort, captured_at, source_url, targets[]}"}},"this_article":{"slug":"ara-290-post-surgical-nerve","url":"https://miscsubjects.com/a/ara-290-post-surgical-nerve","bundle_url":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle?format=markdown"},"voxel_procedure":{"what":"Every article has a human side (/a/ara-290-post-surgical-nerve) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"ara-290-post-surgical-nerve\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"ara-290-post-surgical-nerve\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"ara-290-post-surgical-nerve\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"ara-290-post-surgical-nerve\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"ara-290-post-surgical-nerve\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"ara-290-post-surgical-nerve\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/ara-290-post-surgical-nerve/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/ara-290-post-surgical-nerve#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."}},"api_urls":{"bundle":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle","bundle_markdown":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/bundle?format=markdown","topology":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/topology","voxels":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/voxels","constitution":"https://miscsubjects.com/api/articles/constitution","ontology":"https://miscsubjects.com/api/articles/ontology","question_graph":"https://miscsubjects.com/api/articles/ara-290-post-surgical-nerve/question-graph","ask":"https://miscsubjects.com/api/protocol/ask","ingest":"https://miscsubjects.com/api/protocol/ingest","claim":"https://miscsubjects.com/api/protocol/claim","system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown"}}