{"slug":"ara-290-carpal-tunnel","verification":{"valid":true,"entries":10,"head":"3e42ffedd1ae08a2e99077e8f89c052376d22c711f3674a4c70020126cfb33ef"},"count":10,"sources":[{"id":"s1","type":"pubmed","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4365069/","title":"ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes","quote":"Neuropathic symptoms as assessed by the PainDetect questionnaire improved significantly in the ARA 290 group... In this group, a linear relationship existed between the observed change in CNFD and the change in symptoms... mean change in of +2.6 ± 1.0 fibers/mm² for ARA 290 (n = 18; p = 0.02)","summary":"Phase 2 RCT: 4 mg SC daily ×28 d improved symptoms and CNFD in diabetic neuropathy subgroup.","claim_ids":["c1","c2","c17","c20","c23","c24"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:54:05.451Z","link_status":"ok","quote_status":"unverified","prev":"genesis","hash":"e64b5c5b9b99fedac01e106e9d8ffbcbfe2ce99bb6731ad21bdec8ded6bd7d02","source_role":"cycle_background"},{"id":"s2","type":"review","url":"https://journals.lww.com/painrpts/fulltext/2016/08000/targeting_the_innate_repair_receptor_to_treat.2.aspx","title":"Targeting the innate repair receptor to treat neuropathy","quote":"Swartjes and colleagues... showed that ARA-290 produced long-lasting relief of neuropathic pain in rats","summary":"Reviews preclinical rat data on neuropathic pain relief.","claim_ids":["c4","c23"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T08:54:05.451Z","link_status":"ok","quote_status":"unverified","prev":"e64b5c5b9b99fedac01e106e9d8ffbcbfe2ce99bb6731ad21bdec8ded6bd7d02","hash":"87b2b0e93471913b76c356312f02e7fc53bbcd538645f23089f7fba577b2f3ba","source_role":"mechanism_support"},{"id":"s3","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","quote":"I also have tarsal tunnel syndrome, which is the ankle version of carpal tunnel syndrome; my tibial nerve is entrapped in scar tissue from a surgery. Because that nerve pain is caused by mechanical compression, I don't expect the peptide to help (and so far it has not).","summary":"User reports no benefit for tarsal tunnel (compression neuropathy analogous to carpal tunnel) but positive axonal repair in another nerve injury after 2 months at 5mg/day.","author":"","publisher":"","date":"","claim_ids":["c5","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:01:19.346Z","link_status":"ok","quote_status":"unverified","prev":"87b2b0e93471913b76c356312f02e7fc53bbcd538645f23089f7fba577b2f3ba","hash":"8a505d8fb61a169cd1265a1b51d2b90dc92e539fd2a208f1e89a412f3021374b","source_role":"anecdotal_report"},{"id":"s4","type":"reddit","url":"https://www.reddit.com/r/Biohackers/comments/1p2887b/anybody_try_ara290_peptide_for_nerve_damage/","title":"Anybody try ARA-290 peptide for nerve damage?","quote":"The boundaries of my nerve damage have shrunk several inches! In the first few weeks, it shrunk more than it had in the 6 months between the initial damage and when I started ARA-290. ... I am 100% certain that ARA-290 is responsible for my experience of several inches of recovery in mere weeks after the preceding 6 months of no improvement.","summary":"Positive user experience repairing axonal nerve damage with ARA-290; notes it did not help compression-related tarsal tunnel pain.","author":"","publisher":"","date":"","claim_ids":["c6","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:01:19.346Z","link_status":"ok","quote_status":"unverified","prev":"8a505d8fb61a169cd1265a1b51d2b90dc92e539fd2a208f1e89a412f3021374b","hash":"c357ecd533dfadcd98944b895bf7890cd83a5e4eaa9be966212ebfeed01ec109","source_role":"adjacent_context"},{"id":"s5","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1o33123/peptide_ara290/","title":"Peptide ARA-290 : r/neuropathy","quote":"I titrated up 0.5 mg, 1 mg, 2 mg, 3 mg and finally 4 mg. At 3 and 4 milligrams I experienced painful pins and needles in my heels so I had to stop. ... I began last week at .5 mg, then 1, then 2, then 3 and finally 4 mg. I tittered slowly up due to my Sjogren's disease. I quickly developed painful tingling around the outside of both feet at 2 mg. Those last 3 days were very painful. ... I tried ARA290 last October and had to quit after 6 days.","summary":"Multiple users report bad outcomes with ARA-290 causing painful nerve flares/pins and needles, leading them to stop treatment early despite trying titration for neuropathy (one mentions autoimmune-related