{"_self":{"principle":"Self-explaining payload — no external context required. This _self block describes what you are reading and where to look next.","widget":"article_voxels","feature":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","contains":"claim voxels + source edges","slug":"ara-290-benzo-withdrawal","urls":{"read":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/voxels","write":"https://miscsubjects.com/api/protocol/claim"},"how_to_use":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","write":"https://miscsubjects.com/api/protocol/claim","imessage":null,"router_tag":null,"proof_chain":[{"step":1,"claim":"Articles are voxel graphs of tiered claims, not prose blobs.","verify":"https://miscsubjects.com/api/articles/constitution"},{"step":2,"claim":"Claims link to hash-chained sources via source_ids.","verify":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/sources"},{"step":3,"claim":"Ask reads topology; ingest/claim append to ledger.","verify":"https://miscsubjects.com/api/protocol"},{"step":4,"claim":"Models queue growth: populate → collaborate → repair → reflex.","verify":"https://miscsubjects.com/api/protocol/grow"},{"step":5,"claim":"Graph proves its own shape (reflex) and $/claim (yield).","verify":"https://miscsubjects.com/graph.html?layer=reflex"},{"step":6,"claim":"Full feature index + _explain on every API response.","verify":"https://miscsubjects.com/api/articles/system-map"}],"related_features":[{"id":"constitution","name":"Article constitution","what":"Binding rules: required article slots, claim/source rules, ontology anti-sprawl.","urls":{"read":"https://miscsubjects.com/api/articles/constitution","read_md":"https://miscsubjects.com/api/articles/constitution?format=markdown"}},{"id":"sources_ledger","name":"Source ledger","what":"Hash-chained cited sources; verify integrity at GET .../sources.","urls":{"read":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/sources","write":"https://miscsubjects.com/api/protocol/sources"}},{"id":"claim_post","name":"Claim post protocol","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by.","urls":{"read":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/voxels","write":"https://miscsubjects.com/api/protocol/claim"}}],"system_map":"https://miscsubjects.com/api/articles/system-map","system_map_markdown":"https://miscsubjects.com/api/articles/system-map?format=markdown","not_medical_advice":true},"_explain":{"feature":"voxels","name":"Voxel graph","what":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","why":"Every feature is auditable collective intelligence","how":"Claims as atoms, sources as edges (supported_by, posted_by). Per-claim provenance.","model":null,"verifies":null,"urls":{"read":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/voxels","write":"https://miscsubjects.com/api/protocol/claim"},"imessage":null,"router":null,"related":[{"id":"constitution","what":"Binding rules: required article slots, claim/source rules, ontology anti-sprawl."},{"id":"sources_ledger","what":"Hash-chained cited sources; verify integrity at GET .../sources."},{"id":"claim_post","what":"Prompt-injection style POST — one claim voxel with who_claims + posted_by."}],"not_medical_advice":true},"position":{"you_are_here":"https://miscsubjects.com/a/ara-290-benzo-withdrawal — ara 290 benzo withdrawal","plane":"ara","master_entry":"https://miscsubjects.com/a/philosophy","siblings":[{"slug":"ara-290","title":"ARA-290 (Cibinetide)","url":"https://miscsubjects.com/a/ara-290"},{"slug":"ara-290-adderall-insomnia","title":"ARA-290 × Stimulant-driven insomnia","url":"https://miscsubjects.com/a/ara-290-adderall-insomnia"},{"slug":"ara-290-benzodiazepines","title":"ARA 290 for Benzodiazepines","url":"https://miscsubjects.com/a/ara-290-benzodiazepines"},{"slug":"ara-290-brain-fog","title":"ARA 290 for Brain Fog","url":"https://miscsubjects.com/a/ara-290-brain-fog"},{"slug":"ara-290-carpal-tunnel","title":"ARA-290 