{"slug":"ara-290-herniated-disc","verification":{"valid":true,"entries":17,"head":"34a330ebb8e92bb1fa0e01e28580e0be0e0b10d170e27218d2ef4eb1a1959aa7"},"count":17,"models":["grok/grok-4.3","grok-4.3","system/audit-repair","kimi/moonshot-v1-8k","gemini/gemini-2.5-flash","fill-slots"],"yield":{"passes":17,"energy_spent_rows":0,"total_cost_usd":0.011305,"waste_cost_usd":0,"total_tokens":16552,"material_outputs":7,"usd_per_output":0.001615,"models":[{"model":"kimi/moonshot-v1-8k","passes":2,"cost_usd":0.000934,"tokens_total":6227,"outputs":4,"waste_passes":0,"usd_per_output":0.000234},{"model":"gemini/gemini-2.5-flash","passes":1,"cost_usd":0.000331,"tokens_total":3197,"outputs":3,"waste_passes":0,"usd_per_output":0.00011},{"model":"grok-4.3","passes":6,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"system/audit-repair","passes":4,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"fill-slots","passes":2,"cost_usd":0,"tokens_total":0,"outputs":0,"waste_passes":0,"usd_per_output":null},{"model":"grok/grok-4.3","passes":2,"cost_usd":0.01004,"tokens_total":7128,"outputs":0,"waste_passes":0,"usd_per_output":null}],"constraints":{"constitution":"/api/articles/constitution","collaborate_schema":"POST /api/protocol/collaborate","pricing_ppm":{"grok-4.3":[1.25,2.5],"grok/grok-4.3":[1.25,2.5],"grok-build-0.1":[1,2],"kimi/moonshot-v1-8k":[0.15,0.15],"gemini/gemini-2.5-flash":[0.075,0.3],"gemini/gemini-2.0-flash-lite":[0.075,0.3],"openai/gpt-4o":[2.5,10],"openai/gpt-4o-mini":[0.15,0.6],"system/reflex":[0,0],"ingest:deterministic":[0,0],"fill-slots":[0,0]}}},"contributions":[{"seq":0,"id":"k1","ts":"2026-06-29T08:50:08.816Z","model":"grok/grok-4.3","role":"writer","action":"redraft","payload":{"title":"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data","register":"source_ledger","body":"## Background on Herniated Discs and Nerve Involvement\nHerniated discs can compress spinal nerves, leading to radiculopathy with pain, sensory changes, and potential nerve damage. Standard approaches focus on pain masking or mechanical decompression; repair of damaged nerves is not addressed by these methods.\n\n## ARA-290 Mechanism\nARA-290 is a synthetic 11-amino acid peptide derived from erythropoietin that selectively activates the innate repair receptor (IRR). This activation is described as reprogramming proinflammatory states toward tissue repair and nerve fiber regrowth in preclinical models (mechanistic tier).\n\n## Human Clinical Trial Data\nPhase 2 randomized, double-blind, placebo-controlled trials in patients with sarcoidosis-associated small fiber neuropathy (n=22) and type 2 diabetes with painful neuropathy (n=48-61) showed reductions in neuropathic symptoms and, in some cases, increased corneal nerve fiber density via confocal microscopy after 28 days of subcutaneous 4 mg daily dosing. No significant adverse effects were reported in these studies (human tier). No human trials have examined ARA-290 in herniated disc or radiculopathy populations (no human data).\n\n## Preclinical Evidence\nAnimal and cell studies demonstrate ARA-290 reduces allodynia, suppresses spinal microglia, and promotes nerve fiber regeneration in neuropathy models (preclinical tier).\n\n## User Reports\nAnecdotal reports on forums mention use of ARA-290 alongside other peptides for sciatica or post-surgical nerve pain from lumbar disc issues, with variable self-reported improvements in pain and function (anecdotal tier).\n\n## Evidence Gaps\nDirect data linking ARA-290 to outcomes in herniated disc nerve compression are absent. All human trials to date involve small fiber neuropathy in sarcoidosis or diabetes contexts.","claims":[{"id":"c1","text":"ARA-290 activates the innate repair receptor to promote tissue repair and nerve fiber regrowth.","section":"ARA-290 Mechanism","tier":"mechanistic","source_ids":["s1"],"source_status":"sourced","why_material":"Foundational mechanism for any repair framing.