sensitivity).","author":"","publisher":"","date":"","claim_ids":["c7","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:06:47.277Z","link_status":"ok","quote_status":"unverified","prev":"c357ecd533dfadcd98944b895bf7890cd83a5e4eaa9be966212ebfeed01ec109","hash":"d98046bdd43416e6a32b464a52272f868abfaced64e9c9f8682caee95eb22451","source_role":"adjacent_context"},{"id":"s6","type":"reddit","url":"https://www.reddit.com/r/neuropathy/comments/1tvw5x6/ara290_disc_herniaton_nerve_pain/","title":"ARA-290 Disc Herniaton & Nerve Pain : r/neuropathy","quote":"Periphial neuropathy in hands/shoulder (emg showed carpal tunnel and medial nerve damage) feet and legs to lower back (3 fusions, lt knee replacement, rt hip replacement and waiting on rt knee replacement).","summary":"User with confirmed carpal tunnel (via EMG) and other neuropathy planning 28+ day ARA-290 cycle at 3-6mg/day for nerve pain, no outcome reported yet but notes interest in honest results.","author":"","publisher":"","date":"","claim_ids":["c8","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:06:47.277Z","link_status":"ok","quote_status":"unverified","prev":"d98046bdd43416e6a32b464a52272f868abfaced64e9c9f8682caee95eb22451","hash":"cc7b287dc3194fd4866501bc3f106fdfaace54e007b68412565b6243e9fceced","source_role":"anecdotal_report"},{"id":"s7","type":"reddit","url":"https://www.reddit.com/r/tinnitus/comments/1papfky/anyone_try_ara290_peptide_for_this_tinnitus/","title":"Anyone try ARA290 peptide for this tinnitus? : r/tinnitus","quote":"It's a nerve healing peptide known to regenerate nerves like sciatica and carpal tunnel syndrome ...","summary":"Post discusses ARA-290 as potential for nerve regeneration including carpal tunnel syndrome, seeking user experiences (no detailed personal outcomes in snippet).","author":"","publisher":"","date":"","claim_ids":["c9","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:06:47.277Z","link_status":"ok","quote_status":"unverified","prev":"cc7b287dc3194fd4866501bc3f106fdfaace54e007b68412565b6243e9fceced","hash":"dfdaa03558fae0ebcc13882a123105d15751665f1ed1c7652227a9280f4cc50d","source_role":"anecdotal_report"},{"id":"s8","type":"x","url":"https://x.com/I_Research_Pept/status/2064434147792470183","title":"X post by @I_Research_Pept","quote":"Has anyone out there tried ARA-290? If so, what were you treating and what were the results? I never hear about this peptide, but want to try it for carpal tunnel. I purchased 7 vials from a vendor, but unfortunately, they were bad (floating clouds) and I have not repurchased yet","summary":"User seeking experiences with ARA-290 specifically for carpal tunnel; reports bad batch purchased but no treatment outcome yet.","author":"","publisher":"","date":"","claim_ids":["c10","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:06:47.277Z","link_status":"ok","quote_status":"verified","prev":"dfdaa03558fae0ebcc13882a123105d15751665f1ed1c7652227a9280f4cc50d","hash":"b79271af5579e5690d6874caab23b25408e9da5d2fcd131bfcfd6818ff6463b6","source_role":"anecdotal_report"},{"id":"s9","type":"x","url":"https://x.com/SEpilogueG/status/2049848962459513117","title":"X post by @SEpilogueG","quote":"Where do I buy these, specifically ARA-290? I have severe work induced carpal tunnel.","summary":"User with severe work-induced carpal tunnel inquiring about purchasing ARA-290 (no outcome reported).","author":"","publisher":"","date":"","claim_ids":["c11","c18","c21"],"found_by":"grok/grok-4.3","extra":{},"accessed_at":"2026-06-29T12:06:47.277Z","link_status":"ok","quote_status":"verified","prev":"b79271af5579e5690d6874caab23b25408e9da5d2fcd131bfcfd6818ff6463b6","hash":"4d9806b7585764894cedc926f466840b95bdd22f2bd2d2f99a843e1848bbb018","source_role":"anecdotal_report"},{"id":"s10","type":"pubmed","url":"https://pubmed.ncbi.nlm.nih.gov/40216181/","title":"ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in schwann cells after sciatic nerve injury","quote":"EPO and ARA290 promote repair and regeneration by inhibiting the activation of NLRP3 inflammasome after sciatic nerve injury.","summary":"2025 preclinical study showing ARA290 (cibinetide) inhibits NLRP3 inflammasome in Schwann cells post-sciatic nerve crush injury in rats, promoting nerve repair and regeneration via reduced inflammation and ROS.","author":"","publisher":"","date":"","claim_ids":["c27"],"found_by":"grok-4.3","extra":{},"accessed_at":"2026-06-29T21:28:20.028Z","link_status":"ok","quote_status":"verified","prev":"4d9806b7585764894cedc926f466840b95bdd22f2bd2d2f99a843e1848bbb018","hash":"3e42ffedd1ae08a2e99077e8f89c052376d22c711f3674a4c70020126cfb33ef","source_role":"adjacent_context"}]}