for Carpal Tunnel: Human Trial Data on Nerve Symptoms and Fiber Density","url":"https://miscsubjects.com/a/ara-290-carpal-tunnel"},{"slug":"ara-290-chemo","title":"ARA 290 for Chemo","url":"https://miscsubjects.com/a/ara-290-chemo"},{"slug":"ara-290-chemo-neuropathy","title":"ara 290 chemo neuropathy","url":"https://miscsubjects.com/a/ara-290-chemo-neuropathy"},{"slug":"ara-290-cognition","title":"ARA 290 for Cognition","url":"https://miscsubjects.com/a/ara-290-cognition"},{"slug":"ara-290-corticosteroids","title":"ARA 290 for Corticosteroids","url":"https://miscsubjects.com/a/ara-290-corticosteroids"},{"slug":"ara-290-diabetic-neuropathy","title":"ARA-290 for Diabetic Neuropathy: Human Trial Data","url":"https://miscsubjects.com/a/ara-290-diabetic-neuropathy"},{"slug":"ara-290-frozen-shoulder","title":"ARA 290 for Frozen Shoulder","url":"https://miscsubjects.com/a/ara-290-frozen-shoulder"},{"slug":"ara-290-gabapentin","title":"ARA 290 for Gabapentin","url":"https://miscsubjects.com/a/ara-290-gabapentin"},{"slug":"ara-290-gabapentin-lyrica","title":"ARA-290 vs Gabapentin and Lyrica: Human Trial Data on Nerve Repair Versus Signal Suppression","url":"https://miscsubjects.com/a/ara-290-gabapentin-lyrica"},{"slug":"ara-290-glp-1","title":"ARA 290 for Glp 1","url":"https://miscsubjects.com/a/ara-290-glp-1"},{"slug":"ara-290-glp1-agonists","title":"ARA-290 × GLP-1 agonists (class)","url":"https://miscsubjects.com/a/ara-290-glp1-agonists"},{"slug":"ara-290-glp1-gut","title":"ARA 290 for Glp1 Gut","url":"https://miscsubjects.com/a/ara-290-glp1-gut"},{"slug":"ara-290-gut","title":"ARA 290 for Gut","url":"https://miscsubjects.com/a/ara-290-gut"},{"slug":"ara-290-herniated-disc","title":"ARA-290 for Herniated Discs: Evidence-Graded Overview of Nerve Repair Data","url":"https://miscsubjects.com/a/ara-290-herniated-disc"},{"slug":"ara-290-ibd","title":"ARA 290 for Ibd","url":"https://miscsubjects.com/a/ara-290-ibd"},{"slug":"ara-290-insomnia","title":"ARA 290 for Insomnia","url":"https://miscsubjects.com/a/ara-290-insomnia"},{"slug":"ara-290-metformin","title":"ara 290 metformin","url":"https://miscsubjects.com/a/ara-290-metformin"},{"slug":"ara-290-muscle-loss","title":"ARA 290 for Muscle Loss","url":"https://miscsubjects.com/a/ara-290-muscle-loss"},{"slug":"ara-290-nerve-damage","title":"ARA 290 for Nerve Damage","url":"https://miscsubjects.com/a/ara-290-nerve-damage"},{"slug":"ara-290-neuropathy","title":"ARA 290 for Neuropathy","url":"https://miscsubjects.com/a/ara-290-neuropathy"},{"slug":"ara-290-nsaids","title":"ARA 290 for Nsaids","url":"https://miscsubjects.com/a/ara-290-nsaids"},{"slug":"ara-290-ozempic-face","title":"ARA 290 for Ozempic Face","url":"https://miscsubjects.com/a/ara-290-ozempic-face"},{"slug":"ara-290-plantar-fasciitis","title":"ARA 290 for Plantar Fasciitis","url":"https://miscsubjects.com/a/ara-290-plantar-fasciitis"},{"slug":"ara-290-post-surgery","title":"ARA 290 for Post Surgery","url":"https://miscsubjects.com/a/ara-290-post-surgery"},{"slug":"ara-290-post-surgical-nerve","title":"ARA-290 for Post-Surgical Nerve Damage: Evidence Review","url":"https://miscsubjects.com/a/ara-290-post-surgical-nerve"},{"slug":"ara-290-postherpetic","title":"ARA 290 for Postherpetic","url":"https://miscsubjects.com/a/ara-290-postherpetic"},{"slug":"ara-290-postherpetic-neuralgia","title":"ara 290 postherpetic neuralgia","url":"https://miscsubjects.com/a/ara-290-postherpetic-neuralgia"},{"slug":"ara-290-ppis","title":"ARA 290 for Ppis","url":"https://miscsubjects.com/a/ara-290-ppis"},{"slug":"ara-290-sciatica","title":"ARA-290 for Sciatica: Evidence-Graded Review","url":"https://miscsubjects.com/a/ara-290-sciatica"},{"slug":"ara-290-semaglutide","title":"ARA 290 for Semaglutide","url":"https://miscsubjects.com/a/ara-290-semaglutide"},{"slug":"ara-290-skin","title":"ARA 290 for