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c2","text":"Phase 2 human trials in sarcoidosis SFN and diabetic neuropathy showed symptom reduction and corneal nerve fiber density increases.","section":"Human Clinical Trial Data","tier":"human","source_ids":["s2","s3"],"source_status":"sourced","why_material":"Only human evidence base available.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c3","text":"No human trials exist for ARA-290 in herniated discs or radiculopathy.","section":"Evidence Gaps","tier":"human","source_ids":[],"source_status":"unsourced","why_material":"Plain statement of data absence.","evidence_basis":"derived_inference","weight":0.8,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c4","text":"Preclinical models show reduced allodynia and nerve regeneration with ARA-290.","section":"Preclinical Evidence","tier":"preclinical","source_ids":["s4"],"source_status":"sourced","why_material":"Separates animal data from human.","evidence_basis":"derived_inference","weight":0.5,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}},{"id":"c5","text":"Anecdotal user reports describe ARA-290 use for sciatica from disc herniation with mixed self-reported outcomes.","section":"User Reports","tier":"anecdotal","source_ids":["s5"],"source_status":"sourced","why_material":"Distinguishes user reports.","evidence_basis":"derived_inference","weight":0.3,"status":"active","stance_scores":{"neutral":0,"pro":0,"adversary":0},"extra":{}}],"sources":[{"id":"s1","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"These experimental and clinical studies show that ARA290 effectively reprograms a proinflammatory, tissue-damaging milieu into one of healing and tissue repair.","link_status":"ok","quote_status":"verified"},{"id":"s2","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3563705/","title":"Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy","quote":"ARA 290 appears to be safe in patients with sarcoidosis and can reduce neuropathic symptoms.","link_status":"ok","quote_status":"verified"},{"id":"s3","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290... Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes","quote":"Neuropathic symptoms as assessed by the PainDetect questionnaire improved significantly in the ARA 290 group. ... subjects with a mean CNFD >1 standard deviation from normal showed a significant increase in CNFD","link_status":"ok","quote_status":"unverified"},{"id":"s4","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/24529189/","title":"ARA 290, a peptide derived from the tertiary structure of erythropoietin, reduces allodynia...","quote":"The erythropoietin-analogue ARA290 dose-dependently reduced allodynia coupled to suppression of the spinal microglia response.","link_status":"ok","quote_status":"unverified"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/v44s3q/effectiveness_of_ara290my_assessment/","title":"Effectiveness of ARA-290...My Assessment","quote":"Have sciatica bad from l5 s1 … this with BPC , tb and kpv is working. I feel almost normal.","link_status":"ok","quote_status":"unverified"}]},"rationale":"","tokens_in":0,"tokens_out":0,"prev_hash":"genesis","hash":"eb665ee7f8100d9305265ea27a82d8bb81ea0811692f32c93c2d33d7f29b5718"},{"seq":1,"id":"k2","ts":"2026-06-29T10:28:21.710Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290","quote":"I had a disc herniation 3 years ago. L4/L5 and l5/S1 and have had sciatica on and off from it. ... It definitely helped with pain . We took it for three weeks . And the pain is slowly coming . I've read 90 days is when you can get the healing .","link_status":"ok","quote_status":"unverified"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1srvqv4/thoughts_on_ara290/","title":"Thoughts on ara-290","quote":"Absolutely helps with sciatica, both myself and other people I know that have tried it. 4mg daily is the dose used in all the clinical ...","link_status":"ok","quote_status":"unverified"},{"id":"s8","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1hlaw2f/nerve_damage_but_zero_pain_herniated_disk_in_c6/","title":"Nerve damage but zero pain, herniated disk in c6","quote":"ARA-290 helps with neuropathy so there's a chance it could help other nerve damage. It's not the priciest peptide out there so IMO it's ...","link_status":"ok","quote_status":"unverified"},{"id":"s9","type":"youtube","url":"https://www.youtube.com/watch?v=4uMK9qbrR7U","title":"Could peptides help low back pain and disc injuries?","quote":"I’ve started taking my own healing peptide stack, and I feel that I am definitely improving. TB500, BOC175,GHKcu,ARA290 and I have been using a tens unit for therapy.","link_status":"http_429","quote_status":"unverified"},{"id":"s10","type":"medical","url":"https://bamapain.com/sciatica/","title":"Leg Pain & Sciatica Treatment Birmingham AL","quote":"A patient presenting with leg pain may have lumbar radiculopathy from a herniated disc... Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","link_status":"ok","quote_status":"unverified"},{"id":"s11","type":"other","url":"https://peptidefox.com/content/injury-recovery-peptide-protocol","title":"Peptides for Injury Recovery: Building the Right Stack","quote":"For neuropathic pain from nerve compression, the protocol adds ARA-290 . ... For disc degeneration, the protocol layers in VIP ... For nerve pain from compression, the protocol adds ARA-290 .","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"prev_hash":"eb665ee7f8100d9305265ea27a82d8bb81ea0811692f32c93c2d33d7f29b5718","hash":"2188a482163898357212c87dc3869924ea58e8f16843d7fa59a4bd50de9357f8"},{"seq":2,"id":"k3","ts":"2026-06-29T10:28:41.451Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s12","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome to promote repair and regeneration after sciatic nerve injury","quote":"EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","link_status":"ok","quote_status":"verified"},{"id":"s13","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain","quote":"I’ve been dealing with pretty annoying nerve pain from a herniated disc at C6–C7... I’ve started ARA-290 and I’m planning to run a 28-day cycle to see if it helps with my neuropathic pain.","link_status":"ok","quote_status":"unverified"},{"id":"s14","type":"reddit","url":"https://www.reddit.com/r/Peptides/comments/1krtzg2/peptide_therapy_for_sciatica_np1_bpc157_or_other/","title":"Peptide Therapy for Sciatica – NP-1, BPC-157, or Other","quote":"a herniated disk tho. My sciatica is caused by a herniated disk as well, ARA - 290 peptide For neuropathic pain relief, the dose is 1.32 mg per ...","link_status":"ok","quote_status":"unverified"},{"id":"s15","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1iewcrf/peptide_stack_for_herniated_discspinal_stenosis/","title":"Peptide stack for herniated disc/spinal stenosis","quote":"Herniated discs often lead to nerve damage. I'd be proactive and include ARA - 290 in my stack.","link_status":"ok","quote_status":"unverified"},{"id":"s16","type":"medical","url":"https://www.paragonsportsmedicine.com/peptides/ara-290","title":"ARA-290 Peptide | Inflammation & Nerve Support","quote":"Emerging peptide therapeutics including ARA-290 (cibinetide), which has demonstrated nerve fiber regeneration in Phase II clinical trials for small fiber neuropathy, offer potential for domain-targeted intervention.","link_status":"ok","quote_status":"unverified"},{"id":"s17","type":"other","url":"https://alphacarbonlabs.com/blog/peripheral-nerve-regeneration-the-synergistic-potential-of-ara-290-and-bpc-157-in-neuropathic-research","title":"Healing Nerve Damage: ARA-290 and BPC-157","quote":"When a disc bulges in your back and crushes the sciatic nerve, the ... Cibinetide ( ARA 290 ) for the treatment of small fiber neuropathy in ...","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"prev_hash":"2188a482163898357212c87dc3869924ea58e8f16843d7fa59a4bd50de9357f8","hash":"c9c3b425ec9cdf89863ab70c001e7151c83fbc582065f5bea825419871d7d4a1"},{"seq":3,"id":"k4","ts":"2026-06-29T12:48:00.896Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c18","tier":"system","text":"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data is catalogued in this miscsubjects ledger as a tier-honest evidence graph (claims + hash-chained sources). This page summarizes what is claimed in the literature and online about the topic — not clinical recommendations.