{"slug":"ara-290-herniated-disc","verification":{"valid":true,"entries":23,"head":"c30025929fee8756e6c7a2037b6735929a748c1bbad3979b0edd82e3d4cef8ed"},"energy":{"passes":23,"tokens_in":14532,"tokens_out":2020,"tokens_total":16552,"cost_usd":0,"models":{"grok/grok-4.3":2,"grok-4.3":6,"system/audit-repair":8,"kimi/moonshot-v1-8k":2,"gemini/gemini-2.5-flash":1,"repair":1,"fill-slots":2,"owner":1},"head":"c30025929fee8756e6c7a2037b6735929a748c1bbad3979b0edd82e3d4cef8ed"},"provenance":[{"ts":"2026-06-29T08:50:08.816Z","model":"grok/grok-4.3","action":"write","prompt":"","input":"PEPTIDE DEFINITIONS (use for mechanism accuracy; no medical claims):\nBPC-157 — Body Protection Compound. Derived from gastric juice protein. Builds new blood vessels into damaged tissue locally. 100+ animal/cell studies (tendon, gut, muscle, bone, nerve).\nTB-500 — Synthetic Thymosin Beta-4. Moves repair cells to damage; clears stuck inflammation systemically. Production drops ~60% by age 60.\nARA-290 — Nerve repair peptide with human clinical trial data. Regrows damaged nerves; does not mask nerve pain.\nSemax — Brain peptide; upregulates BDNF for neuroprotection and cognitive recovery.\nSelank — Anxiolytic peptide; reduces anxiety without sedation or addiction (non-benzodiazepine pathway).\nPT-141 — Sexual function; brain-level arousal signaling (FDA-approved mechanism as Vyleesi).\nDSIP — Delta Sleep Inducing Peptide; natural deep sleep without Ambien-class hangover.\nKPV — Gut-specific anti-inflammatory; calms gut lining without systemic immune suppression.\nGHK-Cu — Tissue remodeling; builds collagen scaffolding. Production drops 60-80% with age.\nThymosin Alpha-1 — Immune modulation; supports immune function without suppressing it.\n\nWrite a data-first, evidence-graded article: ARA-290 for Herniated Discs\n\nAudience: 5.7M Americans with herniated discs. The problem: disc compresses nerve; standard treatments mask pain or remove compression but don't repair nerve. Why ARA-290 maps: nerve repair peptide with human clinical trial data; promotes nerve regrowth and function restoration. Novelty: 10/10.\n\nRules: label every claim tier (human|preclinical|anecdotal|mechanistic|speculative). Separate rat studies from human trials from user reports. No medical claims or treatment promises. Use repair-vs-suppression framing where relevant. register: source_ledger.","response":"{\n  \"slug\": \"ara-290-for-herniated-discs\",\n  \"title\": \"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data\",\n  \"body\": \"## Background on Herniated Discs and Nerve Involvement\\nHerniated discs can compress spinal nerves, leading to radiculopathy with pain, sensory changes, and potential nerve damage. Standard approaches focus on pain masking or mechanical decompression; repair of damaged nerves is not addressed by these methods.\\n\\n## ARA-290 Mechanism\\nARA-290 is a synthetic 11-amino acid peptide derived from erythropoietin that selectively activates the innate repair receptor (IRR). This activation is described as reprogramming proinflammatory states toward tissue repair and nerve fiber regrowth in preclinical models (mechanistic tier).\\n\\n## Human Clinical Trial Data\\nPhase 2 randomized, double-blind, placebo-controlled trials in patients with sarcoidosis-associated small fiber neuropathy (n=22) and type 2 diabetes with painful neuropathy (n=48-61) showed reductions in neuropathic symptoms and, in some cases, increased corneal nerve fiber density via confocal microscopy after 28 days of subcutaneous 4 mg daily dosing. No significant adverse effects were reported in these studies (human tier). No human trials have examined ARA-290 in herniated disc or radiculopathy populations (no human data).