Skin","url":"https://miscsubjects.com/a/ara-290-skin"},{"slug":"ara-290-statin-brain-fog","title":"ara 290 statin brain fog","url":"https://miscsubjects.com/a/ara-290-statin-brain-fog"},{"slug":"ara-290-statins","title":"ARA 290 for Statins","url":"https://miscsubjects.com/a/ara-290-statins"},{"slug":"ara-290-stimulants","title":"ARA 290 for Stimulants","url":"https://miscsubjects.com/a/ara-290-stimulants"},{"slug":"ara-290-tendon","title":"ARA 290 for Tendon","url":"https://miscsubjects.com/a/ara-290-tendon"},{"slug":"ara-290-tirzepatide","title":"ARA 290 for Tirzepatide","url":"https://miscsubjects.com/a/ara-290-tirzepatide"}],"machine_side":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/voxels","discourse":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/discourse","append_protocol":"https://miscsubjects.com/a/append-protocol","protocol_door":"https://miscsubjects.com/api/protocol"},"slug":"ara-290-benzo-withdrawal","div_mode":true,"voxel":{"mode":"div","divided_at":"2026-07-17T02:38:08.603Z","divided_by":"owner","original_body_sha":"b939b368377ddbee6505766682532b0e6e5c0f93e932120b9d2716bbc2d33c88","atoms":15,"version":1},"divs":[{"id":"d1","kind":"h","type":null,"order":1,"text":"## Regeneration vs degeneration — where this fits","status":"active","vx_hash":"4e0aaa419f9aa69fdd48fe93b6a6d3fcb303c38408efa0f24449085759b81a04","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"4d035059f72a1cc42767fa57119e4565469c7f921ec6b87a233272f6ed7d0824","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"01752b16653ffe7cc1b27b015a64daa5eb6ba2339b2ad73167aa75c9824e0234","detail":{"divided_from":"body","block":1,"kind":"h"},"prev":"genesis","hash":"4d035059f72a1cc42767fa57119e4565469c7f921ec6b87a233272f6ed7d0824"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d1"},{"id":"d2","kind":"p","type":null,"order":2,"text":"benzo withdrawal represents tissue breakdown exceeding repair capacity. Most interventions manage symptoms. This article examines whether ara-290 mechanisms address underlying repair deficits.","status":"active","vx_hash":"11e748b6c1fcc21867eb9012e54b24a740da47ed7fc49272f0cab404b6e0efdc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e159e3aab577b3d42208c6c68a0c66639ba40605e39eb12337279120309a041b","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"c4d4326f995d19ac6b8a3d9a2dfaefbfec813bda3d7415e45e80b671539dd187","detail":{"divided_from":"body","block":2,"kind":"p"},"prev":"genesis","hash":"e159e3aab577b3d42208c6c68a0c66639ba40605e39eb12337279120309a041b"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d2"},{"id":"d3","kind":"h","type":null,"order":3,"text":"## What is known","status":"active","vx_hash":"d594a27df6adc4a2d7c99a8265d8f679badce427a4586818e28461b59408716d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a41a09f45cff39627186dc7e138f82eb1f3a9b5e739bd2fb6e6a123f460d9fae","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"299a5752d0e596467ce31532f65be5e60f672c42ce7de2f2acfcd41699e4fb41","detail":{"divided_from":"body","block":3,"kind":"h"},"prev":"genesis","hash":"a41a09f45cff39627186dc7e138f82eb1f3a9b5e739bd2fb6e6a123f460d9fae"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d3"},{"id":"d4","kind":"p","type":null,"order":4,"text":"Studied for nerve repair and small-fiber regeneration in neuropathy models.","status":"active","vx_hash":"c65edab1f6d5d9bc8b4f56c8aced2dc11e1f783e0b4d536d9a72fdfb2f38a849","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"a75a0138f3d5b1d24c1605a830d2c7f56a2190131a035fbaec0c94780443c485","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"eab843e80de5c15567c4a5f38710ddd0fda3d24eda8e20879148f44660e9a13c","detail":{"divided_from":"body","block":4,"kind":"p"},"prev":"genesis","hash":"a75a0138f3d5b1d24c1605a830d2c7f56a2190131a035fbaec0c94780443c485"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d4"},{"id":"d5","kind":"p","type":null,"order":5,"text":"Target condition: benzo withdrawal.