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"what_it_is","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:00.896Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c9c3b425ec9cdf89863ab70c001e7151c83fbc582065f5bea825419871d7d4a1","hash":"94d3a114b3ab321e979522a28de6cc894b4c393bb44e7b81b994e40cde8d9118"},{"seq":4,"id":"k5","ts":"2026-06-29T12:48:00.931Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c19","tier":"preclinical","text":"Per this ledger on ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data: 7 scientific and 8 anecdotal sources are catalogued; 3 preclinical claim(s) summarize animal/cell literature in-catalogue.","who_claims":"miscsubjects ledger synthesis","source_ids":[],"slot":"what_is_known","posted_by":{"actor":"miscsubjects ledger synthesis","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:00.931Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"94d3a114b3ab321e979522a28de6cc894b4c393bb44e7b81b994e40cde8d9118","hash":"c6514efc8be1c718618e0c8c57ba2fa7a6420db08e1a10796d78283bcf5030f4"},{"seq":5,"id":"k6","ts":"2026-06-29T12:48:00.966Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c20","tier":"mechanistic","text":"Hash-chained sources verify integrity, not clinical truth. Evidence mix is predominantly preclinical and anecdotal; human data are sparse. No dosing, protocol, or treatment recommendations — catalogue only.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"limitations","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:00.966Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"c6514efc8be1c718618e0c8c57ba2fa7a6420db08e1a10796d78283bcf5030f4","hash":"47fcad37e18e2d0491e3d491677c377967ab0b8a2f7fa654f1155877a548af19"},{"seq":6,"id":"k7","ts":"2026-06-29T12:48:01.005Z","model":"system/audit-repair","role":"claim_post","action":"claim","payload":{"claim_id":"c21","tier":"human","text":"Not medical advice. Tier-honest research catalogue only — consult qualified healthcare professionals for personal health decisions.","who_claims":"miscsubjects protocol","source_ids":[],"slot":"disclaimer","posted_by":{"actor":"miscsubjects protocol","channel":"protocol/fill-slots","ts":"2026-06-29T12:48:01.005Z","model":"system/audit-repair","rationale":""}},"rationale":"","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"47fcad37e18e2d0491e3d491677c377967ab0b8a2f7fa654f1155877a548af19","hash":"8d33305fa87b84706680f6b4f03281628343142796c53e39b1a8ed7820d6b3b4"},{"seq":7,"id":"k8","ts":"2026-06-29T12:57:09.230Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c22","c23"],"challenge_id":null,"rationale":"As collaborator #1 on the miscsubjects peptide evidence ledger, I am adding explicit gaps regarding what is unknown about ARA-290's efficacy in treating herniated discs, as well as naming who claims what from anecdotes that were not explicitly attributed."},"rationale":"As collaborator #1 on the miscsubjects peptide evidence ledger, I am adding explicit gaps regarding what is unknown about ARA-290's efficacy in treating herniated discs, as well as naming who claims what from anecdotes that were not explicitly attributed.","tokens_in":2758,"tokens_out":371,"cost":0.00046934999999999994,"prev_hash":"8d33305fa87b84706680f6b4f03281628343142796c53e39b1a8ed7820d6b3b4","hash":"34d6c5f33e157cb30945b7c2e31c0660477c691e003b0ba0dcaab97553d46c04"},{"seq":8,"id":"k9","ts":"2026-06-29T12:58:04.660Z","model":"kimi/moonshot-v1-8k","role":"collaborator","action":"collaborate","payload":{"claims_added":["c24","c25"],"challenge_id":null,"rationale":"As Kimi, I am adding explicit claims about what is unknown and who claims what from anecdotes that are missing in the ledger. I am not Grok because my role is to provide additional information that fills gaps in the ledger, not to invent new claims or sources."