\\n\\n## Preclinical Evidence\\nAnimal and cell studies demonstrate ARA-290 reduces allodynia, suppresses spinal microglia, and promotes nerve fiber regeneration in neuropathy models (preclinical tier).\\n\\n## User Reports\\nAnecdotal reports on forums mention use of ARA-290 alongside other peptides for sciatica or post-surgical nerve pain from lumbar disc issues, with variable self-reported improvements in pain and function (anecdotal tier).\\n\\n## Evidence Gaps\\nDirect data linking ARA-290 to outcomes in herniated disc nerve compression are absent. All human trials to date involve small fiber neuropathy in sarcoidosis or diabetes contexts.\",\n  \"register\": \"s","tokens_in":0,"tokens_out":0,"cost":0,"prev":"genesis","hash":"7dd2ca1e1a1f838a4040e44e8c741150c154dca5083567cbbeadc6568f12b18a"},{"ts":"2026-06-29T10:28:21.710Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"7dd2ca1e1a1f838a4040e44e8c741150c154dca5083567cbbeadc6568f12b18a","hash":"db34afe5ba316dff5fa0cb69ce42a13f23947b6139287aa69c4f5f5a9ae2f39e"},{"ts":"2026-06-29T10:28:41.451Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"db34afe5ba316dff5fa0cb69ce42a13f23947b6139287aa69c4f5f5a9ae2f39e","hash":"09d084db8794f21c7d1e21c95ff48e937fe108626a6c28114338632d5dda4130"},{"ts":"2026-06-29T12:48:00.324Z","model":"system/audit-repair","action":"repair","prompt":"","input":"ara-290-herniated-disc","response":"{\"materialized\":0,\"before\":[\"missing constitution slots: what_it_is, what_is_known, limitations, disclaimer\"],\"after\":[\"missing constitution slots: what_it_is, what_is_known, limitations, disclaimer\"]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"09d084db8794f21c7d1e21c95ff48e937fe108626a6c28114338632d5dda4130","hash":"d6c0715f47e16d8f15ef10d25825d283369e73468111c2a2c7ca9fca0c845f03"},{"ts":"2026-06-29T12:48:00.896Z","model":"system/audit-repair","action":"claim","prompt":"","input":"ara-290-herniated-disc c18","response":"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"d6c0715f47e16d8f15ef10d25825d283369e73468111c2a2c7ca9fca0c845f03","hash":"1a3d6ab82499da4132edc1d4b6d49bed2ce820d0870bcb33fbea94c4feab5148"},{"ts":"2026-06-29T12:48:00.931Z","model":"system/audit-repair","action":"claim","prompt":"","input":"ara-290-herniated-disc c19","response":"Per this ledger on ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data: 7 scientific and 8 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"1a3d6ab82499da4132edc1d4b6d49bed2ce820d0870bcb33fbea94c4feab5148","hash":"0dc3e7331a2ecbff184eef40c2c12138159bda13ef27ca9d396befaaaf2b5665"},{"ts":"2026-06-29T12:48:00.966Z","model":"system/audit-repair","action":"claim","prompt":"","input":"ara-290-herniated-disc c20","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0dc3e7331a2ecbff184eef40c2c12138159bda13ef27ca9d396befaaaf2b5665","hash":"87d49c0b424e7d5ab51060f889bb561728c452d1d7f56478b9987ac205dcf5e1"},{"ts":"2026-06-29T12:48:01.005Z","model":"system/audit-repair","action":"claim","prompt":"","input":"ara-290-herniated-disc c21","response":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"87d49c0b424e7d5ab51060f889bb561728c452d1d7f56478b9987ac205dcf5e1","hash":"ddc8c274d64bb77e11358270aadad1125a7a82aea2f1a76919d4e8afcfd6e786"},{"ts":"2026-06-29T12:48:01.662Z","model":"system/audit-repair","action":"repair","prompt":"","input":"ara-290-herniated-disc","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ddc8c274d64bb77e11358270aadad1125a7a82aea2f1a76919d4e8afcfd6e786","hash":"f17a659e8c048316309aac445b4a79b51be74d4ec2efdaa84088ab63814508e6"},{"ts":"2026-06-29T12:57:09.230Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"ara-290-herniated-disc","response":"As collaborator #1 on the miscsubjects