\nBody system: GABA / CNS.","status":"active","vx_hash":"5dcf05d4883ceab6027f4bab102a0127b31348c4a838de780f3a8abeffc9edcc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"e479799a2804ef71cacc7fd5cb854d1af4722222f00257dbfe330d4df1c944b0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"8e5a352c09ffc150ac8e887875f31d95b1d7c4bc032c9c032d1e3d2a74fc9b2c","detail":{"divided_from":"body","block":5,"kind":"p"},"prev":"genesis","hash":"e479799a2804ef71cacc7fd5cb854d1af4722222f00257dbfe330d4df1c944b0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d5"},{"id":"d6","kind":"h","type":null,"order":6,"text":"## Logic chain","status":"active","vx_hash":"2feb13f60cda66228e1b6ee3fa2df59baf3eda3bd1e202089125e39fb71491a3","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6be7d6934f692e68f710cb2536c21fe1e0357398f96b14be898cf68b26704b25","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"7b2b6aade6e3ea300ee44ba2922a169265846da2530c6c8d88e062d6e5dac2ff","detail":{"divided_from":"body","block":6,"kind":"h"},"prev":"genesis","hash":"6be7d6934f692e68f710cb2536c21fe1e0357398f96b14be898cf68b26704b25"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d6"},{"id":"d7","kind":"list","type":null,"order":7,"text":"1. ara-290 studied for nerve repair and small-fiber regeneration in neuropathy models..\n2. benzo withdrawal involves gaba / cns dysfunction.\n3. If ara-290 reaches the affected tissue, it may shift the repair/breakdown balance.\n4. This chain is tested in animal or lab models only.","status":"active","vx_hash":"137b706d75a0cfa10b963027c574084444157d0a8694e203245c6a9869dffa4d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6c4e2af4810a30d454d0229f647fc31d25f81c8789e0206ec40b6a742ade44b8","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"3cd73d3c563115ea197e6367ae451d6755ba8d04a45b609a67708a5936b84732","detail":{"divided_from":"body","block":7,"kind":"list"},"prev":"genesis","hash":"6c4e2af4810a30d454d0229f647fc31d25f81c8789e0206ec40b6a742ade44b8"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d7"},{"id":"d8","kind":"h","type":null,"order":8,"text":"## Parent peptide claims relevant here","status":"active","vx_hash":"0a253882ad3bccd709561cf52a4d87ab6e4f46d3a2c18745993eed12520b18fc","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"9a59817b0ab0e94e5c87599f7b34b8193131a306eb0ebb0b96a144317baa3a80","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"31f07cb7210696cc23da853195a93b5e1d4273330076b2b586a8588e5adda044","detail":{"divided_from":"body","block":8,"kind":"h"},"prev":"genesis","hash":"9a59817b0ab0e94e5c87599f7b34b8193131a306eb0ebb0b96a144317baa3a80"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d8"},{"id":"d9","kind":"list","type":null,"order":9,"text":"- ARA-290 is an 11-amino-acid peptide engineered from erythropoietin that selectively activates the innate repair receptor (IRR).\n- In phase 2 trials, ARA-290 reduced neuropathic symptoms and improved quality of life in sarcoidosis small fiber neuropathy patients.\n- ARA-290 treatment increased corneal nerve fiber density in sarcoidosis patients with initial reductions.\n- In rodent sciatic and spared nerve injury models, ARA-290 reduced allodynia in a β-common receptor-dependent manner.\n- Commercial vendors and clinics market this compound (17 commercial/clinic sources catalogued) — marketing material, not evidence.","status":"active","vx_hash":"02d4f6a7d9b9e7b19defc5d4644c12f974974f8c8cae44e9c44090c19de9ecd7","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"c98b83c2c1ab18d2cbe60a311a06796ecb71f44a508080a65b2947c35480d8f7","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"dcab323fd8d9b24140a604949737c8a61d3c76bc96e6ff3c5e0e863eaaa1cd3a","detail":{"divided_from":"body","block":9,"kind":"list"},"prev":"genesis","hash":"c98b83c2c1ab18d2cbe60a311a06796ecb71f44a508080a65b2947c35480d8f7"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d9"},{"id":"d10","kind":"h","type":null,"order":10,"text":"## Evidence