},"rationale":"As Kimi, I am adding explicit claims about what is unknown and who claims what from anecdotes that are missing in the ledger. I am not Grok because my role is to provide additional information that fills gaps in the ledger, not to invent new claims or sources.","tokens_in":2758,"tokens_out":340,"cost":0.00046469999999999997,"prev_hash":"34d6c5f33e157cb30945b7c2e31c0660477c691e003b0ba0dcaab97553d46c04","hash":"66746fd3b6a299757657214219204210c70fd5c3f43306bb4bb0f3a070f35c2c"},{"seq":9,"id":"k10","ts":"2026-06-29T14:22:54.857Z","model":"gemini/gemini-2.5-flash","role":"collaborator","action":"collaborate","payload":{"claims_added":["c26","c27"],"challenge_id":"c28","rationale":"As Gemini, I've added two new claims to address gaps in mechanistic understanding and the presence of ARA-290 in general medical discourse, using available sources. I also challenged a claim where the assigned tier did not match the described evidence type, ensuring tier-honest reporting."},"rationale":"As Gemini, I've added two new claims to address gaps in mechanistic understanding and the presence of ARA-290 in general medical discourse, using available sources. 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Have had 2 microdiscectomies in the past, reinjured approx 8 weeks ago doing standing overhead barbell press, crippling sciatica, 5-10 degrees straight leg raise, pain and limp when walking. ... As a last ditch attempt before cortisone and surgery I stopped Monic and started 2mg ARA-290 with maybe some small improvements over the first 3 days. I decided to run 8mg of ara290 and the next morning instantly felt 10-15 percent better. Across the next 10 days at 8mg I could see a significant improvement every day. ... Between day 3 and day 10 my straight leg raise went from 20 degrees to 50 degrees, I trained a very light leg session for the first time in weeks and spent the whole day moving apartments with only minor irritation. ... I dropped the dose back to 5mg after 20 days and after a further 10 days the numbness has completely gone from my foot. It’s been absolutely life changing.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 1","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"3736c6a0fe7d69fa6cabb09788757a7a7b5616d25c1d8fde05f4debf7301201f","hash":"38bb94ce3aa3cbcccb6bb26ee23eeab29bc587834d30a30ba374752eaea4b031"},{"seq":12,"id":"k13","ts":"2026-06-29T15:50:53.877Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s19","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/ixvi43/what_are_all_the_things_you_use_or_do_to_reduce/","title":"What are all the things you use or do to reduce sciatica pain.","quote":"Peptides and nootropics. I’m currently using these peptides: ARA-290, BPC-157, and TB-500. ... The pain is almost completely gone now.","link_status":"ok","quote_status":"unverified"},{"id":"s20","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/zy6z6u/ara_290_14_days_in_no_relief/","title":"ARA 290 14 days in, no relief.","quote":"14 days into ARA 290 and zero relief. Losing my mind in pain. Home bound/bed bound for years now.","link_status":"ok","quote_status":"unverified"},{"id":"s21","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tncdyo/ara290_peptide_and_rebuilder_2407_have_changed_my/","title":"ARA290 peptide AND Rebuilder 2407 have changed my life!","quote":"I too developed severe sciatica post Covid which evolved to painful neuropathy. ... Your story has given me the final push to try it.","link_status":"ok","quote_status":"unverified"},{"id":"s22","type":"reddit","url":"https://www.reddit.com/r/smallfiberneuropathy/comments/1ce0ub5/do_i_have_sfn_ara290_helped/","title":"Do