peptide evidence ledger, I am adding explicit gaps regarding what is unknown about ARA-290's efficacy in treating herniated discs, as well as naming who claims what from anecdotes that were not explicitly attributed.","tokens_in":2758,"tokens_out":371,"cost":0,"prev":"f17a659e8c048316309aac445b4a79b51be74d4ec2efdaa84088ab63814508e6","hash":"2aef1967a888f15cacc7edbe6e9bfaf4f904a949105c78edbef091a2ae0ad656"},{"ts":"2026-06-29T12:58:04.660Z","model":"kimi/moonshot-v1-8k","action":"collaborate","prompt":"","input":"ara-290-herniated-disc","response":"As Kimi, I am adding explicit claims about what is unknown and who claims what from anecdotes that are missing in the ledger. I am not Grok because my role is to provide additional information that fills gaps in the ledger, not to invent new claims or sources.","tokens_in":2758,"tokens_out":340,"cost":0,"prev":"2aef1967a888f15cacc7edbe6e9bfaf4f904a949105c78edbef091a2ae0ad656","hash":"55b70bc4a51ca1508e982c8c3abea826c97e5fcd50dafd6f8e4a481e14461b82"},{"ts":"2026-06-29T13:21:54.816Z","model":"system/audit-repair","action":"repair","prompt":"","input":"ara-290-herniated-disc","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"55b70bc4a51ca1508e982c8c3abea826c97e5fcd50dafd6f8e4a481e14461b82","hash":"0e1be6639906ade741b6b7df0c7144bd261f9b70953791e94b84a973adec1e01"},{"ts":"2026-06-29T13:21:55.967Z","model":"system/audit-repair","action":"repair","prompt":"","input":"ara-290-herniated-disc","response":"{\"materialized\":0,\"before\":[],\"after\":[]}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"0e1be6639906ade741b6b7df0c7144bd261f9b70953791e94b84a973adec1e01","hash":"c129c2115664da2017462137664b0a1ae722d344c255b556b663ddeb767e5a1e"},{"ts":"2026-06-29T14:22:54.857Z","model":"gemini/gemini-2.5-flash","action":"collaborate","prompt":"","input":"ara-290-herniated-disc","response":"As Gemini, I've added two new claims to address gaps in mechanistic understanding and the presence of ARA-290 in general medical discourse, using available sources. I also challenged a claim where the assigned tier did not match the described evidence type, ensuring tier-honest reporting.","tokens_in":2792,"tokens_out":405,"cost":0,"prev":"c129c2115664da2017462137664b0a1ae722d344c255b556b663ddeb767e5a1e","hash":"c4be4fdf26f1b23b3a5c218e503480330e0c97c53cc4bf3e10527ad7725969ec"},{"ts":"2026-06-29T14:23:49.539Z","model":"grok/grok-4.3","action":"synthesize_body","prompt":"","input":"ara-290-herniated-disc","response":"## Regeneration vs degeneration — where this fits\nNerves degenerate when compressed or injured. A herniated disc can press on nerve roots and cause ongoing damage. Repair requires new nerve fiber growth and reduced inflammation around the injury site. ARA-290 is studied for pathways that may support nerve repair rather than only blocking pain signals.\n\n## What it is\nARA-290 is a peptide that targets the innate repair receptor. It is studied in models of small fiber neuropathy and nerve injury. The ledger lists seven studies and seven Reddit posts about it.\n\n## How it works\nThe peptide binds the innate repair receptor. Binding is proposed to shift cells from a damage state to a repair state. One study links this binding to reduced NLRP3 inflammasome activity after sciatic nerve injury.\n\n## Why it would work (logic chain)\nIf the receptor activates repair signals, then inflammation drops and nerve cells receive signals to regrow. If inflammation stays low and regrowth signals continue, then nerve fiber density may increase and pain from damaged nerves may decrease. This chain is tested in neuropathy models and one sciatic nerve injury model.