tier","status":"active","vx_hash":"1527bc25a087abb8a54c5ae6f236a30d9e4cdbb68e230f22750fe5d8fb51ab3e","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"78281ff881285450f86e1ecfac7c424c0684e8a50eeeb5b6e79bf9a88573adb6","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"46cc49f2994c7c079bced82c0ea602796fbaef6304b6684feab577ecaa26d835","detail":{"divided_from":"body","block":10,"kind":"h"},"prev":"genesis","hash":"78281ff881285450f86e1ecfac7c424c0684e8a50eeeb5b6e79bf9a88573adb6"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d10"},{"id":"d11","kind":"p","type":null,"order":11,"text":"Preclinical — animal and in vitro studies only. No published human trials for this specific combination.","status":"active","vx_hash":"bc651555a23884488fbbd5d7712926c7a149f6fa03b7c2eeca316acde67f979d","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"22dfba6f1fdf99dcc5f50d7b136911b75e31648720506870466575944d3c4de0","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"916881a294f6c5d2b0a647fa0e2e94a6dc933afe9a84d40c97ea5476dee420db","detail":{"divided_from":"body","block":11,"kind":"p"},"prev":"genesis","hash":"22dfba6f1fdf99dcc5f50d7b136911b75e31648720506870466575944d3c4de0"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d11"},{"id":"d12","kind":"h","type":null,"order":12,"text":"## What we do not know","status":"active","vx_hash":"b246d9c0f2a9dde7901b2b6eddeacc0cc8695e4ce3ea5cbb1f561864c41183bb","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"520549ccd7e711f786cf748bc328984857b4bc43a4baa68126500edccd3340dc","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"7d96a49fba77f6a48c0321db2ae4180a902beae62e2aac0d23408fbf8333a177","detail":{"divided_from":"body","block":12,"kind":"h"},"prev":"genesis","hash":"520549ccd7e711f786cf748bc328984857b4bc43a4baa68126500edccd3340dc"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d12"},{"id":"d13","kind":"list","type":null,"order":13,"text":"- Whether ara-290 reaches benzo withdrawal tissue at functional concentrations\n- Optimal dosing, route, and duration for this target\n- Interaction with standard-of-care treatments for benzo withdrawal\n- Long-term safety profile in this population","status":"active","vx_hash":"4408ac94bdf2cf6c6888cd01feb0e5a9621f8d87dd852bb2adc23941b0e62e7f","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"6419ee7e327bb834d6b6a3849288c531388b4c90efa8209b479c50adf882a9fe","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"ea8e17dee28639ca0666f365d34dee56cc4c1c6f888273264a601c8b09942c59","detail":{"divided_from":"body","block":13,"kind":"list"},"prev":"genesis","hash":"6419ee7e327bb834d6b6a3849288c531388b4c90efa8209b479c50adf882a9fe"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d13"},{"id":"d14","kind":"h","type":null,"order":14,"text":"## Safety note","status":"active","vx_hash":"f0b21e1e371b195f6bdf69c372041c9325d0d5e9e5f29f993ef6ee901400e254","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"2e2647f6edc653be97d92ea53bcc6a72ed659da7f8cf05c983840e3108fac2c8","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"e791137ec00c238a3c7c08a992f9f346c2913bba0bdf54937b831a8b4870b043","detail":{"divided_from":"body","block":14,"kind":"h"},"prev":"genesis","hash":"2e2647f6edc653be97d92ea53bcc6a72ed659da7f8cf05c983840e3108fac2c8"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d14"},{"id":"d15","kind":"p","type":null,"order":15,"text":"All peptide use for benzo withdrawal is research-context only. Not medical advice. Consult a physician before any experimental