I have SFN? ARA-290 helped","quote":"I tried the peptide ARA-290 because it was supposed to help with nerve re-growth. It was amazing! Feeling started to come back, and I was surprised by how aware I was of temperature too ... Since then (I ran out -- it was $90 for four days of ARA-290), the symptoms returned quickly.","link_status":"ok","quote_status":"unverified"}]},"rationale":"auto-populate round 2","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"38bb94ce3aa3cbcccb6bb26ee23eeab29bc587834d30a30ba374752eaea4b031","hash":"bce788e3b3ea9724b550210c720ddd9cd9ea3e1e0316b2065aee3c80c84e53bf"},{"seq":13,"id":"k14","ts":"2026-06-29T15:51:25.504Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s23","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","quote":"The boundaries of my nerve damage have shrunk several inches! In the first few weeks, it shrunk more than it had in the 6 months between the initial damage and when I started ARA-290. ... I am 100% certain that ARA-290 is responsible for my experience of several inches of recovery in mere weeks after the preceding 6 months of no improvement.","link_status":"ok","quote_status":"unverified"},{"id":"s24","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"I took 4 units daily for 8 weeks, didn't do anything for my neuropathy!","link_status":"ok","quote_status":"unverified"},{"id":"s25","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1uavvbs/ara290_whats_your_experience/","title":"ARA-290, whats your experience?","quote":"Same 4mg/day for 60 days no effect on my 10 yr idiopathic peripheral neuropathy","link_status":"ok","quote_status":"unverified"},{"id":"s26","type":"reddit","url":"https://www.reddit.com/r/Sciatica/comments/1sgygwx/please_help_chronic_pain_for_months/","title":"Please help chronic pain for months","quote":"I have sciatica from a herniated disc, I’ve been documenting my progress with ARA 290 on tik tok and believe it has helped but not solved my issues completely. May be worth a shot!","link_status":"ok","quote_status":"unverified"},{"id":"s27","type":"x","url":"https://x.com/RickWingfield5/status/2070209027057864822","title":"X post on ARA-290 for fused discs","quote":"Back surgery 20 years ago Fused disc's and doing great with the ARA 290.","link_status":"ok","quote_status":"unverified"},{"id":"s28","type":"x","url":"https://x.com/TheFXWarrior/status/2066480146329076108","title":"X post on peptides for herniated disc","quote":"I found them ineffective for herniated disc but Cartlax and ARA-290 did great and right away.","link_status":"ok","quote_status":"verified"}]},"rationale":"auto-populate round 3","tokens_in":0,"tokens_out":0,"cost":0,"prev_hash":"bce788e3b3ea9724b550210c720ddd9cd9ea3e1e0316b2065aee3c80c84e53bf","hash":"8f313eca808e0f81bcb3fb3781a29c7257c3fb1b5a01ac46aaa543406754c198"},{"seq":14,"id":"k15","ts":"2026-06-29T15:52:30.732Z","model":"grok-4.3","role":"source_hunt","action":"sources","payload":{"added":[{"id":"s29","type":"reddit","url":"https://www.reddit.com/r/saferpeptides/comments/1qiagy8/ara_290_canada_warehouse/","title":"ARA 290 Canada Warehouse","quote":"Didn't do anything for me at 4mg/day for 35 days. I did it for neuropathy and have some messed up discs too.","link_status":"ok","quote_status":"unverified"},{"id":"s30","type":"reddit","url":"https://www.reddit.com/r/BioHackingGuide/comments/1u6zfcg/ara290_for_sciatica_and_nerve_pain_can_this/","title":"ARA-290 for Sciatica and Nerve Pain — Can This Peptide ...","quote":"Studies show ARA-290 promotes nerve repair instead of just blocking pain","link_status":"ok","quote_status":"unverified"},{"id":"s31","type":"anecdotal","url":"https://www.tiktok.com/@hackiebackup/video/7643927944624082190","title":"ARA 290 Results: Why this peptide surprised me","quote":"There is no way this stuff works this good. ... after one dose, I'm feeling the effects. ... 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