\n\n## Why people take it\nPeople report taking it for nerve pain after disc herniation. They describe sciatica from L4/L5, L5/S1, or C6/C7 discs. The goal stated in posts is reduction of neuropathic pain and support of nerve recovery.\n\n## How many people take it\nThe ledger contains seven Reddit posts and one YouTube comment. No population count exists. Use is unknown outside these reports.\n\n## Evidence inventory\n- Human studies: 2 (s2, s3)\n- Preclinical studies: 3 (s1, s4, s12)\n- Anecdotal sources: 8 (s5–s9, s13–s15)\n- Total sources catalogued: 17\n\n## What scientists say\nSource s1 is a review. It states that ARA-290 reprograms a proinflammatory state into one of healing. Sources s2 and s3 are Phase 2 human trials in sarcoidosis small fiber neuropathy and type 2 diabetes neuropathy. Both report reduced neuropathic symptoms on questionn","tokens_in":6224,"tokens_out":904,"cost":0,"prev":"c4be4fdf26f1b23b3a5c218e503480330e0c97c53cc4bf3e10527ad7725969ec","hash":"e3297b24685bebb4baad724efbfedd5bc9296ac02f807160dff5c8fc0ecee30f"},{"ts":"2026-06-29T15:50:29.058Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"1 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"e3297b24685bebb4baad724efbfedd5bc9296ac02f807160dff5c8fc0ecee30f","hash":"ad525e69ce796fab91b96ebee069c26a1e0bc838e456f145227c7bc7207d2159"},{"ts":"2026-06-29T15:50:53.877Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"4 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"ad525e69ce796fab91b96ebee069c26a1e0bc838e456f145227c7bc7207d2159","hash":"6cc1183a4e9b7c7524288183cc0ae36bcea3e996f46f78c0583ed2ae15f2adfe"},{"ts":"2026-06-29T15:51:25.504Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"6 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6cc1183a4e9b7c7524288183cc0ae36bcea3e996f46f78c0583ed2ae15f2adfe","hash":"6e2504a6d1eaab7ffc2b14e48b9a7b5501bfaf8aeaec453b4227232e9b3ff60e"},{"ts":"2026-06-29T15:52:30.732Z","model":"grok-4.3","action":"sources","prompt":"","input":"ara-290-herniated-disc","response":"5 source(s) added","tokens_in":0,"tokens_out":0,"cost":0,"prev":"6e2504a6d1eaab7ffc2b14e48b9a7b5501bfaf8aeaec453b4227232e9b3ff60e","hash":"024dbc18e1a42d0741ac5fe39a6cb71254155c3ae9abbad5be9eaff8c457cb30"},{"ts":"2026-06-29T19:38:03.239Z","model":"repair","action":"repair","prompt":"","input":"ara-290-herniated-disc","response":"{\"materialized\":0,\"before\":[],\"after\":[],\"focus_stats\":{\"roles_assigned\":0,\"excluded_sources\":0,\"commercial_sources\":0,\"cut_claims\":0,\"core\":2,\"cycle\":3,\"adjacent\":13}}","tokens_in":0,"tokens_out":0,"cost":0,"prev":"024dbc18e1a42d0741ac5fe39a6cb71254155c3ae9abbad5be9eaff8c457cb30","hash":"55357f10608718ccffca7bc286a7bf143171ade0ef465b7c9de12761e7c9f936"},{"ts":"2026-06-29T20:52:03.813Z","model":"fill-slots","action":"claim","prompt":"","input":"ara-290-herniated-disc c45","response":"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"55357f10608718ccffca7bc286a7bf143171ade0ef465b7c9de12761e7c9f936","hash":"30bbee1e0bc41cf2685ffd0b3fd5ed492701eb86815a349f26ab13aad0e9f45c"},{"ts":"2026-06-29T20:52:04.979Z","model":"fill-slots","action":"claim","prompt":"","input":"ara-290-herniated-disc c46","response":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","tokens_in":0,"tokens_out":0,"cost":0,"prev":"30bbee1e0bc41cf2685ffd0b3fd5ed492701eb86815a349f26ab13aad0e9f45c","hash":"4eac2936fb478ce9fbbbb7be8710238633be050bd625b20b465747e9fa207416"},{"ts":"2026-07-17T02:38:13.022Z","model":"owner","action":"voxel_divide","prompt":"","input":"ara-290-herniated-disc","response":"24 DIVs from body (verbatim, roundtrip-checked)","tokens_in":0,"tokens_out":0,"cost":0,"prev":"4eac2936fb478ce9fbbbb7be8710238633be050bd625b20b465747e9fa207416","hash":"c30025929fee8756e6c7a2037b6735929a748c1bbad3979b0edd82e3d4cef8ed"}]}