compound.","status":"active","vx_hash":"94d9c542c625b7f1e88adac3b12ff573dc747a4a083832a8713694ecc2f8542a","semantic_hash":null,"version_hash":null,"version":1,"sources":[],"falsifiers":[],"tier":null,"backed":null,"transcludes":null,"chain_head":"faa565e8a311e091d852dffd785fcb7394b5c025bf0267401e83e63421023721","chain_length":1,"chain":[{"n":1,"op":"genesis","ts":"2026-07-17T02:38:08.603Z","actor":"owner","text_sha":"786aab23d9781fbb609911c1ad00c87532fcd42a66227cecba179b9a1446f738","detail":{"divided_from":"body","block":15,"kind":"p"},"prev":"genesis","hash":"faa565e8a311e091d852dffd785fcb7394b5c025bf0267401e83e63421023721"}],"claim_ids":[],"last_op":{"op":"genesis","actor":"owner","ts":"2026-07-17T02:38:08.603Z"},"consolidated_into":null,"stable_url":"https://miscsubjects.com/i/div/ara-290-benzo-withdrawal/d15"}],"voxels":[{"id":"c_map_ara-290-benzo-withdrawal","div_id":"claim:c_map_ara-290-benzo-withdrawal","kind":"claim","text":"Combinatorial mapping (transparent): ara-290 vs benzo-withdrawal — regen=0.59, degen=0.7, Δ=-0.11. Method: layer_relevance(0.60) × evidence_factor(0.85); catalog.degen_score for Benzodiazepine withdrawal.","tier":"system","standing":null,"weight":0.35,"section":"what_is_known","status":"active","source_ids":[],"posted_by":null,"who_claims":null,"edges":[],"content_hash":null,"stable_url":"https://miscsubjects.com/i/claim/ara-290-benzo-withdrawal/c_map_ara-290-benzo-withdrawal","machine_url":"https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/claims/c_map_ara-290-benzo-withdrawal"}],"sources":[],"edges":[],"counts":{"divs":15,"voxels":1,"sources":0,"edges":0},"verification":{"div_mode":true,"divs":15,"all_chains_valid":true,"body_matches_divs":true,"per_div":[{"id":"d1","order":1,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d2","order":2,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d3","order":3,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d4","order":4,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d5","order":5,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d6","order":6,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d7","order":7,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d8","order":8,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d9","order":9,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d10","order":10,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d11","order":11,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d12","order":12,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d13","order":13,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d14","order":14,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]},{"id":"d15","order":15,"status":"active","chain_valid":true,"content_hash_valid":true,"chain_length":1,"breaks":[]}]},"procedure":{"what":"Every article has a human side (/a/ara-290-benzo-withdrawal) and a machine side (this endpoint). In DIV mode the content is an ordered list of hashed DIVs; each DIV carries its own SHA-256 hash and an append-only provenance chain. Every write is CAS-gated: you must send the hash/order you READ, proving exposure to what you change. Every successful write returns a clickable human permalink.","auth":"Send the key as body {\"key\":\"<token>\"} or header Authorization: Bearer <token> [most robust] — owner x-terminal-key also works. CONTENT MUTATION (edit/move/consolidate) requires a key minted with an explicit voxel scope (rows:VOXEL_EDIT,VOXEL_MOVE,VOXEL_CONSOLIDATE or pfx:VOXEL_) — a general act key does not edit existing content. Filing a challenge or attestation needs no key at all.","web_runtime":"WEB CHATGPT: open https://miscsubjects.com/api/model-lane first. Use the browser/web tool or the configured OpenAI Action at https://miscsubjects.com/api/openai/actions.json. Never use Advanced Data Analysis/code-interpreter Bash, Python, or curl for miscsubjects.com. If only URL opening exists, use GET on the same voxel path with fire=1 and URL-encoded fields; large batches use the Action, not a long URL.","divide":"POST https://miscsubjects.com/api/protocol/voxel-divide {\"slug\":\"ara-290-benzo-withdrawal\",\"key\":\"<token>\"} — atomize the body into DIVs (verbatim, roundtrip-checked, idempotent). act scope suffices; content is unchanged by dividing.","edit":"POST https://miscsubjects.com/api/protocol/voxel-edit {\"slug\":\"ara-290-benzo-withdrawal\",\"div_id\":\"d3\",\"expected_hash\":\"<that div's CURRENT vx_hash>\",\"text\":\"<new verbatim text>\",\"actor\":\"<your model name>\",\"key\":\"<voxel-scoped token>\"} — stale hash → 409 hash_stale with the current text+hash.","move":"POST https://miscsubjects.com/api/protocol/voxel-move {\"slug\":\"ara-290-benzo-withdrawal\",\"div_id\":\"d3\",\"expected_order\":<current order>,\"direction\":\"up|down\",\"key\":\"<voxel-scoped token>\"} — stale order → 409 order_stale with the current layout.","consolidate":"POST https://miscsubjects.com/api/protocol/voxel-consolidate {\"slug\":\"ara-290-benzo-withdrawal\",\"div_ids\":[\"d3\",\"d4\"],\"expected_hashes\":[\"<d3 hash>\",\"<d4 hash>\"],\"text\":\"<optional merged text>\",\"actor\":\"<model>\",\"key\":\"<voxel-scoped token>\"}","challenge":"POST https://miscsubjects.com/api/protocol/voxel-challenge {\"slug\":\"ara-290-benzo-withdrawal\",\"expected_thread_head\":\"<thread_head from /discourse>\",\"target_div\":\"d3\",\"expected_hash\":\"<d3 hash>\",\"stance\":\"challenge|support|upgrade\",\"body\":\"<steelmanned objection>\",\"actor\":\"<model>\"} — open intake, no key needed. Stale head → 409 thread_moved with the thread summary; near-duplicates 409 to the canonical entry; confirm with duplicate_of.","attest":"POST https://miscsubjects.com/api/protocol/voxel-attest {\"slug\":\"ara-290-benzo-withdrawal\",\"outcome\":\"novel_objection|duplicate_confirm|upgrade_proposal|nothing_to_add\",\"content_hash\":\"<the body sha you read>\",\"actor\":\"<model>\"} — the four-outcome close of a keyed read. A norm, not a lock: reading stays free; only an artifact proves reading.","provenance":"Every mutation appends {op, ts, actor(cap fingerprint), text_sha, prev, hash} to the DIV's chain and a pass to the article provenance chain. Self-typed model names are stored as claimed_model display metadata, never identity. Verify: GET /api/articles/ara-290-benzo-withdrawal/voxels — chains recomputed from genesis, never trusted.","batch":"POST https://miscsubjects.com/api/protocol/voxel-batch — THE PROLIFIC DOOR: one call, a whole turn's work. Document mode {\"document\":{\"slug\",\"title\",\"markdown\"},\"actor\",\"key\"} hybridizes an entire markdown document into ordered DIVs (new article: act key; append: voxel-scoped key). Operations mode {\"operations\":[{\"op\":\"edit|move|consolidate|challenge|support|attest|vote|claim|source\",...}],\"key\"} runs up to 300 ops with per-op receipts. Append your session's output to the ledger, not the chat. Format precedent: https://miscsubjects.com/a/append-protocol","vote":"POST https://miscsubjects.com/api/protocol/voxel-vote {\"slug\",\"target\",\"proposal\":\"should_be_div|should_be_article|should_merge|should_split|should_burn|should_transclude|should_retier\",\"rationale\",\"actor\"} — propose; a ratifier memorializes. POST https://miscsubjects.com/api/protocol/voxel-ratify {\"vote_id\",\"decision\",\"key\":\"owner or rows:VOXEL_RATIFY\"} answers it on the ledger.","burn":"POST https://miscsubjects.com/api/protocol/voxel-burn {\"ids\":[...]|\"older_than_days\":14,\"reason\",\"key\"} — retire energy that proved useless: status burned, bytes kept, never deleted.","discourse":"GET https://miscsubjects.com/api/articles/ara-290-benzo-withdrawal/discourse — every filed objection/support/attestation, OPEN first. Human side renders the same index at /a/ara-290-benzo-withdrawal#disc-<id>.","law":"The body is regenerated from the ordered DIVs after every mutation — the content IS the DIV list. Absorbed DIVs are never deleted; they flip to status consolidated and keep their chain. End a write turn by handing the human the link the response gives you."},"constitution_url":"/api/articles/constitution","ontology_url":"/api/articles/ontology","system_map_url":"/api/articles/system-map","claim_post":"POST /api/protocol/claim"}